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Items: 1 to 50 of 87

1.

The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.

Trovò L, Fuchs C, De Rosa R, Barbiero I, Tramarin M, Ciani E, Rusconi L, Kilstrup-Nielsen C.

Neurobiol Dis. 2020 May;138:104791. doi: 10.1016/j.nbd.2020.104791. Epub 2020 Feb 4.

2.

Pregnenolone and pregnenolone-methyl-ether rescue neuronal defects caused by dysfunctional CLIP170 in a neuronal model of CDKL5 Deficiency Disorder.

Barbiero I, Peroni D, Siniscalchi P, Rusconi L, Tramarin M, De Rosa R, Motta P, Bianchi M, Kilstrup-Nielsen C.

Neuropharmacology. 2020 Mar 1;164:107897. doi: 10.1016/j.neuropharm.2019.107897. Epub 2019 Nov 30.

PMID:
31794725
3.

Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.

Menichincheri M, Ardini E, Magnaghi P, Avanzi N, Banfi P, Bossi R, Buffa L, Canevari G, Ceriani L, Colombo M, Corti L, Donati D, Fasolini M, Felder E, Fiorelli C, Fiorentini F, Galvani A, Isacchi A, Borgia AL, Marchionni C, Nesi M, Orrenius C, Panzeri A, Pesenti E, Rusconi L, Saccardo MB, Vanotti E, Perrone E, Orsini P.

J Med Chem. 2019 Sep 12;62(17):8364. doi: 10.1021/acs.jmedchem.9b01259. Epub 2019 Aug 19. No abstract available.

PMID:
31424209
4.

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder.

Vigli D, Rusconi L, Valenti D, La Montanara P, Cosentino L, Lacivita E, Leopoldo M, Amendola E, Gross C, Landsberger N, Laviola G, Kilstrup-Nielsen C, Vacca RA, De Filippis B.

Neuropharmacology. 2019 Jan;144:104-114. doi: 10.1016/j.neuropharm.2018.10.018. Epub 2018 Oct 13.

PMID:
30326240
5.

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.

Tramarin M, Rusconi L, Pizzamiglio L, Barbiero I, Peroni D, Scaramuzza L, Guilliams T, Cavalla D, Antonucci F, Kilstrup-Nielsen C.

Hum Mol Genet. 2018 Jun 15;27(12):2052-2063. doi: 10.1093/hmg/ddy108.

PMID:
29618004
6.

The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex.

Barbiero I, Peroni D, Tramarin M, Chandola C, Rusconi L, Landsberger N, Kilstrup-Nielsen C.

Hum Mol Genet. 2017 Sep 15;26(18):3520-3530. doi: 10.1093/hmg/ddx237.

PMID:
28641386
7.

Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.

Menichincheri M, Ardini E, Magnaghi P, Avanzi N, Banfi P, Bossi R, Buffa L, Canevari G, Ceriani L, Colombo M, Corti L, Donati D, Fasolini M, Felder E, Fiorelli C, Fiorentini F, Galvani A, Isacchi A, Borgia AL, Marchionni C, Nesi M, Orrenius C, Panzeri A, Pesenti E, Rusconi L, Saccardo MB, Vanotti E, Perrone E, Orsini P.

J Med Chem. 2016 Apr 14;59(7):3392-408. doi: 10.1021/acs.jmedchem.6b00064. Epub 2016 Mar 30. Erratum in: J Med Chem. 2019 Sep 12;62(17):8364.

PMID:
27003761
8.

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.

Nawaz MS, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, Alberio T, Landsberger N, Rusconi L, Kilstrup-Nielsen C.

PLoS One. 2016 Feb 5;11(2):e0148634. doi: 10.1371/journal.pone.0148634. eCollection 2016.

9.

Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5.

La Montanara P, Rusconi L, Locarno A, Forti L, Barbiero I, Tramarin M, Chandola C, Kilstrup-Nielsen C, Landsberger N.

J Biol Chem. 2015 Feb 13;290(7):4512-27. doi: 10.1074/jbc.M114.589762. Epub 2015 Jan 2.

10.

