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Items: 1 to 50 of 58

1.

Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.

Carril E, Valdecantos MP, Lanzón B, Angulo S, Valverde ÁM, Godzien J, Rupérez FJ.

J Pharm Biomed Anal. 2019 Nov 1:112958. doi: 10.1016/j.jpba.2019.112958. [Epub ahead of print]

PMID:
31718984
2.

Recent Developments along the Analytical Process for Metabolomics Workflows.

González-Riano C, Dudzik D, Garcia A, Gil-de-la-Fuente A, Gradillas A, Godzien J, López-Gonzálvez Á, Rey-Stolle F, Rojo D, Ruperez FJ, Saiz J, Barbas C.

Anal Chem. 2019 Nov 1. doi: 10.1021/acs.analchem.9b04553. [Epub ahead of print] No abstract available.

PMID:
31625723
3.

LAS: A Lipid Annotation Service Capable of Explaining the Annotations It Generates.

Fernández-López M, Gil-de-la-Fuente A, Godzien J, Rupérez FJ, Barbas C, Otero A.

Comput Struct Biotechnol J. 2019 Jul 30;17:1113-1122. doi: 10.1016/j.csbj.2019.07.016. eCollection 2019.

4.

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.

Villar-Lorenzo A, Rada P, Rey E, Marañón P, Arroba AI, Santamaría B, Sáiz J, Rupérez FJ, Barbas C, García-Monzón C, Valverde ÁM, González-Rodríguez Á.

Dis Model Mech. 2019 Jul 16;12(7). pii: dmm038810. doi: 10.1242/dmm.038810.

5.

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.

Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E, Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N, Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D.

Immunity. 2019 Feb 19;50(2):446-461.e9. doi: 10.1016/j.immuni.2018.12.020. Epub 2019 Jan 29.

6.

Flow Cytometry Has a Significant Impact on the Cellular Metabolome.

Binek A, Rojo D, Godzien J, Rupérez FJ, Nuñez V, Jorge I, Ricote M, Vázquez J, Barbas C.

J Proteome Res. 2019 Jan 4;18(1):169-181. doi: 10.1021/acs.jproteome.8b00472. Epub 2018 Nov 2.

PMID:
30362351
7.

Metabolomics changes in patients with PAPP-A2 deficiency in response to rhIGF1 treatment.

Mastrangelo A, Martos-Moreno GÁ, Rupérez FJ, Chowen JA, Barbas C, Argente J.

Growth Horm IGF Res. 2018 Oct - Dec;42-43:28-31. doi: 10.1016/j.ghir.2018.08.002. Epub 2018 Aug 12.

PMID:
30119035
8.

Knowledge-based metabolite annotation tool: CEU Mass Mediator.

Gil de la Fuente A, Godzien J, Fernández López M, Rupérez FJ, Barbas C, Otero A.

J Pharm Biomed Anal. 2018 May 30;154:138-149. doi: 10.1016/j.jpba.2018.02.046. Epub 2018 Feb 23.

PMID:
29547800
9.

Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells.

Faccio AT, Ruperez FJ, Singh NS, Angulo S, Tavares MFM, Bernier M, Barbas C, Wainer IW.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1505-1515. doi: 10.1016/j.bbagen.2018.03.008. Epub 2018 Mar 9.

10.

Multiplatform plasma fingerprinting in cancer cachexia: a pilot observational and translational study.

Cala MP, Agulló-Ortuño MT, Prieto-García E, González-Riano C, Parrilla-Rubio L, Barbas C, Díaz-García CV, García A, Pernaut C, Adeva J, Riesco MC, Rupérez FJ, Lopez-Martin JA.

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):348-357. doi: 10.1002/jcsm.12270. Epub 2018 Feb 20.

11.

Discriminant biomarkers of acute respiratory distress syndrome associated to H1N1 influenza identified by metabolomics HPLC-QTOF-MS/MS platform.

