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The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

Jacobsen LM, Bocchino L, Evans-Molina C, DiMeglio L, Goland R, Wilson DM, Atkinson MA, Aye T, Russell WE, Wentworth JM, Boulware D, Geyer S, Sosenko JM.

Diabetologia. 2019 Nov 25. doi: 10.1007/s00125-019-05047-w. [Epub ahead of print]


An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group.

N Engl J Med. 2019 Aug 15;381(7):603-613. doi: 10.1056/NEJMoa1902226. Epub 2019 Jun 9.


Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.

Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group.

Diabetes. 2019 Jun;68(6):1267-1276. doi: 10.2337/db19-0057. Epub 2019 Apr 9.


Randomized Trial of a Positive Psychology Intervention for Adolescents With Type 1 Diabetes.

Jaser SS, Whittemore R, Choi L, Nwosu S, Russell WE.

J Pediatr Psychol. 2019 Jun 1;44(5):620-629. doi: 10.1093/jpepsy/jsz006.


Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset.

Virostko J, Williams J, Hilmes M, Bowman C, Wright JJ, Du L, Kang H, Russell WE, Powers AC, Moore DJ.

Diabetes Care. 2019 Feb;42(2):248-257. doi: 10.2337/dc18-1507. Epub 2018 Dec 14.


Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.

Scheving LA, Zhang X, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G807-G816. doi: 10.1152/ajpgi.00423.2015. Epub 2016 Sep 1.


Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.

Scheving LA, Zhang X, Stevenson MC, Weintraub MA, Abbasi A, Clarke AM, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15;309(12):G942-54. doi: 10.1152/ajpgi.00089.2015. Epub 2015 Oct 22.


A review of adolescent adherence in type 1 diabetes and the untapped potential of diabetes providers to improve outcomes.

Datye KA, Moore DJ, Russell WE, Jaser SS.

Curr Diab Rep. 2015 Aug;15(8):51. doi: 10.1007/s11892-015-0621-6. Review.


Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.

Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G364-77. doi: 10.1152/ajpgi.00364.2014. Epub 2014 Nov 20.


Development and validation of the diabetes adolescent problem solving questionnaire.

Mulvaney SA, Jaser SS, Rothman RL, Russell WE, Pittel EJ, Lybarger C, Wallston KA.

Patient Educ Couns. 2014 Oct;97(1):96-100. doi: 10.1016/j.pec.2014.07.005. Epub 2014 Jul 12.


Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.

Rigby MR, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR; T1DAL Study Team.

Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23.


Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice.

Scheving LA, Zhang X, Garcia OA, Wang RF, Stevenson MC, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G370-81. doi: 10.1152/ajpgi.00116.2013. Epub 2014 Jan 9.


Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment.

Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Peakman M, Raskin P, Russell WE, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS; Type 1 Diabetes TrialNet Abatacept Study Group.

Diabetes Care. 2014 Apr;37(4):1069-75. doi: 10.2337/dc13-0604. Epub 2013 Dec 2.


Factors that influence parental attitudes toward enrollment in type 1 diabetes trials.

Buscariollo DL, Davidson MA, Black M, Russell WE, Rothman RL, Moore DJ.

PLoS One. 2012;7(8):e44341. doi: 10.1371/journal.pone.0044341. Epub 2012 Aug 28.


Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.

Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS; Type 1 Diabetes TrialNet Abatacept Study Group.

Lancet. 2011 Jul 30;378(9789):412-9. doi: 10.1016/S0140-6736(11)60886-6. Epub 2011 Jun 28.


Pediatric endocrinologists' management of children with type 2 diabetes.

Wong K, Potter A, Mulvaney S, Russell WE, Schlundt DG, Rothman RL.

Diabetes Care. 2010 Mar;33(3):512-4. doi: 10.2337/dc09-1333. Epub 2009 Dec 10.


Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW.

Mol Biol Cell. 2009 Dec;20(24):5236-49. doi: 10.1091/mbc.E08-12-1256.


Clinical, genetic, and enzymatic characterization of P450 oxidoreductase deficiency in four patients.

Sahakitrungruang T, Huang N, Tee MK, Agrawal V, Russell WE, Crock P, Murphy N, Migeon CJ, Miller WL.

J Clin Endocrinol Metab. 2009 Dec;94(12):4992-5000. doi: 10.1210/jc.2009-1460. Epub 2009 Oct 16.


Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms.

Onuma H, Oeser JK, Nelson BA, Wang Y, Flemming BP, Scheving LA, Russell WE, O'Brien RM.

Biochem J. 2009 Jan 15;417(2):611-20. doi: 10.1042/BJ20080999.


Self-management in type 2 diabetes: the adolescent perspective.

Mulvaney SA, Mudasiru E, Schlundt DG, Baughman CL, Fleming M, VanderWoude A, Russell WE, Elasy TA, Rothman R.

Diabetes Educ. 2008 Jul-Aug;34(4):674-82. doi: 10.1177/0145721708320902.


Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner.

Scheving LA, Stevenson MC, Zhang X, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G322-31. doi: 10.1152/ajpgi.00597.2007. Epub 2008 Jun 5.


Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis.

Mathew RP, Byrne DW, Linton MF, Vaughan DE, Fazio S, Russell WE.

Metabolism. 2008 Jun;57(6):733-40. doi: 10.1016/j.metabol.2008.01.010.


Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes.

Rothman RL, Mulvaney S, Elasy TA, VanderWoude A, Gebretsadik T, Shintani A, Potter A, Russell WE, Schlundt D.

Pediatrics. 2008 Apr;121(4):e912-9. doi: 10.1542/peds.2007-1484.


It's about time: clock genes unveiled in the gut.

Scheving LA, Russell WE.

Gastroenterology. 2007 Oct;133(4):1373-6. No abstract available.


Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes.

Scheving LA, Buchanan R, Krause MA, Zhang X, Stevenson MC, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G552-9. Epub 2007 Jun 21.


Beta-catenin in the liver: an integrator of proliferation and metabolism?

Scheving LA, Russell WE.

Gastroenterology. 2006 Nov;131(5):1641-3. No abstract available.


The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling.

Scheving LA, Zhang L, Stevenson MC, Kwak ES, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G16-25. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G751.


Parent perceptions of caring for adolescents with type 2 diabetes.

Mulvaney SA, Schlundt DG, Mudasiru E, Fleming M, Vander Woude AM, Russell WE, Elasy TA, Rothman R.

Diabetes Care. 2006 May;29(5):993-7.


Implementing pediatric growth charts into an electronic health record system.

Rosenbloom ST, Qi X, Riddle WR, Russell WE, DonLevy SC, Giuse D, Sedman AB, Spooner SA.

J Am Med Inform Assoc. 2006 May-Jun;13(3):302-8. Epub 2006 Feb 24.


Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.

Romero-Gallo J, Sozmen EG, Chytil A, Russell WE, Whitehead R, Parks WT, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM.

Oncogene. 2005 Apr 21;24(18):3028-41.


Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.

Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE, Lee DC.

J Biol Chem. 2004 Jun 4;279(23):24179-88. Epub 2004 Apr 5.


TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase.

Lee DC, Sunnarborg SW, Hinkle CL, Myers TJ, Stevenson MY, Russell WE, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Chang A, Jackson LF.

Ann N Y Acad Sci. 2003 May;995:22-38. Review.


Diverse expression of ErbB receptor proteins during rat liver development and regeneration.

Carver RS, Stevenson MC, Scheving LA, Russell WE.

Gastroenterology. 2002 Dec;123(6):2017-27.


Premature pubarche in girls is associated with functional adrenal but not ovarian hyperandrogenism.

Mathew RP, Najjar JL, Lorenz RA, Mayes DE, Russell WE.

J Pediatr. 2002 Jul;141(1):91-8.


Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

Sunnarborg SW, Hinkle CL, Stevenson M, Russell WE, Raska CS, Peschon JJ, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Lee DC.

J Biol Chem. 2002 Apr 12;277(15):12838-45. Epub 2002 Jan 31.


Integral role of the EGF receptor in HGF-mediated hepatocyte proliferation.

Scheving LA, Stevenson MC, Taylormoore JM, Traxler P, Russell WE.

Biochem Biophys Res Commun. 2002 Jan 11;290(1):197-203.


Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity.

Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, Shawver LK, Arteaga CL.

J Biol Chem. 2000 Mar 10;275(10):6987-95.


Liver regeneration is transiently impaired in urokinase-deficient mice.

Roselli HT, Su M, Washington K, Kerins DM, Vaughan DE, Russell WE.

Am J Physiol. 1998 Dec;275(6):G1472-9. doi: 10.1152/ajpgi.1998.275.6.G1472.


An essential role for ectodomain shedding in mammalian development.

Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA.

Science. 1998 Nov 13;282(5392):1281-4.


Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors.

Carver RS, Mathew PM, Russell WE.

Endocrinology. 1997 Dec;138(12):5195-201.


Structure, glycosylation, and localization of rat intestinal guanylyl cyclase C: modulation by fasting.

Scheving LA, Russell WE, Chong KM.

Am J Physiol. 1996 Dec;271(6 Pt 1):G959-68.


Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.

Berkowitz EA, Seroogy KB, Schroeder JA, Russell WE, Evans EP, Riedel RF, Phillips HK, Harrison CA, Lee DC, Luetteke NC.

Cell Growth Differ. 1996 Sep;7(9):1271-82.


Insulin regulates heregulin binding and ErbB3 expression in rat hepatocytes.

Carver RS, Sliwkowski MX, Sitaric S, Russell WE.

J Biol Chem. 1996 Jun 7;271(23):13491-6.


Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice.

Russell WE, Kaufmann WK, Sitaric S, Luetteke NC, Lee DC.

Mol Carcinog. 1996 Mar;15(3):183-9.


Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology.

Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ.

Gastroenterology. 1995 Feb;108(2):564-80. Review. No abstract available.


Protect your assets from future claims.

Russell WE.

CDS Rev. 1993 May;86(4):14-5. No abstract available.


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