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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

Willoughby CE, Jiang Y, Thomas HD, Willmore E, Kyle S, Wittner A, Phillips N, Zhao Y, Tudhope SJ, Prendergast L, Junge G, Madia Lourenco L, Finlay MRV, Turner P, Munck JM, Griffin RJ, Rennison T, Pickles J, Cano C, Newell DR, Reeves HL, Ryan AJ, Wedge SR.

J Clin Invest. 2019 Oct 3. pii: 127483. doi: 10.1172/JCI127483. [Epub ahead of print]


Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer.

Carter R, Cheraghchi-Bashi A, Westhorpe A, Yu S, Shanneik Y, Seraia E, Ouaret D, Inoue Y, Koch C, Wilding J, Ebner D, Ryan AJ, Buffa FM, Sharma RA.

Cancer Biol Med. 2019 May;16(2):234-246. doi: 10.20892/j.issn.2095-3941.2018.0284.


Ligand Shell Structure in Lead Sulfide-Oleic Acid Colloidal Quantum Dots Revealed by Small-Angle Scattering.

Weir MP, Toolan DTW, Kilbride RC, Penfold NJW, Washington AL, King SM, Xiao J, Zhang Z, Gray V, Dowland S, Winkel J, Greenham NC, Friend RH, Rao A, Ryan AJ, Jones RAL.

J Phys Chem Lett. 2019 Aug 15;10(16):4713-4719. doi: 10.1021/acs.jpclett.9b01008. Epub 2019 Aug 6.


Correction: Thermoreversible crystallization-driven aggregation of diblock copolymer nanoparticles in mineral oil.

Derry MJ, Mykhaylyk OO, Ryan AJ, Armes SP.

Chem Sci. 2018 Dec 20;10(3):947. doi: 10.1039/c8sc90241k. eCollection 2019 Jan 21.


Cardio-Respiratory synchronized bSSFP MRI for high throughput in vivo lung tumour quantification.

Gomes AL, Kinchesh P, Gilchrist S, Allen PD, Lourenço LM, Ryan AJ, Smart SC.

PLoS One. 2019 Feb 12;14(2):e0212172. doi: 10.1371/journal.pone.0212172. eCollection 2019.


Isolation of U(ii) compounds using strong donor ligands, C5Me4H and N(SiMe3)2, including a three-coordinate U(ii) complex.

Ryan AJ, Angadol MA, Ziller JW, Evans WJ.

Chem Commun (Camb). 2019 Feb 19;55(16):2325-2327. doi: 10.1039/c8cc08767a.


Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo.

Ryan EJ, Ryan AJ, González-Vázquez A, Philippart A, Ciraldo FE, Hobbs C, Nicolosi V, Boccaccini AR, Kearney CJ, O'Brien FJ.

Biomaterials. 2019 Mar;197:405-416. doi: 10.1016/j.biomaterials.2019.01.031. Epub 2019 Jan 23.


Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.

Mumin NH, Drobnitzky N, Patel A, Lourenco LM, Cahill FF, Jiang Y, Kong A, Ryan AJ.

BMC Cancer. 2019 Jan 24;19(1):102. doi: 10.1186/s12885-019-5295-z.


Correction to: Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.

Formentini L, Ryan AJ, Gálvez-Santisteban M, Carter L, Taub P, Lapek JD Jr, Gonzalez DJ, Villarreal F, Ciaraldi TP, Cuezva JM, Henry RR.

Diabetologia. 2018 Dec;61(12):2674. doi: 10.1007/s00125-018-4747-3.


Mechanistic Insights into Diblock Copolymer Nanoparticle-Crystal Interactions Revealed via in Situ Atomic Force Microscopy.

Hendley CT 4th, Fielding LA, Jones ER, Ryan AJ, Armes SP, Estroff LA.

J Am Chem Soc. 2018 Jun 27;140(25):7936-7945. doi: 10.1021/jacs.8b03828. Epub 2018 Jun 19.


Thermoreversible crystallization-driven aggregation of diblock copolymer nanoparticles in mineral oil.

Derry MJ, Mykhaylyk OO, Ryan AJ, Armes SP.

