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Items: 35


A data-entrained computational model for testing the regulatory logic of the vertebrate unfolded protein response.

Diedrichs DR, Gomez JA, Huang CS, Rutkowski DT, Curtu R.

Mol Biol Cell. 2018 Jun 15;29(12):1502-1517. doi: 10.1091/mbc.E17-09-0565. Epub 2018 Apr 18.


Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response.

Rutkowski DT.

FEBS J. 2019 Jan;286(2):356-378. doi: 10.1111/febs.14389. Epub 2018 Feb 7. Review.


Long-term correction of hemophilia A mice following lentiviral mediated delivery of an optimized canine factor VIII gene.

Staber JM, Pollpeter MJ, Anderson CG, Burrascano M, Cooney AL, Sinn PL, Rutkowski DT, Raschke WC, McCray PB.

Gene Ther. 2017 Nov;24(11):742-748. doi: 10.1038/gt.2017.67. Epub 2017 Sep 14.


ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.

DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT.

Cell Rep. 2017 May 30;19(9):1794-1806. doi: 10.1016/j.celrep.2017.05.020.


Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression.

Gomez JA, Rutkowski DT.

Elife. 2016 Dec 10;5. pii: e20390. doi: 10.7554/eLife.20390.


Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt.

Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD.

Hypertension. 2015 Jun;65(6):1341-8. doi: 10.1161/HYPERTENSIONAHA.115.05377. Epub 2015 Apr 20.


Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling.

Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M.

J Biol Chem. 2014 Aug 29;289(35):24417-27. doi: 10.1074/jbc.M114.588764. Epub 2014 Jul 17.


Inositol-requiring enzyme 1 inhibits respiratory syncytial virus replication.

Hassan I, Gaines KS, Hottel WJ, Wishy RM, Miller SE, Powers LS, Rutkowski DT, Monick MM.

J Biol Chem. 2014 Mar 14;289(11):7537-46. doi: 10.1074/jbc.M113.510594. Epub 2014 Feb 4.


piggyBac-mediated phenotypic correction of factor VIII deficiency.

Staber JM, Pollpeter MJ, Arensdorf A, Sinn PL, Rutkowski DT, McCray PB Jr.

Mol Ther Methods Clin Dev. 2014 Sep 10;1:14042. doi: 10.1038/mtm.2014.42. eCollection 2014.


The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.

DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT.

PLoS Genet. 2013;9(12):e1003937. doi: 10.1371/journal.pgen.1003937. Epub 2013 Dec 19.


Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.

Arensdorf AM, Diedrichs D, Rutkowski DT.

Front Genet. 2013 Dec 2;4:256. doi: 10.3389/fgene.2013.00256. Review.


Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6α.

Gomez JA, Tyra HM, DeZwaan-McCabe D, Olivier AK, Rutkowski DT.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):115-9. doi: 10.1016/j.bbrc.2013.11.060. Epub 2013 Nov 22.


Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network.

Arensdorf AM, Dezwaan McCabe D, Kaufman RJ, Rutkowski DT.

Front Genet. 2013 Sep 24;4:188. doi: 10.3389/fgene.2013.00188. eCollection 2013.


Endoplasmic reticulum stress impairs IL-4/IL-13 signaling through C/EBPβ-mediated transcriptional suppression.

Arensdorf AM, Rutkowski DT.

J Cell Sci. 2013 Sep 1;126(Pt 17):4026-36. doi: 10.1242/jcs.130757. Epub 2013 Jun 26.


Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response.

Sadighi Akha AA, Theriot CM, Erb-Downward JR, McDermott AJ, Falkowski NR, Tyra HM, Rutkowski DT, Young VB, Huffnagle GB.

Immunology. 2013 Sep;140(1):111-22. doi: 10.1111/imm.12122.


C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.

Chikka MR, McCabe DD, Tyra HM, Rutkowski DT.

J Biol Chem. 2013 Feb 8;288(6):4405-15. doi: 10.1074/jbc.M112.432344. Epub 2012 Dec 31.


Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress.

Tyra HM, Spitz DR, Rutkowski DT.

Mol Biol Cell. 2012 Mar;23(5):811-9. doi: 10.1091/mbc.E11-12-1011. Epub 2012 Jan 19.


Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway.

Hassan IH, Zhang MS, Powers LS, Shao JQ, Baltrusaitis J, Rutkowski DT, Legge K, Monick MM.

J Biol Chem. 2012 Feb 10;287(7):4679-89. doi: 10.1074/jbc.M111.284695. Epub 2011 Dec 22.


2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines.

Zagorodna O, Martin SM, Rutkowski DT, Kuwana T, Spitz DR, Knudson CM.

Oncogene. 2012 May 31;31(22):2738-49. doi: 10.1038/onc.2011.454. Epub 2011 Oct 10.


Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity.

Sadighi Akha AA, Harper JM, Salmon AB, Schroeder BA, Tyra HM, Rutkowski DT, Miller RA.

J Biol Chem. 2011 Sep 2;286(35):30344-51. doi: 10.1074/jbc.M111.220541. Epub 2011 Jul 12.


The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.

Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM.

Cell Metab. 2011 Feb 2;13(2):160-9. doi: 10.1016/j.cmet.2011.01.003.


Regulation of basal cellular physiology by the homeostatic unfolded protein response.

Rutkowski DT, Hegde RS.

J Cell Biol. 2010 May 31;189(5):783-94. doi: 10.1083/jcb.201003138. Review.


A gluconeogenic tryst in the nucleus, with ER stress as the third wheel.

Rutkowski DT.

Sci Signal. 2009 Nov 10;2(96):pe72. doi: 10.1126/scisignal.296pe72.


Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.

Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR 3rd, Perrin S, Feany MB, Horwich AL.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1392-7. doi: 10.1073/pnas.0813045106. Epub 2009 Jan 26.


UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ.

Dev Cell. 2008 Dec;15(6):829-40. doi: 10.1016/j.devcel.2008.10.015.


That which does not kill me makes me stronger: adapting to chronic ER stress.

Rutkowski DT, Kaufman RJ.

Trends Biochem Sci. 2007 Oct;32(10):469-76.


ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.

Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ.

Dev Cell. 2007 Sep;13(3):351-64.


The role of p58IPK in protecting the stressed endoplasmic reticulum.

Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS.

Mol Biol Cell. 2007 Sep;18(9):3681-91. Epub 2007 Jun 13.


Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.

Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ.

PLoS Biol. 2006 Nov;4(11):e374.


Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.

Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ.

Cell. 2006 Feb 10;124(3):587-99.


A trip to the ER: coping with stress.

Rutkowski DT, Kaufman RJ.

Trends Cell Biol. 2004 Jan;14(1):20-8. Review.


Signal sequences initiate the pathway of maturation in the endoplasmic reticulum lumen.

Rutkowski DT, Ott CM, Polansky JR, Lingappa VR.

J Biol Chem. 2003 Aug 8;278(32):30365-72. Epub 2003 May 27.


All roads lead to ATF4.

Rutkowski DT, Kaufman RJ.

Dev Cell. 2003 Apr;4(4):442-4. Review.


Conformational control through translocational regulation: a new view of secretory and membrane protein folding.

Lingappa VR, Rutkowski DT, Hegde RS, Andersen OS.

Bioessays. 2002 Aug;24(8):741-8. Review.


Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences.

Rutkowski DT, Lingappa VR, Hegde RS.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7823-8. Epub 2001 Jun 19.

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