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Items: 9


Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome.

Parlati F, Lee SJ, Aujay M, Suzuki E, Levitsky K, Lorens JB, Micklem DR, Ruurs P, Sylvain C, Lu Y, Shenk KD, Bennett MK.

Blood. 2009 Oct 15;114(16):3439-47. doi: 10.1182/blood-2009-05-223677. Epub 2009 Aug 11.


Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.

van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradère JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL, Moolenaar WH, Jonkers J.

Mol Cell Biol. 2006 Jul;26(13):5015-22.


Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.

van Meeteren LA, Ruurs P, Christodoulou E, Goding JW, Takakusa H, Kikuchi K, Perrakis A, Nagano T, Moolenaar WH.

J Biol Chem. 2005 Jun 3;280(22):21155-61. Epub 2005 Mar 15.


Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.

van der Luit AH, Budde M, Ruurs P, Verheij M, van Blitterswijk WJ.

J Biol Chem. 2002 Oct 18;277(42):39541-7. Epub 2002 Aug 14.


Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

Tepper AD, Ruurs P, Borst J, van Blitterswijk WJ.

Biochem Biophys Res Commun. 2001 Jan 26;280(3):634-9.


Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology.

Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ.

J Cell Biol. 2000 Jul 10;150(1):155-64.


Protein kinase C activation by acidic proteins including 14-3-3.

Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Blitterswijk WJ.

Biochem J. 2000 May 1;347 Pt 3:781-5.


14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation.

Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J.

Biochem J. 2000 Jan 15;345 Pt 2:297-306.


Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells.

Franken NA, Ruurs P, Ludwików G, van Bree C, Kipp JB, Darroudi F, Barendsen GW.

Int J Radiat Biol. 1999 Mar;75(3):293-9.


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