Chem Sci. 2018 Apr 2;9(17):4071-4082. doi: 10.1039/c8sc00762d. eCollection 2018 May 7. Erratum in: Chem Sci. 2018 Dec 20;10(3):947.


Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts.

Legrand AJ, Poletto M, Pankova D, Clementi E, Moore J, Castro-Giner F, Ryan AJ, O'Neill E, Markkanen E, Dianov GL.

Oncotarget. 2018 Feb 7;9(17):13666-13681. doi: 10.18632/oncotarget.24446. eCollection 2018 Mar 2.


Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity.

Ryan AJ, Kearney CJ, Shen N, Khan U, Kelly AG, Probst C, Brauchle E, Biccai S, Garciarena CD, Vega-Mayoral V, Loskill P, Kerrigan SW, Kelly DJ, Schenke-Layland K, Coleman JN, O'Brien FJ.

Adv Mater. 2018 Apr;30(15):e1706442. doi: 10.1002/adma.201706442. Epub 2018 Mar 5.


Synthesis, Structure, and Magnetism of Tris(amide) [Ln{N(SiMe3 )2 }3 ]1- Complexes of the Non-traditional +2 Lanthanide Ions.

Ryan AJ, Darago LE, Balasubramani SG, Chen GP, Ziller JW, Furche F, Long JR, Evans WJ.

Chemistry. 2018 May 28;24(30):7702-7709. doi: 10.1002/chem.201800610. Epub 2018 May 3.


PARP Inhibition Combined With Thoracic Irradiation Exacerbates Esophageal and Skin Toxicity in C57BL6 Mice.

Lourenco LM, Jiang Y, Drobnitzky N, Green M, Cahill F, Patel A, Shanneik Y, Moore J, Ryan AJ.

Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):767-775. doi: 10.1016/j.ijrobp.2017.10.051. Epub 2017 Nov 6.


Evaluating the electronic structure of formal LnII ions in LnII(C5H4SiMe3)31- using XANES spectroscopy and DFT calculations.

Fieser ME, Ferrier MG, Su J, Batista E, Cary SK, Engle JW, Evans WJ, Lezama Pacheco JS, Kozimor SA, Olson AC, Ryan AJ, Stein BW, Wagner GL, Woen DH, Vitova T, Yang P.

Chem Sci. 2017 Sep 1;8(9):6076-6091. doi: 10.1039/c7sc00825b. Epub 2017 Jun 30.


A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair.

Ryan AJ, Lackington WA, Hibbitts AJ, Matheson A, Alekseeva T, Stejskalova A, Roche P, O'Brien FJ.

Adv Healthc Mater. 2017 Dec;6(24). doi: 10.1002/adhm.201700954. Epub 2017 Oct 4.


Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation.

Ryan AJ, O'Neill HS, Duffy GP, O'Brien FJ.

Curr Opin Pharmacol. 2017 Oct;36:66-71. doi: 10.1016/j.coph.2017.07.013. Epub 2017 Aug 31. Review.


Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.

Formentini L, Ryan AJ, Gálvez-Santisteban M, Carter L, Taub P, Lapek JD Jr, Gonzalez DJ, Villarreal F, Ciaraldi TP, Cuezva JM, Henry RR.

Diabetologia. 2017 Oct;60(10):2052-2065. doi: 10.1007/s00125-017-4379-z. Epub 2017 Aug 2. Erratum in: Diabetologia. 2018 Oct 15;:.


TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy.

Pirovano G, Ashton TM, Herbert KJ, Bryant RJ, Verrill CL, Cerundolo L, Buffa FM, Prevo R, Harrap I, Ryan AJ, Macaulay V, McKenna WG, Higgins GS.

Br J Cancer. 2017 Aug 8;117(4):503-512. doi: 10.1038/bjc.2017.197. Epub 2017 Jul 4.


The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non-Small Cell Lung Cancer.

Cascone T, Xu L, Lin HY, Liu W, Tran HT, Liu Y, Howells K, Haddad V, Hanrahan E, Nilsson MB, Cortez MA, Giri U, Kadara H, Saigal B, Park YY, Peng W, Lee JS, Ryan AJ, Jüergensmeier JM, Herbst RS, Wang J, Langley RR, Wistuba II, Lee JJ, Heymach JV.

