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Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Lewis L, Chappell GA, Kobets T, O'Brian BE, Sangaraju D, Kosyk O, Bodnar W, Tretyakova NY, Pogribny IP, Rusyn I.

Arch Toxicol. 2018 Dec 14. doi: 10.1007/s00204-018-2374-x. [Epub ahead of print]


Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.

Onel M, Beykal B, Wang M, Grimm FA, Zhou L, Wright FA, Phillips TD, Rusyn I, Pistikopoulos EN.

ESCAPE. 2018;43:421-426. doi: 10.1016/B978-0-444-64235-6.50076-0. Epub 2018 Jul 4.


Histopathological and molecular signatures of a mouse model of acute-on-chronic alcoholic liver injury demonstrate concordance with human alcoholic hepatitis.

Furuya S, Cichocki JA, Konganti K, Dreval K, Uehara T, Katou Y, Fukushima H, Kono H, Pogribny IP, Argemi J, Bataller R, Rusyn I.

Toxicol Sci. 2018 Dec 4. doi: 10.1093/toxsci/kfy292. [Epub ahead of print]


Oy Vey! A Comment on "Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility".

Alves VM, Borba J, Capuzzi SJ, Muratov E, Andrade CH, Rusyn I, Tropsha A.

Toxicol Sci. 2019 Jan 1;167(1):3-4. doi: 10.1093/toxsci/kfy286. No abstract available.


Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers.

Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I.

Regul Toxicol Pharmacol. 2019 Feb;101:91-102. doi: 10.1016/j.yrtph.2018.11.011. Epub 2018 Nov 22.


Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification.

Shapiro AJ, Antoni S, Guyton KZ, Lunn RM, Loomis D, Rusyn I, Jahnke GD, Schwingl PJ, Mehta SS, Addington J, Guha N.

Environ Health Perspect. 2018 Oct;126(10):104501. doi: 10.1289/EHP4224.


Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships.

Low YS, Alves VM, Fourches D, Sedykh A, Andrade CH, Muratov EN, Rusyn I, Tropsha A.

J Chem Inf Model. 2018 Nov 26;58(11):2203-2213. doi: 10.1021/acs.jcim.8b00450. Epub 2018 Nov 9.


Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships.

Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA.

Clin Pharmacol Ther. 2018 Oct 22. doi: 10.1002/cpt.1259. [Epub ahead of print]


Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip.

Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I.

Sci Rep. 2018 Oct 5;8(1):14882. doi: 10.1038/s41598-018-33099-2.


Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice.

Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2019 Jan 1;167(1):126-137. doi: 10.1093/toxsci/kfy223.


High-Content Assay Multiplexing for Muscle Toxicity Screening in Human-Induced Pluripotent Stem Cell-Derived Skeletal Myoblasts.

Klaren WD, Rusyn I.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):333-342. doi: 10.1089/adt.2018.860. Epub 2018 Aug 2.


Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains.

Luo YS, Hsieh NH, Soldatow VY, Chiu WA, Rusyn I.

Toxicology. 2018 Nov 1;409:33-43. doi: 10.1016/j.tox.2018.07.012. Epub 2018 Jul 24.


A human population-based organotypic in vitro model for cardiotoxicity screening.

Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I.

ALTEX. 2018;35(4):441-452. doi: 10.14573/altex.1805301. Epub 2018 Jul 8.


Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.

Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT.

Carcinogenesis. 2018 Jul 3. doi: 10.1093/carcin/bgy082. [Epub ahead of print] No abstract available.


Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice.

Luo YS, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I.

Toxicol Sci. 2018 Aug 1;164(2):489-500. doi: 10.1093/toxsci/kfy099.


gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population.

Konganti K, Ehrlich A, Rusyn I, Threadgill DW.

G3 (Bethesda). 2018 Jul 31;8(8):2559-2562. doi: 10.1534/g3.118.200230.


Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice.

Dalaijamts C, Cichocki JA, Luo YS, Rusyn I, Chiu WA.

Toxicol Appl Pharmacol. 2018 Aug 1;352:142-152. doi: 10.1016/j.taap.2018.05.033. Epub 2018 May 29.


Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals.

Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA.

Environ Health Perspect. 2018 May 29;126(5):057008. doi: 10.1289/EHP2998. eCollection 2018 May.


Editorial overview of the special issue on genomic toxicology epigenetics.

Rusyn I, Pogribny IP.

Curr Opin Toxicol. 2017 Oct;6:i-iii. doi: 10.1016/j.cotox.2017.11.006. Epub 2017 Nov 30. No abstract available.


Application of the key characteristics of carcinogens in cancer hazard identification.

Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT.

Carcinogenesis. 2018 Apr 5;39(4):614-622. doi: 10.1093/carcin/bgy031.


ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM.

BMC Bioinformatics. 2018 Mar 5;19(1):80. doi: 10.1186/s12859-018-2089-2.


Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes.

Rusyn I, Kleeberger SR, McAllister KA, French JE, Svenson KL.

Mamm Genome. 2018 Feb;29(1-2):1-4. doi: 10.1007/s00335-018-9740-0. No abstract available.


Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.

