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Items: 46

1.

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.

Overgaard NH, Principe DR, Schachtschneider KM, Jakobsen JT, Rund LA, Grippo PJ, Schook LB, Jungersen G.

Front Immunol. 2018 Jun 7;9:1301. doi: 10.3389/fimmu.2018.01301. eCollection 2018.

2.

Characterization of an Inducible Alcoholic Liver Fibrosis Model for Hepatocellular Carcinoma Investigation in a Transgenic Porcine Tumorigenic Platform.

Gaba RC, Mendoza-Elias N, Regan DP, Garcia KD, Lokken RP, Schwind RM, Eichner M, Thomas FM, Rund LA, Schook LB, Schachtschneider KM.

J Vasc Interv Radiol. 2018 Aug;29(8):1194-1202.e1. doi: 10.1016/j.jvir.2018.03.007. Epub 2018 Jun 7.

PMID:
29887183
3.

A minimally invasive catheter-based ultrasound technology for therapeutic interventions in brain: initial preclinical studies.

Ghoshal G, Gee L, Heffter T, Williams E, Bromfield C, Rund L, Ehrhardt JM, Diederich CJ, Fischer GS, Pilitsis JG, Burdette EC.

Neurosurg Focus. 2018 Feb;44(2):E13. doi: 10.3171/2017.11.FOCUS17631.

4.

A validated, transitional and translational porcine model of hepatocellular carcinoma.

Schachtschneider KM, Schwind RM, Darfour-Oduro KA, De AK, Rund LA, Singh K, Principe DR, Guzman G, Ray CE Jr, Ozer H, Gaba RC, Schook LB.

Oncotarget. 2017 Jun 29;8(38):63620-63634. doi: 10.18632/oncotarget.18872. eCollection 2017 Sep 8.

5.

The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform.

Schachtschneider KM, Schwind RM, Newson J, Kinachtchouk N, Rizko M, Mendoza-Elias N, Grippo P, Principe DR, Park A, Overgaard NH, Jungersen G, Garcia KD, Maker AV, Rund LA, Ozer H, Gaba RC, Schook LB.

Front Oncol. 2017 Aug 23;7:190. doi: 10.3389/fonc.2017.00190. eCollection 2017. Review.

6.

Oncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas.

Schachtschneider KM, Liu Y, Mäkeläinen S, Madsen O, Rund LA, Groenen MAM, Schook LB.

Sci Rep. 2017 Jun 1;7(1):2624. doi: 10.1038/s41598-017-02912-9.

7.

Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development.

Schachtschneider KM, Liu Y, Rund LA, Madsen O, Johnson RW, Groenen MA, Schook LB.

BMC Genomics. 2016 Nov 3;17(1):856.

8.

Emerging Technologies to Create Inducible and Genetically Defined Porcine Cancer Models.

Schook LB, Rund L, Begnini KR, Remião MH, Seixas FK, Collares T.

Front Genet. 2016 Feb 29;7:28. doi: 10.3389/fgene.2016.00028. eCollection 2016. Review.

9.

Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model.

Schachtschneider KM, Madsen O, Park C, Rund LA, Groenen MA, Schook LB.

BMC Genomics. 2015 Oct 5;16:743. doi: 10.1186/s12864-015-1938-x.

10.

Trimodal Therapy: Combining Hyperthermia with Repurposed Bexarotene and Ultrasound for Treating Liver Cancer.

Misra SK, Ghoshal G, Gartia MR, Wu Z, De AK, Ye M, Bromfield CR, Williams EM, Singh K, Tangella KV, Rund L, Schulten K, Schook LB, Ray PS, Burdette EC, Pan D.

ACS Nano. 2015 Nov 24;9(11):10695-10718. doi: 10.1021/acsnano.5b05974. Epub 2015 Oct 12.

11.

A porcine model system of BRCA1 driven breast cancer.

Donninger H, Hobbing K, Schmidt ML, Walters E, Rund L, Schook L, Clark GJ.

Front Genet. 2015 Aug 25;6:269. doi: 10.3389/fgene.2015.00269. eCollection 2015.

12.

A Genetic Porcine Model of Cancer.

Schook LB, Collares TV, Hu W, Liang Y, Rodrigues FM, Rund LA, Schachtschneider KM, Seixas FK, Singh K, Wells KD, Walters EM, Prather RS, Counter CM.

