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Items: 1 to 50 of 79

1.

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus.

Tegtmeyer PK, Spanier J, Borst K, Becker J, Riedl A, Hirche C, Ghita L, Skerra J, Baumann K, Lienenklaus S, Doering M, Ruzsics Z, Kalinke U.

Nat Commun. 2019 Jun 27;10(1):2830. doi: 10.1038/s41467-019-10863-0.

2.

Author Correction: Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice.

Murillo-León M, Müller UB, Zimmermann I, Singh S, Widdershoven P, Campos C, Alvarez C, Könen-Waisman S, Lukes N, Ruzsics Z, Howard JC, Schwemmle M, Steinfeldt T.

Nat Commun. 2019 Apr 4;10(1):1645. doi: 10.1038/s41467-019-09648-2.

3.

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice.

Murillo-León M, Müller UB, Zimmermann I, Singh S, Widdershooven P, Campos C, Alvarez C, Könen-Waisman S, Lukes N, Ruzsics Z, Howard JC, Schwemmle M, Steinfeldt T.

Nat Commun. 2019 Mar 15;10(1):1233. doi: 10.1038/s41467-019-09200-2. Erratum in: Nat Commun. 2019 Apr 4;10(1):1645.

4.

Comprehensive analysis of nuclear export of herpes simplex virus type 1 tegument proteins and their Epstein-Barr virus orthologs.

Funk C, Raschbichler V, Lieber D, Wetschky J, Arnold EK, Leimser J, Biggel M, Friedel CC, Ruzsics Z, Bailer SM.

Traffic. 2019 Feb;20(2):152-167. doi: 10.1111/tra.12627. Epub 2019 Jan 11.

5.

Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques.

Ragonnaud E, Schroedel S, Mariya S, Iskandriati D, Pamungkas J, Fougeroux C, Daradoumis J, Thomsen AR, Neukirch L, Ruzsics Z, Salomon M, Thirion C, Holst PJ.

Vaccine. 2018 Oct 1;36(41):6212-6222. doi: 10.1016/j.vaccine.2018.07.075. Epub 2018 Sep 3.

PMID:
30190120
6.

Human MxB Protein Is a Pan-herpesvirus Restriction Factor.

Schilling M, Bulli L, Weigang S, Graf L, Naumann S, Patzina C, Wagner V, Bauersfeld L, Goujon C, Hengel H, Halenius A, Ruzsics Z, Schaller T, Kochs G.

J Virol. 2018 Aug 16;92(17). pii: e01056-18. doi: 10.1128/JVI.01056-18. Print 2018 Sep 1.

7.

Evaluation of adenovirus 19a as a novel vector for mucosal vaccination against influenza A viruses.

Lapuente D, Ruzsics Z, Thirion C, Tenbusch M.

Vaccine. 2018 May 3;36(19):2712-2720. doi: 10.1016/j.vaccine.2018.02.075. Epub 2018 Apr 5.

PMID:
29628150
8.

Vaccine vectors based on Adenovirus 19a/64 exhibit broad cellular tropism and potently restimulate HCMV-specific T cell responses ex vivo.

Kiener R, Fleischmann M, Schwegler C, Ruzsics Z, Thirion C, Schrödel S, Asbach B, Wagner R.

Sci Rep. 2018 Jan 24;8(1):1474. doi: 10.1038/s41598-018-19874-1.

9.

Erratum for Maler et al., "Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages".

Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WW, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G.

MBio. 2017 Sep 26;8(5). pii: e01445-17. doi: 10.1128/mBio.01445-17. No abstract available.

10.

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.

Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WWA, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G.

MBio. 2017 Aug 1;8(4). pii: e00670-17. doi: 10.1128/mBio.00670-17. Erratum in: MBio. 2017 Sep 26;8(5):.

11.

Herpesviral vectors and their application in oncolytic therapy, vaccination, and gene transfer.

Bailer SM, Funk C, Riedl A, Ruzsics Z.

Virus Genes. 2017 Oct;53(5):741-748. doi: 10.1007/s11262-017-1482-7. Epub 2017 Jun 20. Review.

PMID:
28634751
12.

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M, Meyer C, Lemmermann NA, Holtappels R, Arens R, Klenerman P, Früh K, Reddehase MJ, Riemer AB, Cicin-Sain L.

