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Intrinsic Activity of C57BL/6 Substrains Associates with High-Fat Diet-Induced Mechanical Sensitivity in Mice.

Cooper MA, O'Meara B, Jack MM, Elliot D, Lamb B, Khan ZW, Menta BW, Ryals JM, Winter MK, Wright DE.

J Pain. 2018 Nov;19(11):1285-1295. doi: 10.1016/j.jpain.2018.05.005. Epub 2018 May 25.


A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice.

Cooper MA, Menta BW, Perez-Sanchez C, Jack MM, Khan ZW, Ryals JM, Winter M, Wright DE.

Exp Neurol. 2018 Aug;306:149-157. doi: 10.1016/j.expneurol.2018.05.011. Epub 2018 May 17.


Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels.

Grote CW, Wilson NM, Katz NK, Guilford BL, Ryals JM, Novikova L, Stehno-Bittel L, Wright DE.

Exp Neurol. 2018 Jul;305:97-107. doi: 10.1016/j.expneurol.2018.04.002. Epub 2018 Apr 9.


Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain.

Cooper MA, Jack MM, Ryals JM, Hayley P, Escher T, Koch LG, Britton SL, Raupp SM, Winter MK, McCarson KE, Geiger PC, Thyfault JP, Wright DE.

Brain Behav. 2017 Sep 6;7(10):e00780. doi: 10.1002/brb3.780. eCollection 2017 Oct.


Less is More in Diabetic Neuropathy Diagnosis: Comparison of Quantitative Sudomotor Axon Reflex and Skin Biopsy.

Abuzinadah AR, Kluding P, Wright D, DʼSilva L, Ryals J, Hendry B, Jawdat O, Herbelin L, McVey AL, Barohn RJ, Dimachkie MM, Pasnoor M.

J Clin Neuromuscul Dis. 2017 Sep;19(1):5-11. doi: 10.1097/CND.0000000000000150.


Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet.

Guilford BL, Ryals JM, Lezi E, Swerdlow RH, Wright DE.

J Neurol Neurosci. 2017;8(2). pii: 180. doi: 10.21767/2171-6625.1000180. Epub 2017 Mar 27.


Increased FNDC5 is associated with insulin resistance in high fat-fed mice.

Guilford BL, Parson JC, Grote CW, Vick SN, Ryals JM, Wright DE.

Physiol Rep. 2017 Jul;5(13). pii: e13319. doi: 10.14814/phy2.13319.


Modulation of diet-induced mechanical allodynia by metabolic parameters and inflammation.

Cooper MA, Ryals JM, Wu PY, Wright KD, Walter KR, Wright DE.

J Peripher Nerv Syst. 2017 Mar;22(1):39-46. doi: 10.1111/jns.12199.


Erratum to: Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.

Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LAD, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH.

J Inherit Metab Dis. 2016 Sep;39(5):757. doi: 10.1007/s10545-016-9944-y. No abstract available.


Proteomics and metabolomics analyses reveal the cucurbit sieve tube system as a complex metabolic space.

Hu C, Ham BK, El-Shabrawi HM, Alexander D, Zhang D, Ryals J, Lucas WJ.

Plant J. 2016 Sep;87(5):442-54. doi: 10.1111/tpj.13209. Epub 2016 Jul 7.


Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress.

Pierce AN, Di Silvestro ER, Eller OC, Wang R, Ryals JM, Christianson JA.

Brain Res. 2016 May 15;1639:58-73. doi: 10.1016/j.brainres.2016.02.039. Epub 2016 Mar 2.


Plasma metabolomic profiles enhance precision medicine for volunteers of normal health.

Guo L, Milburn MV, Ryals JA, Lonergan SC, Mitchell MW, Wulff JE, Alexander DC, Evans AM, Bridgewater B, Miller L, Gonzalez-Garay ML, Caskey CT.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4901-10. doi: 10.1073/pnas.1508425112. Epub 2015 Aug 17.


Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic-pituitary-adrenal axis output in female mice.

Pierce AN, Zhang Z, Fuentes IM, Wang R, Ryals JM, Christianson JA.

Pain. 2015 Oct;156(10):2021-31. doi: 10.1097/j.pain.0000000000000264.


Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.

Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LA, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH.

J Inherit Metab Dis. 2015 Nov;38(6):1029-39. doi: 10.1007/s10545-015-9843-7. Epub 2015 Apr 15. Erratum in: J Inherit Metab Dis. 2016 Sep;39(5):757.


Central or peripheral delivery of an adenosine A1 receptor agonist improves mechanical allodynia in a mouse model of painful diabetic neuropathy.

Katz NK, Ryals JM, Wright DE.

Neuroscience. 2015 Jan 29;285:312-23. doi: 10.1016/j.neuroscience.2014.10.065. Epub 2014 Nov 8.


Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics.