PLoS One. 2015 Jul 1;10(7):e0128864. doi: 10.1371/journal.pone.0128864. eCollection 2015.

13.

Unraveling the swine genome: implications for human health.

Schook LB, Collares TV, Darfour-Oduro KA, De AK, Rund LA, Schachtschneider KM, Seixas FK.

Annu Rev Anim Biosci. 2015;3:219-44. doi: 10.1146/annurev-animal-022114-110815. Review.

PMID:
25689318
14.

Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism.

Ganu R, Garrow T, Koutmos M, Rund L, Schook LB.

Gene. 2013 Oct 25;529(2):228-37. doi: 10.1016/j.gene.2013.07.103. Epub 2013 Aug 13.

15.

Analyses of pig genomes provide insight into porcine demography and evolution.

Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF, Rogel-Gaillard C, Park C, Milan D, Megens HJ, Li S, Larkin DM, Kim H, Frantz LA, Caccamo M, Ahn H, Aken BL, Anselmo A, Anthon C, Auvil L, Badaoui B, Beattie CW, Bendixen C, Berman D, Blecha F, Blomberg J, Bolund L, Bosse M, Botti S, Bujie Z, Bystrom M, Capitanu B, Carvalho-Silva D, Chardon P, Chen C, Cheng R, Choi SH, Chow W, Clark RC, Clee C, Crooijmans RP, Dawson HD, Dehais P, De Sapio F, Dibbits B, Drou N, Du ZQ, Eversole K, Fadista J, Fairley S, Faraut T, Faulkner GJ, Fowler KE, Fredholm M, Fritz E, Gilbert JG, Giuffra E, Gorodkin J, Griffin DK, Harrow JL, Hayward A, Howe K, Hu ZL, Humphray SJ, Hunt T, Hornshøj H, Jeon JT, Jern P, Jones M, Jurka J, Kanamori H, Kapetanovic R, Kim J, Kim JH, Kim KW, Kim TH, Larson G, Lee K, Lee KT, Leggett R, Lewin HA, Li Y, Liu W, Loveland JE, Lu Y, Lunney JK, Ma J, Madsen O, Mann K, Matthews L, McLaren S, Morozumi T, Murtaugh MP, Narayan J, Nguyen DT, Ni P, Oh SJ, Onteru S, Panitz F, Park EW, Park HS, Pascal G, Paudel Y, Perez-Enciso M, Ramirez-Gonzalez R, Reecy JM, Rodriguez-Zas S, Rohrer GA, Rund L, Sang Y, Schachtschneider K, Schraiber JG, Schwartz J, Scobie L, Scott C, Searle S, Servin B, Southey BR, Sperber G, Stadler P, Sweedler JV, Tafer H, Thomsen B, Wali R, Wang J, Wang J, White S, Xu X, Yerle M, Zhang G, Zhang J, Zhang J, Zhao S, Rogers J, Churcher C, Schook LB.

Nature. 2012 Nov 15;491(7424):393-8. doi: 10.1038/nature11622.

16.

Large-scale sequencing based on full-length-enriched cDNA libraries in pigs: contribution to annotation of the pig genome draft sequence.

Uenishi H, Morozumi T, Toki D, Eguchi-Ogawa T, Rund LA, Schook LB.

BMC Genomics. 2012 Nov 15;13:581. doi: 10.1186/1471-2164-13-581.

17.

A highly selective Hsp90 affinity chromatography resin with a cleavable linker.

Hughes PF, Barrott JJ, Carlson DA, Loiselle DR, Speer BL, Bodoor K, Rund LA, Haystead TA.

Bioorg Med Chem. 2012 May 15;20(10):3298-305. doi: 10.1016/j.bmc.2012.03.043. Epub 2012 Mar 29.

18.

Association of the porcine transforming growth factor beta type I receptor (TGFBR1) gene with growth and carcass traits.

Chen K, Hawken R, Flickinger GH, Rodriguez-Zas SL, Rund LA, Wheeler MB, Abrahamsen M, Rutherford MS, Beever JE, Schook LB.

Anim Biotechnol. 2012;23(1):43-63. doi: 10.1080/10495398.2011.630897.

PMID:
22292700
19.

Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow.

Lin C, Kolossov VL, Tsvid G, Trump L, Henry JJ, Henderson JL, Rund LA, Kenis PJ, Schook LB, Gaskins HR, Timp G.

Integr Biol (Camb). 2011 Mar;3(3):208-17. doi: 10.1039/c0ib00071j. Epub 2010 Dec 23.

