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Adaptation of an R5 Simian-human Immunodeficiency Virus Encoding an HIV Clade A Envelope With or Without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants.

Zhou M, Humbert M, Mukhtar MM, Scinto HB, Vyas HK, Lakhashe SK, Byrareddy SN, Maurer G, Thorat S, Owuor J, Lai Z, Chen Y, Griffiths A, Chenine AL, Gumber S, Villinger F, Montefiori D, Ruprecht RM.

J Virol. 2019 Feb 13. pii: JVI.02267-18. doi: 10.1128/JVI.02267-18. [Epub ahead of print]


Anti-HIV IgM protects against mucosal SHIV transmission.

Gong S, Tomusange K, Kulkarni V, Adeniji OS, Lakhashe SK, Hariraju D, Strickland A, Plake E, Frost PA, Ratcliffe SJ, Wang L, Lafer EM, Ruprecht RM.

AIDS. 2018 Jul 17;32(11):F5-F13. doi: 10.1097/QAD.0000000000001857.


Novel Strategy To Adapt Simian-Human Immunodeficiency Virus E1 Carrying env from an RV144 Volunteer to Rhesus Macaques: Coreceptor Switch and Final Recovery of a Pathogenic Virus with Exclusive R5 Tropism.

Scinto HB, Gupta S, Thorat S, Mukhtar MM, Griffiths A, Delgado J, Plake E, Vyas HK, Strickland A, Byrareddy SN, Montefiori DC, LaBranche C, Pal R, Treece J, Orndorff S, Ferrari MG, Weiss D, Chenine AL, McLinden R, Michael N, Kim JH, Robb ML, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Ruprecht RM.

J Virol. 2018 Jun 29;92(14). pii: e02222-17. doi: 10.1128/JVI.02222-17. Print 2018 Jul 15.


Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.

Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O'Connell RJ, Spudich S, Michael NL, Vasan S.

J Virol. 2018 May 14;92(11). pii: e00222-18. doi: 10.1128/JVI.00222-18. Print 2018 Jun 1.


Mucosal IgA Responses: Damaged in Established HIV Infection-Yet, Effective Weapon against HIV Transmission.

Kulkarni V, Ruprecht RM.

Front Immunol. 2017 Nov 15;8:1581. doi: 10.3389/fimmu.2017.01581. eCollection 2017. Review.


Anti-HIV Passive Immunization: New Weapons in the Arsenal.

Ruprecht RM.

Trends Microbiol. 2017 Dec;25(12):954-956. doi: 10.1016/j.tim.2017.10.006. Epub 2017 Oct 30.


Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge.

Malherbe DC, Mendy J, Vang L, Barnette PT, Reed J, Lakhashe SK, Owuor J, Gach JS, Legasse AW, Axthelm MK, LaBranche CC, Montefiori D, Forthal DN, Park B, Wilson JM, McLinden JH, Xiang J, Stapleton JT, Sacha JB, Haynes BF, Liao HX, Ruprecht RM, Smith J, Gurwith M, Haigwood NL, Alexander J.

J Virol. 2018 Jan 2;92(2). pii: e01092-17. doi: 10.1128/JVI.01092-17. Print 2018 Jan 15.


Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV.

Anderson DJ, Politch JA, Zeitlin L, Hiatt A, Kadasia K, Mayer KH, Ruprecht RM, Villinger F, Whaley KJ.

AIDS. 2017 Jul 17;31(11):1505-1517. doi: 10.1097/QAD.0000000000001521. Review.


Antibody-mediated immune exclusion of HIV.

Ruprecht RM, Lakhashe SK.

Curr Opin HIV AIDS. 2017 May;12(3):222-228. doi: 10.1097/COH.0000000000000369. Review.


Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.

Sholukh AM, Watkins JD, Vyas HK, Gupta S, Lakhashe SK, Thorat S, Zhou M, Hemashettar G, Bachler BC, Forthal DN, Villinger F, Sattentau QJ, Weiss RA, Agatic G, Corti D, Lanzavecchia A, Heeney JL, Ruprecht RM.

Vaccine. 2015 Apr 21;33(17):2086-95. doi: 10.1016/j.vaccine.2015.02.020. Epub 2015 Mar 11.


Are anti-HIV IgAs good guys or bad guys?

Zhou M, Ruprecht RM.

Retrovirology. 2014 Dec 14;11:109. doi: 10.1186/s12977-014-0109-5. Review.


Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus.

