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Items: 35


Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer.

Martinez LM, Robila V, Clark NM, Du W, Idowu MO, Rutkowski MR, Bos PD.

Front Immunol. 2019 Aug 29;10:1942. doi: 10.3389/fimmu.2019.01942. eCollection 2019.


Impact of the microbiome on cancer progression and response to anti-cancer therapies.

Buchta Rosean C, Feng TY, Azar FN, Rutkowski MR.

Adv Cancer Res. 2019;143:255-294. doi: 10.1016/bs.acr.2019.03.005. Epub 2019 Apr 17.


Preexisting Commensal Dysbiosis Is a Host-Intrinsic Regulator of Tissue Inflammation and Tumor Cell Dissemination in Hormone Receptor-Positive Breast Cancer.

Buchta Rosean C, Bostic RR, Ferey JCM, Feng TY, Azar FN, Tung KS, Dozmorov MG, Smirnova E, Bos PD, Rutkowski MR.

Cancer Res. 2019 Jul 15;79(14):3662-3675. doi: 10.1158/0008-5472.CAN-18-3464. Epub 2019 May 7.


IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.

Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJP, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodriguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz JR.

Nature. 2018 Oct;562(7727):423-428. doi: 10.1038/s41586-018-0597-x. Epub 2018 Oct 10.


Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy.

Perales-Puchalt A, Perez-Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, Anadon C, Calmette J, Biswas S, Mine JA, Costich TL, Nickels L, Wickramasinghe J, Rutkowski MR, Conejo-Garcia JR.

J Leukoc Biol. 2018 May;103(5):799-805. doi: 10.1002/JLB.5HI1117-446RR. Epub 2018 Mar 14.


The influence of the commensal microbiota on distal tumor-promoting inflammation.

Buchta Rosean CM, Rutkowski MR.

Semin Immunol. 2017 Aug;32:62-73. doi: 10.1016/j.smim.2017.06.002. Epub 2017 Jul 4. Review.


Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis.

Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Perales-Puchalt A, Nguyen JM, Payne KK, Singhal S, Eruslanov EB, Tchou J, Conejo-Garcia JR.

Cancer Res. 2016 Nov 1;76(21):6253-6265.


Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.

Svoronos N, Perales-Puchalt A, Allegrezza MJ, Rutkowski MR, Payne KK, Tesone AJ, Nguyen JM, Curiel TJ, Cadungog MG, Singhal S, Eruslanov EB, Zhang P, Tchou J, Zhang R, Conejo-Garcia JR.

Cancer Discov. 2017 Jan;7(1):72-85. doi: 10.1158/2159-8290.CD-16-0502. Epub 2016 Sep 30.


BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression.

Zhu H, Bengsch F, Svoronos N, Rutkowski MR, Bitler BG, Allegrezza MJ, Yokoyama Y, Kossenkov AV, Bradner JE, Conejo-Garcia JR, Zhang R.

Cell Rep. 2016 Sep 13;16(11):2829-2837. doi: 10.1016/j.celrep.2016.08.032.


Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target.

Perales-Puchalt A, Svoronos N, Rutkowski MR, Allegrezza MJ, Tesone AJ, Payne KK, Wickramasinghe J, Nguyen JM, O'Brien SW, Gumireddy K, Huang Q, Cadungog MG, Connolly DC, Tchou J, Curiel TJ, Conejo-Garcia JR.

Clin Cancer Res. 2017 Jan 15;23(2):441-453. doi: 10.1158/1078-0432.CCR-16-0492. Epub 2016 Jul 19.


State-of-the-art of regulatory dendritic cells in cancer.

Conejo-Garcia JR, Rutkowski MR, Cubillos-Ruiz JR.

Pharmacol Ther. 2016 Aug;164:97-104. doi: 10.1016/j.pharmthera.2016.04.003. Epub 2016 Apr 23. Review.


IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.

Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Tesone AJ, Perales-Puchalt A, Nguyen JM, Sarmin F, Sheen MR, Jeng EK, Tchou J, Wong HC, Fiering SN, Conejo-Garcia JR.

Cancer Res. 2016 May 1;76(9):2561-72. doi: 10.1158/0008-5472.CAN-15-2808. Epub 2016 Mar 15.


Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.

Tesone AJ, Rutkowski MR, Brencicova E, Svoronos N, Perales-Puchalt A, Stephen TL, Allegrezza MJ, Payne KK, Nguyen JM, Wickramasinghe J, Tchou J, Borowsky ME, Rabinovich GA, Kossenkov AV, Conejo-Garcia JR.

Cell Rep. 2016 Feb 23;14(7):1774-1786. doi: 10.1016/j.celrep.2016.01.056. Epub 2016 Feb 11.


Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies.

Conejo-Garcia JR, Rutkowski MR.

Immunity. 2015 Dec 15;43(6):1037-9. doi: 10.1016/j.immuni.2015.11.014.


TLR5 signaling, commensal microbiota and systemic tumor promoting inflammation: the three parcae of malignant progression.

Rutkowski MR, Conejo-Garcia JR.

Oncoimmunology. 2015 Jun 3;4(8):e1021542. eCollection 2015 Aug.


The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds.

Rutkowski MR, Svoronos N, Perales-Puchalt A, Conejo-Garcia JR.

