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Items: 1 to 50 of 80

1.

An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice.

Eyer L, Nougairède A, Uhlířová M, Driouich JS, Zouharová D, Valdés JJ, Haviernik J, Gould EA, De Clercq E, de Lamballerie X, Ruzek D.

J Virol. 2019 Jul 30;93(16). pii: e00367-19. doi: 10.1128/JVI.00367-19. Print 2019 Aug 15.

PMID:
31142664
2.

Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate).

Hönig V, Švec P, Marek L, Mrkvička T, Dana Z, Wittmann MV, Masař O, Szturcová D, Růžek D, Pfister K, Grubhoffer L.

Int J Environ Res Public Health. 2019 Apr 2;16(7). pii: E1173. doi: 10.3390/ijerph16071173.

3.

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus.

Krol E, Wandzik I, Brzuska G, Eyer L, Růžek D, Szewczyk B.

Molecules. 2019 Mar 21;24(6). pii: E1129. doi: 10.3390/molecules24061129.

4.

Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines.

Ruzek D, Avšič Županc T, Borde J, Chrdle A, Eyer L, Karganova G, Kholodilov I, Knap N, Kozlovskaya L, Matveev A, Miller AD, Osolodkin DI, Överby AK, Tikunova N, Tkachev S, Zajkowska J.

Antiviral Res. 2019 Apr;164:23-51. doi: 10.1016/j.antiviral.2019.01.014. Epub 2019 Jan 31. Review.

PMID:
30710567
5.

Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection.

Eyer L, Fojtíková M, Nencka R, Rudolf I, Hubálek Z, Ruzek D.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02093-18. doi: 10.1128/AAC.02093-18. Print 2019 Mar.

6.

Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells.

Sirmarova J, Salat J, Palus M, Hönig V, Langhansova H, Holbrook MR, Ruzek D.

Emerg Microbes Infect. 2018 Nov 7;7(1):175. doi: 10.1038/s41426-018-0177-z.

7.

Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use.

Salát J, Formanová P, Huňady M, Eyer L, Palus M, Ruzek D.

Vaccine. 2018 Nov 19;36(48):7257-7261. doi: 10.1016/j.vaccine.2018.10.034. Epub 2018 Oct 15.

PMID:
30337175
8.

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors.

Šebera J, Dubankova A, Sychrovský V, Ruzek D, Boura E, Nencka R.

Sci Rep. 2018 Jul 24;8(1):11132. doi: 10.1038/s41598-018-29459-7.

9.

A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus.

Palus M, Sohrabi Y, Broman KW, Strnad H, Šíma M, Růžek D, Volkova V, Slapničková M, Vojtíšková J, Mrázková L, Salát J, Lipoldová M.

BMC Neurosci. 2018 Jul 6;19(1):39. doi: 10.1186/s12868-018-0438-8.

10.

Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin.

Marosi A, Dufkova L, Forró B, Felde O, Erdélyi K, Širmarová J, Palus M, Hönig V, Salát J, Tikos R, Gyuranecz M, Růžek D, Martina B, Koraka P, Osterhaus ADME, Bakonyi T.

Vaccine. 2019 Aug 2;37(33):4724-4735. doi: 10.1016/j.vaccine.2018.05.066. Epub 2018 May 24.

PMID:
29805091
11.

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses.

Haviernik J, Štefánik M, Fojtíková M, Kali S, Tordo N, Rudolf I, Hubálek Z, Eyer L, Ruzek D.

Viruses. 2018 Apr 10;10(4). pii: E184. doi: 10.3390/v10040184.

12.

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

Eyer L, Nencka R, de Clercq E, Seley-Radtke K, Růžek D.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618761299. doi: 10.1177/2040206618761299. Review.

13.

Characterisation of Zika virus infection in primary human astrocytes.

Stefanik M, Formanova P, Bily T, Vancova M, Eyer L, Palus M, Salat J, Braconi CT, Zanotto PMA, Gould EA, Ruzek D.

BMC Neurosci. 2018 Feb 20;19(1):5. doi: 10.1186/s12868-018-0407-2.

14.

Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody.