Lakhashe SK, Byrareddy SN, Zhou M, Bachler BC, Hemashettar G, Hu SL, Villinger F, Else JG, Stock S, Lee SJ, Vargas-Inchaustegui DA, Cofano EB, Robert-Guroff M, Johnson WE, Polonis VR, Forthal DN, Loret EP, Rasmussen RA, Ruprecht RM.

Vaccine. 2014 Nov 12;32(48):6527-36. doi: 10.1016/j.vaccine.2014.08.065. Epub 2014 Sep 20.


Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus.

Courtney CL, Ethun KF, Villinger F, Ruprecht RM, Byrareddy SN.

J Med Primatol. 2015 Feb;44(1):35-9. doi: 10.1111/jmp.12142. Epub 2014 Sep 1.


Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose.

Sholukh AM, Byrareddy SN, Shanmuganathan V, Hemashettar G, Lakhashe SK, Rasmussen RA, Watkins JD, Vyas HK, Thorat S, Brandstoetter T, Mukhtar MM, Yoon JK, Novembre FJ, Villinger F, Landucci G, Forthal DN, Ratcliffe S, Tuero I, Robert-Guroff M, Polonis VR, Bilska M, Montefiori DC, Johnson WE, Ertl HC, Ruprecht RM.

Retrovirology. 2014 Jan 20;11:8. doi: 10.1186/1742-4690-11-8.


The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells.

Gupta S, Gach JS, Becerra JC, Phan TB, Pudney J, Moldoveanu Z, Joseph SB, Landucci G, Supnet MJ, Ping LH, Corti D, Moldt B, Hel Z, Lanzavecchia A, Ruprecht RM, Burton DR, Mestecky J, Anderson DJ, Forthal DN.

PLoS Pathog. 2013;9(11):e1003776. doi: 10.1371/journal.ppat.1003776. Epub 2013 Nov 21. Erratum in: PLoS Pathog. 2013 Nov;9(11). doi:10.1371/annotation/31430955-703b-484a-96eb-e180f917d683.


Live attenuated Rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques.

Byrareddy SN, Ayash-Rashkovsky M, Kramer VG, Lee SJ, Correll M, Novembre FJ, Villinger F, Johnson WE, von Gegerfelt A, Felber BK, Ruprecht RM.

PLoS One. 2013 Sep 30;8(9):e75556. doi: 10.1371/journal.pone.0075556. eCollection 2013.


Variations in the Biological Functions of HIV-1 Clade C Envelope in a SHIV-Infected Rhesus Macaque during Disease Progression.

Tso FY, Abrahamyan L, Hu SL, Ruprecht RM, Wood C.

PLoS One. 2013 Jun 26;8(6):e66973. doi: 10.1371/journal.pone.0066973. Print 2013.


Live-virus exposure of vaccine-protected macaques alters the anti-HIV-1 antibody repertoire in the absence of viremia.

Bachler BC, Humbert M, Lakhashe SK, Rasmussen RA, Ruprecht RM.

Retrovirology. 2013 Jun 21;10:63. doi: 10.1186/1742-4690-10-63.


Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission.

Watkins JD, Sholukh AM, Mukhtar MM, Siddappa NB, Lakhashe SK, Kim M, Reinherz EL, Gupta S, Forthal DN, Sattentau QJ, Villinger F, Corti D, Ruprecht RM; CAVD Project Group.

AIDS. 2013 Jun 1;27(9):F13-20. doi: 10.1097/QAD.0b013e328360eac6.


Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence.

Rao VR, Neogi U, Talboom JS, Padilla L, Rahman M, Fritz-French C, Gonzalez-Ramirez S, Verma A, Wood C, Ruprecht RM, Ranga U, Azim T, Joska J, Eugenin E, Shet A, Bimonte-Nelson H, Tyor WR, Prasad VR.

Retrovirology. 2013 Jun 8;10:61. doi: 10.1186/1742-4690-10-61.


Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques.

Demberg T, Brocca-Cofano E, Kuate S, Aladi S, Vargas-Inchaustegui DA, Venzon D, Kalisz I, Kalyanaraman VS, Lee EM, Pal R, DiPasquale J, Ruprecht RM, Montefiori DC, Srivastava I, Barnett SW, Robert-Guroff M.

Virology. 2013 Jun 5;440(2):210-21. doi: 10.1016/j.virol.2013.02.024. Epub 2013 Mar 22.


