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Items: 1 to 50 of 294

1.

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.

Jaafar R, Tran S, Shah A, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A.

J Clin Invest. 2019 Jul 2;130. pii: 127021. doi: 10.1172/JCI127021.

2.

An essential role for the Zn2+ transporter ZIP7 in B cell development.

Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S.

Nat Immunol. 2019 Mar;20(3):350-361. doi: 10.1038/s41590-018-0295-8. Epub 2019 Feb 4.

PMID:
30718914
3.

Correction: Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion.

Nguyen-Tu MS, da Silva Xavier G, Leclerc I, Rutter GA.

J Biol Chem. 2018 Nov 23;293(47):18420. doi: 10.1074/jbc.AAC118.006541. No abstract available.

4.

The α-cell in diabetes mellitus.

Gromada J, Chabosseau P, Rutter GA.

Nat Rev Endocrinol. 2018 Dec;14(12):694-704. doi: 10.1038/s41574-018-0097-y. Review.

PMID:
30310153
5.

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis.

Benninger RKP, Dorrell C, Hodson DJ, Rutter GA.

Curr Diab Rep. 2018 Sep 24;18(11):112. doi: 10.1007/s11892-018-1085-2. Review.

6.

Chronic d-serine supplementation impairs insulin secretion.

Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S.

Mol Metab. 2018 Oct;16:191-202. doi: 10.1016/j.molmet.2018.07.002. Epub 2018 Jul 25.

7.

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.

Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada J.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649. doi: 10.1073/pnas.1721418115. Epub 2018 Jul 23.

8.

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity.

Kimura T, Obata A, Shimoda M, Shimizu I, da Silva Xavier G, Okauchi S, Hirukawa H, Kohara K, Mune T, Moriuchi S, Hiraoka A, Tamura K, Chikazawa G, Ishida A, Yoshitaka H, Rutter GA, Kaku K, Kaneto H.

Sci Rep. 2018 Jul 13;8(1):10644. doi: 10.1038/s41598-018-28849-1.

9.

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Izzi-Engbeaya C, Comninos AN, Clarke SA, Jomard A, Yang L, Jones S, Abbara A, Narayanaswamy S, Eng PC, Papadopoulou D, Prague JK, Bech P, Godsland IF, Bassett P, Sands C, Camuzeaux S, Gomez-Romero M, Pearce JTM, Lewis MR, Holmes E, Nicholson JK, Tan T, Ratnasabapathy R, Hu M, Carrat G, Piemonti L, Bugliani M, Marchetti P, Johnson PR, Hughes SJ, James Shapiro AM, Rutter GA, Dhillo WS.

Diabetes Obes Metab. 2018 Dec;20(12):2800-2810. doi: 10.1111/dom.13460. Epub 2018 Aug 16.

10.

Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion.

Nguyen-Tu MS, da Silva Xavier G, Leclerc I, Rutter GA.

J Biol Chem. 2018 Sep 7;293(36):14178-14189. doi: 10.1074/jbc.RA118.003613. Epub 2018 Jul 2. Erratum in: J Biol Chem. 2018 Nov 23;293(47):18420.

11.

Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28-30, 2016 - Israel.

Jenkins A, Lengyel I, Rutter GA, Lowe N, Shai I, Tirosh A, Petro T, Khamaisi M, Andrews S, Zmora N, Gross A, Maret W, Lewis EC, Moran A.

J Trace Elem Med Biol. 2018 Sep;49:79-85. doi: 10.1016/j.jtemb.2018.04.021. Epub 2018 Apr 24. No abstract available.

12.

Neuronatin regulates pancreatic β cell insulin content and secretion.

Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ.

J Clin Invest. 2018 Aug 1;128(8):3369-3381. doi: 10.1172/JCI120115. Epub 2018 Jul 9.

13.

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis.

Ma Y, Ratnasabapathy R, Izzi-Engbeaya C, Nguyen-Tu MS, Richardson E, Hussain S, De Backer I, Holton C, Norton M, Carrat G, Schwappach B, Rutter GA, Dhillo WS, Gardiner J.

Diabetes Obes Metab. 2018 Sep;20(9):2246-2254. doi: 10.1111/dom.13359. Epub 2018 Jun 12.

