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KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.

Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ.

Am J Pathol. 2019 Aug 9. pii: S0002-9440(19)30659-5. doi: 10.1016/j.ajpath.2019.07.004. [Epub ahead of print]


Minimally invasive approaches to the management of anastomotic leakage following restorative rectal cancer resection.

Creavin B, Ryan ÉJ, Kelly ME, Moynihan A, Redmond CE, Ahern D, Kennelly R, Hanly A, Martin ST, O'Connell PR, Brophy DP, Winter DC.

Colorectal Dis. 2019 Jun 29. doi: 10.1111/codi.14742. [Epub ahead of print]


Meta-analysis of the effect of extending the interval after long-course chemoradiotherapy before surgery in locally advanced rectal cancer.

Ryan ÉJ, O'Sullivan DP, Kelly ME, Syed AZ, Neary PC, O'Connell PR, Kavanagh DO, Winter DC, O'Riordan JM.

Br J Surg. 2019 Sep;106(10):1298-1310. doi: 10.1002/bjs.11220. Epub 2019 Jun 19. Review.


Massive corals maintain a positive carbonate budget of a Maldivian upper reef platform despite major bleaching event.

Ryan EJ, Hanmer K, Kench PS.

Sci Rep. 2019 Apr 24;9(1):6515. doi: 10.1038/s41598-019-42985-2.


Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer.

Climent M, Ryan ÉJ, Stakelum Á, Khaw YL, Creavin B, Lloyd A, Alhassan D, Mohan HM, Kennelly R, Sheahan K, Winter DC.

Int J Colorectal Dis. 2019 Jun;34(6):1069-1078. doi: 10.1007/s00384-019-03274-6. Epub 2019 Apr 16.


DUBLIN (Degree of Ulcerative colitis Burden of Luminal INflammation) score, a simple method to quantify inflammatory burden in Ulcerative Colitis.

Rowan CR, Cullen G, Mulcahy HE, Sheridan J, Moss AC, Ryan EJ, Doherty GA.

J Crohns Colitis. 2019 Mar 26. pii: jjz067. doi: 10.1093/ecco-jcc/jjz067. [Epub ahead of print]


Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme.

McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K.

Gastroenterol Res Pract. 2019 Feb 6;2019:1592306. doi: 10.1155/2019/1592306. eCollection 2019.


The prevalence of venous thromboembolism in rectal surgery: a systematic review and meta-analysis.

Hayes JW, Ryan ÉJ, Boland PA, Creavin B, Kelly ME, Beddy D.

Int J Colorectal Dis. 2019 May;34(5):849-860. doi: 10.1007/s00384-019-03244-y. Epub 2019 Mar 1.


Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo.

Ryan EJ, Ryan AJ, González-Vázquez A, Philippart A, Ciraldo FE, Hobbs C, Nicolosi V, Boccaccini AR, Kearney CJ, O'Brien FJ.

Biomaterials. 2019 Mar;197:405-416. doi: 10.1016/j.biomaterials.2019.01.031. Epub 2019 Jan 23.


Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair-deficient colorectal cancer.

Ryan ÉJ, Creavin B, Khaw YL, Kelly ME, Mohan HM, Geraghty R, Ryan EJ, Kennelly R, Hanly A, Martin ST, Fennelly D, McDermott R, Gibbons D, O'Connell PR, Sheahan K, Winter DC.

BJS Open. 2018 Jul 24;2(6):456-463. doi: 10.1002/bjs5.91. eCollection 2018 Dec.


Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation.

Amodio G, Cichy J, Conde P, Matteoli G, Moreau A, Ochando J, Oral BH, Pekarova M, Ryan EJ, Roth J, Sohrabi Y, Cuturi MC, Gregori S.

Cancer Immunol Immunother. 2019 Apr;68(4):661-672. doi: 10.1007/s00262-018-2264-3. Epub 2018 Oct 24. Review.


Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review.

Fulton JL, Dinas PC, Carrillo AE, Edsall JR, Ryan EJ, Ryan EJ.