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

Bellini E, Pavesi G, Barbiero I, Bergo A, Chandola C, Nawaz MS, Rusconi L, Stefanelli G, Strollo M, Valente MM, Kilstrup-Nielsen C, Landsberger N.

Front Cell Neurosci. 2014 Aug 13;8:236. doi: 10.3389/fncel.2014.00236. eCollection 2014. Review.

11.

What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.

Kilstrup-Nielsen C, Rusconi L, La Montanara P, Ciceri D, Bergo A, Bedogni F, Landsberger N.

Neural Plast. 2012;2012:728267. doi: 10.1155/2012/728267. Epub 2012 Jun 17. Review.

12.

Extrasynaptic N-methyl-D-aspartate (NMDA) receptor stimulation induces cytoplasmic translocation of the CDKL5 kinase and its proteasomal degradation.

Rusconi L, Kilstrup-Nielsen C, Landsberger N.

J Biol Chem. 2011 Oct 21;286(42):36550-8. doi: 10.1074/jbc.M111.235630. Epub 2011 Aug 5.

13.

Identification of candidate substrates for poly(ADP-ribose) polymerase-2 (PARP2) in the absence of DNA damage using high-density protein microarrays.

Troiani S, Lupi R, Perego R, Depaolini SR, Thieffine S, Bosotti R, Rusconi L.

FEBS J. 2011 Oct;278(19):3676-87. doi: 10.1111/j.1742-4658.2011.08286.x. Epub 2011 Sep 6.

14.

[Hypertensive emergency and urgency: clinical update].

Rusconi L.

G Ital Cardiol (Rome). 2011 Mar;12(3):230; author reply 230-1. Italian. No abstract available.

PMID:
21560481
15.

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase.

Colombo R, Caldarelli M, Mennecozzi M, Giorgini ML, Sola F, Cappella P, Perrera C, Depaolini SR, Rusconi L, Cucchi U, Avanzi N, Bertrand JA, Bossi RT, Pesenti E, Galvani A, Isacchi A, Colotta F, Donati D, Moll J.

Cancer Res. 2010 Dec 15;70(24):10255-64. doi: 10.1158/0008-5472.CAN-10-2101.

16.

Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors.

Bossi RT, Saccardo MB, Ardini E, Menichincheri M, Rusconi L, Magnaghi P, Orsini P, Avanzi N, Borgia AL, Nesi M, Bandiera T, Fogliatto G, Bertrand JA.

Biochemistry. 2010 Aug 17;49(32):6813-25. doi: 10.1021/bi1005514.

PMID:
20695522
17.

Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

Perrera C, Colombo R, Valsasina B, Carpinelli P, Troiani S, Modugno M, Gianellini L, Cappella P, Isacchi A, Moll J, Rusconi L.

J Biol Chem. 2010 Apr 16;285(16):11775-85. doi: 10.1074/jbc.M109.068312. Epub 2010 Feb 22.

18.

A Perl procedure for protein identification by Peptide Mass Fingerprinting.

Tiengo A, Barbarini N, Troiani S, Rusconi L, Magni P.

BMC Bioinformatics. 2009 Oct 15;10 Suppl 12:S11. doi: 10.1186/1471-2105-10-S12-S11.

19.

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.

Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C.

EMBO Rep. 2009 Dec;10(12):1327-33. doi: 10.1038/embor.2009.217. Epub 2009 Oct 9.

20.

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.

Rusconi L, Salvatoni L, Giudici L, Bertani I, Kilstrup-Nielsen C, Broccoli V, Landsberger N.

J Biol Chem. 2008 Oct 31;283(44):30101-11. doi: 10.1074/jbc.M804613200. Epub 2008 Aug 13.

21.

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

Baumli S, Lolli G, Lowe ED, Troiani S, Rusconi L, Bullock AN, Debreczeni JE, Knapp S, Johnson LN.

EMBO J. 2008 Jul 9;27(13):1907-18. doi: 10.1038/emboj.2008.121. Epub 2008 Jun 19.

22.

