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Items: 42


Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast.

Irie H, Yamamoto I, Tarumoto Y, Tashiro S, Runge KW, Ishikawa F.

PLoS Genet. 2019 Aug 27;15(8):e1008335. doi: 10.1371/journal.pgen.1008335. eCollection 2019 Aug.


Exon 2 skipping eliminates γ-glutamyl carboxylase activity, indicating a partial splicing defect in a patient with vitamin K clotting factor deficiency.

Rishavy MA, Hallgren KW, Zhang H, Runge KW, Berkner KL.

J Thromb Haemost. 2019 Jul;17(7):1053-1063. doi: 10.1111/jth.14456. Epub 2019 Jun 7.


The inhibition of checkpoint activation by telomeres does not involve exclusion of dimethylation of histone H4 lysine 20 (H4K20me2).

Audry J, Wang J, Eisenstatt JR, Berkner KL, Runge KW.

Version 2. F1000Res. 2018 Jul 9 [revised 2018 Jan 1];7:1027. doi: 10.12688/f1000research.15166.2. eCollection 2018.


A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres.

Wang J, Eisenstatt JR, Audry J, Cornelius K, Shaughnessy M, Berkner KL, Runge KW.

Mol Cell Biol. 2018 Jul 16;38(15). pii: e00393-17. doi: 10.1128/MCB.00393-17. Print 2018 Aug 1.


Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.

Rishavy MA, Hallgren KW, Wilson L, Singh S, Runge KW, Berkner KL.

Blood. 2018 Jun 21;131(25):2826-2835. doi: 10.1182/blood-2017-09-804666. Epub 2018 Mar 28.


Rif1 phosphorylation site analysis in telomere length regulation and the response to damaged telomeres.

Wang J, Zhang H, Al Shibar M, Willard B, Ray A, Runge KW.

DNA Repair (Amst). 2018 May;65:26-33. doi: 10.1016/j.dnarep.2018.03.001. Epub 2018 Mar 7.


A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining.

Runge KW, Li Y.

Curr Genet. 2018 Apr;64(2):359-364. doi: 10.1007/s00294-017-0760-1. Epub 2017 Oct 10. Review.


Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe.

Li Y, Wang J, Zhou G, Lajeunesse M, Le N, Stawicki BN, Corcino YL, Berkner KL, Runge KW.

Genetics. 2017 May;206(1):481-496. doi: 10.1534/genetics.117.200972. Epub 2017 Mar 14.


Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Liu Y, Lee IJ, Sun M, Lower CA, Runge KW, Ma J, Wu JQ.

Mol Biol Cell. 2016 Aug 15;27(16):2528-41. doi: 10.1091/mbc.E16-03-0156. Epub 2016 Jul 6.


Editorial: The Evolving Telomeres.

Runge KW, Lustig AJ.

Front Genet. 2016 Apr 6;7:50. doi: 10.3389/fgene.2016.00050. eCollection 2016. No abstract available.


Zinc finger protein Loz1 is required for zinc-responsive regulation of gene expression in fission yeast.

Corkins ME, May M, Ehrensberger KM, Hu YM, Liu YH, Bloor SD, Jenkins B, Runge KW, Bird AJ.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15371-6. doi: 10.1073/pnas.1300853110. Epub 2013 Sep 3.


The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation.

Rishavy MA, Hallgren KW, Wilson LA, Usubalieva A, Runge KW, Berkner KL.

J Biol Chem. 2013 Nov 1;288(44):31556-66. doi: 10.1074/jbc.M113.497297. Epub 2013 Aug 5.


Identification of a lifespan extending mutation in the Schizosaccharomyces pombe cyclin gene clg1+ by direct selection of long-lived mutants.

Chen BR, Li Y, Eisenstatt JR, Runge KW.

PLoS One. 2013 Jul 9;8(7):e69084. doi: 10.1371/journal.pone.0069084. Print 2013.


A new method to efficiently induce a site-specific double-strand break in the fission yeast Schizosaccharomyces pombe.