Lawton KA, Brown MV, Alexander D, Li Z, Wulff JE, Lawson R, Jaffa M, Milburn MV, Ryals JA, Bowser R, Cudkowicz ME, Berry JD; Northeast ALS Consortium.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):362-70. doi: 10.3109/21678421.2014.908311. Epub 2014 Jul 1.


Vaginal hypersensitivity and hypothalamic-pituitary-adrenal axis dysfunction as a result of neonatal maternal separation in female mice.

Pierce AN, Ryals JM, Wang R, Christianson JA.

Neuroscience. 2014 Mar 28;263:216-30. doi: 10.1016/j.neuroscience.2014.01.022. Epub 2014 Jan 23.


Peripheral nervous system insulin resistance in ob/ob mice.

Grote CW, Groover AL, Ryals JM, Geiger PC, Feldman EL, Wright DE.

Acta Neuropathol Commun. 2013 May 10;1:15. doi: 10.1186/2051-5960-1-15.


Assessment of genetically modified soybean in relation to natural variation in the soybean seed metabolome.

Clarke JD, Alexander DC, Ward DP, Ryals JA, Mitchell MW, Wulff JE, Guo L.

Sci Rep. 2013 Oct 30;3:3082. doi: 10.1038/srep03082. Erratum in: Sci Rep. 2014;4:3871.


In vivo peripheral nervous system insulin signaling.

Grote CW, Ryals JM, Wright DE.

J Peripher Nerv Syst. 2013 Sep;18(3):209-19. doi: 10.1111/jns5.12033.


Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice.

Groover AL, Ryals JM, Guilford BL, Wilson NM, Christianson JA, Wright DE.

Pain. 2013 Dec;154(12):2658-67. doi: 10.1016/j.pain.2013.07.052. Epub 2013 Aug 6.


Serum metabolomics indicate altered cellular energy metabolism in children with cystic fibrosis.

Joseloff E, Sha W, Bell SC, Wetmore DR, Lawton KA, Milburn MV, Ryals JA, Guo L, Muhlebach MS.

Pediatr Pulmonol. 2014 May;49(5):463-72. doi: 10.1002/ppul.22859. Epub 2013 Jul 12.


Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS.

Ann N Y Acad Sci. 2013 May;1287:1-16. doi: 10.1111/nyas.12116. Epub 2013 May 9.


Examining the validity of the Structured Assessment of Violence Risk in Youth (SAVRY) for predicting probation outcomes among adjudicated juvenile offenders.

Childs KK, Ryals J Jr, Frick PJ, Lawing K, Phillippi SW, Deprato DK.

Behav Sci Law. 2013 Mar-Apr;31(2):256-70. doi: 10.1002/bsl.2060. Epub 2013 Apr 22.


Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.

Yamazaki M, Miyake M, Sato H, Masutomi N, Tsutsui N, Adam KP, Alexander DC, Lawton KA, Milburn MV, Ryals JA, Wulff JE, Guo L.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89. doi: 10.1016/j.taap.2013.01.018. Epub 2013 Jan 27.


Metabolic profiling of transgenic potato tubers expressing Arabidopsis dehydration response element-binding protein 1A (DREB1A).

Iwaki T, Guo L, Ryals JA, Yasuda S, Shimazaki T, Kikuchi A, Watanabe KN, Kasuga M, Yamaguchi-Shinozaki K, Ogawa T, Ohta D.

J Agric Food Chem. 2013 Jan 30;61(4):893-900. doi: 10.1021/jf304071n. Epub 2013 Jan 16.


Metabolomic profiling in Selaginella lepidophylla at various hydration states provides new insights into the mechanistic basis of desiccation tolerance.

Yobi A, Wone BW, Xu W, Alexander DC, Guo L, Ryals JA, Oliver MJ, Cushman JC.

Mol Plant. 2013 Mar;6(2):369-85. doi: 10.1093/mp/sss155. Epub 2012 Dec 13.


Comparative metabolic profiling between desiccation-sensitive and desiccation-tolerant species of Selaginella reveals insights into the resurrection trait.

Yobi A, Wone BW, Xu W, Alexander DC, Guo L, Ryals JA, Oliver MJ, Cushman JC.

Plant J. 2012 Dec;72(6):983-99. doi: 10.1111/tpj.12008. Epub 2012 Oct 19.


Protection from diabetes-induced peripheral sensory neuropathy--a role for elevated glyoxalase I?

Jack MM, Ryals JM, Wright DE.

Exp Neurol. 2012 Mar;234(1):62-9. doi: 10.1016/j.expneurol.2011.12.015. Epub 2011 Dec 19.


Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice.

Guilford BL, Ryals JM, Wright DE.

Exp Diabetes Res. 2011;2011:848307. doi: 10.1155/2011/848307. Epub 2011 Nov 14.


Biochemical alterations associated with ALS.

Lawton KA, Cudkowicz ME, Brown MV, Alexander D, Caffrey R, Wulff JE, Bowser R, Lawson R, Jaffa M, Milburn MV, Ryals JA, Berry JD.