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

Carpinelli P, Ceruti R, Giorgini ML, Cappella P, Gianellini L, Croci V, Degrassi A, Texido G, Rocchetti M, Vianello P, Rusconi L, Storici P, Zugnoni P, Arrigoni C, Soncini C, Alli C, Patton V, Marsiglio A, Ballinari D, Pesenti E, Fancelli D, Moll J.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3158-68.

23.

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.

Modugno M, Casale E, Soncini C, Rosettani P, Colombo R, Lupi R, Rusconi L, Fancelli D, Carpinelli P, Cameron AD, Isacchi A, Moll J.

Cancer Res. 2007 Sep 1;67(17):7987-90.

24.

Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.

Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD.

J Mol Biol. 2007 May 4;368(3):691-705. Epub 2007 Feb 20.

PMID:
17368478
25.

Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin 2/VAMP2.

Bonanomi D, Rusconi L, Colombo CA, Benfenati F, Valtorta F.

Biochem J. 2007 Jun 15;404(3):525-34.

26.

Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation.

Bertani I, Rusconi L, Bolognese F, Forlani G, Conca B, De Monte L, Badaracco G, Landsberger N, Kilstrup-Nielsen C.

J Biol Chem. 2006 Oct 20;281(42):32048-56. Epub 2006 Aug 24.

27.

Transient left ventricular apical ballooning at the onset of multiple system atrophy.

Ripa S, Scaglione C, Rusconi LC.

J Cardiovasc Med (Hagerstown). 2006 Aug;7(8):631-6.

PMID:
16858244
28.

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello P, Rusconi L, Storici P, Zugnoni P, Pesenti E, Croci V, Ceruti R, Giorgini ML, Cappella P, Ballinari D, Sola F, Varasi M, Bravo R, Moll J.

Clin Cancer Res. 2006 Jul 1;12(13):4080-9.

29.

Role of ventricular Autocapture function in increasing longevity of DDDR pacemakers: a prospective study.

Boriani G, Rusconi L, Biffi M, Pavia L, Sassara M, Malfitano D, Bongiorni MG, Padeletti L, Filice I, Sanfelici D, Maffei P, Vicentini A, Branzi A.

Europace. 2006 Mar;8(3):216-20. Epub 2006 Feb 10.

PMID:
16627443
30.

Regulation of the wild-type and Y1235D mutant Met kinase activation.

Cristiani C, Rusconi L, Perego R, Schiering N, Kalisz HM, Knapp S, Isacchi A.

Biochemistry. 2005 Nov 1;44(43):14110-9.

PMID:
16245927
31.

Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approach.

Troiani S, Uggeri M, Moll J, Isacchi A, Kalisz HM, Rusconi L, Valsasina B.

J Proteome Res. 2005 Jul-Aug;4(4):1296-303.

PMID:
16083279
32.

Combined Abciximab REteplase Stent Study in acute myocardial infarction (CARESS in AMI).

Di Mario C, Bolognese L, Maillard L, Dudek D, Gambarati G, Manari A, Guiducci V, Patrizi G, Rusconi LC, Piovaccari G, Hibon AR, Belpomme V, Indolfi C, Olivari Z, Steffenino G, Zmudka K, Airoldi F, Panzarasa R, Flather M, Steg PG.

Am Heart J. 2004 Sep;148(3):378-85.

PMID:
15389222
33.

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

Gasparini L, Rusconi L, Xu H, del Soldato P, Ongini E.

J Neurochem. 2004 Jan;88(2):337-48.

34.

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14.

35.

A new approach to phosphoserine and phosphothreonine analysis in peptides and proteins: chemical modification, enrichment via solid-phase reversible binding, and analysis by mass spectrometry.

Thaler F, Valsasina B, Baldi R, Xie J, Stewart A, Isacchi A, Kalisz HM, Rusconi L.

Anal Bioanal Chem. 2003 Jun;376(3):366-73. Epub 2003 May 7.

PMID:
12734628
36.

Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.

Visco C, Magistrelli G, Bosotti R, Perego R, Rusconi L, Toma S, Zamai M, Acuto O, Isacchi A.

Biochemistry. 2000 Mar 14;39(10):2784-91.

PMID:
10704231
37.