Sunder S, Greeson-Lott NT, Runge KW, Sanders SL.

Yeast. 2012 Jul;29(7):275-91. doi: 10.1002/yea.2908. Epub 2012 Jun 6.


Generation and analysis of a barcode-tagged insertion mutant library in the fission yeast Schizosaccharomyces pombe.

Chen BR, Hale DC, Ciolek PJ, Runge KW.

BMC Genomics. 2012 May 3;13:161. doi: 10.1186/1471-2164-13-161.


Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.

Ye Y, Lee IJ, Runge KW, Wu JQ.

Mol Biol Cell. 2012 Apr;23(7):1181-95. doi: 10.1091/mbc.E11-09-0800. Epub 2012 Feb 1.


Mec1p associates with functionally compromised telomeres.

Hector RE, Ray A, Chen BR, Shtofman R, Berkner KL, Runge KW.

Chromosoma. 2012 Jun;121(3):277-90. doi: 10.1007/s00412-011-0359-0.


Genetic approaches to aging in budding and fission yeasts: new connections and new opportunities.

Chen BR, Runge KW.

Subcell Biochem. 2012;57:291-314. doi: 10.1007/978-94-007-2561-4_13. Review.


A two-step model for senescence triggered by a single critically short telomere.

Abdallah P, Luciano P, Runge KW, Lisby M, Géli V, Gilson E, Teixeira MT.

Nat Cell Biol. 2009 Aug;11(8):988-93. doi: 10.1038/ncb1911. Epub 2009 Jul 13. Erratum in: Nat Cell Biol. 2010 May;12(5):520.


A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity.

Chen BR, Runge KW.

Exp Gerontol. 2009 Aug;44(8):493-502. doi: 10.1016/j.exger.2009.04.004. Epub 2009 May 4.


Tel1p preferentially associates with short telomeres to stimulate their elongation.

Hector RE, Shtofman RL, Ray A, Chen BR, Nyun T, Berkner KL, Runge KW.

Mol Cell. 2007 Sep 7;27(5):851-8.


Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation.

Rishavy MA, Hallgren KW, Yakubenko AV, Shtofman RL, Runge KW, Berkner KL.

Biochemistry. 2006 Nov 7;45(44):13239-48.


The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation.

Rishavy MA, Hallgren KW, Yakubenko AV, Zuerner RL, Runge KW, Berkner KL.

J Biol Chem. 2005 Oct 14;280(41):34870-7. Epub 2005 Aug 1.


The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis.

Berkner KL, Runge KW.

J Thromb Haemost. 2004 Dec;2(12):2118-32. Review.


A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.

Rishavy MA, Pudota BN, Hallgren KW, Qian W, Yakubenko AV, Song JH, Runge KW, Berkner KL.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13732-7. Epub 2004 Sep 13.


Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.

Ray A, Hector RE, Roy N, Song JH, Berkner KL, Runge KW.

Nat Genet. 2003 Apr;33(4):522-6. Epub 2003 Mar 17. Erratum in: Nat Genet. 2003 May;34(1):113.


Yeast telomerase appears to frequently copy the entire template in vivo.

Ray A, Runge KW.

Nucleic Acids Res. 2001 Jun 1;29(11):2382-94.


The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids.

Roy N, Runge KW.

Chromosoma. 1999 Jul;108(3):146-61. Erratum in: Chromosoma 2000 Mar;108(8):533.


Effects of excess centromeres and excess telomeres on chromosome loss rates.

Runge KW, Wellinger RJ, Zakian VA.

Mol Cell Biol. 1991 Jun;11(6):2919-28.


Properties of the transcriptional enhancer in Saccharomyces cerevisiae telomeres.

Runge KW, Zakian VA.

Nucleic Acids Res. 1990 Apr 11;18(7):1783-7.


Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway.

Runge KW, Huffaker TC, Robbins PW.

J Biol Chem. 1984 Jan 10;259(1):412-7.

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