Israel JW, Chappell GA, Simon JM, Pott S, Safi A, Lewis L, Cotney P, Boulos HS, Bodnar W, Lieb JD, Crawford GE, Furey TS, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):153-167. doi: 10.1007/s00335-018-9739-6. Epub 2018 Feb 10.


The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives.

Rusyn I, Greene N.

Toxicol Sci. 2018 Feb 1;161(2):276-284. doi: 10.1093/toxsci/kfx196.


Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):168-181. doi: 10.1007/s00335-018-9734-y. Epub 2018 Jan 20.


Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities.

Chiu WA, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):182-189. doi: 10.1007/s00335-017-9731-6. Epub 2018 Jan 3.


Genetic and epigenetic determinants of inter-individual variability in responses to toxicants.

Lewis L, Crawford GE, Furey TS, Rusyn I.

Curr Opin Toxicol. 2017 Oct;6:50-59. doi: 10.1016/j.cotox.2017.08.006. Epub 2017 Sep 12.


Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse.

Seniutkin O, Furuya S, Luo YS, Cichocki JA, Fukushima H, Kato Y, Sugimoto H, Matsumoto T, Uehara T, Rusyn I.

Toxicol Appl Pharmacol. 2018 Jan 15;339:1-9. doi: 10.1016/j.taap.2017.11.024. Epub 2017 Dec 6.


Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.

Luo YS, Furuya S, Chiu W, Rusyn I.

J Toxicol Environ Health A. 2018;81(1-3):37-52. doi: 10.1080/15287394.2017.1408512. Epub 2017 Nov 30.


MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis.

de Conti A, Ortega JF, Tryndyak V, Dreval K, Moreno FS, Rusyn I, Beland FA, Pogribny IP.

Oncotarget. 2017 Aug 1;8(51):88517-88528. doi: 10.18632/oncotarget.19774. eCollection 2017 Oct 24.


A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics.

House JS, Grimm FA, Jima DD, Zhou YH, Rusyn I, Wright FA.

Front Genet. 2017 Nov 1;8:168. doi: 10.3389/fgene.2017.00168. eCollection 2017.


Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.

Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA.

FASEB J. 2018 Mar;32(3):1591-1601. doi: 10.1096/fj.201700866R. Epub 2018 Jan 3.


Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice.

Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Furey TS.

Environ Health Perspect. 2017 Oct 16;125(10):107006. doi: 10.1289/EHP1937.


An empirical Bayes approach for multiple tissue eQTL analysis.

Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB.

Biostatistics. 2018 Jul 1;19(3):391-406. doi: 10.1093/biostatistics/kxx048.


Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.

Zhou YH, Cichocki JA, Soldatow VY, Scholl EH, Gallins PJ, Jima D, Yoo HS, Chiu WA, Wright FA, Rusyn I.

Toxicol Sci. 2017 Nov 1;160(1):95-110. doi: 10.1093/toxsci/kfx165.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Oct 1;159(2):481. doi: 10.1093/toxsci/kfx158. No abstract available.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Sep 1;159(1):102-113. doi: 10.1093/toxsci/kfx120. Erratum in: Toxicol Sci. 2017 Oct 1;159(2):481.


High-Content Assay Multiplexing for Vascular Toxicity Screening in Induced Pluripotent Stem Cell-Derived Endothelial Cells and Human Umbilical Vein Endothelial Cells.

Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I.

Assay Drug Dev Technol. 2017 Aug/Sep;15(6):267-279. doi: 10.1089/adt.2017.786. Epub 2017 Aug 3.


Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I.

ALTEX. 2018;35(1):51-64. doi: 10.14573/altex.1703231. Epub 2017 Jul 24.


Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.

Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I.

Environ Health Perspect. 2017 May 30;125(5):057006. doi: 10.1289/EHP788.


Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across.

Grimm FA, Russell WK, Luo YS, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I.

Environ Sci Technol. 2017 Jun 20;51(12):7197-7207. doi: 10.1021/acs.est.6b06413. Epub 2017 May 26.


Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.

Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I.

Toxicol Sci. 2017 Jul 1;158(1):48-62. doi: 10.1093/toxsci/kfx065.


miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice.

Dreval K, de Conti A, Furuya S, Beland FA, Rusyn I, Pogribny IP.

Toxicology. 2017 Jun 1;384:40-49. doi: 10.1016/j.tox.2017.03.004. Epub 2017 Mar 8.


In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model.

Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR.

Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1.


Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform.

Ibrahim YM, Garimella SV, Prost SA, Wojcik R, Norheim RV, Baker ES, Rusyn I, Smith RD.

Anal Chem. 2016 Dec 20;88(24):12152-12160. doi: 10.1021/acs.analchem.6b03027. Epub 2016 Dec 1.


Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

J Pharmacol Exp Ther. 2017 Apr;361(1):17-28. doi: 10.1124/jpet.116.238790. Epub 2017 Feb 1.


A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives.

Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I.

Green Chem. 2016 Aug 21;18(16):4407-4419. doi: 10.1039/c6gc01147k. Epub 2016 May 16.


A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.

Chiu WA, Wright FA, Rusyn I.

ALTEX. 2017;34(3):377-388. doi: 10.14573/altex.1608251. Epub 2016 Dec 13.


The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.

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