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Items: 49


Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis.

Zhao H, Martin E, Matalkah F, Shah N, Ivanov A, Ruppert JM, Lockman PR, Agazie YM.

Oncogene. 2019 Mar;38(13):2275-2290. doi: 10.1038/s41388-018-0574-8. Epub 2018 Nov 22.


Kruppel-like Pluripotency Factors as Modulators of Cancer Cell Therapeutic Responses.

Farrugia MK, Vanderbilt DB, Salkeni MA, Ruppert JM.

Cancer Res. 2016 Apr 1;76(7):1677-82. doi: 10.1158/0008-5472.CAN-15-1806. Epub 2016 Mar 10. Review.


MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.

Sharma SB, Ruppert JM.

Drug Dev Res. 2015 Sep;76(6):328-42. doi: 10.1002/ddr.21270. Epub 2015 Aug 18. Review.


Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival.

Lin CC, Sharma SB, Farrugia MK, McLaughlin SL, Ice RJ, Loskutov YV, Pugacheva EN, Brundage KM, Chen D, Ruppert JM.

Oncogenesis. 2015 Jun 8;4:e155. doi: 10.1038/oncsis.2015.8.


Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.

Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JM.

Cell Death Dis. 2015 Mar 19;6:e1699. doi: 10.1038/cddis.2015.65.


SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.

Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM.

J Cell Sci. 2015 Mar 15;128(6):1123-38. doi: 10.1242/jcs.162164. Epub 2015 Jan 27.


KAP1 promotes proliferation and metastatic progression of breast cancer cells.

Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV.

Cancer Res. 2015 Jan 15;75(2):344-55. doi: 10.1158/0008-5472.CAN-14-1561. Epub 2014 Nov 24.


MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1.

Sharma SB, Lin CC, Farrugia MK, McLaughlin SL, Ellis EJ, Brundage KM, Salkeni MA, Ruppert JM.

Mol Cell Biol. 2014 Nov 15;34(22):4143-64. doi: 10.1128/MCB.00480-14. Epub 2014 Sep 8.


Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.

Adair-Kirk TL, Griffin GL, Meyer MJ, Kelley DG, Miner JH, Keene DR, Marinkovich MP, Ruppert JM, Uitto J, Senior RM.

PLoS One. 2012;7(9):e45546. doi: 10.1371/journal.pone.0045546. Epub 2012 Sep 18.


A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context.

Lin CC, Liu LZ, Addison JB, Wonderlin WF, Ivanov AV, Ruppert JM.

Mol Cell Biol. 2011 Jun;31(12):2513-27. doi: 10.1128/MCB.01189-10. Epub 2011 Apr 25.


Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.

Liu Z, Teng L, Bailey SK, Frost AR, Bland KI, LoBuglio AF, Ruppert JM, Lobo-Ruppert SM.

Cancer Biol Ther. 2009 Oct;8(19):1840-51.


Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.

Jiang W, Deng W, Bailey SK, Nail CD, Frost AR, Brouillette WJ, Muccio DD, Grubbs CJ, Ruppert JM, Lobo-Ruppert SM.

Cancer Biol Ther. 2009 Feb;8(3):289-98. Epub 2009 Feb 21.


Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis.

Lubet RA, Boring D, Steele VE, Ruppert JM, Juliana MM, Grubbs CJ.

Cancer Prev Res (Phila). 2009 Feb;2(2):161-7. doi: 10.1158/1940-6207.CAPR-08-0134.


Bad things happen in the basal layer: KLF4 and squamous cell carcinoma.

Jiang W, Lobo-Ruppert SM, Ruppert JM.

Cancer Biol Ther. 2008 May;7(5):783-5. Epub 2008 May 14. No abstract available.


Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin.

Li X, Deng W, Lobo-Ruppert SM, Ruppert JM.

Oncogene. 2007 Jul 5;26(31):4489-98. Epub 2007 Feb 5.


Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.

Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP, Welch DR, Lobo-Ruppert SM, Ruppert JM, Johnson MR, Frost AR.

Cancer Biol Ther. 2006 Jun;5(6):674-83. Epub 2006 Jun 18.


KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia.

Huang CC, Liu Z, Li X, Bailey SK, Nail CD, Foster KW, Frost AR, Ruppert JM, Lobo-Ruppert SM.

Cancer Biol Ther. 2005 Dec;4(12):1401-8. Epub 2005 Dec 23.


Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation.

Li X, Deng W, Nail CD, Bailey SK, Kraus MH, Ruppert JM, Lobo-Ruppert SM.

Oncogene. 2006 Jan 26;25(4):609-21.


Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.

Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow JE, Lobo-Ruppert SM, Ruppert JM.

Oncogene. 2005 Feb 24;24(9):1491-500.


Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer.

Pandya AY, Talley LI, Frost AR, Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng DC, Grizzle WE, Engler JA, Krontiras H, Bland KI, LoBuglio AF, Lobo-Ruppert SM, Ruppert JM.

Clin Cancer Res. 2004 Apr 15;10(8):2709-19.


Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements.

Casillas MA, Brotherton SL, Andrews LG, Ruppert JM, Tollefsbol TO.

Gene. 2003 Oct 16;316:57-65.


Inhibition of tumorigenicity by the 5'-untranslated RNA of the human c-myc P0 transcript.

Blume SW, Miller DM, Guarcello V, Shrestha K, Meng Z, Snyder RC, Grizzle WE, Ruppert JM, Gartland GL, Stockard CR, Jones DE Jr, Emanuel PD.

Exp Cell Res. 2003 Aug 1;288(1):131-42.


Suppression subtractive hybridization for identification and functional analysis of tumor suppressor genes.

Louro ID, Bailey EC, Ruppert JM.

Methods Mol Biol. 2003;222:453-62. No abstract available.


