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Items: 36


C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism.

Ling GS, Crawford G, Buang N, Bartok I, Tian K, Thielens NM, Bally I, Harker JA, Ashton-Rickardt PG, Rutschmann S, Strid J, Botto M.

Science. 2018 May 4;360(6388):558-563. doi: 10.1126/science.aao4555.


Elevation in tropical sky islands as the common driver in structuring genes and communities of freshwater organisms.

Gueuning M, Suchan T, Rutschmann S, Gattolliat JL, Jamsari J, Kamil AI, Pitteloud C, Buerki S, Balke M, Sartori M, Alvarez N.

Sci Rep. 2017 Nov 23;7(1):16089. doi: 10.1038/s41598-017-16069-y.


Assessing the potential of RAD-sequencing to resolve phylogenetic relationships within species radiations: The fly genus Chiastocheta (Diptera: Anthomyiidae) as a case study.

Suchan T, Espíndola A, Rutschmann S, Emerson BC, Gori K, Dessimoz C, Arrigo N, Ronikier M, Alvarez N.

Mol Phylogenet Evol. 2017 Sep;114:189-198. doi: 10.1016/j.ympev.2017.06.012. Epub 2017 Jun 21.


Colonization and diversification of aquatic insects on three Macaronesian archipelagos using 59 nuclear loci derived from a draft genome.

Rutschmann S, Detering H, Simon S, Funk DH, Gattolliat JL, Hughes SJ, Raposeiro PM, DeSalle R, Sartori M, Monaghan MT.

Mol Phylogenet Evol. 2017 Feb;107:27-38. doi: 10.1016/j.ympev.2016.10.007. Epub 2016 Oct 11.


Molecular phylogeny and timing of diversification in Alpine Rhithrogena (Ephemeroptera: Heptageniidae).

Vuataz L, Rutschmann S, Monaghan MT, Sartori M.

BMC Evol Biol. 2016 Sep 21;16(1):194.


discomark: nuclear marker discovery from orthologous sequences using draft genome data.

Rutschmann S, Detering H, Simon S, Fredslund J, Monaghan MT.

Mol Ecol Resour. 2017 Mar;17(2):257-266. doi: 10.1111/1755-0998.12576. Epub 2016 Aug 23.


T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.

Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, Crouse J, Choi O, Heathcote D, Lovo E, Mauro C, Abdi R, Oxenius A, Rutschmann S, Ashton-Rickardt PG.

Science. 2015 May 29;348(6238):995-1001. doi: 10.1126/science.aaa7516. Epub 2015 Apr 16. Erratum in: Science. 2015 Oct 23;350(6259):aad6462. Retraction in: Science. 2016 Dec 16;354(6318):1385.


ENU-induced phenovariance in mice: inferences from 587 mutations.

Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B.

BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.


Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.

Siggs OM, Cruite JT, Du X, Rutschmann S, Masliah E, Beutler B, Oldstone MB.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13733-8. doi: 10.1073/pnas.1211499109. Epub 2012 Aug 6.


Dissecting immunity by germline mutagenesis.

Choi O, Rutschmann S.

Immunology. 2012 Oct;137(2):124-30. doi: 10.1111/j.1365-2567.2012.03613.x. Review.


Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice.

Rutschmann S, Crozat K, Li X, Du X, Hanselman JC, Shigeoka AA, Brandl K, Popkin DL, McKay DB, Xia Y, Moresco EM, Beutler B.

G3 (Bethesda). 2012 Apr;2(4):499-504. doi: 10.1534/g3.112.002196. Epub 2012 Apr 1.


A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival.

Choi O, Heathcote DA, Ho KK, Müller PJ, Ghani H, Lam EW, Ashton-Rickardt PG, Rutschmann S.

J Immunol. 2012 Apr 15;188(8):3920-7. doi: 10.4049/jimmunol.1102587. Epub 2012 Mar 9.


Parallel ecological diversification in Antarctic notothenioid fishes as evidence for adaptive radiation.