Nutrients. 2018 Sep 25;10(10). pii: E1373. doi: 10.3390/nu10101373.


Orphan Nuclear Receptors in Colorectal Cancer.

Kelly ME, Mohan HM, Baird AW, Ryan EJ, Winter DC.

Pathol Oncol Res. 2018 Oct;24(4):815-819. doi: 10.1007/s12253-018-0440-6. Epub 2018 Jun 28. Review.


Subcutaneous rather than intravenous ustekinumab induction is associated with comparable circulating drug levels and early clinical response: a pilot study.

Rowan CR, Keegan D, Byrne K, Cullen G, Mulcahy HE, Sheridan J, Ryan EJ, de Vries A, D'Haens G, Doherty GA.

Aliment Pharmacol Ther. 2018 Aug;48(3):333-339. doi: 10.1111/apt.14834. Epub 2018 Jun 19.


Depleted polymorphonuclear leukocytes in human metastatic liver reflect an altered immune microenvironment associated with recurrent metastasis.

Hand F, Harmon C, Elliott LA, Caiazza F, Lavelle A, Maguire D, Hoti E, Nolan N, Geoghegan JG, Ryan EJ, O'Farrelly C.

Cancer Immunol Immunother. 2018 Jul;67(7):1041-1052. doi: 10.1007/s00262-018-2149-5. Epub 2018 Mar 23.


Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions.

Kavanagh N, Ryan EJ, Widaa A, Sexton G, Fennell J, O'Rourke S, Cahill KC, Kearney CJ, O'Brien FJ, Kerrigan SW.

Clin Microbiol Rev. 2018 Feb 14;31(2). pii: e00084-17. doi: 10.1128/CMR.00084-17. Print 2018 Apr. Review.


Emerging methods in colorectal cancer screening.

Ryan EJ, Creagh EM.

Br J Surg. 2018 Jan;105(2):e16-e18. doi: 10.1002/bjs.10650. No abstract available.


Tumor Budding and PDC Grade Are Stage Independent Predictors of Clinical Outcome in Mismatch Repair Deficient Colorectal Cancer.

Ryan É, Khaw YL, Creavin B, Geraghty R, Ryan EJ, Gibbons D, Hanly A, Martin ST, O'Connell PR, Winter DC, Sheahan K.

Am J Surg Pathol. 2018 Jan;42(1):60-68. doi: 10.1097/PAS.0000000000000931.


HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients.

Dunne MR, Michielsen AJ, O'Sullivan KE, Cathcart MC, Feighery R, Doyle B, Watson JA, O'Farrell NJ, Ravi N, Kay E, Reynolds JV, Ryan EJ, O'Sullivan J.

Cancer Immunol Immunother. 2017 Jul;66(7):841-850. doi: 10.1007/s00262-017-1983-1. Epub 2017 Mar 18.


Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity.

Elliott LA, Doherty GA, Sheahan K, Ryan EJ.

Front Immunol. 2017 Feb 6;8:86. doi: 10.3389/fimmu.2017.00086. eCollection 2017. Review.


Exercise Physiology, Cognitive Function, and Physiologic Alterations in Extreme Conditions 2016.

Glickman EL, Ryan EJ, Bellar D.

Biomed Res Int. 2016;2016:7640898. doi: 10.1155/2016/7640898. Epub 2016 Dec 21. No abstract available.


Microsatellite instability is associated with reduced disease specific survival in stage III colon cancer.

Mohan HM, Ryan E, Balasubramanian I, Kennelly R, Geraghty R, Sclafani F, Fennelly D, McDermott R, Ryan EJ, O'Donoghue D, Hyland JM, Martin ST, O'Connell PR, Gibbons D, Winter D, Sheahan K.

Eur J Surg Oncol. 2016 Nov;42(11):1680-1686. doi: 10.1016/j.ejso.2016.05.013. Epub 2016 Jun 22.


Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway.

Kelly A, Robinson MW, Roche G, Biron CA, O'Farrelly C, Ryan EJ.