Novel biopanning strategy to identify epitopes associated with vaccine protection.

Bachler BC, Humbert M, Palikuqi B, Siddappa NB, Lakhashe SK, Rasmussen RA, Ruprecht RM.

J Virol. 2013 Apr;87(8):4403-16. doi: 10.1128/JVI.02888-12. Epub 2013 Feb 6.


Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.

Zhang MY, Yuan T, Li J, Rosa Borges A, Watkins JD, Guenaga J, Yang Z, Wang Y, Wilson R, Li Y, Polonis VR, Pincus SH, Ruprecht RM, Dimitrov DS.

PLoS One. 2012;7(9):e44241. doi: 10.1371/journal.pone.0044241. Epub 2012 Sep 10.


Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

Desimmie BA, Humbert M, Lescrinier E, Hendrix J, Vets S, Gijsbers R, Ruprecht RM, Dietrich U, Debyser Z, Christ F.

Mol Ther. 2012 Nov;20(11):2064-75. doi: 10.1038/mt.2012.132. Epub 2012 Jul 24.


Isolation of monoclonal antibodies with predetermined conformational epitope specificity.

Sholukh AM, Mukhtar MM, Humbert M, Essono SS, Watkins JD, Vyas HK, Shanmuganathan V, Hemashettar G, Kahn M, Hu SL, Montefiori DC, Polonis VR, Schur PH, Ruprecht RM.

PLoS One. 2012;7(6):e38943. doi: 10.1371/journal.pone.0038943. Epub 2012 Jun 21.


Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing.

Tso FY, Tully DC, Gonzalez S, Quince C, Ho O, Polacino P, Ruprecht RM, Hu SL, Wood C.

PLoS One. 2012;7(3):e32827. doi: 10.1371/journal.pone.0032827. Epub 2012 Mar 12.


No acquisition: a new ambition for HIV vaccine development?

Lakhashe SK, Silvestri G, Ruprecht RM.

Curr Opin Virol. 2011 Oct;1(4):246-53. doi: 10.1016/j.coviro.2011.07.005. Review.


Efficiency of neutralizing antibodies targeting the CD4-binding site: influence of conformational masking by the V2 loop in R5-tropic clade C simian-human immunodeficiency virus.

Watkins JD, Diaz-Rodriguez J, Siddappa NB, Corti D, Ruprecht RM.

J Virol. 2011 Dec;85(23):12811-4. doi: 10.1128/JVI.05994-11. Epub 2011 Sep 28.


High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia.

Rasmussen RA, Siddappa NB, Lakhashe SK, Watkins J, Villinger F, Ibegbu C, Florese RH, Robert-Guroff M, Montefiori DC, Forthal DN, O'Connor D, Ruprecht RM; Clade C Program Project Group.

AIDS. 2012 Jan 14;26(2):149-55. doi: 10.1097/QAD.0b013e32834d3c4f.


Molecularly cloned SHIV-CN97001: a replication-competent, R5 simian/human immunodeficiency virus containing env of a primary Chinese HIV-1 clade C isolate.

Liu Q, Li Y, Yang G, Dai J, Ruprecht RM, Shao Y.

J Med Primatol. 2011 Dec;40(6):427-36. doi: 10.1111/j.1600-0684.2011.00497.x. Epub 2011 Sep 6.


Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV.

Siddappa NB, Hemashettar G, Shanmuganathan V, Semenya AA, Sweeney ED, Paul KS, Lee SJ, Secor WE, Ruprecht RM.

PLoS Negl Trop Dis. 2011 Aug;5(8):e1270. doi: 10.1371/journal.pntd.0001270. Epub 2011 Aug 2.


Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.

Lakhashe SK, Wang W, Siddappa NB, Hemashettar G, Polacino P, Hu SL, Villinger F, Else JG, Novembre FJ, Yoon JK, Lee SJ, Montefiori DC, Ruprecht RM, Rasmussen RA.

PLoS One. 2011;6(7):e22010. doi: 10.1371/journal.pone.0022010. Epub 2011 Jul 20.


Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.

Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM.

Vaccine. 2011 Aug 5;29(34):5611-22. doi: 10.1016/j.vaccine.2011.06.017. Epub 2011 Jul 14.


An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM.

PLoS One. 2011 Mar 31;6(3):e18207. doi: 10.1371/journal.pone.0018207.


R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.