PLoS Pathog. 2016 Dec 15;12(12):e1006072. doi: 10.1371/journal.ppat.1006072. eCollection 2016 Dec.

13.

Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains.

Striebinger H, Zhang J, Ott M, Funk C, Radtke K, Duron J, Ruzsics Z, Haas J, Lippé R, Bailer SM.

J Gen Virol. 2015 Nov;96(11):3313-25.

PMID:
26265177
14.

Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses.

Mück-Häusl M, Solanki M, Zhang W, Ruzsics Z, Ehrhardt A.

Nucleic Acids Res. 2015 Apr 30;43(8):e50. doi: 10.1093/nar/gkv031. Epub 2015 Jan 21.

15.

The amphipathic helix of adenovirus capsid protein VI contributes to penton release and postentry sorting.

Martinez R, Schellenberger P, Vasishtan D, Aknin C, Austin S, Dacheux D, Rayne F, Siebert A, Ruzsics Z, Gruenewald K, Wodrich H.

J Virol. 2015 Feb;89(4):2121-35. doi: 10.1128/JVI.02257-14. Epub 2014 Dec 3.

16.

Nuclear herpesvirus capsid motility is not dependent on F-actin.

Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW.

MBio. 2014 Oct 7;5(5):e01909-14. doi: 10.1128/mBio.01909-14.

17.

A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Beverley PC, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, Marchi E, O'Hara G, Klenerman P, Koszinowski UH, Tchilian EZ.

J Immunol. 2014 Sep 1;193(5):2306-16. doi: 10.4049/jimmunol.1302523. Epub 2014 Jul 28.

18.

A modified screening system for loss-of-function and dominant negative alleles of essential MCMV genes.

Pogoda M, Bosse JB, Conzelmann KK, Koszinowski UH, Ruzsics Z.

PLoS One. 2014 Apr 14;9(4):e94918. doi: 10.1371/journal.pone.0094918. eCollection 2014.

19.

Engineering adenovirus genome by bacterial artificial chromosome (BAC) technology.

Ruzsics Z, Lemnitzer F, Thirion C.

Methods Mol Biol. 2014;1089:143-58. doi: 10.1007/978-1-62703-679-5_11.

PMID:
24132484
20.

Metabolic labeling of newly transcribed RNA for high resolution gene expression profiling of RNA synthesis, processing and decay in cell culture.

Rädle B, Rutkowski AJ, Ruzsics Z, Friedel CC, Koszinowski UH, Dölken L.

J Vis Exp. 2013 Aug 8;(78). doi: 10.3791/50195.

21.

Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.

Stahl S, Burkhart JM, Hinte F, Tirosh B, Mohr H, Zahedi RP, Sickmann A, Ruzsics Z, Budt M, Brune W.

PLoS Pathog. 2013;9(8):e1003544. doi: 10.1371/journal.ppat.1003544. Epub 2013 Aug 8.

22.

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.

Fejer G, Wegner MD, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Z, Dölken L, Prazeres da Costa O, Branzk N, Huber M, Prasse A, Schneider R, Apte RN, Galanos C, Freudenberg MA.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2191-8. doi: 10.1073/pnas.1302877110. Epub 2013 May 24.

23.

Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, Vivier E, Dalod M, Jonjić S, Dölken L, Koszinowski UH.

Cell Host Microbe. 2013 May 15;13(5):535-545. doi: 10.1016/j.chom.2013.04.007.

24.

The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens.

Dekhtiarenko I, Jarvis MA, Ruzsics Z, Čičin-Šain L.

J Immunol. 2013 Apr 1;190(7):3399-409. doi: 10.4049/jimmunol.1203173. Epub 2013 Mar 4.

25.

Systemic and local infection routes govern different cellular dissemination pathways during gammaherpesvirus infection in vivo.

Vidy A, Sacher T, Adler H, Jordan S, Koszinowski UH, Ruzsics Z.

J Virol. 2013 Apr;87(8):4596-608. doi: 10.1128/JVI.03135-12. Epub 2013 Feb 13.

26.

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.

Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P.

Immunity. 2013 Jan 24;38(1):106-18. doi: 10.1016/j.immuni.2012.11.004. Epub 2012 Dec 27.

27.

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.

Ebermann L, Ruzsics Z, Guzmán CA, van Rooijen N, Casalegno-Garduño R, Koszinowski U, Čičin-Šain L.

