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Extracellular Vesicles in Type 1 Diabetes: Messengers and Regulators.

Negi S, Rutman AK, Paraskevas S.

Curr Diab Rep. 2019 Jul 31;19(9):69. doi: 10.1007/s11892-019-1193-7. Review.


Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects.

Bonnefoy S, Watson CM, Kernohan KD, Lemos M, Hutchinson S, Poulter JA, Crinnion LA, Berry I, Simmonds J, Vasudevan P, O'Callaghan C, Hirst RA, Rutman A, Huang L, Hartley T, Grynspan D, Moya E, Li C, Carr IM, Bonthron DT, Leroux M; Care4Rare Canada Consortium, Boycott KM, Bastin P, Sheridan EG.

Am J Hum Genet. 2018 Nov 1;103(5):727-739. doi: 10.1016/j.ajhg.2018.10.003.


Immune Response to Extracellular Vesicles From Human Islets of Langerhans in Patients With Type 1 Diabetes.

Rutman AK, Negi S, Gasparrini M, Hasilo CP, Tchervenkov J, Paraskevas S.

Endocrinology. 2018 Nov 1;159(11):3834-3847. doi: 10.1210/en.2018-00649.


Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia.

Best S, Shoemark A, Rubbo B, Patel MP, Fassad MR, Dixon M, Rogers AV, Hirst RA, Rutman A, Ollosson S, Jackson CL, Goggin P, Thomas S, Pengelly R, Cullup T, Pissaridou E, Hayward J, Onoufriadis A, O'Callaghan C, Loebinger MR, Wilson R, Chung EM, Kenia P, Doughty VL, Carvalho JS, Lucas JS, Mitchison HM, Hogg C.

Thorax. 2019 Feb;74(2):203-205. doi: 10.1136/thoraxjnl-2018-212104. Epub 2018 Aug 30.


Ciliated conical epithelial cell protrusions point towards a diagnosis of primary ciliary dyskinesia.

O'Callaghan C, Rutman A, Williams G, Kulkarni N, Hayes J, Hirst RA.

Respir Res. 2018 Jun 25;19(1):125. doi: 10.1186/s12931-018-0782-3.


Imaging and Management of Blunt Cerebrovascular Injury.

Rutman AM, Vranic JE, Mossa-Basha M.

Radiographics. 2018 Mar-Apr;38(2):542-563. doi: 10.1148/rg.2018170140. Review.


Diffusion Tensor Imaging of the Spinal Cord: Clinical Value, Investigational Applications, and Technical Limitations.

Rutman AM, Peterson DJ, Cohen WA, Mossa-Basha M.

Curr Probl Diagn Radiol. 2018 Jul - Aug;47(4):257-269. doi: 10.1067/j.cpradiol.2017.07.005. Epub 2017 Jul 29. Review.


Test-Retest and Interreader Reproducibility of Semiautomated Atlas-Based Analysis of Diffusion Tensor Imaging Data in Acute Cervical Spine Trauma in Adult Patients.

Peterson DJ, Rutman AM, Hippe DS, Jarvik JG, Chokshi FH, Reyes MR, Bombardier CH, Mossa-Basha M.

AJNR Am J Neuroradiol. 2017 Oct;38(10):2015-2020. doi: 10.3174/ajnr.A5334. Epub 2017 Aug 17.


High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations.

Shoemark A, Moya E, Hirst RA, Patel MP, Robson EA, Hayward J, Scully J, Fassad MR, Lamb W, Schmidts M, Dixon M, Patel-King RS, Rogers AV, Rutman A, Jackson CL, Goggin P, Rubbo B, Ollosson S, Carr S, Walker W, Adler B, Loebinger MR, Wilson R, Bush A, Williams H, Boustred C, Jenkins L, Sheridan E, Chung EMK, Watson CM, Cullup T, Lucas JS, Kenia P, O'Callaghan C, King SM, Hogg C, Mitchison HM.

Thorax. 2018 Feb;73(2):157-166. doi: 10.1136/thoraxjnl-2017-209999. Epub 2017 Aug 8.


T2*-Weighted and Diffusion Magnetic Resonance Imaging Differentiation of Cerebral Fat Embolism From Diffuse Axonal Injury.

