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Items: 1 to 50 of 193


ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants.

Govindan JA, Jayamani E, Ruvkun G.

Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21651-21658. doi: 10.1073/pnas.1912628116. Epub 2019 Oct 7.


Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection.

Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE.

Astrobiology. 2019 Sep;19(9):1139-1152. doi: 10.1089/ast.2018.1929. Epub 2019 Jun 11.


Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes.

Armakola M, Ruvkun G.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12327-12336. doi: 10.1073/pnas.1820928116. Epub 2019 Jun 4.


Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.

Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.

Cell. 2019 May 30;177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. Epub 2019 Apr 25.


Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression.

Lehrbach NJ, Breen PC, Ruvkun G.

Cell. 2019 Apr 18;177(3):737-750.e15. doi: 10.1016/j.cell.2019.03.035.


Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification.

Warnhoff K, Ruvkun G.

Nat Chem Biol. 2019 May;15(5):480-488. doi: 10.1038/s41589-019-0249-y. Epub 2019 Mar 25.


Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells.

Kniazeva M, Ruvkun G.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3784-3792. doi: 10.1073/pnas.1815656116. Epub 2019 Feb 11.


Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes.

Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G.

Cell Metab. 2019 May 7;29(5):1182-1191.e4. doi: 10.1016/j.cmet.2019.01.022. Epub 2019 Feb 21.


DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.

Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR 3rd, Ruvkun G, Riedel CG.

Nat Commun. 2018 Oct 23;9(1):4400. doi: 10.1038/s41467-018-06624-0.


Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.

Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH.

Genetics. 2018 Dec;210(4):1329-1337. doi: 10.1534/genetics.118.301450. Epub 2018 Oct 4.


Acceleration profiles and processing methods for parabolic flight.

Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT.

NPJ Microgravity. 2018 Aug 7;4:14. doi: 10.1038/s41526-018-0050-3. eCollection 2018.


Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection.

Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE.

Life Sci Space Res (Amst). 2018 Aug;18:80-86. doi: 10.1016/j.lssr.2018.05.004. Epub 2018 May 16.


Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs.

Ambros V, Ruvkun G.

Genetics. 2018 Jul;209(3):651-673. doi: 10.1534/genetics.118.300291.


The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes.

Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G.

Genes Dev. 2018 May 1;32(9-10):670-681. doi: 10.1101/gad.311514.118. Epub 2018 May 8.


CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing.

Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE.

BMC Bioinformatics. 2018 Mar 27;19(1):108. doi: 10.1186/s12859-018-2124-3.


Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars.

Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE.

Front Microbiol. 2017 Sep 26;8:1819. doi: 10.3389/fmicb.2017.01819. eCollection 2017.


Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection.

Mojarro A, Ruvkun G, Zuber MT, Carr CE.

Astrobiology. 2017 Aug;17(8):747-760. doi: 10.1089/ast.2016.1535. Epub 2017 Jul 13.


Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.

Lehrbach NJ, Ruvkun G.

Elife. 2016 Aug 16;5. pii: e17721. doi: 10.7554/eLife.17721.


A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.

Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G.

Genes Dev. 2016 Jul 1;30(13):1515-28. doi: 10.1101/gad.283895.116.


Caenorhabditis elegans responses to bacteria from its natural habitats.

Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3941-9. doi: 10.1073/pnas.1607183113. Epub 2016 Jun 17.


Planetary Protection and Mars Special Regions--A Suggestion for Updating the Definition.

Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F.

Astrobiology. 2016 Feb;16(2):119-25. doi: 10.1089/ast.2016.1472. Epub 2016 Feb 5.


Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.

Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12456-61. doi: 10.1073/pnas.1517448112. Epub 2015 Sep 21.


Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.

Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G.

Nat Cell Biol. 2015 Oct;17(10):1294-303. doi: 10.1038/ncb3229. Epub 2015 Aug 31.


piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.

Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA.

Dev Cell. 2015 Aug 24;34(4):457-65. doi: 10.1016/j.devcel.2015.07.009. Epub 2015 Aug 13.


PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles.

Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y.

Nucleic Acids Res. 2015 Jul 1;43(W1):W154-9. doi: 10.1093/nar/gkv452. Epub 2015 May 9.


Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.

Kirienko NV, Ausubel FM, Ruvkun G.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1821-6. doi: 10.1073/pnas.1424954112. Epub 2015 Jan 26.



Govindan JA, Ruvkun G.