J Interferon Cytokine Res. 2016 Dec;36(12):671-680. Epub 2016 Sep 12.


Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: a double-blind, placebo-controlled trial.

Thomas RM, Algrain HA, Ryan EJ, Popojas A, Carrigan P, Abdulrahman A, Carrillo AE.

Ir J Med Sci. 2017 May;186(2):285-291. doi: 10.1007/s11845-016-1478-7. Epub 2016 Jul 1.


Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1.

Dunne MR, Ryan C, Nolan B, Tosetto M, Geraghty R, Winter DC, O'Connell PR, Hyland JM, Doherty GA, Sheahan K, Ryan EJ, Fletcher JM.

Front Oncol. 2016 Mar 7;6:50. doi: 10.3389/fonc.2016.00050. eCollection 2016.


Undergraduate nursing students' attitudes and use of research and evidence-based practice - an integrative literature review.

Ryan EJ.

J Clin Nurs. 2016 Jun;25(11-12):1548-56. doi: 10.1111/jocn.13229. Epub 2016 Mar 16. Review.


Preclinical evaluation of the AR inhibitor enzalutamide in triple-negative breast cancer cells.

Caiazza F, Murray A, Madden SF, Synnott NC, Ryan EJ, O'Donovan N, Crown J, Duffy MJ.

Endocr Relat Cancer. 2016 Apr;23(4):323-34. doi: 10.1530/ERC-16-0068. Epub 2016 Mar 1.


DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.

McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, Harris RA, Kellermayer R, Mill J, Cullen G, Doherty GA, Mulcahy H, Murphy TM.

J Crohns Colitis. 2016 Jan;10(1):77-86. doi: 10.1093/ecco-jcc/jjv176. Epub 2015 Sep 28.


Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease.

Gibson DJ, Elliott L, McDermott E, Tosetto M, Keegan D, Byrne K, Martin ST, Rispens T, Cullen G, Mulcahy HE, Cheifetz AS, Moss AC, Robson SC, Doherty GA, Ryan EJ.

Inflamm Bowel Dis. 2015 Dec;21(12):2806-14. doi: 10.1097/MIB.0000000000000566.


Low intensity exercise does not impact cognitive function during exposure to normobaric hypoxia.

Kim CH, Ryan EJ, Seo Y, Peacock C, Gunstad J, Muller MD, Ridgel AL, Glickman EL.

Physiol Behav. 2015 Nov 1;151:24-8. doi: 10.1016/j.physbeh.2015.07.003. Epub 2015 Jul 6.


Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.

Flood B, Oficjalska K, Laukens D, Fay J, O'Grady A, Caiazza F, Heetun Z, Mills KH, Sheahan K, Ryan EJ, Doherty GA, Kay E, Creagh EM.

Clin Exp Immunol. 2015 Jul;181(1):39-50. doi: 10.1111/cei.12617. Epub 2015 May 6.


Exercise physiology, cognitive function, and physiologic alterations in extreme conditions.

Glickman E, Ryan EJ, Bellar D.

Biomed Res Int. 2015;2015:359325. doi: 10.1155/2015/359325. Epub 2015 Mar 25. No abstract available.


Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer Patients Receiving Adjuvant Chemotherapy.

Lee CS, Murphy DJ, McMahon C, Nolan B, Cullen G, Mulcahy H, Sheahan K, Barnes E, Fennelly D, Ryan EJ, Doherty GA.

J Gastrointest Cancer. 2015 Sep;46(3):243-50. doi: 10.1007/s12029-015-9709-0.


Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies.

Caiazza F, Elliott L, Fennelly D, Sheahan K, Doherty GA, Ryan EJ.

Biomark Med. 2015;9(4):363-75. doi: 10.2217/bmm.15.5. Review.


Estrogen receptors and their implications in colorectal carcinogenesis.

Caiazza F, Ryan EJ, Doherty G, Winter DC, Sheahan K.

Front Oncol. 2015 Feb 2;5:19. doi: 10.3389/fonc.2015.00019. eCollection 2015. Review.


Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive.

O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ.

Br J Cancer. 2014 Aug 26;111(5):927-32. doi: 10.1038/bjc.2014.367. Epub 2014 Jul 24.


Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.

Lee CS, Ryan EJ, Doherty GA.

World J Gastroenterol. 2014 Apr 14;20(14):3751-61. doi: 10.3748/wjg.v20.i14.3751. Review.


Reply to: "Dendritic cell subset composition in the human liver is more complex than it seems".

Kelly A, Ryan EJ, O'Farrelly C.

J Hepatol. 2014 May;60(5):1098-9. doi: 10.1016/j.jhep.2013.12.029. Epub 2014 Jan 10. No abstract available.


Cognitive function during lower body water immersion and post-immersion afterdrop.

Seo Y, Kim CH, Ryan EJ, Gunstad J, Glickman EL, Muller MD.

Aviat Space Environ Med. 2013 Sep;84(9):921-6.


CD141⁺ myeloid dendritic cells are enriched in healthy human liver.

Kelly A, Fahey R, Fletcher JM, Keogh C, Carroll AG, Siddachari R, Geoghegan J, Hegarty JE, Ryan EJ, O'Farrelly C.

J Hepatol. 2014 Jan;60(1):135-42. doi: 10.1016/j.jhep.2013.08.007. Epub 2013 Aug 19.


Keeping the bowel regular: the emerging role of Treg as a therapeutic target in inflammatory bowel disease.

Gibson DJ, Ryan EJ, Doherty GA.

Inflamm Bowel Dis. 2013 Nov;19(12):2716-24. doi: 10.1097/MIB.0b013e31829ed7df. Review.


Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C.

FEBS Lett. 2013 May 21;587(10):1571-8. doi: 10.1016/j.febslet.2013.03.041. Epub 2013 Apr 12.


Cold habituation does not improve manual dexterity during rest and exercise in 5 °C.

Muller MD, Seo Y, Kim CH, Ryan EJ, Pollock BS, Burns KJ, Glickman EL.

Int J Biometeorol. 2014 Apr;58(3):383-94. doi: 10.1007/s00484-013-0633-3. Epub 2013 Feb 7.


Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment.

Michielsen AJ, Ryan EJ, O'Sullivan JN.

Oncoimmunology. 2012 Nov 1;1(8):1445-1447.


Hemodynamic and thermoregulatory responses to lower body water immersion.

Muller MD, Kim CH, Seo Y, Ryan EJ, Glickman EL.

Aviat Space Environ Med. 2012 Oct;83(10):935-41.


Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation.

Michielsen AJ, O'Sullivan JN, Ryan EJ.

Oncoimmunology. 2012 Aug 1;1(5):751-753.


Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection.

Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ.

Cytokine. 2012 Nov;60(2):328-33. doi: 10.1016/j.cyto.2012.07.006. Epub 2012 Aug 3.


When do (or don't) you administer drugs to patients on hemodialysis?

Ryan EJ.

Nursing. 2012 Aug;42(8):47-9. doi: 10.1097/01.NURSE.0000413613.21436.8c. Review. No abstract available.


Inhibition of dendritic cell maturation by the tumor microenvironment correlates with the survival of colorectal cancer patients following bevacizumab treatment.

Michielsen AJ, Noonan S, Martin P, Tosetto M, Marry J, Biniecka M, Maguire AA, Hyland JM, Sheahan KD, O'Donoghue DP, Mulcahy HE, Fennelly D, Ryan EJ, O'Sullivan JN.

Mol Cancer Ther. 2012 Aug;11(8):1829-37. doi: 10.1158/1535-7163.MCT-12-0162. Epub 2012 Jun 6.


Caffeine gum and cycling performance: a timing study.

Ryan EJ, Kim CH, Fickes EJ, Williamson M, Muller MD, Barkley JE, Gunstad J, Glickman EL.

J Strength Cond Res. 2013 Jan;27(1):259-64. doi: 10.1519/JSC.0b013e3182541d03.


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