Rutman AM, Rapp EJ, Hippe DS, Vu B, Mossa-Basha M.

J Comput Assist Tomogr. 2017 Nov/Dec;41(6):877-883. doi: 10.1097/RCT.0000000000000635.


Presence of diabetes autoantigens in extracellular vesicles derived from human islets.

Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S.

Sci Rep. 2017 Jul 10;7(1):5000. doi: 10.1038/s41598-017-04977-y.


A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.

Banks G, Lassi G, Hoerder-Suabedissen A, Tinarelli F, Simon MM, Wilcox A, Lau P, Lawson TN, Johnson S, Rutman A, Sweeting M, Chesham JE, Barnard AR, Horner N, Westerberg H, Smith LB, Molnár Z, Hastings MH, Hirst RA, Tucci V, Nolan PM.

Mol Psychiatry. 2018 Mar;23(3):713-722. doi: 10.1038/mp.2017.54. Epub 2017 Apr 4.


High-resolution intracranial vessel wall imaging: imaging beyond the lumen.

Alexander MD, Yuan C, Rutman A, Tirschwell DL, Palagallo G, Gandhi D, Sekhar LN, Mossa-Basha M.

J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):589-97. doi: 10.1136/jnnp-2015-312020. Epub 2016 Jan 8. Review.


A computed tomography radiogenomic biomarker predicts microvascular invasion and clinical outcomes in hepatocellular carcinoma.

Banerjee S, Wang DS, Kim HJ, Sirlin CB, Chan MG, Korn RL, Rutman AM, Siripongsakun S, Lu D, Imanbayev G, Kuo MD.

Hepatology. 2015 Sep;62(3):792-800. doi: 10.1002/hep.27877. Epub 2015 Jul 1.


CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.

Hjeij R, Onoufriadis A, Watson CM, Slagle CE, Klena NT, Dougherty GW, Kurkowiak M, Loges NT, Diggle CP, Morante NF, Gabriel GC, Lemke KL, Li Y, Pennekamp P, Menchen T, Konert F, Marthin JK, Mans DA, Letteboer SJ, Werner C, Burgoyne T, Westermann C, Rutman A, Carr IM, O'Callaghan C, Moya E, Chung EM; UK10K Consortium, Sheridan E, Nielsen KG, Roepman R, Bartscherer K, Burdine RD, Lo CW, Omran H, Mitchison HM.

Am J Hum Genet. 2014 Sep 4;95(3):257-74. doi: 10.1016/j.ajhg.2014.08.005.


MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia.

Boon M, Wallmeier J, Ma L, Loges NT, Jaspers M, Olbrich H, Dougherty GW, Raidt J, Werner C, Amirav I, Hevroni A, Abitbul R, Avital A, Soferman R, Wessels M, O'Callaghan C, Chung EM, Rutman A, Hirst RA, Moya E, Mitchison HM, Van Daele S, De Boeck K, Jorissen M, Kintner C, Cuppens H, Omran H.

Nat Commun. 2014 Jul 22;5:4418. doi: 10.1038/ncomms5418.


Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid.

Hirst RA, Jackson CL, Coles JL, Williams G, Rutman A, Goggin PM, Adam EC, Page A, Evans HJ, Lackie PM, O'Callaghan C, Lucas JS.

PLoS One. 2014 Feb 25;9(2):e89675. doi: 10.1371/journal.pone.0089675. eCollection 2014.


Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.

Onoufriadis A, Shoemark A, Schmidts M, Patel M, Jimenez G, Liu H, Thomas B, Dixon M, Hirst RA, Rutman A, Burgoyne T, Williams C, Scully J, Bolard F, Lafitte JJ, Beales PL, Hogg C, Yang P, Chung EM, Emes RD, O'Callaghan C; UK10K, Bouvagnet P, Mitchison HM.

Hum Mol Genet. 2014 Jul 1;23(13):3362-74. doi: 10.1093/hmg/ddu046. Epub 2014 Feb 11.


Ciliary dyskinesia is an early feature of respiratory syncytial virus infection.

Smith CM, Kulkarni H, Radhakrishnan P, Rutman A, Bankart MJ, Williams G, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C.

Eur Respir J. 2014 Feb;43(2):485-96. doi: 10.1183/09031936.00205312. Epub 2013 Mar 21.


Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.

Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD; Uk10k, Chung EM, Shoemark A, Knowles MR, Omran H, Mitchison HM.

Hum Mutat. 2013 Mar;34(3):462-72. doi: 10.1002/humu.22261. Epub 2013 Feb 11.


Persistent disruption of ciliated epithelium following paediatric lung transplantation.

Thomas B, Aurora P, Spencer H, Elliott M, Rutman A, Hirst RA, O'Callaghan C.

Eur Respir J. 2012 Nov;40(5):1245-52. doi: 10.1183/09031936.00174711. Epub 2012 Apr 20.


Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

O'Callaghan C, Rutman A, Williams GM, Hirst RA.

Eur Respir J. 2011 Sep;38(3):603-7. doi: 10.1183/09031936.00108410. Epub 2011 Mar 15.


Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma.

Thomas B, Rutman A, Hirst RA, Haldar P, Wardlaw AJ, Bankart J, Brightling CE, O'Callaghan C.

J Allergy Clin Immunol. 2010 Oct;126(4):722-729.e2. doi: 10.1016/j.jaci.2010.05.046. Epub 2010 Jul 31.


Ciliated air-liquid cultures as an aid to diagnostic testing of primary ciliary dyskinesia.

Hirst RA, Rutman A, Williams G, O'Callaghan C.

Chest. 2010 Dec;138(6):1441-7. doi: 10.1378/chest.10-0175. Epub 2010 Jul 8.


The behaviour of both Listeria monocytogenes and rat ciliated ependymal cells is altered during their co-culture.

Fadaee-Shohada MJ, Hirst RA, Rutman A, Roberts IS, O'Callaghan C, Andrew PW.

PLoS One. 2010 May 4;5(5):e10450. doi: 10.1371/journal.pone.0010450.


Diagnostic testing of patients suspected of primary ciliary dyskinesia.

Stannard WA, Chilvers MA, Rutman AR, Williams CD, O'Callaghan C.

Am J Respir Crit Care Med. 2010 Feb 15;181(4):307-14. doi: 10.1164/rccm.200903-0459OC. Epub 2009 Nov 12.


Disrupted ciliated epithelium shows slower ciliary beat frequency and increased dyskinesia.

Thomas B, Rutman A, O'Callaghan C.

Eur Respir J. 2009 Aug;34(2):401-4. doi: 10.1183/09031936.00153308.


Practice-related improvement in working memory is modulated by changes in processing external interference.

Berry AS, Zanto TP, Rutman AM, Clapp WC, Gazzaley A.

J Neurophysiol. 2009 Sep;102(3):1779-89. doi: 10.1152/jn.00179.2009. Epub 2009 Jul 8.


Early top-down control of visual processing predicts working memory performance.

Rutman AM, Clapp WC, Chadick JZ, Gazzaley A.

J Cogn Neurosci. 2010 Jun;22(6):1224-34. doi: 10.1162/jocn.2009.21257.


Radiogenomics: creating a link between molecular diagnostics and diagnostic imaging.

Rutman AM, Kuo MD.

Eur J Radiol. 2009 May;70(2):232-41. doi: 10.1016/j.ejrad.2009.01.050. Epub 2009 Mar 19. Review.


Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities.

Castleman VH, Romio L, Chodhari R, Hirst RA, de Castro SC, Parker KA, Ybot-Gonzalez P, Emes RD, Wilson SW, Wallis C, Johnson CA, Herrera RJ, Rutman A, Dixon M, Shoemark A, Bush A, Hogg C, Gardiner RM, Reish O, Greene ND, O'Callaghan C, Purton S, Chung EM, Mitchison HM.

Am J Hum Genet. 2009 Feb;84(2):197-209. doi: 10.1016/j.ajhg.2009.01.011. Epub 2009 Feb 5.


Hydrogen peroxide at a concentration used during neurosurgery disrupts ciliary function and causes extensive damage to the ciliated ependyma of the brain.

Hirst RA, Rutman A, O'Callaghan C.

Childs Nerv Syst. 2009 May;25(5):559-61. doi: 10.1007/s00381-008-0768-4. Epub 2008 Dec 24.


DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.

