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Items: 15

1.

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.

Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M.

Cell Death Differ. 2019 Apr 11. doi: 10.1038/s41418-019-0329-2. [Epub ahead of print]

PMID:
30976094
2.

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe.

Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB, Burden RE, Salvesen GS, Drag M, Scott CJ.

Nanoscale. 2019 Jan 3;11(2):742-751. doi: 10.1039/c8nr07859a.

PMID:
30566168
3.

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples.

Rut W, Poręba M, Kasperkiewicz P, Snipas SJ, Drąg M.

J Med Chem. 2018 Jun 28;61(12):5222-5234. doi: 10.1021/acs.jmedchem.8b00026. Epub 2018 Jun 9.

PMID:
29806773
4.

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.

Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M.

Chem Sci. 2018 Jan 16;9(8):2113-2129. doi: 10.1039/c7sc04303a. eCollection 2018 Feb 28.

5.

Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus.

Stach N, Kalinska M, Zdzalik M, Kitel R, Karim A, Serwin K, Rut W, Larsen K, Jabaiah A, Firlej M, Wladyka B, Daugherty P, Stennicke H, Drag M, Potempa J, Dubin G.

Structure. 2018 Apr 3;26(4):572-579.e4. doi: 10.1016/j.str.2018.02.008. Epub 2018 Mar 8.

6.

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions.

Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R.

Biochimie. 2017 Aug;139:27-37. doi: 10.1016/j.biochi.2017.05.009. Epub 2017 May 17.

PMID:
28528272
7.

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.

Sci Rep. 2017 Feb 23;7:43135. doi: 10.1038/srep43135.

8.

Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease.

Rut W, Zhang L, Kasperkiewicz P, Poreba M, Hilgenfeld R, Drąg M.

Antiviral Res. 2017 Mar;139:88-94. doi: 10.1016/j.antiviral.2016.12.018. Epub 2016 Dec 26.

PMID:
28034744
9.

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M.

Cell Chem Biol. 2016 Aug 18;23(8):1023-35. doi: 10.1016/j.chembiol.2016.05.020. Epub 2016 Jul 28.

10.

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.

Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S.

Biochem J. 2016 Oct 1;473(19):3189-204. doi: 10.1042/BCJ20160550. Epub 2016 Jul 26.

PMID:
27462122
11.

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

Rut W, Drag M.

Biol Chem. 2016 Sep 1;397(9):921-6. doi: 10.1515/hsz-2016-0176.

PMID:
27176742
12.

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase.

Modak JK, Rut W, Wijeyewickrema LC, Pike RN, Drag M, Roujeinikova A.

Biochimie. 2016 Feb;121:60-71. doi: 10.1016/j.biochi.2015.11.021. Epub 2015 Dec 1.

PMID:
26616008
13.

Small Molecule Active Site Directed Tools for Studying Human Caspases.

Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M.

Chem Rev. 2015 Nov 25;115(22):12546-629. doi: 10.1021/acs.chemrev.5b00434. Epub 2015 Nov 9. Review.

14.

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.

Békés M, Rut W, Kasperkiewicz P, Mulder MP, Ovaa H, Drag M, Lima CD, Huang TT.

Biochem J. 2015 Jun 1;468(2):215-26. doi: 10.1042/BJ20141170.

15.

Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids.

Rut W, Kasperkiewicz P, Byzia A, Poreba M, Groborz K, Drag M.

Biol Chem. 2015 Apr;396(4):329-37. doi: 10.1515/hsz-2014-0315. Review.

PMID:
25719315

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