Ferrarini A, Righetti L, Martínez MP, Fernández-López M, Mastrangelo A, Horcajada JP, Betbesé A, Esteban A, Ordóñez J, Gea J, Cabello JR, Pellati F, Lorente JA, Nin N, Rupérez FJ.

Electrophoresis. 2017 Sep;38(18):2341-2348. doi: 10.1002/elps.201700112. Epub 2017 Aug 25.

PMID:
28714069
12.

Metabolomics allows the discrimination of the pathophysiological relevance of hyperinsulinism in obese prepubertal children.

Martos-Moreno GÁ, Mastrangelo A, Barrios V, García A, Chowen JA, Rupérez FJ, Barbas C, Argente J.

Int J Obes (Lond). 2017 Oct;41(10):1473-1480. doi: 10.1038/ijo.2017.137. Epub 2017 Jun 7.

PMID:
28588306
13.

A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema.

Navarrete A, Rupérez FJ, Mendes TO, Pérez-Rial S, Girón-Martínez A, Terrón-Expósito R, Díaz-Gil JJ, Peces-Barba G, Barbas C, García A.

J Pharm Biomed Anal. 2017 May 30;139:238-246. doi: 10.1016/j.jpba.2017.02.045. Epub 2017 Feb 27.

PMID:
28314215
14.

A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice.

Valdecantos MP, Pardo V, Ruiz L, Castro-Sánchez L, Lanzón B, Fernández-Millán E, García-Monzón C, Arroba AI, González-Rodríguez Á, Escrivá F, Álvarez C, Rupérez FJ, Barbas C, Konkar A, Naylor J, Hornigold D, Santos AD, Bednarek M, Grimsby J, Rondinone CM, Valverde ÁM.

Hepatology. 2017 Mar;65(3):950-968. doi: 10.1002/hep.28962. Epub 2017 Jan 30.

PMID:
27880981
15.

Proteomics and metabolomics in biomarker discovery for cardiovascular diseases: progress and potential.

Tuñón J, Barbas C, Blanco-Colio L, Burillo E, Lorenzo Ó, Martín-Ventura JL, Más S, Rupérez FJ, Egido J.

Expert Rev Proteomics. 2016 Sep;13(9):857-71. doi: 10.1080/14789450.2016.1217775. Epub 2016 Aug 5. Review.

PMID:
27459711
16.

Genomics and Metabolomics in Obesity and Type 2 Diabetes.

Kretowski A, Ruperez FJ, Ciborowski M.

J Diabetes Res. 2016;2016:9415645. doi: 10.1155/2016/9415645. Epub 2016 May 25. No abstract available.

17.

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics.

Mastrangelo A, Panadero MI, Pérez LM, Gálvez BG, García A, Barbas C, Rupérez FJ.

Biochem J. 2016 Jul 15;473(14):2187-203. doi: 10.1042/BCJ20160241. Epub 2016 May 19.

PMID:
27208167
18.

Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations.

Mastrangelo A, Martos-Moreno GÁ, García A, Barrios V, Rupérez FJ, Chowen JA, Barbas C, Argente J.

Int J Obes (Lond). 2016 Oct;40(10):1494-1502. doi: 10.1038/ijo.2016.92. Epub 2016 May 10.

19.

A Single In-Vial Dual Extraction Strategy for the Simultaneous Lipidomics and Proteomics Analysis of HDL and LDL Fractions.

Godzien J, Ciborowski M, Armitage EG, Jorge I, Camafeita E, Burillo E, Martín-Ventura JL, Rupérez FJ, Vázquez J, Barbas C.

J Proteome Res. 2016 Jun 3;15(6):1762-75. doi: 10.1021/acs.jproteome.5b00898. Epub 2016 May 4.

PMID:
27117984
20.

To treat or not to treat: metabolomics reveals biomarkers for treatment indication in chronic lymphocytic leukaemia patients.