Santosuosso M, Righi E, Hill ED, Leblanc PR, Kodish B, Mylvaganam HN, Siddappa NB, Stevceva L, Hu SL, Ghebremichael M, Chenine AL, Hovav AH, Ruprecht RM, Poznansky MC.

PLoS One. 2011 Apr 5;6(4):e18465. doi: 10.1371/journal.pone.0018465.


Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV.

Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM.

J Immune Based Ther Vaccines. 2011 Jan 18;9:2. doi: 10.1186/1476-8518-9-2.


A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly.

Sciaranghella G, Lakhashe SK, Ayash-Rashkovsky M, Mirshahidi S, Siddappa NB, Novembre FJ, Velu V, Amara RR, Zhou C, Li S, Li Z, Frankel FR, Ruprecht RM.

Vaccine. 2011 Jan 10;29(3):476-86. doi: 10.1016/j.vaccine.2010.10.072. Epub 2010 Nov 9.


Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis.

Siddappa NB, Hemashettar G, Wong YL, Lakhashe S, Rasmussen RA, Watkins JD, Novembre FJ, Villinger F, Else JG, Montefiori DC, Ruprecht RM.

J Med Primatol. 2011 Apr;40(2):120-8. doi: 10.1111/j.1600-0684.2010.00454.x. Epub 2010 Nov 2.


R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.

Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM.

PLoS One. 2010 Jul 21;5(7):e11689. doi: 10.1371/journal.pone.0011689.


Bimodal AIDS vaccine approach: induction of cellular as well as humoral immunity can protect from systemic infection.

Rasmussen RA, Lakhashe SK, Ruprecht RM.

Vaccine. 2010 May 26;28 Suppl 2:B25-31. doi: 10.1016/j.vaccine.2009.10.131.


AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.

García A, Siddappa NB, Li Q, Haase AT, Paul K, Stroud F, Zhang X, Fountain JA, Villinger F, Novembre FJ, Else JG, Evan Secor W, Ruprecht RM.

J Med Primatol. 2010 Oct;39(5):356-60. doi: 10.1111/j.1600-0684.2010.00416.x.


Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.

Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM.

J Infect Dis. 2010 Apr 15;201(8):1155-63. doi: 10.1086/651274.


A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression.

Tso FY, Hoffmann FG, Tully DC, Lemey P, Rasmussen RA, Zhang H, Ruprecht RM, Wood C.

AIDS. 2009 Sep 10;23(14):1817-28. doi: 10.1097/QAD.0b013e32832f3da6.


Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus.

Ho O, Larsen K, Polacino P, Li Y, Anderson D, Song R, Ruprecht RM, Hu SL.

Retrovirology. 2009 Jul 14;6:65. doi: 10.1186/1742-4690-6-65.


CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.

Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB.

J Exp Med. 2009 Jun 8;206(6):1409-22. doi: 10.1084/jem.20082480. Epub 2009 May 25. Erratum in: J Exp Med. 2009 Aug 3;206(8):1831. Barral, Duarte [corrected to Barral, Duarte C].


Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in macaque models: experimental approaches.

Ruprecht RM.

Methods Mol Biol. 2009;525:559-66, xiv. doi: 10.1007/978-1-59745-554-1_31.


Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival.

Mirshahidi S, Kramer VG, Whitney JB, Essono S, Lee S, Dranoff G, Anderson KS, Ruprecht RM.

Vaccine. 2009 Mar 13;27(12):1825-33. doi: 10.1016/j.vaccine.2009.01.089. Epub 2009 Feb 6.


Generation of recombinant vaccinia viruses via green fluorescent protein selection.

Popov S, Mirshahidi S, Essono S, Song R, Wang X, Ruprecht RM.

DNA Cell Biol. 2009 Mar;28(3):103-8. doi: 10.1089/dna.2008.0792.


Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing.

Humbert M, Rasmussen RA, Ong H, Kaiser FM, Hu SL, Ruprecht RM.

PLoS One. 2008;3(12):e3937. doi: 10.1371/journal.pone.0003937. Epub 2008 Dec 15.


Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection.

Siddappa NB, Song R, Kramer VG, Chenine AL, Velu V, Ong H, Rasmussen RA, Grisson RD, Wood C, Zhang H, Kankasa C, Amara RR, Else JG, Novembre FJ, Montefiori DC, Ruprecht RM.

J Virol. 2009 Feb;83(3):1422-32. doi: 10.1128/JVI.02066-08. Epub 2008 Nov 19. Erratum in: J Virol. 2009 Aug;83(16):8297.

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