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Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13016-13025. doi: 10.1073/pnas.1904064116. Epub 2019 Jun 11.


Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis.

Hu Y, Wang B, Shen J, Low SA, Putt KS, Niessen HWM, Matteson EL, Murphy L, Ruppert C, Jansen G, Oliver SJ, Feng Y, Dimitrov DS, Nickerson-Nutter C, Low PS.

Arthritis Res Ther. 2019 Jun 7;21(1):143. doi: 10.1186/s13075-019-1912-0.


Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.

Weiss A, Neubauer MC, Yerabolu D, Kojonazarov B, Schlueter BC, Neubert L, Jonigk D, Baal N, Ruppert C, Dorfmuller P, Pullamsetti SS, Weissmann N, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT.

Nat Commun. 2019 May 17;10(1):2204. doi: 10.1038/s41467-019-10135-x.


Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank.

Krauss E, Froehler M, Degen M, Mahavadi P, Dartsch RC, Korfei M, Ruppert C, Seeger W, Guenther A.

J Clin Med. 2019 May 9;8(5). pii: E643. doi: 10.3390/jcm8050643.


Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells.

Klymenko O, Huehn M, Wilhelm J, Wasnick R, Shalashova I, Ruppert C, Henneke I, Hezel S, Guenther K, Mahavadi P, Samakovlis C, Seeger W, Guenther A, Korfei M.

J Mol Med (Berl). 2019 Jul;97(7):973-990. doi: 10.1007/s00109-019-01787-9. Epub 2019 Apr 26.


A smartphone readout system for gold nanoparticle-based lateral flow assays: application to monitoring of digoxigenin.

Ruppert C, Phogat N, Laufer S, Kohl M, Deigner HP.

Mikrochim Acta. 2019 Jan 19;186(2):119. doi: 10.1007/s00604-018-3195-6.


Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis.

Korfei M, Stelmaszek D, MacKenzie B, Skwarna S, Chillappagari S, Bach AC, Ruppert C, Saito S, Mahavadi P, Klepetko W, Fink L, Seeger W, Lasky JA, Pullamsetti SS, Krämer OH, Guenther A.

PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.


Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR.

Nat Commun. 2018 Nov 2;9(1):4600. doi: 10.1038/s41467-018-06833-7.


Stimulated two-photon emission in bulk CdSe.

Melzer S, Ruppert C, Bristow AD, Betz M.

Opt Lett. 2018 Oct 15;43(20):5066-5069. doi: 10.1364/OL.43.005066.


Repeat epidural steroid injections for radicular pain due to lumbar or cervical disc herniation: what happens after ‘salvage treatment’?.

Joswig H, Neff A, Ruppert C, Hildebrandt G, Stienen MN.

Bone Joint J. 2018 Oct;100-B(10):1364-1371. doi: 10.1302/0301-620X.100B10.BJJ-2018-0461.R1.


Data Discovery for Integration of Heterogeneous Medical Datasets in the German Center for Lung Research (DZL).

Majeed RW, Stöhr MR, Ruppert C, Günther A.

Stud Health Technol Inform. 2018;253:65-69.


Alveolar Micromechanics in Bleomycin-induced Lung Injury.

Knudsen L, Lopez-Rodriguez E, Berndt L, Steffen L, Ruppert C, Bates JHT, Ochs M, Smith BJ.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):757-769. doi: 10.1165/rcmb.2018-0044OC.


Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

El Agha E, Schwind F, Ruppert C, Günther A, Bellusci S, Schermuly RT, Kosanovic D.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L248-L252. doi: 10.1152/ajplung.00140.2018. Epub 2018 May 3.


The value of short-term pain relief in predicting the long-term outcome of 'indirect' cervical epidural steroid injections.

Joswig H, Neff A, Ruppert C, Hildebrandt G, Stienen MN.