Loges NT, Olbrich H, Fenske L, Mussaffi H, Horvath J, Fliegauf M, Kuhl H, Baktai G, Peterffy E, Chodhari R, Chung EM, Rutman A, O'Callaghan C, Blau H, Tiszlavicz L, Voelkel K, Witt M, Zietkiewicz E, Neesen J, Reinhardt R, Mitchison HM, Omran H.

Am J Hum Genet. 2008 Nov;83(5):547-58. doi: 10.1016/j.ajhg.2008.10.001. Epub 2008 Oct 23.


Black-pigmented material in airway macrophages from healthy children: association with lung function and modeled PM10.

Grigg J, Kulkarni N, Pierse N, Rushton L, O'Callaghan C, Rutman A.

Res Rep Health Eff Inst. 2008 Jun;(134):1-23; discussion 25-33.


The effect of viscous loading on brain ependymal cilia.

O'Callaghan CL, Sikand K, Rutman A, Hirst RA.

Neurosci Lett. 2008 Jul 4;439(1):56-60. doi: 10.1016/j.neulet.2008.04.095. Epub 2008 May 2.


Streptococcus pneumoniae deficient in pneumolysin or autolysin has reduced virulence in meningitis.

Hirst RA, Gosai B, Rutman A, Guerin CJ, Nicotera P, Andrew PW, O'Callaghan C.

J Infect Dis. 2008 Mar 1;197(5):744-51. doi: 10.1086/527322.


Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing.

Gazzaley A, Rissman J, Cooney J, Rutman A, Seibert T, Clapp W, D'Esposito M.

Cereb Cortex. 2007 Sep;17 Suppl 1:i125-35.


Recovery of the ciliated epithelium following acute bronchiolitis in infancy.

Wong JY, Rutman A, O'Callaghan C.

Thorax. 2005 Jul;60(7):582-7.


Ciliary central microtubular orientation is of no clinical significance in bronchiectasis.

Tsang KW, Tipoe GL, Mak JC, Sun J, Wong M, Leung R, Tan KC, MedStat CK, Ho JC, Ho PL, Rutman A, Lam WK.

Respir Med. 2005 Mar;99(3):290-7.


Central microtubular agenesis causing primary ciliary dyskinesia.

Stannard W, Rutman A, Wallis C, O'Callaghan C.

Am J Respir Crit Care Med. 2004 Mar 1;169(5):634-7.


Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis.

Hirst RA, Gosai B, Rutman A, Andrew PW, O'Callaghan C.

Infect Immun. 2003 Oct;71(10):6095-100.


Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia.

Chilvers MA, Rutman A, O'Callaghan C.

J Allergy Clin Immunol. 2003 Sep;112(3):518-24.


Haemophilus parainfluenzae infection of respiratory mucosa.

Middleton AM, Dowling RB, Mitchell JL, Watanabe S, Rutman A, Pritchard K, Tillotson G, Hill SL, Wilson R.

Respir Med. 2003 Apr;97(4):375-81.


The effects of coronavirus on human nasal ciliated respiratory epithelium.

Chilvers MA, McKean M, Rutman A, Myint BS, Silverman M, O'Callaghan C.

Eur Respir J. 2001 Dec;18(6):965-70.


Sensitivities of human monocytes and epithelial cells to pneumolysin are different.

Hirst RA, Yesilkaya H, Clitheroe E, Rutman A, Dufty N, Mitchell TJ, O'Callaghan C, Andrew PW.

Infect Immun. 2002 Feb;70(2):1017-22.


Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells.

Hirst RA, Rutman A, Sikand K, Andrew PW, Mitchell TJ, O'Callaghan C.

Pediatr Res. 2000 Mar;47(3):381-4.


Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency.

Hirst RA, Sikand KS, Rutman A, Mitchell TJ, Andrew PW, O'Callaghan C.

Infect Immun. 2000 Mar;68(3):1557-62.


Respiratory and brain ependymal ciliary function.

O'Callaghan C, Sikand K, Rutman A.

Pediatr Res. 1999 Dec;46(6):704-7.


Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth.

Kerr JR, Taylor GW, Rutman A, Høiby N, Cole PJ, Wilson R.

J Clin Pathol. 1999 May;52(5):385-7.

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