Amyotroph Lateral Scler. 2012 Jan;13(1):110-8. doi: 10.3109/17482968.2011.619197. Epub 2011 Nov 25.


Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy.

Grote CW, Morris JK, Ryals JM, Geiger PC, Wright DE.

Exp Diabetes Res. 2011;2011:212571. doi: 10.1155/2011/212571. Epub 2011 Jun 15.


Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy.

Jack MM, Ryals JM, Wright DE.

Diabetologia. 2011 Aug;54(8):2174-82. doi: 10.1007/s00125-011-2196-3. Epub 2011 Jun 3.


A sister group contrast using untargeted global metabolomic analysis delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus.

Oliver MJ, Guo L, Alexander DC, Ryals JA, Wone BW, Cushman JC.

Plant Cell. 2011 Apr;23(4):1231-48. doi: 10.1105/tpc.110.082800. Epub 2011 Apr 5.


Metabolomic profiling reveals biochemical pathways and biomarkers associated with pathogenesis in cystic fibrosis cells.

Wetmore DR, Joseloff E, Pilewski J, Lee DP, Lawton KA, Mitchell MW, Milburn MV, Ryals JA, Guo L.

J Biol Chem. 2010 Oct 1;285(40):30516-22. doi: 10.1074/jbc.M110.140806. Epub 2010 Jul 30.


Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family.

Takei M, Ando Y, Saitoh W, Tanimoto T, Kiyosawa N, Manabe S, Sanbuissho A, Okazaki O, Iwabuchi H, Yamoto T, Adam KP, Weiel JE, Ryals JA, Milburn MV, Guo L.

Toxicol Sci. 2010 Dec;118(2):643-52. doi: 10.1093/toxsci/kfq211. Epub 2010 Jul 8.


alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.

Gall WE, Beebe K, Lawton KA, Adam KP, Mitchell MW, Nakhle PJ, Ryals JA, Milburn MV, Nannipieri M, Camastra S, Natali A, Ferrannini E; RISC Study Group.

PLoS One. 2010 May 28;5(5):e10883. doi: 10.1371/journal.pone.0010883.


Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.

Romero R, Mazaki-Tovi S, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Gomez R, Nien JK, Yoon BH, Mazor M, Luo J, Banks D, Ryals J, Beecher C.

J Matern Fetal Neonatal Med. 2010 Dec;23(12):1344-59. doi: 10.3109/14767058.2010.482618. Epub 2010 May 26.


Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain.

Sharma NK, Ryals JM, Gajewski BJ, Wright DE.

Phys Ther. 2010 May;90(5):714-25. doi: 10.2522/ptj.20090168. Epub 2010 Mar 25.


Acidic saline-induced primary and secondary mechanical hyperalgesia in mice.

Sharma NK, Ryals JM, Liu H, Liu W, Wright DE.

J Pain. 2009 Dec;10(12):1231-41. doi: 10.1016/j.jpain.2009.04.014. Epub 2009 Jul 9.


Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats.

Ohta T, Masutomi N, Tsutsui N, Sakairi T, Mitchell M, Milburn MV, Ryals JA, Beebe KD, Guo L.

Toxicol Pathol. 2009 Jun;37(4):521-35. doi: 10.1177/0192623309336152.


Early loss of peptidergic intraepidermal nerve fibers in an STZ-induced mouse model of insensate diabetic neuropathy.

Johnson MS, Ryals JM, Wright DE.

Pain. 2008 Nov 15;140(1):35-47. doi: 10.1016/j.pain.2008.07.007. Epub 2008 Aug 30.


Analysis of the adult human plasma metabolome.

Lawton KA, Berger A, Mitchell M, Milgram KE, Evans AM, Guo L, Hanson RW, Kalhan SC, Ryals JA, Milburn MV.

Pharmacogenomics. 2008 Apr;9(4):383-97. doi: 10.2217/14622416.9.4.383.


Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice.

Muller KA, Ryals JM, Feldman EL, Wright DE.

Diabetes. 2008 Jun;57(6):1693-701. doi: 10.2337/db08-0022. Epub 2008 Mar 24.


Selective changes in nocifensive behavior despite normal cutaneous axon innervation in leptin receptor-null mutant (db/db) mice.

Wright DE, Johnson MS, Arnett MG, Smittkamp SE, Ryals JM.

J Peripher Nerv Syst. 2007 Dec;12(4):250-61.


Pro-NGF, sortilin, and p75NTR: potential mediators of injury-induced apoptosis in the mouse dorsal root ganglion.

Arnett MG, Ryals JM, Wright DE.

Brain Res. 2007 Dec 5;1183:32-42. Epub 2007 Oct 26.


Metabolon, Inc.

Ryals J, Lawton K, Stevens D, Milburn M.

Pharmacogenomics. 2007 Jul;8(7):863-6.


Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice.

Christianson JA, Ryals JM, Johnson MS, Dobrowsky RT, Wright DE.

Neuroscience. 2007 Mar 2;145(1):303-13. Epub 2006 Dec 16.

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