Piszcz J, Armitage EG, Ferrarini A, Rupérez FJ, Kulczynska A, Bolkun L, Kloczko J, Kretowski A, Urbanowicz A, Ciborowski M, Barbas C.

Oncotarget. 2016 Apr 19;7(16):22324-38. doi: 10.18632/oncotarget.8078.

21.

Metabolomic-Driven Elucidation of Serum Disturbances Associated with Alzheimer's Disease and Mild Cognitive Impairment.

González-Domínguez R, Rupérez FJ, García-Barrera T, Barbas C, Gómez-Ariza JL.

Curr Alzheimer Res. 2016;13(6):641-53.

PMID:
26825096
22.

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

Wai T, García-Prieto J, Baker MJ, Merkwirth C, Benit P, Rustin P, Rupérez FJ, Barbas C, Ibañez B, Langer T.

Science. 2015 Dec 4;350(6265):aad0116. doi: 10.1126/science.aad0116.

PMID:
26785494
23.

Unveiling differences between patients with acute coronary syndrome with and without ST elevation through fingerprinting with CE-MS and HILIC-MS targeted analysis.

Naz S, Calderón ÁA, García A, Gallafrio J, Mestre RT, González EG, de Cabo CM, Delgado MCM, Balanza JÁL, Simionato AVC, Vaeza NN, Barbas C, Rupérez FJ.

Electrophoresis. 2015 Sep;36(18):2303-2313. doi: 10.1002/elps.201500169. Epub 2015 Aug 27.

PMID:
26177736
24.

Metabolomics reveals metabolite changes in acute pulmonary embolism.

Bujak R, García-Álvarez A, Rupérez FJ, Nuño-Ayala M, García A, Ruiz-Cabello J, Fuster V, Ibáñez B, Barbas C.

J Proteome Res. 2014 Feb 7;13(2):805-16. doi: 10.1021/pr400872j. Epub 2014 Jan 8.

PMID:
24367941
25.

Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.

Ramírez E, Klett-Mingo M, Ares-Carrasco S, Picatoste B, Ferrarini A, Rupérez FJ, Caro-Vadillo A, Barbas C, Egido J, Tuñón J, Lorenzo Ó.

Cardiovasc Diabetol. 2013 Nov 21;12:172. doi: 10.1186/1475-2840-12-172.

26.

In-vial dual extraction liquid chromatography coupled to mass spectrometry applied to streptozotocin-treated diabetic rats. Tips and pitfalls of the method.

Godzien J, Ciborowski M, Whiley L, Legido-Quigley C, Ruperez FJ, Barbas C.

J Chromatogr A. 2013 Aug 23;1304:52-60. doi: 10.1016/j.chroma.2013.07.029. Epub 2013 Jul 11.

PMID:
23871561
27.

Plasma and urine metabolic fingerprinting of type 1 diabetic children.

Balderas C, Rupérez FJ, Ibañez E, Señorans J, Guerrero-Fernández J, Casado IG, Gracia-Bouthelier R, García A, Barbas C.

Electrophoresis. 2013 Oct;34(19):2882-90. doi: 10.1002/elps.201300062. Epub 2013 Sep 10.

PMID:
23857511
28.

Fingerprinting-based metabolomic approach with LC-MS to sleep apnea and hypopnea syndrome: a pilot study.

Ferrarini A, Rupérez FJ, Erazo M, Martínez MP, Villar-Álvarez F, Peces-Barba G, González-Mangado N, Troncoso MF, Ruiz-Cabello J, Barbas C.

Electrophoresis. 2013 Oct;34(19):2873-81. doi: 10.1002/elps.201300081. Epub 2013 Aug 16.

PMID:
23775633
29.

Ceramide mediates acute oxygen sensing in vascular tissues.

Moreno L, Moral-Sanz J, Morales-Cano D, Barreira B, Moreno E, Ferrarini A, Pandolfi R, Ruperez FJ, Cortijo J, Sanchez-Luna M, Villamor E, Perez-Vizcaino F, Cogolludo A.