Clin Cancer Res. 2017 Sep 15;23(18):5489-5501. doi: 10.1158/1078-0432.CCR-16-3216. Epub 2017 May 30.


Breast arterial calcification association with coronary artery calcium scoring and implications for cardiovascular risk assessment in women.

Ryan AJ, Choi AD, Choi BG, Lewis JF.

Clin Cardiol. 2017 Sep;40(9):648-653. doi: 10.1002/clc.22702. Epub 2017 Apr 26. Review.


Redox Potential and Electronic Structure Effects of Proximal Nonredox Active Cations in Cobalt Schiff Base Complexes.

Reath AH, Ziller JW, Tsay C, Ryan AJ, Yang JY.

Inorg Chem. 2017 Mar 20;56(6):3713-3718. doi: 10.1021/acs.inorgchem.6b03098. Epub 2017 Feb 27.


Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.

Weber AM, Drobnitzky N, Devery AM, Bokobza SM, Adams RA, Maughan TS, Ryan AJ.

Oncotarget. 2016 Sep 20;7(38):60807-60822. doi: 10.18632/oncotarget.11845.


Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes.

Ciaraldi TP, Ryan AJ, Mudaliar SR, Henry RR.

PLoS One. 2016 Jul 25;11(7):e0158209. doi: 10.1371/journal.pone.0158209. eCollection 2016.


Towards 3D in vitro models for the study of cardiovascular tissues and disease.

Ryan AJ, Brougham CM, Garciarena CD, Kerrigan SW, O'Brien FJ.

Drug Discov Today. 2016 Sep;21(9):1437-1445. doi: 10.1016/j.drudis.2016.04.014. Epub 2016 Apr 23. Review.


Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.

Jiang Y, Verbiest T, Devery AM, Bokobza SM, Weber AM, Leszczynska KB, Hammond EM, Ryan AJ.

Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):772-81. doi: 10.1016/j.ijrobp.2016.01.035. Epub 2016 Jan 23.


Validation of the novel International Society of Urological Pathology 2014 five-tier Gleason grade grouping: biochemical recurrence rates for 3+5 disease may be overestimated.

van den Bergh RC, van der Kwast TH, de Jong J, Zargar H, Ryan AJ, Costello AJ, Murphy DG, van der Poel HG.

BJU Int. 2016 Oct;118(4):502-5. doi: 10.1111/bju.13478. Epub 2016 Apr 1. No abstract available.


Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.

Larson-Casey JL, Deshane JS, Ryan AJ, Thannickal VJ, Carter AB.

Immunity. 2016 Mar 15;44(3):582-596. doi: 10.1016/j.immuni.2016.01.001. Epub 2016 Feb 23.


An unusual cause of plantar pustulosis.

Ryan AJ, Cerio R, Paige D, Goldsmith P.

Clin Exp Dermatol. 2016 Jul;41(5):568-9. doi: 10.1111/ced.12792. Epub 2016 Jan 23. No abstract available.


Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis.

He C, Larson-Casey JL, Gu L, Ryan AJ, Murthy S, Carter AB.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):58-71. doi: 10.1165/rcmb.2015-0183OC.


Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC.

Cancer Cell. 2015 Nov 9;28(5):557-568. doi: 10.1016/j.ccell.2015.09.015.


Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells.

Ryan AJ, O'Brien FJ.

Biomaterials. 2015 Dec;73:296-307. doi: 10.1016/j.biomaterials.2015.09.003. Epub 2015 Sep 25.


Eosinophilic perimyositis manifesting as localized urticaria.

Lai FY, Palmer VM, Monagle S, Ryan AJ, Su JC.

Int J Dermatol. 2016 Mar;55(3):325-7. doi: 10.1111/ijd.13055. Epub 2015 Sep 4. No abstract available.


Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture.

Jiang Y, Allen D, Kersemans V, Devery AM, Bokobza SM, Smart S, Ryan AJ.

Lung Cancer. 2015 Nov;90(2):191-8. doi: 10.1016/j.lungcan.2015.08.009. Epub 2015 Aug 20.


Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer.