Acta Neurochir (Wien). 2018 May;160(5):935-943. doi: 10.1007/s00701-018-3511-2. Epub 2018 Mar 14.


FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.

Al-Tamari HM, Dabral S, Schmall A, Sarvari P, Ruppert C, Paik J, DePinho RA, Grimminger F, Eickelberg O, Guenther A, Seeger W, Savai R, Pullamsetti SS.

EMBO Mol Med. 2018 Feb;10(2):276-293. doi: 10.15252/emmm.201606261.


The Value of Short-Term Pain Relief in Predicting the Long-Term Outcome of Lumbar Transforaminal Epidural Steroid Injections.

Joswig H, Neff A, Ruppert C, Hildebrandt G, Stienen MN.

World Neurosurg. 2017 Nov;107:764-771. doi: 10.1016/j.wneu.2017.08.055. Epub 2017 Aug 23.


Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model.

Steffen L, Ruppert C, Hoymann HG, Funke M, Ebener S, Kloth C, Mühlfeld C, Ochs M, Knudsen L, Lopez-Rodriguez E.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L313-L327. doi: 10.1152/ajplung.00033.2017. Epub 2017 Apr 27.


Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptors.

Backhaus S, Zakrzewicz A, Richter K, Damm J, Wilker S, Fuchs-Moll G, Küllmar M, Hecker A, Manzini I, Ruppert C, McIntosh JM, Padberg W, Grau V.

J Lipid Res. 2017 Jun;58(6):1055-1066. doi: 10.1194/jlr.M071506. Epub 2017 Apr 12.


The Role of Electronic and Phononic Excitation in the Optical Response of Monolayer WS2 after Ultrafast Excitation.

Ruppert C, Chernikov A, Hill HM, Rigosi AF, Heinz TF.

Nano Lett. 2017 Feb 8;17(2):644-651. doi: 10.1021/acs.nanolett.6b03513. Epub 2017 Jan 11.


Tissue remodelling in pulmonary fibrosis.

Knudsen L, Ruppert C, Ochs M.

Cell Tissue Res. 2017 Mar;367(3):607-626. doi: 10.1007/s00441-016-2543-2. Epub 2016 Dec 16. Review.


The value of short-term pain relief in predicting the 1-month outcome of 'indirect' cervical epidural steroid injections.

Joswig H, Neff A, Ruppert C, Hildebrandt G, Stienen MN.

Acta Neurochir (Wien). 2017 Feb;159(2):291-300. doi: 10.1007/s00701-016-2997-8. Epub 2016 Oct 28.


The Value of Short-Term Pain Relief in Predicting the One-Month Outcome of Lumbar Transforaminal Epidural Steroid Injections.

Joswig H, Neff A, Ruppert C, Hildebrandt G, Stienen MN.

World Neurosurg. 2016 Dec;96:323-333. doi: 10.1016/j.wneu.2016.09.016. Epub 2016 Sep 15.


Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis.

Mahavadi P, Knudsen L, Venkatesan S, Henneke I, Hegermann J, Wrede C, Ochs M, Ahuja S, Chillappagari S, Ruppert C, Seeger W, Korfei M, Guenther A.

J Pathol Clin Res. 2015 Jun 3;1(4):252-63. doi: 10.1002/cjp2.20. eCollection 2015 Oct.


Thermochromic modulation of surface plasmon polaritons in vanadium dioxide nanocomposites.

Jostmeier T, Mangold M, Zimmer J, Karl H, Krenner HJ, Ruppert C, Betz M.

Opt Express. 2016 Jul 25;24(15):17321-31. doi: 10.1364/OE.24.017321.


Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626.


MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.

Ahuja S, Knudsen L, Chillappagari S, Henneke I, Ruppert C, Korfei M, Gochuico BR, Bellusci S, Seeger W, Ochs M, Guenther A, Mahavadi P.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L519-31. doi: 10.1152/ajplung.00213.2015. Epub 2015 Dec 30.


Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.

Korfei M, Skwarna S, Henneke I, MacKenzie B, Klymenko O, Saito S, Ruppert C, von der Beck D, Mahavadi P, Klepetko W, Bellusci S, Crestani B, Pullamsetti SS, Fink L, Seeger W, Krämer OH, Guenther A.

Thorax. 2015 Nov;70(11):1022-32. doi: 10.1136/thoraxjnl-2014-206411. Epub 2015 Sep 10.


Differences in natural history of low- and high-gradient aortic stenosis from nonsevere to severe stage of the disease.

Herrmann S, Fries B, Liu D, Hu K, Stoerk S, Voelker W, Ruppert C, Lorenz K, Ertl G, Weidemann F.

J Am Soc Echocardiogr. 2015 Nov;28(11):1270-1282.e4. doi: 10.1016/j.echo.2015.07.016. Epub 2015 Aug 28.


Regulation of immunoproteasome function in the lung.

Keller IE, Vosyka O, Takenaka S, Kloß A, Dahlmann B, Willems LI, Verdoes M, Overkleeft HS, Marcos E, Adnot S, Hauck SM, Ruppert C, Günther A, Herold S, Ohno S, Adler H, Eickelberg O, Meiners S.

Sci Rep. 2015 May 19;5:10230. doi: 10.1038/srep10230.


Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.

Birkelbach B, Lutz D, Ruppert C, Henneke I, Lopez-Rodriguez E, Günther A, Ochs M, Mahavadi P, Knudsen L.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L63-75. doi: 10.1152/ajplung.00279.2014. Epub 2015 May 8.


Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.

Oruqaj G, Karnati S, Vijayan V, Kotarkonda LK, Boateng E, Zhang W, Ruppert C, Günther A, Shi W, Baumgart-Vogt E.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2048-57. doi: 10.1073/pnas.1415111112. Epub 2015 Apr 6.


Optical properties and band gap of single- and few-layer MoTe2 crystals.

Ruppert C, Aslan OB, Heinz TF.

Nano Lett. 2014 Nov 12;14(11):6231-6. doi: 10.1021/nl502557g. Epub 2014 Oct 29.


Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.

Mahavadi P, Henneke I, Ruppert C, Knudsen L, Venkatesan S, Liebisch G, Chambers RC, Ochs M, Schmitz G, Vancheri C, Seeger W, Korfei M, Guenther A.

Toxicol Sci. 2014 Nov;142(1):285-97. doi: 10.1093/toxsci/kfu177. Epub 2014 Aug 27.


Georg Büchner, Sigmund Freud and the "Schädelnerven" (cranial nerves) - research on the brain and soul in the 19th century.

Hildebrandt G, Ruppert C, Stienen MN, Surbeck W.

Acta Neurochir (Wien). 2014 Oct;156(10):1999-2014. doi: 10.1007/s00701-014-2198-2. Epub 2014 Aug 14.


Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: role of surfactant protein B and C.

Beck-Broichsitter M, Ruppert C, Schmehl T, Günther A, Seeger W.

Acta Biomater. 2014 Nov;10(11):4678-4684. doi: 10.1016/j.actbio.2014.07.026. Epub 2014 Aug 1.


Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis.

Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, Günther A, Klepetko W, Bates JH, Smith B, Geiser T, Ochs M, Knudsen L.

Am J Respir Cell Mol Biol. 2015 Feb;52(2):232-43. doi: 10.1165/rcmb.2014-0078OC.


Phase-retrieval of femtosecond pulses utilizing ω/2ω quantum interference control of electrical currents.

Sternemann E, Betz M, Ruppert C.

Opt Lett. 2014 Jun 15;39(12):3654-7. doi: 10.1364/OL.39.003654.


Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles.

Beck-Broichsitter M, Ruppert C, Schmehl T, Günther A, Seeger W.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):474-81. doi: 10.1016/j.bbamem.2013.10.016. Epub 2013 Nov 1.


Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis.

Nkyimbeng T, Ruppert C, Shiomi T, Dahal B, Lang G, Seeger W, Okada Y, D'Armiento J, Günther A.

PLoS One. 2013 Sep 2;8(9):e73279. doi: 10.1371/journal.pone.0073279. eCollection 2013.


Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors.

Korfei M, von der Beck D, Henneke I, Markart P, Ruppert C, Mahavadi P, Ghanim B, Klepetko W, Fink L, Meiners S, Krämer OH, Seeger W, Vancheri C, Guenther A.

J Proteomics. 2013 Jun 24;85:109-28. doi: 10.1016/j.jprot.2013.04.033. Epub 2013 May 6.


Interference with ERK(Thr188) phosphorylation impairs pathological but not physiological cardiac hypertrophy.

Ruppert C, Deiss K, Herrmann S, Vidal M, Oezkur M, Gorski A, Weidemann F, Lohse MJ, Lorenz K.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7440-5. doi: 10.1073/pnas.1221999110. Epub 2013 Apr 15.


Ultrafast field-resolved semiconductor spectroscopy utilizing quantum interference control of currents.

Ruppert C, Lohrenz J, Thunich S, Betz M.

Opt Lett. 2012 Sep 15;37(18):3879-81. doi: 10.1364/OL.37.003879.


Electrical control of interdot electron tunneling in a double InGaAs quantum-dot nanostructure.

Müller K, Bechtold A, Ruppert C, Zecherle M, Reithmaier G, Bichler M, Krenner HJ, Abstreiter G, Holleitner AW, Villas-Boas JM, Betz M, Finley JJ.

Phys Rev Lett. 2012 May 11;108(19):197402. Epub 2012 May 8.


Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area.

Graulich T, Das SK, Krasteva G, Ruppert C, Wessels L, Hoefler G, Mühlfeld C.

Histochem Cell Biol. 2012 Nov;138(5):803-13. doi: 10.1007/s00418-012-0995-3. Epub 2012 Jul 19.


Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.

Günther A, Korfei M, Mahavadi P, von der Beck D, Ruppert C, Markart P.

Eur Respir Rev. 2012 Jun 1;21(124):152-60. doi: 10.1183/09059180.00001012. Review.


Field-resolved characterization of femtosecond electromagnetic pulses with 400 THz bandwidth.

Thunich S, Ruppert C, Holleitner AW, Betz M.

Opt Lett. 2011 May 15;36(10):1791-3. doi: 10.1364/OL.36.001791.


Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs.

Korfei M, Schmitt S, Ruppert C, Henneke I, Markart P, Loeh B, Mahavadi P, Wygrecka M, Klepetko W, Fink L, Bonniaud P, Preissner KT, Lochnit G, Schaefer L, Seeger W, Guenther A.

J Proteome Res. 2011 May 6;10(5):2185-205. doi: 10.1021/pr1009355. Epub 2011 Mar 29.


Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury.

Spragg RG, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Günther A.

Am J Respir Crit Care Med. 2011 Apr 15;183(8):1055-61. doi: 10.1164/rccm.201009-1424OC. Epub 2010 Dec 10.


Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro.

Beck-Broichsitter M, Ruppert C, Schmehl T, Guenther A, Betz T, Bakowsky U, Seeger W, Kissel T, Gessler T.

Nanomedicine. 2011 Jun;7(3):341-50. doi: 10.1016/j.nano.2010.10.007. Epub 2010 Nov 6.


Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung.

Ruppert C, Kuchenbuch T, Boensch M, Schmidt S, Mathes U, Hillebrand V, Henneke I, Markart P, Reiss I, Schermuly RT, Seeger W, Günther A.

Crit Care Med. 2010 Jul;38(7):1584-91. doi: 10.1097/CCM.0b013e3181dfcb3b.


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