Rutschmann S, Matschiner M, Damerau M, Muschick M, Lehmann MF, Hanel R, Salzburger W.

Mol Ecol. 2011 Nov;20(22):4707-21. doi: 10.1111/j.1365-294X.2011.05279.x. Epub 2011 Sep 27.


Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

Popkin DL, Teijaro JR, Sullivan BM, Urata S, Rutschmann S, de la Torre JC, Kunz S, Beutler B, Oldstone M.

Cell Host Microbe. 2011 Mar 17;9(3):212-222. doi: 10.1016/j.chom.2011.02.006.


Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.

Blasius AL, Arnold CN, Georgel P, Rutschmann S, Xia Y, Lin P, Ross C, Li X, Smart NG, Beutler B.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19973-8. doi: 10.1073/pnas.1014051107. Epub 2010 Nov 2.


Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response.

Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3300-5. doi: 10.1073/pnas.0813036106. Epub 2009 Feb 6.


Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.

Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15028-33. doi: 10.1073/pnas.0806619105. Epub 2008 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19561. Rutschmann, Sophie [added].


Dissecting innate immunity by germline mutagenesis.

Rutschmann S, Hoebe K.

Immunology. 2008 Apr;123(4):459-68. doi: 10.1111/j.1365-2567.2007.02786.x. Epub 2008 Jan 18. Review.


Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.

Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E, Rutschmann S, Mudd S, Sovath S, Vivier E, Beutler B.

J Exp Med. 2007 Apr 16;204(4):853-63. Epub 2007 Apr 9. Erratum in: J Exp Med. 2008 Mar 17;205(3):737.


Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.

Munafó DB, Johnson JL, Ellis BA, Rutschmann S, Beutler B, Catz SD.

Biochem J. 2007 Mar 1;402(2):229-39.


Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.

Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson IA, Olson A, Beutler B.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10961-6. Epub 2006 Jul 10.


Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.

Janssen E, Tabeta K, Barnes MJ, Rutschmann S, McBride S, Bahjat KS, Schoenberger SP, Theofilopoulos AN, Beutler B, Hoebe K.

Immunity. 2006 Jun;24(6):787-99.


PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.

Rutschmann S, Hoebe K, Zalevsky J, Du X, Mann N, Dahiyat BI, Steed P, Beutler B.

J Immunol. 2006 Jun 15;176(12):7525-32.


Analysis of the MCMV resistome by ENU mutagenesis.

Crozat K, Georgel P, Rutschmann S, Mann N, Du X, Hoebe K, Beutler B.

Mamm Genome. 2006 May;17(5):398-406.


Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.

Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K.

Annu Rev Immunol. 2006;24:353-89. Review.


Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).

Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K.

Brief Funct Genomic Proteomic. 2005 Nov;4(3):203-13. Review.


A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.

Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B.

Infect Immun. 2005 Aug;73(8):4512-21.


CD36 is a sensor of diacylglycerides.

Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zähringer U, Beutler B.

Nature. 2005 Feb 3;433(7025):523-7.


Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffmann JA, Ferrandon D.

Science. 2003 Dec 19;302(5653):2126-30.


Role of Drosophila IKK gamma in a toll-independent antibacterial immune response.

Rutschmann S, Jung AC, Zhou R, Silverman N, Hoffmann JA, Ferrandon D.

Nat Immunol. 2000 Oct;1(4):342-7.


Microfluorometer assay to measure the expression of beta-galactosidase and green fluorescent protein reporter genes in single Drosophila flies.

Jung AC, Criqui MC, Rutschmann S, Hoffmann JA, Ferrandon D.

Biotechniques. 2001 Mar;30(3):594-8, 600-1.


The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila.

Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D.

Immunity. 2000 May;12(5):569-80.


Human IL-13 production is negatively influenced by CD3 engagement. Enhancement of IL-13 production by cyclosporin A.

van der Pouw Kraan TC, Boeije LC, Troon JT, Rutschmann SK, Wijdenes J, Aarden LA.

J Immunol. 1996 Mar 1;156(5):1818-23.


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