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Items: 15


Metabolites Involved in Immune Evasion by Batrachochytrium dendrobatidis Include the Polyamine Spermidine.

Rollins-Smith LA, Ruzzini AC, Fites JS, Reinert LK, Hall EM, Joosse BA, Ravikumar VI, Huebner MI, Aka A, Kehs MH, Gillard BM, Doe E, Tasca JA, Umile TP, Clardy J, Minbiole KPC.

Infect Immun. 2019 Apr 23;87(5). pii: e00035-19. doi: 10.1128/IAI.00035-19. Print 2019 Mar.


Pyrazines from bacteria and ants: convergent chemistry within an ecological niche.

Silva-Junior EA, Ruzzini AC, Paludo CR, Nascimento FS, Currie CR, Clardy J, Pupo MT.

Sci Rep. 2018 Feb 7;8(1):2595. doi: 10.1038/s41598-018-20953-6.


Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete.

Wyche TP, Ruzzini AC, Schwab L, Currie CR, Clardy J.

J Am Chem Soc. 2017 Sep 20;139(37):12899-12902. doi: 10.1021/jacs.7b06176. Epub 2017 Sep 6.


Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J.

Org Lett. 2017 Apr 7;19(7):1772-1775. doi: 10.1021/acs.orglett.7b00545. Epub 2017 Mar 22.


Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.

Van Arnam EB, Ruzzini AC, Sit CS, Horn H, Pinto-Tomás AA, Currie CR, Clardy J.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12940-12945. Epub 2016 Nov 1.


Gene Flow and Molecular Innovation in Bacteria.

Ruzzini AC, Clardy J.

Curr Biol. 2016 Sep 26;26(18):R859-R864. doi: 10.1016/j.cub.2016.08.004. Review.


Genome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower.

Chagas FO, Ruzzini AC, Bacha LV, Samborskyy M, Conti R, Pessotti RC, de Oliveira LG, Clardy J, Pupo MT.

Genome Announc. 2016 Jul 21;4(4). pii: e00693-16. doi: 10.1128/genomeA.00693-16.


Whole-Genome Sequence of Bacillus sp. SDLI1, Isolated from the Social Bee Scaptotrigona depilis.

Paludo CR, Ruzzini AC, Silva-Junior EA, Pishchany G, Currie CR, Nascimento FS, Kolter RG, Clardy J, Pupo MT.

Genome Announc. 2016 Mar 24;4(2). pii: e00174-16. doi: 10.1128/genomeA.00174-16.


A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.

Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy J.

J Am Chem Soc. 2015 Nov 18;137(45):14272-4. doi: 10.1021/jacs.5b09794. Epub 2015 Nov 10.


Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants.

Sit CS, Ruzzini AC, Van Arnam EB, Ramadhar TR, Currie CR, Clardy J.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13150-4. doi: 10.1073/pnas.1515348112. Epub 2015 Oct 5. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6717.


A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules.

Kulig JK, Spandolf C, Hyde R, Ruzzini AC, Eltis LD, Grönberg G, Hayes MA, Grogan G.

Bioorg Med Chem. 2015 Sep 1;23(17):5603-9. doi: 10.1016/j.bmc.2015.07.025. Epub 2015 Jul 21.


A substrate-assisted mechanism of nucleophile activation in a Ser-His-Asp containing C-C bond hydrolase.

Ruzzini AC, Bhowmik S, Ghosh S, Yam KC, Bolin JT, Eltis LD.

Biochemistry. 2013 Oct 22;52(42):7428-38. doi: 10.1021/bi401156a. Epub 2013 Oct 9.


The lid domain of the MCP hydrolase DxnB2 contributes to the reactivity toward recalcitrant PCB metabolites.

Ruzzini AC, Bhowmik S, Yam KC, Ghosh S, Bolin JT, Eltis LD.

Biochemistry. 2013 Aug 20;52(33):5685-5695. doi: 10.1021/bi400774m. Epub 2013 Aug 9.


The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage.

Ruzzini AC, Horsman GP, Eltis LD.

Biochemistry. 2012 Jul 24;51(29):5831-40. doi: 10.1021/bi300663r. Epub 2012 Jul 11.


Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad.

Ruzzini AC, Ghosh S, Horsman GP, Foster LJ, Bolin JT, Eltis LD.

J Am Chem Soc. 2012 Mar 14;134(10):4615-24. doi: 10.1021/ja208544g. Epub 2012 Mar 5.


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