14.

Targeting GLP-1 receptor trafficking to improve agonist efficacy.

Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Corrêa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR.

Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2.

15.

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish.

Janjuha S, Singh SP, Tsakmaki A, Mousavy Gharavy SN, Murawala P, Konantz J, Birke S, Hodson DJ, Rutter GA, Bewick GA, Ninov N.

Elife. 2018 Apr 6;7. pii: e32965. doi: 10.7554/eLife.32965.

16.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI.

Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21.

17.

Manipulation and Measurement of AMPK Activity in Pancreatic Islets.

Martinez-Sanchez A, Nguyen-Tu MS, Leclerc I, Rutter GA.

Methods Mol Biol. 2018;1732:413-431. doi: 10.1007/978-1-4939-7598-3_26.

PMID:
29480490
18.

Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

Rutter GA, Hodson DJ.

Cell Mol Life Sci. 2018 Apr;75(7):1303-1305. doi: 10.1007/s00018-018-2767-2.

PMID:
29450573
19.

Sensors for measuring subcellular zinc pools.

Chabosseau P, Woodier J, Cheung R, Rutter GA.

Metallomics. 2018 Feb 21;10(2):229-239. doi: 10.1039/c7mt00336f. Review.

PMID:
29431830
20.

Control of insulin secretion by GLP-1.

Jones B, Bloom SR, Buenaventura T, Tomas A, Rutter GA.

Peptides. 2018 Feb;100:75-84. doi: 10.1016/j.peptides.2017.12.013. Review.

21.

Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes.

Tuncay E, Bitirim CV, Olgar Y, Durak A, Rutter GA, Turan B.

Mitochondrion. 2019 Jan;44:41-52. doi: 10.1016/j.mito.2017.12.011. Epub 2018 Jan 4.

PMID:
29307859
22.

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR Jr, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A.

Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28.

23.

MiR-184 expression is regulated by AMPK in pancreatic islets.

Martinez-Sanchez A, Nguyen-Tu MS, Cebola I, Yavari A, Marchetti P, Piemonti L, de Koning E, Shapiro AMJ, Johnson P, Sakamoto K, Smith DM, Leclerc I, Ashrafian H, Ferrer J, Rutter GA.

FASEB J. 2018 May;32(5):2587-2600. doi: 10.1096/fj.201701100R. Epub 2018 Jan 8.

24.

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion.

Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ.

Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4.

25.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

26.

Local and regional control of calcium dynamics in the pancreatic islet.

Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc I.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:30-41. doi: 10.1111/dom.12990. Review.

27.

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene.

Pullen TJ, Huising MO, Rutter GA.

Front Genet. 2017 Apr 10;8:41. doi: 10.3389/fgene.2017.00041. eCollection 2017.

28.

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M.

Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr.

29.

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice.

Mitchell RK, Nguyen-Tu MS, Chabosseau P, Callingham RM, Pullen TJ, Cheung R, Leclerc I, Hodson DJ, Rutter GA.

J Biol Chem. 2017 May 26;292(21):8892-8906. doi: 10.1074/jbc.M117.784629. Epub 2017 Apr 4.

30.

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

da Silva Xavier G, Mondragon A, Mourougavelou V, Cruciani-Guglielmacci C, Denom J, Herrera PL, Magnan C, Rutter GA.

Diabetologia. 2017 Jun;60(6):1043-1050. doi: 10.1007/s00125-017-4242-2. Epub 2017 Mar 25.

31.

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome.

Perez Y, Shorer Z, Liani-Leibson K, Chabosseau P, Kadir R, Volodarsky M, Halperin D, Barber-Zucker S, Shalev H, Schreiber R, Gradstein L, Gurevich E, Zarivach R, Rutter GA, Landau D, Birk OS.

Brain. 2017 Apr 1;140(4):928-939. doi: 10.1093/brain/awx013.

32.

Remote control of glucose homeostasis in vivo using photopharmacology.

Mehta ZB, Johnston NR, Nguyen-Tu MS, Broichhagen J, Schultz P, Larner DP, Leclerc I, Trauner D, Rutter GA, Hodson DJ.