Adv Cancer Res. 2015;128:235-62. doi: 10.1016/bs.acr.2015.04.011. Epub 2015 May 21. Review.


ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH.

Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11.


Size does not matter: commensal microorganisms forge tumor-promoting inflammation and anti-tumor immunity.

Rutkowski MR, Conejo-Garcia JR.

Oncoscience. 2015 Mar 23;2(3):239-46. eCollection 2015.


Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.

Rutkowski MR, Stephen TL, Svoronos N, Allegrezza MJ, Tesone AJ, Perales-Puchalt A, Brencicova E, Escovar-Fadul X, Nguyen JM, Cadungog MG, Zhang R, Salatino M, Tchou J, Rabinovich GA, Conejo-Garcia JR.

Cancer Cell. 2015 Jan 12;27(1):27-40. doi: 10.1016/j.ccell.2014.11.009. Epub 2014 Dec 18.


Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Stephen TL, Rutkowski MR, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Svoronos N, Nguyen JM, Sarmin F, Borowsky ME, Tchou J, Conejo-Garcia JR.

Immunity. 2014 Sep 18;41(3):427-439. doi: 10.1016/j.immuni.2014.08.012.


Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer.

Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, Nguyen J, Zhang PJ, Fiering SN, Tchou J, Conejo-Garcia JR.

J Vis Exp. 2014 Mar 26;(85). doi: 10.3791/51171.


Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.

Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ.

Cancer Res. 2013 Jul 1;73(13):3842-51. doi: 10.1158/0008-5472.CAN-12-1974. Epub 2013 May 23.


Reprogramming immune responses via microRNA modulation.

Cubillos-Ruiz JR, Rutkowski MR, Tchou J, Conejo-Garcia JR.

Microrna Diagn Ther. 2013 Apr 26;1(1). pii: 2013-0001.


Anti-tumor immunity: myeloid leukocytes control the immune landscape.

Rutkowski MR, Stephen TL, Conejo-Garcia JR.

Cell Immunol. 2012 Jul-Aug;278(1-2):21-6. doi: 10.1016/j.cellimm.2012.06.014. Epub 2012 Jul 14. Review.


Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?

Hampton TH, Ballok AE, Bomberger JM, Rutkowski MR, Barnaby R, Coutermarsh B, Conejo-Garcia JR, O'Toole GA, Stanton BA.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L509-18. doi: 10.1152/ajplung.00226.2011. Epub 2012 Jul 20.


Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.

Scarlett UK, Rutkowski MR, Rauwerdink AM, Fields J, Escovar-Fadul X, Baird J, Cubillos-Ruiz JR, Jacobs AC, Gonzalez JL, Weaver J, Fiering S, Conejo-Garcia JR.

J Exp Med. 2012 Mar 12;209(3):495-506. doi: 10.1084/jem.20111413. Epub 2012 Feb 20.


Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.

Cubillos-Ruiz JR, Baird JR, Tesone AJ, Rutkowski MR, Scarlett UK, Camposeco-Jacobs AL, Anadon-Arnillas J, Harwood NM, Korc M, Fiering SN, Sempere LF, Conejo-Garcia JR.

Cancer Res. 2012 Apr 1;72(7):1683-93. doi: 10.1158/0008-5472.CAN-11-3160. Epub 2012 Feb 3.


Impaired memory CD8 T cell responses against an immunodominant retroviral cryptic epitope.

Rutkowski MR, Stevens CA, Green WR.

Virology. 2011 Apr 10;412(2):256-68. doi: 10.1016/j.virol.2010.11.013. Epub 2011 Feb 4.


CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.

Cubillos-Ruiz JR, Martinez D, Scarlett UK, Rutkowski MR, Nesbeth YC, Camposeco-Jacobs AL, Conejo-Garcia JR.

Oncotarget. 2010 Sep;1(5):329-38.


CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.

Nesbeth YC, Martinez DG, Toraya S, Scarlett UK, Cubillos-Ruiz JR, Rutkowski MR, Conejo-Garcia JR.

J Immunol. 2010 May 15;184(10):5654-62. doi: 10.4049/jimmunol.0903247. Epub 2010 Apr 16.


Defining the mechanism(s) of protection by cytolytic CD8 T cells against a cryptic epitope derived from a retroviral alternative reading frame.

Rutkowski MR, Ho O, Green WR.

Virology. 2009 Aug 1;390(2):228-38. doi: 10.1016/j.virol.2009.05.003. Epub 2009 Jun 18.


Influenza virus infection decreases tracheal mucociliary velocity and clearance of Streptococcus pneumoniae.

Pittet LA, Hall-Stoodley L, Rutkowski MR, Harmsen AG.

Am J Respir Cell Mol Biol. 2010 Apr;42(4):450-60. doi: 10.1165/rcmb.2007-0417OC. Epub 2009 Jun 11.


Tritrichomonas foetus: pathogenesis of acute infection in normal, estradiol-treated, and stressed mice.

Rutkowski MR, Harmsen AG.

Exp Parasitol. 2007 Feb;115(2):143-59. Epub 2006 Oct 2.


Sudden death in young patients with congenital aortic stenosis.

Doyle EF, Arumugham P, Lara E, Rutkowski MR, Kiely B.

Pediatrics. 1974 Apr;53(4):481-9. No abstract available.


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