PLoS Pathog. 2012;8(12):e1003062. doi: 10.1371/journal.ppat.1003062. Epub 2012 Dec 13.

28.

Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin-A2.

Lemnitzer F, Raschbichler V, Kolodziejczak D, Israel L, Imhof A, Bailer SM, Koszinowski U, Ruzsics Z.

Cell Microbiol. 2013 Feb;15(2):335-51. doi: 10.1111/cmi.12080. Epub 2012 Dec 24.

PMID:
23189961
29.

Characterization of conserved region 2-deficient mutants of the cytomegalovirus egress protein pM53.

Pogoda M, Bosse JB, Wagner FM, Schauflinger M, Walther P, Koszinowski UH, Ruzsics Z.

J Virol. 2012 Dec;86(23):12512-24. doi: 10.1128/JVI.00471-12. Epub 2012 Sep 19.

30.

Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection.

Marcinowski L, Lidschreiber M, Windhager L, Rieder M, Bosse JB, Rädle B, Bonfert T, Györy I, de Graaf M, Prazeres da Costa O, Rosenstiel P, Friedel CC, Zimmer R, Ruzsics Z, Dölken L.

PLoS Pathog. 2012 Sep;8(9):e1002908. doi: 10.1371/journal.ppat.1002908. Epub 2012 Sep 6.

31.

A beta-herpesvirus with fluorescent capsids to study transport in living cells.

Bosse JB, Bauerfeind R, Popilka L, Marcinowski L, Taeglich M, Jung C, Striebinger H, von Einem J, Gaul U, Walther P, Koszinowski UH, Ruzsics Z.

PLoS One. 2012;7(7):e40585. doi: 10.1371/journal.pone.0040585. Epub 2012 Jul 11.

32.

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.

Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z.

PLoS Pathog. 2012;8(6):e1002728. doi: 10.1371/journal.ppat.1002728. Epub 2012 Jun 7.

33.

A cell free protein fragment complementation assay for monitoring the core interaction of the human cytomegalovirus nuclear egress complex.

Schnee M, Wagner FM, Koszinowski UH, Ruzsics Z.

Antiviral Res. 2012 Jul;95(1):12-8. doi: 10.1016/j.antiviral.2012.04.009. Epub 2012 May 9.

PMID:
22580129
34.

Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution.

Windhager L, Bonfert T, Burger K, Ruzsics Z, Krebs S, Kaufmann S, Malterer G, L'Hernault A, Schilhabel M, Schreiber S, Rosenstiel P, Zimmer R, Eick D, Friedel CC, Dölken L.

Genome Res. 2012 Oct;22(10):2031-42. doi: 10.1101/gr.131847.111. Epub 2012 Apr 26.

35.

Transcriptional activation of the adenoviral genome is mediated by capsid protein VI.

Schreiner S, Martinez R, Groitl P, Rayne F, Vaillant R, Wimmer P, Bossis G, Sternsdorf T, Marcinowski L, Ruzsics Z, Dobner T, Wodrich H.

PLoS Pathog. 2012 Feb;8(2):e1002549. doi: 10.1371/journal.ppat.1002549. Epub 2012 Feb 23.

36.

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

Marcinowski L, Tanguy M, Krmpotic A, Rädle B, Lisnić VJ, Tuddenham L, Chane-Woon-Ming B, Ruzsics Z, Erhard F, Benkartek C, Babic M, Zimmer R, Trgovcich J, Koszinowski UH, Jonjic S, Pfeffer S, Dölken L.

PLoS Pathog. 2012 Feb;8(2):e1002510. doi: 10.1371/journal.ppat.1002510. Epub 2012 Feb 9.

37.

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Sacher T, Andrassy J, Kalnins A, Dölken L, Jordan S, Podlech J, Ruzsics Z, Jauch KW, Reddehase MJ, Koszinowski UH.

PLoS Pathog. 2011 Nov;7(11):e1002366. doi: 10.1371/journal.ppat.1002366. Epub 2011 Nov 17.

38.

M94 is essential for the secondary envelopment of murine cytomegalovirus.

Maninger S, Bosse JB, Lemnitzer F, Pogoda M, Mohr CA, von Einem J, Walther P, Koszinowski UH, Ruzsics Z.