Regulation of E2F1 by BRCT domain-containing protein TopBP1.

Liu K, Lin FT, Ruppert JM, Lin WC.

Mol Cell Biol. 2003 May;23(9):3287-304.


Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation.

Louro ID, Bailey EC, Li X, South LS, McKie-Bell PR, Yoder BK, Huang CC, Johnson MR, Hill AE, Johnson RL, Ruppert JM.

Cancer Res. 2002 Oct 15;62(20):5867-73.


Increase of GKLF messenger RNA and protein expression during progression of breast cancer.

Foster KW, Frost AR, McKie-Bell P, Lin CY, Engler JA, Grizzle WE, Ruppert JM.

Cancer Res. 2000 Nov 15;60(22):6488-95.


Alternatively spliced hBRF variants function at different RNA polymerase III promoters.

McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM.

EMBO J. 2000 Aug 1;19(15):4134-43.


The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma.

Ren S, Smith MJ, Louro ID, McKie-Bell P, Bani MR, Wagner M, Zochodne B, Redden DT, Grizzle WE, Wang Nd, Smith DI, Herbst RA, Bardenheuer W, Opalka B, Schütte J, Trent JM, Ben-David Y, Ruppert JM.

Oncogene. 2000 Mar 9;19(11):1419-27.


Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3-F442A fibroblasts.

Kim SO, Houtman JC, Jiang J, Ruppert JM, Bertics PJ, Frank SJ.

J Biol Chem. 1999 Dec 10;274(50):36015-24.


The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin.

Louro ID, McKie-Bell P, Gosnell H, Brindley BC, Bucy RP, Ruppert JM.

Cell Growth Differ. 1999 Jul;10(7):503-16.


Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF.

Foster KW, Ren S, Louro ID, Lobo-Ruppert SM, McKie-Bell P, Grizzle W, Hayes MR, Broker TR, Chow LT, Ruppert JM.

Cell Growth Differ. 1999 Jun;10(6):423-34.


Gene therapy strategies for carcinoma of the breast.

Ruppert JM, Wright M, Rosenfeld M, Grushcow J, Bilbao G, Curiel DT, Strong TV.

Breast Cancer Res Treat. 1997 Jun;44(2):93-114. Review. No abstract available.


Ligation of single adaptors allows efficient cloning of long PCR products.

Ren S, Ruppert JM.

Biotechniques. 1997 Jan;22(1):36-8, 40. No abstract available.


Allelotype of head and neck squamous cell carcinoma.

Nawroz H, van der Riet P, Hruban RH, Koch W, Ruppert JM, Sidransky D.

Cancer Res. 1994 Mar 1;54(5):1152-5.


Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele.

van der Riet P, Karp D, Farmer E, Wei Q, Grossman L, Tokino K, Ruppert JM, Sidransky D.

Cancer Res. 1994 Jan 1;54(1):25-7.


Microsatellite instability in bladder cancer.

Gonzalez-Zulueta M, Ruppert JM, Tokino K, Tsai YC, Spruck CH 3rd, Miyao N, Nichols PW, Hermann GG, Horn T, Steven K, et al.

Cancer Res. 1993 Dec 1;53(23):5620-3.


Evidence for two bladder cancer suppressor loci on human chromosome 9.

Ruppert JM, Tokino K, Sidransky D.

Cancer Res. 1993 Nov 1;53(21):5093-5.


The incidence of p53 mutations increases with progression of head and neck cancer.

Boyle JO, Hakim J, Koch W, van der Riet P, Hruban RH, Roa RA, Correo R, Eby YJ, Ruppert JM, Sidransky D.

Cancer Res. 1993 Oct 1;53(19):4477-80.


Inhibition of DNA replication factor RPA by p53.

Dutta A, Ruppert JM, Aster JC, Winchester E.

Nature. 1993 Sep 2;365(6441):79-82.


Analysis of a protein-binding domain of p53.

Ruppert JM, Stillman B.

Mol Cell Biol. 1993 Jun;13(6):3811-20.


Structural alterations of the epidermal growth factor receptor gene in human gliomas.

Wong AJ, Ruppert JM, Bigner SH, Grzeschik CH, Humphrey PA, Bigner DS, Vogelstein B.

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2965-9.


The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

Ruppert JM, Vogelstein B, Kinzler KW.

Mol Cell Biol. 1991 Mar;11(3):1724-8.


Scrambled exons.

Nigro JM, Cho KR, Fearon ER, Kern SE, Ruppert JM, Oliner JD, Kinzler KW, Vogelstein B.

Cell. 1991 Feb 8;64(3):607-13.


GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

Ruppert JM, Vogelstein B, Arheden K, Kinzler KW.

Mol Cell Biol. 1990 Oct;10(10):5408-15.


Identification of a chromosome 18q gene that is altered in colorectal cancers.

Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW, et al.

Science. 1990 Jan 5;247(4938):49-56.


The GLI-Kruppel family of human genes.

Ruppert JM, Kinzler KW, Wong AJ, Bigner SH, Kao FT, Law ML, Seuanez HN, O'Brien SJ, Vogelstein B.

Mol Cell Biol. 1988 Aug;8(8):3104-13.


The GLI gene is a member of the Kruppel family of zinc finger proteins.

Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B.

Nature. 1988 Mar 24;332(6162):371-4.


Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.

Wong AJ, Ruppert JM, Eggleston J, Hamilton SR, Baylin SB, Vogelstein B.

Science. 1986 Jul 25;233(4762):461-4.


Disseminated calcitonin-poor medullary thyroid carcinoma in a patient with calcitonin-rich primary tumor.

Ruppert JM, Eggleston JC, deBustros A, Baylin SB.

Am J Surg Pathol. 1986 Jul;10(7):513-8.


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