Füzik T, Formanová P, Růžek D, Yoshii K, Niedrig M, Plevka P.

Nat Commun. 2018 Jan 30;9(1):436. doi: 10.1038/s41467-018-02882-0.

15.

Mannitol treatment is not effective in therapy of rabies virus infection in mice.

Dufkova L, Sirmarova J, Salat J, Honig V, Palus M, Ruzek D, Fooks AR, Mansfield KL, Tordo N, Jochmans D, Neyts J, Martina B, Koraka P, Osterhaus ADME; ASKLEPIOS consortium.

Vaccine. 2019 Aug 2;37(33):4710-4714. doi: 10.1016/j.vaccine.2017.12.028. Epub 2017 Dec 20.

PMID:
29274698
16.

Tick-Borne Encephalitis in Sheep, Romania.

Salat J, Mihalca AD, Mihaiu M, Modrý D, Ruzek D.

Emerg Infect Dis. 2017 Dec;23(12):2065-2067. doi: 10.3201/eid2312.170166.

17.

Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic.

Honig V, Carolan HE, Vavruskova Z, Massire C, Mosel MR, Crowder CD, Rounds MA, Ecker DJ, Ruzek D, Grubhoffer L, Luft BJ, Eshoo MW.

FEMS Microbiol Ecol. 2017 Nov 1;93(11). doi: 10.1093/femsec/fix129.

18.

Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness.

Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D.

J Virol. 2017 Oct 13;91(21). pii: e01028-17. doi: 10.1128/JVI.01028-17. Print 2017 Nov 1.

19.

A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties.

Bukin YS, Dzhioev YP, Tkachev SE, Kozlova IV, Paramonov AI, Ruzek D, Qu Z, Zlobin VI.

Virus Res. 2017 Jun 15;238:124-132. doi: 10.1016/j.virusres.2017.06.006. Epub 2017 Jun 15.

PMID:
28625666
20.

Europe-Wide Meta-Analysis of Borrelia burgdorferi Sensu Lato Prevalence in Questing Ixodes ricinus Ticks.

Strnad M, Hönig V, Růžek D, Grubhoffer L, Rego ROM.

Appl Environ Microbiol. 2017 Jul 17;83(15). pii: e00609-17. doi: 10.1128/AEM.00609-17. Print 2017 Aug 1.

21.

Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity.

Palus M, Vancova M, Sirmarova J, Elsterova J, Perner J, Ruzek D.

Virology. 2017 Jul;507:110-122. doi: 10.1016/j.virol.2017.04.012. Epub 2017 Apr 19.

22.

Comparative analysis of complete genome sequences of European subtype tick-borne encephalitis virus strains isolated from Ixodes persulcatus ticks, long-tailed ground squirrel (Spermophilus undulatus), and human blood in the Asian part of Russia.

Demina TV, Tkachev SE, Kozlova IV, Doroshchenko EK, Lisak OV, Suntsova OV, Verkhozina MM, Dzhioev YP, Paramonov AI, Tikunov AY, Tikunova NV, Zlobin VI, Ruzek D.

Ticks Tick Borne Dis. 2017 Jun;8(4):547-553. doi: 10.1016/j.ttbdis.2017.03.002. Epub 2017 Mar 9.

PMID:
28336423
23.

Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses.

Eyer L, Zouharová D, Širmarová J, Fojtíková M, Štefánik M, Haviernik J, Nencka R, de Clercq E, Růžek D.

Antiviral Res. 2017 Jun;142:63-67. doi: 10.1016/j.antiviral.2017.03.012. Epub 2017 Mar 21.

PMID:
28336346
24.

Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.

Valdés JJ, Butterill PT, Růžek D.

Biochem Biophys Res Commun. 2017 Oct 28;492(4):652-658. doi: 10.1016/j.bbrc.2017.03.068. Epub 2017 Mar 18. Review.

PMID:
28322784
25.

Novel hantavirus identified in European bat species Nyctalus noctula.

Straková P, Dufkova L, Širmarová J, Salát J, Bartonička T, Klempa B, Pfaff F, Höper D, Hoffmann B, Ulrich RG, Růžek D.