J Virol. 2011 Sep;85(18):9254-67. doi: 10.1128/JVI.00443-11. Epub 2011 Jun 29.

39.

The role of cell types in cytomegalovirus infection in vivo.

Sacher T, Mohr CA, Weyn A, Schlichting C, Koszinowski UH, Ruzsics Z.

Eur J Cell Biol. 2012 Jan;91(1):70-7. doi: 10.1016/j.ejcb.2011.02.002. Epub 2011 Apr 13. Review.

PMID:
21492952
40.

Stepwise loss of fluorescent core protein V from human adenovirus during entry into cells.

Puntener D, Engelke MF, Ruzsics Z, Strunze S, Wilhelm C, Greber UF.

J Virol. 2011 Jan;85(1):481-96. doi: 10.1128/JVI.01571-10. Epub 2010 Nov 3.

41.

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands.

Dölken L, Krmpotic A, Kothe S, Tuddenham L, Tanguy M, Marcinowski L, Ruzsics Z, Elefant N, Altuvia Y, Margalit H, Koszinowski UH, Jonjic S, Pfeffer S.

PLoS Pathog. 2010 Oct 14;6(10):e1001150. doi: 10.1371/journal.ppat.1001150.

42.

Dominant negative mutants of the murine cytomegalovirus M53 gene block nuclear egress and inhibit capsid maturation.

Popa M, Ruzsics Z, Lötzerich M, Dölken L, Buser C, Walther P, Koszinowski UH.

J Virol. 2010 Sep;84(18):9035-46. doi: 10.1128/JVI.00681-10. Epub 2010 Jul 7.

43.

A spread-deficient cytomegalovirus for assessment of first-target cells in vaccination.

Mohr CA, Arapovic J, Mühlbach H, Panzer M, Weyn A, Dölken L, Krmpotic A, Voehringer D, Ruzsics Z, Koszinowski U, Sacher T.

J Virol. 2010 Aug;84(15):7730-42. doi: 10.1128/JVI.02696-09. Epub 2010 May 12.

44.

Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.

Dölken L, Malterer G, Erhard F, Kothe S, Friedel CC, Suffert G, Marcinowski L, Motsch N, Barth S, Beitzinger M, Lieber D, Bailer SM, Hoffmann R, Ruzsics Z, Kremmer E, Pfeffer S, Zimmer R, Koszinowski UH, Grässer F, Meister G, Haas J.

Cell Host Microbe. 2010 Apr 22;7(4):324-34. doi: 10.1016/j.chom.2010.03.008.

45.

A capsid-encoded PPxY-motif facilitates adenovirus entry.

Wodrich H, Henaff D, Jammart B, Segura-Morales C, Seelmeir S, Coux O, Ruzsics Z, Wiethoff CM, Kremer EJ.

PLoS Pathog. 2010 Mar 19;6(3):e1000808. doi: 10.1371/journal.ppat.1000808.

46.

The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV.

Scrivano L, Esterlechner J, Mühlbach H, Ettischer N, Hagen C, Grünewald K, Mohr CA, Ruzsics Z, Koszinowski U, Adler B.

J Virol. 2010 May;84(9):4469-80. doi: 10.1128/JVI.02441-09. Epub 2010 Feb 24.

47.

Dominant-negative proteins in herpesviruses - from assigning gene function to intracellular immunization.

Mühlbach H, Mohr CA, Ruzsics Z, Koszinowski UH.

Viruses. 2009 Dec;1(3):420-40. doi: 10.3390/v1030420. Epub 2009 Oct 19.

48.

Genetic reconstitution of the human adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape.

Imelli N, Ruzsics Z, Puntener D, Gastaldelli M, Greber UF.

Virol J. 2009 Oct 27;6:174. doi: 10.1186/1743-422X-6-174.

49.

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life.

Friedel CC, Dölken L, Ruzsics Z, Koszinowski UH, Zimmer R.

Nucleic Acids Res. 2009 Sep;37(17):e115. doi: 10.1093/nar/gkp542. Epub 2009 Jun 26.

50.

Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.

Arapovic J, Lenac T, Antulov R, Polic B, Ruzsics Z, Carayannopoulos LN, Koszinowski UH, Krmpotic A, Jonjic S.

J Virol. 2009 Aug;83(16):8198-207. doi: 10.1128/JVI.02549-08. Epub 2009 Jun 3.

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