Antioxid Redox Signal. 2014 Jan 1;20(1):1-14. doi: 10.1089/ars.2012.4752. Epub 2013 Aug 21.

30.

In-vial dual extraction for direct LC-MS analysis of plasma for comprehensive and highly reproducible metabolic fingerprinting.

Whiley L, Godzien J, Ruperez FJ, Legido-Quigley C, Barbas C.

Anal Chem. 2012 Jul 17;84(14):5992-9. doi: 10.1021/ac300716u. Epub 2012 Jul 3.

PMID:
22702345
31.

LC-MS metabolomics of polar compounds.

Rojo D, Barbas C, Rupérez FJ.

Bioanalysis. 2012 Jun;4(10):1235-43. doi: 10.4155/bio.12.100. Review.

PMID:
22651567
32.

Metabolomic study of plasma of patients with abdominal aortic aneurysm.

Rupérez FJ, Ramos-Mozo P, Teul J, Martinez-Pinna R, Garcia A, Malet-Martino M, Camafeita E, Lopez JA, Pastor-Vargas C, Egido J, Balayssac S, Gilard V, Barbas C, Martin-Ventura JL.

Anal Bioanal Chem. 2012 Jun;403(6):1651-60. doi: 10.1007/s00216-012-5982-y. Epub 2012 Apr 29.

PMID:
22543712
33.

Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate.

García A, Rupérez FJ, Ceppa F, Pellati F, Barbas C.

J Pharm Biomed Anal. 2012 Mar 5;61:230-6. doi: 10.1016/j.jpba.2011.12.014. Epub 2011 Dec 19.

PMID:
22226040
34.

Metabolomic assessment with CE-MS of the nutraceutical effect of Cystoseira spp extracts in an animal model.

Moraes EP, Rupérez FJ, Plaza M, Herrero M, Barbas C.

Electrophoresis. 2011 Aug;32(15):2055-62. doi: 10.1002/elps.201000546.

PMID:
21792987
35.

Targeted and non-targeted metabolic time trajectory in plasma of patients after acute coronary syndrome.

Teul J, Garcia A, Tuñón J, Martin-Ventura JL, Tarín N, Bescós LL, Egido J, Barbas C, Rupérez FJ.

J Pharm Biomed Anal. 2011 Sep 10;56(2):343-51. doi: 10.1016/j.jpba.2011.05.020. Epub 2011 May 20.

PMID:
21696905
36.

Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography.

Debrus B, Lebrun P, Ceccato A, Caliaro G, Rozet E, Nistor I, Oprean R, Rupérez FJ, Barbas C, Boulanger B, Hubert P.

Anal Chim Acta. 2011 Apr 8;691(1-2):33-42. doi: 10.1016/j.aca.2011.02.035. Epub 2011 Feb 23.

PMID:
21458628
37.

Metabolites secreted by human atherothrombotic aneurysms revealed through a metabolomic approach.

Ciborowski M, Martin-Ventura JL, Meilhac O, Michel JB, Ruperez FJ, Tuñon J, Egido J, Barbas C.

J Proteome Res. 2011 Mar 4;10(3):1374-82. doi: 10.1021/pr101138m. Epub 2011 Jan 31.

PMID:
21166478
38.

Metabolomic approach with LC-QTOF to study the effect of a nutraceutical treatment on urine of diabetic rats.

Godzien J, Ciborowski M, Angulo S, Ruperez FJ, Martínez MP, Señorans FJ, Cifuentes A, Ibañez E, Barbas C.

J Proteome Res. 2011 Feb 4;10(2):837-44. doi: 10.1021/pr100993x. Epub 2010 Dec 20.

PMID:
21087057
39.

Metabolomic approach to the nutraceutical effect of rosemary extract plus Ω-3 PUFAs in diabetic children with capillary electrophoresis.