Infect Genet Evol. 2017 Mar;48:127-130. doi: 10.1016/j.meegid.2016.12.025. Epub 2016 Dec 23.

PMID:
28025098
26.

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.

Hercík K, Kozak J, Šála M, Dejmek M, Hřebabecký H, Zborníková E, Smola M, Ruzek D, Nencka R, Boura E.

Antiviral Res. 2017 Jan;137:131-133. doi: 10.1016/j.antiviral.2016.11.020. Epub 2016 Nov 27.

PMID:
27902932
27.

Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin.

Elsterova J, Palus M, Sirmarova J, Kopecky J, Niller HH, Ruzek D.

Ticks Tick Borne Dis. 2017 Feb;8(2):253-258. doi: 10.1016/j.ttbdis.2016.11.007. Epub 2016 Nov 18.

PMID:
27884572
28.

Tick-borne encephalitis: What travelers should know when visiting an endemic country.

Chrdle A, Chmelík V, Růžek D.

Hum Vaccin Immunother. 2016 Oct 2;12(10):2694-2699. doi: 10.1080/21645515.2016.1218098. Review.

29.

An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein.

Fernando S, Fernando T, Stefanik M, Eyer L, Ruzek D.

Mol Biotechnol. 2016 Dec;58(12):801-806.

PMID:
27683255
30.

Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection.

Valdés JJ, Cabezas-Cruz A, Sima R, Butterill PT, Růžek D, Nuttall PA.

Sci Rep. 2016 Sep 1;6:32372. doi: 10.1038/srep32372.

31.

An all-atom, active site exploration of antiviral drugs that target Flaviviridae polymerases.

Valdés JJ, Gil VA, Butterill PT, Růžek D.

J Gen Virol. 2016 Oct;97(10):2552-2565. doi: 10.1099/jgv.0.000569. Epub 2016 Aug 1.

PMID:
27489039
32.

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.

Eyer L, Šmídková M, Nencka R, Neča J, Kastl T, Palus M, De Clercq E, Růžek D.

Antiviral Res. 2016 Sep;133:119-29. doi: 10.1016/j.antiviral.2016.07.018. Epub 2016 Jul 28.

PMID:
27476046
33.
34.

Nucleoside Inhibitors of Zika Virus.

Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, De Clercq E, Růžek D.

J Infect Dis. 2016 Sep 1;214(5):707-11. doi: 10.1093/infdis/jiw226. Epub 2016 May 27.

PMID:
27234417
35.

Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells.

Černý J, Selinger M, Palus M, Vavrušková Z, Tykalová H, Bell-Sakyi L, Štěrba J, Grubhoffer L, Růžek D.

Virus Genes. 2016 Jun;52(3):309-16. doi: 10.1007/s11262-015-1273-y. Epub 2016 Feb 29.

PMID:
26924586
36.

Antiviral activities of 2,6-diaminopurine-based acyclic nucleoside phosphonates against herpesviruses: In vitro study results with pseudorabies virus (PrV, SuHV-1).

Zouharova D, Lipenska I, Fojtikova M, Kulich P, Neca J, Slany M, Kovarcik K, Turanek-Knotigova P, Hubatka F, Celechovska H, Masek J, Koudelka S, Prochazka L, Eyer L, Plockova J, Bartheldyova E, Miller AD, Ruzek D, Raska M, Janeba Z, Turanek J.

Vet Microbiol. 2016 Feb 29;184:84-93. doi: 10.1016/j.vetmic.2016.01.010. Epub 2016 Jan 18.

PMID:
26854349
37.

[Tick-borne encefalitis - pathogenesis and -therapeutic approaches].

Růžek D.

Epidemiol Mikrobiol Imunol. 2015 Oct;64(4):204-9. Review. Czech.

PMID:
26795224
38.

A Review of Methods for Detecting Tick-Borne Encephalitis Virus Infection in Tick, Animal, and Human Specimens.

Ergunay K, Tkachev S, Kozlova I, Růžek D.

Vector Borne Zoonotic Dis. 2016 Jan;16(1):4-12. doi: 10.1089/vbz.2015.1896. Epub 2016 Jan 15.