Sci Rep. 2017 Mar 22;7(1):291. doi: 10.1038/s41598-017-00397-0.

33.

Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.

Tuncay E, Bitirim VC, Durak A, Carrat GRJ, Taylor KM, Rutter GA, Turan B.

Diabetes. 2017 May;66(5):1346-1358. doi: 10.2337/db16-1099. Epub 2017 Feb 23.

34.

GABA signaling: A route to new pancreatic β cells.

Rutter GA.

Cell Res. 2017 Mar;27(3):309-310. doi: 10.1038/cr.2017.20. Epub 2017 Feb 10.

35.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA.

Am J Hum Genet. 2017 Feb 2;100(2):238-256. doi: 10.1016/j.ajhg.2017.01.011. Epub 2017 Jan 26.

36.

MiRNAs in β-Cell Development, Identity, and Disease.

Martinez-Sanchez A, Rutter GA, Latreille M.

Front Genet. 2017 Jan 11;7:226. doi: 10.3389/fgene.2016.00226. eCollection 2016. Review.

37.

Diabetes: Controlling the identity of the adult pancreatic β cell.

Rutter GA.

Nat Rev Endocrinol. 2017 Mar;13(3):129-130. doi: 10.1038/nrendo.2017.1. Epub 2017 Jan 20. No abstract available.

38.

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.

Merriman C, Huang Q, Rutter GA, Fu D.

J Biol Chem. 2016 Dec 30;291(53):26950-26957. doi: 10.1074/jbc.M116.764605. Epub 2016 Nov 8.

39.

Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs.

Rutter GA.

Cell Stem Cell. 2016 Sep 1;19(3):281-2. doi: 10.1016/j.stem.2016.08.010.

40.

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D.

Nat Chem Biol. 2016 Sep;12(9):755-62. doi: 10.1038/nchembio.2141. Epub 2016 Jul 25.

41.

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ.

Cell Metab. 2016 Sep 13;24(3):389-401. doi: 10.1016/j.cmet.2016.06.020. Epub 2016 Jul 21.

42.

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.

Solomou A, Philippe E, Chabosseau P, Migrenne-Li S, Gaitan J, Lang J, Magnan C, Rutter GA.

Nutr Metab (Lond). 2016 Jul 7;13:46. doi: 10.1186/s12986-016-0104-z. eCollection 2016.

43.

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.

Semplici F, Mondragon A, Macintyre B, Madeyski-Bengston K, Persson-Kry A, Barr S, Ramne A, Marley A, McGinty J, French P, Soedling H, Yokosuka R, Gaitan J, Lang J, Migrenne-Li S, Philippe E, Herrera PL, Magnan C, da Silva Xavier G, Rutter GA.

Diabetologia. 2016 Sep;59(9):1938-47. doi: 10.1007/s00125-016-4025-1. Epub 2016 Jun 24.

44.

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.

Mehta ZB, Fine N, Pullen TJ, Cane MC, Hu M, Chabosseau P, Meur G, Velayos-Baeza A, Monaco AP, Marselli L, Marchetti P, Rutter GA.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E488-507. doi: 10.1152/ajpendo.00074.2016. Epub 2016 Jun 21.

45.

Zinc and diabetes.

Chabosseau P, Rutter GA.

Arch Biochem Biophys. 2016 Dec 1;611:79-85. doi: 10.1016/j.abb.2016.05.022. Epub 2016 Jun 1. Review.

46.

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

Gerber PA, Rutter GA.

Antioxid Redox Signal. 2017 Apr 1;26(10):501-518. doi: 10.1089/ars.2016.6755. Epub 2016 Jun 30. Review.

47.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.

48.

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJ.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5865-8. doi: 10.1002/anie.201600957. Epub 2016 Apr 5.

49.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA.

PLoS One. 2016 Mar 24;11(3):e0149549. doi: 10.1371/journal.pone.0149549. eCollection 2016.

50.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Denton RM, Pullen TJ, Armstrong CT, Heesom KJ, Rutter GA.

Biochem J. 2016 May 1;473(9):1165-78. doi: 10.1042/BCJ20160135. Epub 2016 Mar 2.

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