Virulence. 2014;5(7):695-6. doi: 10.4161/viru.36667. No abstract available.


Gene pathways that delay Caenorhabditis elegans reproductive senescence.

Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G.

PLoS Genet. 2014 Dec 4;10(12):e1004752. doi: 10.1371/journal.pgen.1004752. eCollection 2014 Dec.


Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.

Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G.

Nat Struct Mol Biol. 2014 Aug;21(8):712-20. doi: 10.1038/nsmb.2858. Epub 2014 Jul 20.


Caenorhabditis elegans pathways that surveil and defend mitochondria.

Liu Y, Samuel BS, Breen PC, Ruvkun G.

Nature. 2014 Apr 17;508(7496):406-10. doi: 10.1038/nature13204. Epub 2014 Apr 2.


MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.

Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA.

Curr Biol. 2014 Apr 14;24(8):839-44. doi: 10.1016/j.cub.2014.02.060. Epub 2014 Mar 27.


Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.

Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G.

Genes Dev. 2013 Dec 15;27(24):2678-95. doi: 10.1101/gad.233254.113.


High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.

Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A.

Cell. 2013 Dec 5;155(6):1409-21. doi: 10.1016/j.cell.2013.10.047. Epub 2013 Nov 21.


Genetic regulation of Caenorhabditis elegans lysosome related organelle function.

Soukas AA, Carr CE, Ruvkun G.

PLoS Genet. 2013 Oct;9(10):e1003908. doi: 10.1371/journal.pgen.1003908. Epub 2013 Oct 24.


Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G.

Mol Syst Biol. 2013 Oct 1;9:692. doi: 10.1038/msb.2013.50.


Dual regulation of the lin-14 target mRNA by the lin-4 miRNA.

Shi Z, Hayes G, Ruvkun G.

PLoS One. 2013 Sep 13;8(9):e75475. doi: 10.1371/journal.pone.0075475. eCollection 2013.


Radiation resistance of sequencing chips for in situ life detection.

Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G.

Astrobiology. 2013 Jun;13(6):560-9. doi: 10.1089/ast.2012.0923. Epub 2013 Jun 4.


A cytoprotective perspective on longevity regulation.

Shore DE, Ruvkun G.

Trends Cell Biol. 2013 Sep;23(9):409-20. doi: 10.1016/j.tcb.2013.04.007. Epub 2013 May 30. Review.


MicroRNAs visit the ER.

Montgomery TA, Ruvkun G.

Cell. 2013 Apr 25;153(3):511-2. doi: 10.1016/j.cell.2013.04.014.


DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G.

Nat Cell Biol. 2013 May;15(5):491-501. doi: 10.1038/ncb2720. Epub 2013 Apr 21.


MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

O'Rourke EJ, Ruvkun G.

Nat Cell Biol. 2013 Jun;15(6):668-76. doi: 10.1038/ncb2741. Epub 2013 Apr 21. Erratum in: Nat Cell Biol. 2015 Jan;17(1):104.


Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death.

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM.

Cell Host Microbe. 2013 Apr 17;13(4):406-16. doi: 10.1016/j.chom.2013.03.003.


ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.

O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G.

Genes Dev. 2013 Feb 15;27(4):429-40. doi: 10.1101/gad.205294.112. Epub 2013 Feb 7.


Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.

Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G.

Nature. 2013 Jan 31;493(7434):694-8. doi: 10.1038/nature11779. Epub 2012 Dec 23.


High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.

Shi Z, Montgomery TA, Qi Y, Ruvkun G.

Genome Res. 2013 Mar;23(3):497-508. doi: 10.1101/gr.149112.112. Epub 2013 Jan 30.


Radiation resistance of biological reagents for in situ life detection.

Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G.

Astrobiology. 2013 Jan;13(1):68-78. doi: 10.1089/ast.2012.0869.


Prediction of C. elegans longevity genes by human and worm longevity networks.

Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP.

PLoS One. 2012;7(10):e48282. doi: 10.1371/journal.pone.0048282. Epub 2012 Oct 29.


New insights into siRNA amplification and RNAi.

Zhang C, Ruvkun G.

RNA Biol. 2012 Aug;9(8):1045-9. doi: 10.4161/rna.21246. Epub 2012 Aug 1.


Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.

Shore DE, Carr CE, Ruvkun G.

PLoS Genet. 2012;8(7):e1002792. doi: 10.1371/journal.pgen.1002792. Epub 2012 Jul 19.

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