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GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis.

Wiegering A, Petzsch P, Köhrer K, Rüther U, Gerhardt C.

Dev Biol. 2019 Jun 15;450(2):141-154. doi: 10.1016/j.ydbio.2019.02.018. Epub 2019 Apr 3.


The Role of Primary Cilia in the Crosstalk between the Ubiquitin⁻Proteasome System and Autophagy.

Wiegering A, Rüther U, Gerhardt C.

Cells. 2019 Mar 14;8(3). pii: E241. doi: 10.3390/cells8030241. Review.


FTO affects hippocampal function by regulation of BDNF processing.

Spychala A, Rüther U.

PLoS One. 2019 Feb 7;14(2):e0211937. doi: 10.1371/journal.pone.0211937. eCollection 2019.


The ciliary protein Rpgrip1l in development and disease.

Wiegering A, Rüther U, Gerhardt C.

Dev Biol. 2018 Oct 1;442(1):60-68. doi: 10.1016/j.ydbio.2018.07.024. Epub 2018 Aug 1. Review.


Cell type-specific regulation of ciliary transition zone assembly in vertebrates.

Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier JM, Zobel T, Dahmen S, Leu T, Struchtrup A, Legendre F, Vesque C, Schneider-Maunoury S, Saunier S, Rüther U, Gerhardt C.

EMBO J. 2018 May 15;37(10). pii: e97791. doi: 10.15252/embj.201797791. Epub 2018 Apr 12.


The Role of Hedgehog Signalling in the Formation of the Ventricular Septum.

Wiegering A, Rüther U, Gerhardt C.

J Dev Biol. 2017 Dec 12;5(4). pii: E17. doi: 10.3390/jdb5040017. Review.


The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.

Struchtrup A, Wiegering A, Stork B, Rüther U, Gerhardt C.

Autophagy. 2018;14(4):567-583. doi: 10.1080/15548627.2018.1429874. Epub 2018 Feb 21.


Control of Hedgehog Signalling by the Cilia-Regulated Proteasome.

Gerhardt C, Wiegering A, Leu T, Rüther U.

J Dev Biol. 2016 Sep 3;4(3). pii: E27. doi: 10.3390/jdb4030027. Review.


A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

Kim HS, Cheon JH, Jung ES, Park J, Aum S, Park SJ, Eun S, Lee J, Rüther U, Yeo GSH, Ma M, Park KS, Naito T, Kakuta Y, Lee JH, Kim WH, Lee MG.

Gut. 2017 Nov;66(11):1926-1935. doi: 10.1136/gutjnl-2016-311921. Epub 2016 Aug 24.


The cilia-regulated proteasome and its role in the development of ciliopathies and cancer.

Gerhardt C, Leu T, Lier JM, Rüther U.

Cilia. 2016 Jun 10;5:14. doi: 10.1186/s13630-016-0035-3. eCollection 2016. Review.


FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study.

Thron C, Akhyari P, Godehardt E, Lichtenberg A, Rüther U, Seehaus S.

PLoS One. 2015 Oct 2;10(10):e0139419. doi: 10.1371/journal.pone.0139419. eCollection 2015.


The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium.

Gerhardt C, Lier JM, Burmühl S, Struchtrup A, Deutschmann K, Vetter M, Leu T, Reeg S, Grune T, Rüther U.

J Cell Biol. 2015 Jul 6;210(1):115-33. doi: 10.1083/jcb.201408060.


Impact of eNOS-Dependent Oxidative Stress on Endothelial Function and Neointima Formation.

Suvorava T, Nagy N, Pick S, Lieven O, Rüther U, Dao VT, Fischer JW, Weber M, Kojda G.

Antioxid Redox Signal. 2015 Sep 20;23(9):711-23. doi: 10.1089/ars.2014.6059. Epub 2015 Jun 8.


Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo.

Lieven O, Dronka J, Burmühl S, Rüther U.

PLoS One. 2014 Dec 29;9(12):e115442. doi: 10.1371/journal.pone.0115442. eCollection 2014.


FTO is a relevant factor for the development of the metabolic syndrome in mice.