The "SPEM" (Studio Policentrico Elettrocateteri Membrane): a multicenter study on membrane leads.

Rusconi L, Sigliano R, Mininno A.

Pacing Clin Electrophysiol. 1998 Oct;21(10):1943-8.

PMID:
9793091
38.

Italian experience with AutoCapture in conjunction with a membrane lead. Pacesetter Automatic Control of Energy and Membrane Automatic Threshold Evaluation (Pacemate) Study Group.

Sermasi S, Marconi M, Libero L, Moracchini PV, Rusconi L, Mininno A, Sigliano R.

Pacing Clin Electrophysiol. 1996 Nov;19(11 Pt 2):1799-804.

PMID:
8945044
39.

[Carotid sinus syndrome associated with a left parapharyngeal non-Hodgkin's lymphoma].

Rusconi L, Zenchi GP.

G Ital Cardiol. 1996 Jun;26(6):681-7. Italian.

PMID:
8803589
40.

Bombesin receptor antagonists. 2. Analogues based on substance P antagonists.

Rusconi L, de Castiglione R, Gozzini L, Ciomei M, Molinari I, Basilico L, Rubino T, Vinayek R, Gardner JD.

Farmaco. 1991 Jun;46(6):725-42.

PMID:
1722978
41.

Replenishment of brain catecholamine stores does not restore the impaired growth hormone (GH) responsiveness to GHRH in aged rats.

Lima L, Dall'Ara A, Parenti M, Rusconi L, Müller EE, Cocchi D.

Pharmacol Res. 1989 Jan-Feb;21(1):87-8. No abstract available.

PMID:
2498860
42.

Serotonergic control of phenylephrine-induced cyclic 3,5'-adenosine monophosphate and inositol phosphates formation in rat hippocampus.

Consolo S, Cicioni P, Ladinsky H, Rusconi L, Parenti M, Vinci R.

J Pharmacol Exp Ther. 1988 Dec;247(3):1187-92.

PMID:
2849665
43.

Role of dopamine in manganese neurotoxicity.

Parenti M, Rusconi L, Cappabianca V, Parati EA, Groppetti A.

Brain Res. 1988 Nov 15;473(2):236-40.

PMID:
2852985
44.

Effect of aspirin on serotonin and met-enkephalin in brain: correlation with the antinociceptive activity of the drug.

Groppetti A, Braga PC, Biella G, Parenti M, Rusconi L, Mantegazza P.

Neuropharmacology. 1988 May;27(5):499-505.

PMID:
2455874
45.

Different regulation of growth hormone-releasing factor-sensitive adenylate cyclase in the anterior pituitary of young and aged rats.

Parenti M, Dall'ara A, Rusconi L, Cocchi D, Müller EE.

Endocrinology. 1987 Nov;121(5):1649-53.

PMID:
3117520
46.

Absence of D1 dopamine receptors that stimulate prolactin release in the rat pituitary.

Cocchi D, Ingrassia S, Rusconi L, Villa I, Müller EE.

Eur J Pharmacol. 1987 Oct 27;142(3):425-9.

PMID:
2962879
47.

Behavioural and biochemical studies on 6-methylamino-4,5,6,7-tetrahydrobenzothiazole (14.839JL), a new potent dopaminergic agonist.

Ponzio F, Algeri S, Garattini S, Cioce V, Rusconi L, Sacchetti G, Manuel C, Notelle C, Duvert L, Legeai J.

Pharmacol Res Commun. 1987 Aug;19(8):555-65.

PMID:
3432322
48.

Dopamine receptor changes in response to prolonged treatment with L-dopa.

Groppetti A, Flauto C, Parati E, Vescovi A, Rusconi L, Parenti M.

J Neural Transm Suppl. 1986;22:33-45.

PMID:
2946813
49.

Bicyclic compounds with potential antiulcer and/or antisecretory activity. I. 4,5,6,7-Tetrahydrobenzimidazoles.

Scarponi U, Cimaschi R, Rusconi L, Santangelo F, Arcari G, Castello R, Toti D, de Castiglione R.

Farmaco Sci. 1985 Nov;40(11):818-32.

PMID:
2867933

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