Devery AM, Wadekar R, Bokobza SM, Weber AM, Jiang Y, Ryan AJ.

Int J Oncol. 2015 Sep;47(3):849-56. doi: 10.3892/ijo.2015.3082. Epub 2015 Jul 14.


Self-Assembly-Driven Electrospinning: The Transition from Fibers to Intact Beaded Morphologies.

Wang L, Topham PD, Mykhaylyk OO, Yu H, Ryan AJ, Fairclough JP, Bras W.

Macromol Rapid Commun. 2015 Aug;36(15):1437-43. doi: 10.1002/marc.201500149. Epub 2015 Jun 2.


Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis.

Osborn-Heaford HL, Murthy S, Gu L, Larson-Casey JL, Ryan AJ, Shi L, Glogauer M, Neighbors JD, Hohl R, Carter AB.

Free Radic Biol Med. 2015 Sep;86:47-56. doi: 10.1016/j.freeradbiomed.2015.04.031. Epub 2015 May 7.


Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure.

Murthy S, Larson-Casey JL, Ryan AJ, He C, Kobzik L, Carter AB.

FASEB J. 2015 Aug;29(8):3527-36. doi: 10.1096/fj.15-271304. Epub 2015 May 7.


Testing the vesicular morphology to destruction: birth and death of diblock copolymer vesicles prepared via polymerization-induced self-assembly.

Warren NJ, Mykhaylyk OO, Ryan AJ, Williams M, Doussineau T, Dugourd P, Antoine R, Portale G, Armes SP.

J Am Chem Soc. 2015 Feb 11;137(5):1929-37. doi: 10.1021/ja511423m. Epub 2015 Jan 27.


ATM and ATR as therapeutic targets in cancer.

Weber AM, Ryan AJ.

Pharmacol Ther. 2015 May;149:124-38. doi: 10.1016/j.pharmthera.2014.12.001. Epub 2014 Dec 13. Review.


Effect of different hydroxyapatite incorporation methods on the structural and biological properties of porous collagen scaffolds for bone repair.

Ryan AJ, Gleeson JP, Matsiko A, Thompson EM, O'Brien FJ.

J Anat. 2015 Dec;227(6):732-45. doi: 10.1111/joa.12262. Epub 2014 Nov 20.


Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis.

Larson-Casey JL, Murthy S, Ryan AJ, Carter AB.

J Biol Chem. 2014 Dec 26;289(52):36204-19. doi: 10.1074/jbc.M114.593285. Epub 2014 Nov 5.


Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages.

Ryan AJ, Larson-Casey JL, He C, Murthy S, Carter AB.

J Biol Chem. 2014 Nov 28;289(48):33391-403. doi: 10.1074/jbc.M114.579870. Epub 2014 Oct 16.


Combination of microstereolithography and electrospinning to produce membranes equipped with niches for corneal regeneration.

Ortega I, Sefat F, Deshpande P, Paterson T, Ramachandran C, Ryan AJ, MacNeil S, Claeyssens F.

J Vis Exp. 2014 Sep 12;(91):51826. doi: 10.3791/51826.


EGFR biomarkers predict benefit from vandetanib in combination with docetaxel in a randomized phase III study of second-line treatment of patients with advanced non-small cell lung cancer.

Heymach JV, Lockwood SJ, Herbst RS, Johnson BE, Ryan AJ.

Ann Oncol. 2014 Oct;25(10):1941-8. doi: 10.1093/annonc/mdu269. Epub 2014 Jul 23.


Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.

Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):106-15. doi: 10.1165/rcmb.2013-0519OC.


An experimental investigation of the effect of mechanical and biochemical stimuli on cell migration within a decellularized vascular construct.

Sheridan WS, Ryan AJ, Duffy GP, O'Brien FJ, Murphy BP.

Ann Biomed Eng. 2014 Oct;42(10):2029-38. doi: 10.1007/s10439-014-1063-z. Epub 2014 Jul 2.


Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer.

Bokobza SM, Jiang Y, Weber AM, Devery AM, Ryan AJ.

Int J Radiat Oncol Biol Phys. 2014 Mar 15;88(4):947-54. doi: 10.1016/j.ijrobp.2013.12.038.


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