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Items: 9

1.

Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy.

Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C.

Mol Cancer Ther. 2017 Sep;16(9):1887-1897. doi: 10.1158/1535-7163.MCT-17-0108. Epub 2017 May 22.

2.

The Bacterial Enzyme IdeS Cleaves the IgG-Type of B Cell Receptor (BCR), Abolishes BCR-Mediated Cell Signaling, and Inhibits Memory B Cell Activation.

Järnum S, Bockermann R, Runström A, Winstedt L, Kjellman C.

J Immunol. 2015 Dec 15;195(12):5592-601. doi: 10.4049/jimmunol.1501929. Epub 2015 Nov 9.

3.

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity.

Winstedt L, Järnum S, Nordahl EA, Olsson A, Runström A, Bockermann R, Karlsson C, Malmström J, Palmgren GS, Malmqvist U, Björck L, Kjellman C.

PLoS One. 2015 Jul 15;10(7):e0132011. doi: 10.1371/journal.pone.0132011. eCollection 2015.

4.

Inhibition of the development of chronic experimental autoimmune encephalomyelitis by laquinimod (ABR-215062) in IFN-beta k.o. and wild type mice.

Runström A, Leanderson T, Ohlsson L, Axelsson B.

J Neuroimmunol. 2006 Apr;173(1-2):69-78. Epub 2006 Feb 10.

PMID:
16472873
5.

Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.

Jönsson S, Andersson G, Fex T, Fristedt T, Hedlund G, Jansson K, Abramo L, Fritzson I, Pekarski O, Runström A, Sandin H, Thuvesson I, Björk A.

J Med Chem. 2004 Apr 8;47(8):2075-88.

PMID:
15056005
6.

The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis.

Brunmark C, Runström A, Ohlsson L, Sparre B, Brodin T, Aström M, Hedlund G.

J Neuroimmunol. 2002 Sep;130(1-2):163-72.

PMID:
12225898
7.

Interference with CD28, CD80, CD86 or CD152 in collagen-induced arthritis. Limited role of IFN-gamma in anti-B7-mediated suppression of disease.

Tellander AC, Pettersson U, Runström A, Andersson M, Michaëlsson E.

J Autoimmun. 2001 Aug;17(1):39-50.

PMID:
11488636
8.

Prolonged airway activity and improved selectivity of budesonide possibly due to esterification.

Miller-Larsson A, Jansson P, Runström A, Brattsand R.

Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1455-61.

PMID:
11029361
9.

Adrenalectomy permits a late, local TNF-alpha release in LPS-challenged rat airways.

Miller-Larsson A, Runström A, Brattsand R.

Eur Respir J. 1999 Jun;13(6):1310-7.

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