Balderas C, Villaseñor A, García A, Rupérez FJ, Ibañez E, Señorans J, Guerrero-Fernández J, González-Casado I, Gracia-Bouthelier R, Barbas C.

J Pharm Biomed Anal. 2010 Dec 15;53(5):1298-304. doi: 10.1016/j.jpba.2010.07.034. Epub 2010 Jul 30.

PMID:
20719450
40.

Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints.

Teul J, Rupérez FJ, Garcia A, Vaysse J, Balayssac S, Gilard V, Malet-Martino M, Martin-Ventura JL, Blanco-Colio LM, Tuñón J, Egido J, Barbas C.

J Proteome Res. 2009 Dec;8(12):5580-9. doi: 10.1021/pr900668v.

PMID:
19813770
41.

Dunaliella salina extract effect on diabetic rats: metabolic fingerprinting and target metabolite analysis.

Ruperez FJ, Garcia-Martinez D, Baena B, Maeso N, Vallejo M, Angulo S, Garcia A, Ibañez E, Señorans FJ, Cifuentes A, Barbas C.

J Pharm Biomed Anal. 2009 Apr 5;49(3):786-92. doi: 10.1016/j.jpba.2008.12.041. Epub 2009 Jan 21.

PMID:
19232850
42.

Evolution of oxidative stress parameters and response to oral vitamins E and C in streptozotocin-induced diabetic rats.

Rupérez FJ, García-Martínez D, Baena B, Maeso N, Cifuentes A, Barbas C, Herrera E.

J Pharm Pharmacol. 2008 Jul;60(7):871-8. doi: 10.1211/jpp.60.7.0008.

PMID:
18549673
43.

Tocopherol fate in plasma and liver of streptozotocin-treated rats that orally received antioxidants and Spirulina extracts.

García-Martínez D, Rupérez FJ, Ugarte P, Barbas C.

Int J Vitam Nutr Res. 2007 Jul;77(4):263-71.

PMID:
18271281
44.

Capillary electrophoresis for short chain organic acids in faeces Reference values in a Mediterranean elderly population.

Garcia A, Olmo B, Lopez-Gonzalvez A, Cornejo L, Rupérez FJ, Barbas C.

J Pharm Biomed Anal. 2008 Jan 22;46(2):356-61. Epub 2007 Oct 26.

PMID:
18055154
45.

Isolation, identification and determination of the major degradation product in alprazolam tablets during their stability assay.

Huidobro AL, Rupérez FJ, Barbas C.

J Pharm Biomed Anal. 2007 Jun 28;44(2):404-13. Epub 2006 Dec 15.

PMID:
17250986
46.

Tandem column for the simultaneous determination of arginine, ibuprofen and related impurities by liquid chromatography.

Huidobro AL, Rupérez FJ, Barbas C.

J Chromatogr A. 2006 Jun 30;1119(1-2):238-45. Epub 2005 Dec 20.

PMID:
16364348
47.

Capillary electrophoresis of glutathione to monitor oxidative stress and response to antioxidant treatments in an animal model.

Maeso N, García-Martínez D, Rupérez FJ, Cifuentes A, Barbas C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):61-9.

PMID:
15979953
48.

LC methods for acyclovir and related impurities determination.

Huidobro AL, Rupérez FJ, Barbas C.

J Pharm Biomed Anal. 2005 Apr 1;37(4):687-94. Epub 2005 Jan 4.

PMID:
15797789
49.

Tocopherol measurement in edible products of vegetable origin.

Gómez-Coronado DJ, Ibañez E, Rupérez FJ, Barbas C.

J Chromatogr A. 2004 Oct 29;1054(1-2):227-33.

PMID:
15553148
50.

Direct liquid chromatography method for retinol, alpha- and gamma-tocopherols in rat plasma.

Rupérez FJ, Mach M, Barbas C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Feb 5;800(1-2):225-30.

PMID:
14698258

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