Ikels K, Kuschel S, Fischer J, Kaisers W, Eberhard D, Rüther U.

PLoS One. 2014 Aug 21;9(8):e105349. doi: 10.1371/journal.pone.0105349. eCollection 2014.


Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus.

Schreiner AE, Durry S, Aida T, Stock MC, Rüther U, Tanaka K, Rose CR, Kafitz KW.

J Comp Neurol. 2014 Jan 1;522(1):204-24. doi: 10.1002/cne.23450.


A link between FTO, ghrelin, and impaired brain food-cue responsivity.

Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Rüther UU, Brüning JC, Withers DJ, Zelaya FO, Batterham RL.

J Clin Invest. 2013 Aug;123(8):3539-51. doi: 10.1172/JCI44403. Epub 2013 Jul 15.


The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.

Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC.

Nat Neurosci. 2013 Aug;16(8):1042-8. doi: 10.1038/nn.3449. Epub 2013 Jun 30.


FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes.

Tews D, Fischer-Posovszky P, Fromme T, Klingenspor M, Fischer J, Rüther U, Marienfeld R, Barth TF, Möller P, Debatin KM, Wabitsch M.

Endocrinology. 2013 Sep;154(9):3141-51. doi: 10.1210/en.2012-1873. Epub 2013 Jun 10.


The ciliary protein Ftm is required for ventricular wall and septal development.

Gerhardt C, Lier JM, Kuschel S, Rüther U.

PLoS One. 2013;8(2):e57545. doi: 10.1371/journal.pone.0057545. Epub 2013 Feb 28.


FTO levels affect RNA modification and the transcriptome.

Berulava T, Ziehe M, Klein-Hitpass L, Mladenov E, Thomale J, Rüther U, Horsthemke B.

Eur J Hum Genet. 2013 Mar;21(3):317-23. doi: 10.1038/ejhg.2012.168. Epub 2012 Aug 8.


The Dkk1 dose is critical for eye development.

Lieven O, Rüther U.

Dev Biol. 2011 Jul 1;355(1):124-37. doi: 10.1016/j.ydbio.2011.04.023. Epub 2011 Apr 22.


Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.

Besse L, Neti M, Anselme I, Gerhardt C, Rüther U, Laclef C, Schneider-Maunoury S.

Development. 2011 May;138(10):2079-88. doi: 10.1242/dev.059808. Epub 2011 Apr 13.


The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice.

Kim B, Kim Y, Cooke PS, Rüther U, Jorgensen JS.

Biol Reprod. 2011 May;84(5):1024-32. doi: 10.1095/biolreprod.110.088559. Epub 2011 Feb 3.


Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice.

Poritsanos NJ, Lew PS, Fischer J, Mobbs CV, Nagy JI, Wong D, Rüther U, Mizuno TM.

Nutr Diabetes. 2011 Oct 31;1:e19. doi: 10.1038/nutd.2011.15.


Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.

Kim B, Kim Y, Sakuma R, Hui CC, Rüther U, Jorgensen JS.

Dev Biol. 2011 Jan 15;349(2):417-26. doi: 10.1016/j.ydbio.2010.10.010. Epub 2010 Oct 20.


The regulation of Dkk1 expression during embryonic development.

Lieven O, Knobloch J, Rüther U.

Dev Biol. 2010 Apr 15;340(2):256-68. doi: 10.1016/j.ydbio.2010.01.037. Epub 2010 Feb 6.


Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense.

Knobloch J, Reimann K, Klotz LO, Rüther U.

Mol Pharm. 2008 Nov-Dec;5(6):1138-44. doi: 10.1021/mp8001232.


A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.

Hill P, Götz K, Rüther U.

Dev Biol. 2009 Apr 15;328(2):506-16. doi: 10.1016/j.ydbio.2009.02.017. Epub 2009 Feb 24.


Inactivation of the Fto gene protects from obesity.

Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U.

Nature. 2009 Apr 16;458(7240):894-8. doi: 10.1038/nature07848. Epub 2009 Feb 22.


Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.