PMID:
26771446
39.

Fatal tick-borne encephalitis in an immunosuppressed 12-year-old patient.

Chmelík V, Chrdle A, Růžek D.

J Clin Virol. 2016 Jan;74:73-4. doi: 10.1016/j.jcv.2015.11.029. Epub 2015 Nov 27. No abstract available.

PMID:
26679831
40.

Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis.

Weisheit S, Villar M, Tykalová H, Popara M, Loecherbach J, Watson M, Růžek D, Grubhoffer L, de la Fuente J, Fazakerley JK, Bell-Sakyi L.

Parasit Vectors. 2015 Nov 18;8:599. doi: 10.1186/s13071-015-1210-x.

41.

A deep phylogeny of viral and cellular right-hand polymerases.

Černý J, Černá Bolfíková B, de A Zanotto PM, Grubhoffer L, Růžek D.

Infect Genet Evol. 2015 Dec;36:275-286. doi: 10.1016/j.meegid.2015.09.026. Epub 2015 Oct 22.

PMID:
26431690
42.

Detection of Diverse Novel Bat Astrovirus Sequences in the Czech Republic.

Dufkova L, Straková P, Širmarová J, Salát J, Moutelíková R, Chrudimský T, Bartonička T, Nowotny N, Růžek D.

Vector Borne Zoonotic Dis. 2015 Aug;15(8):518-21. doi: 10.1089/vbz.2015.1813.

PMID:
26273815
43.

Nucleoside inhibitors of tick-borne encephalitis virus.

Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, Salát J, Černý J, Palus M, De Clercq E, Růžek D.

Antimicrob Agents Chemother. 2015 Sep;59(9):5483-93. doi: 10.1128/AAC.00807-15. Epub 2015 Jun 29.

44.

Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons.

Bílý T, Palus M, Eyer L, Elsterová J, Vancová M, Růžek D.

Sci Rep. 2015 Jun 15;5:10745. doi: 10.1038/srep10745.

45.

Analysis of serum levels of cytokines, chemokines, growth factors, and monoamine neurotransmitters in patients with tick-borne encephalitis: identification of novel inflammatory markers with implications for pathogenesis.

Palus M, Formanová P, Salát J, Žampachová E, Elsterová J, Růžek D.

J Med Virol. 2015 May;87(5):885-92. doi: 10.1002/jmv.24140. Epub 2015 Feb 11.

PMID:
25675945
46.

Detection panel for identification of twelve hemorrhagic viruses using real-time RT-PCR.

Fajfr M, Neubauerová V, Pajer P, Kubíčková P, Růžek D.

Epidemiol Mikrobiol Imunol. 2014 Sep;63(3):238-44.

PMID:
25412490
47.

Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells.

Lieskovská J, Páleníková J, Širmarová J, Elsterová J, Kotsyfakis M, Campos Chagas A, Calvo E, Růžek D, Kopecký J.

Parasite Immunol. 2015 Feb;37(2):70-8. doi: 10.1111/pim.12162.

48.

Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients.

Formanová P, Černý J, Bolfíková BČ, Valdés JJ, Kozlova I, Dzhioev Y, Růžek D.

Ticks Tick Borne Dis. 2015 Feb;6(1):38-46. doi: 10.1016/j.ttbdis.2014.09.002. Epub 2014 Oct 11.

PMID:
25311899
49.

Full-length genome analysis of Čalovo strains of Batai orthobunyavirus (Bunyamwera serogroup): implications to taxonomy.

Dufkova L, Pachler K, Kilian P, Chrudimský T, Danielová V, Růžek D, Nowotny N.

Infect Genet Evol. 2014 Oct;27:96-104. doi: 10.1016/j.meegid.2014.07.005. Epub 2014 Jul 11.

PMID:
25017655
50.

Infection and injury of human astrocytes by tick-borne encephalitis virus.

Palus M, Bílý T, Elsterová J, Langhansová H, Salát J, Vancová M, Růžek D.

J Gen Virol. 2014 Nov;95(Pt 11):2411-26. doi: 10.1099/vir.0.068411-0. Epub 2014 Jul 7.

PMID:
25000960

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