Driver EC, Pryor SP, Hill P, Turner J, Rüther U, Biesecker LG, Griffith AJ, Kelley MW.

J Neurosci. 2008 Jul 16;28(29):7350-8. doi: 10.1523/JNEUROSCI.0312-08.2008.


Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects.

Knobloch J, Rüther U.

Cell Cycle. 2008 May 1;7(9):1121-7. Epub 2008 Feb 14. Review.


Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death.

Knobloch J, Schmitz I, Götz K, Schulze-Osthoff K, Rüther U.

Mol Cell Biol. 2008 Jan;28(2):529-38. doi: 10.1128/MCB.00533-07. Erratum in: Mol Cell Biol. 2012 May;32(9):1757.


On the history of Fto.

Fischer J, Emmerling C, Ruther U.

Obes Facts. 2008;1(1):43-4. doi: 10.1159/000113466. Epub 2008 Feb 8. No abstract available.


Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.

Walz M, Kellermann S, Bylaite M, Andrée B, Rüther U, Paus R, Kloepper JE, Reifenberger J, Ruzicka T.

Exp Dermatol. 2007 Sep;16(9):715-23.


The molecular basis of Pallister Hall associated polydactyly.

Hill P, Wang B, Rüther U.

Hum Mol Genet. 2007 Sep 1;16(17):2089-96. Epub 2007 Jun 22.


The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome.

Delous M, Baala L, Salomon R, Laclef C, Vierkotten J, Tory K, Golzio C, Lacoste T, Besse L, Ozilou C, Moutkine I, Hellman NE, Anselme I, Silbermann F, Vesque C, Gerhardt C, Rattenberry E, Wolf MT, Gubler MC, Martinovic J, Encha-Razavi F, Boddaert N, Gonzales M, Macher MA, Nivet H, Champion G, Berthélémé JP, Niaudet P, McDonald F, Hildebrandt F, Johnson CA, Vekemans M, Antignac C, Rüther U, Schneider-Maunoury S, Attié-Bitach T, Saunier S.

Nat Genet. 2007 Jul;39(7):875-81. Epub 2007 Jun 10.


Ftm is a novel basal body protein of cilia involved in Shh signalling.

Vierkotten J, Dildrop R, Peters T, Wang B, Rüther U.

Development. 2007 Jul;134(14):2569-77. Epub 2007 Jun 6.


Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear.

Bok J, Dolson DK, Hill P, Rüther U, Epstein DJ, Wu DK.

Development. 2007 May;134(9):1713-22. Epub 2007 Mar 29.


Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway.

Knobloch J, Shaughnessy JD Jr, Rüther U.

FASEB J. 2007 May;21(7):1410-21. Epub 2007 Feb 5.


Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes.

Anselme I, Laclef C, Lanaud M, Rüther U, Schneider-Maunoury S.

Dev Biol. 2007 Apr 1;304(1):208-20. Epub 2006 Dec 15.


Expression of the zebrafish Iroquois genes during early nervous system formation and patterning.

Lecaudey V, Anselme I, Dildrop R, Rüther U, Schneider-Maunoury S.

J Comp Neurol. 2005 Nov 21;492(3):289-302.


Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury.

Martin M, Meyer-Kirchrath J, Kaber G, Jacoby C, Flögel U, Schrader J, Rüther U, Schrör K, Hohlfeld T.

Circulation. 2005 Jul 19;112(3):400-6. Epub 2005 Jul 11.


Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.

Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R.

Hepatology. 2005 Apr;41(4):857-67.


Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase.

Lauer N, Suvorava T, Rüther U, Jacob R, Meyer W, Harrison DG, Kojda G.

Cardiovasc Res. 2005 Jan 1;65(1):254-62.


Organization of Iroquois genes in fish.

Dildrop R, Rüther U.

Dev Genes Evol. 2004 Jun;214(6):267-76. Epub 2004 May 6.


Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.

Rabeler R, Mittag J, Geffers L, Rüther U, Leitges M, Parlow AF, Visser TJ, Bauer K.

Mol Endocrinol. 2004 Jun;18(6):1450-60. Epub 2004 Feb 26.


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