20.

Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes.

Ganu RS, Garrow TA, Sodhi M, Rund LA, Schook LB.

Gene. 2011 Mar 1;473(2):133-8. doi: 10.1016/j.gene.2010.11.015. Epub 2010 Dec 13.

21.

Tuning the non-equilibrium state of a drug-encapsulated poly(ethylene glycol) hydrogel for stem and progenitor cell mobilization.

Liang Y, Jensen TW, Roy EJ, Cha C, Devolder RJ, Kohman RE, Zhang BZ, Textor KB, Rund LA, Schook LB, Tong YW, Kong H.

Biomaterials. 2011 Mar;32(7):2004-12. doi: 10.1016/j.biomaterials.2010.11.021. Epub 2010 Dec 7.

22.

DNA-based animal models of human disease: from genotype to phenotype.

Schook LB, Kuzmuk K, Adam S, Rund L, Chen K, Rogatcheva M, Mazur M, Pollock C, Counter C.

Dev Biol (Basel). 2008;132:15-25.

PMID:
18817282
23.

Creating porcine biomedical models through recombineering.

Rogatcheva MM, Rund LA, Swanson KS, Marron BM, Beever JE, Counter CM, Schook LB.

Comp Funct Genomics. 2004;5(3):262-7. doi: 10.1002/cfg.404.

24.

Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia.

Rogatcheva MB, Fritz KL, Rund LA, Pollock CB, Beever JE, Counter CM, Schook LB.

Gene. 2007 Dec 15;405(1-2):27-35. Epub 2007 Aug 30.

PMID:
17933474
25.

Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets.

Chowdhury SR, King DE, Willing BP, Band MR, Beever JE, Lane AB, Loor JJ, Marini JC, Rund LA, Schook LB, Van Kessel AG, Gaskins HR.

BMC Genomics. 2007 Jul 5;8:215.

26.

Genetic induction of tumorigenesis in swine.

Adam SJ, Rund LA, Kuzmuk KN, Zachary JF, Schook LB, Counter CM.

Oncogene. 2007 Feb 15;26(7):1038-45. Epub 2006 Sep 11.

PMID:
16964292
27.

Isolation and molecular characterization of the porcine transforming growth factor beta type I receptor (TGFBR1) gene.

Chen K, Rund LA, Beever JE, Schook LB.

Gene. 2006 Dec 15;384:62-72. Epub 2006 Jul 25.

PMID:
16950575
28.

Genomics and clinical medicine: rationale for creating and effectively evaluating animal models.

Swanson KS, Mazur MJ, Vashisht K, Rund LA, Beever JE, Counter CM, Schook LB.

Exp Biol Med (Maywood). 2004 Oct;229(9):866-75. Review.

PMID:
15388881
29.

Harvesting the genomic promise: recombineering sequences for phenotypes.

Rogatcheva MB, Rund LA, Beever JE, Schook LB.

Anim Biotechnol. 2003 Nov;14(2):103-18.

PMID:
14703070
30.
31.

IL-12 treatment of endogenously arising murine brain tumors.

Roy EJ, Gawlick U, Orr BA, Rund LA, Webb AG, Kranz DM.

J Immunol. 2000 Dec 15;165(12):7293-9.

32.

Bispecific agents target endogenous murine T cells against human tumor xenografts.

Rund LA, Cho BK, Manning TC, Holler PD, Roy EJ, Kranz DM.

Int J Cancer. 1999 Sep 24;83(1):141-9.

33.

Targeting tumor cells with bispecific antibodies and T cells.

Kranz DM, Manning TC, Rund LA, Cho BK, Gruber MM, Roy EJ.

J Control Release. 1998 Apr 30;53(1-3):77-84.

PMID:
9741915
34.

Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate.

Roy EJ, Cho BK, Rund LA, Patrick TA, Kranz DM.

Int J Cancer. 1998 May 29;76(5):761-6.

35.

Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.

Manning TC, Rund LA, Gruber MM, Fallarino F, Gajewski TF, Kranz DM.

J Immunol. 1997 Nov 15;159(10):4665-75.

PMID:
9366389
36.

The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein.

Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB.

Nature. 1997 Apr 24;386(6627):838-42.

PMID:
9126743
37.

Distribution of beta-endorphin immunoreactivity in the arcuate nucleus and median eminence of postpartum anestrus and luteal phase cows.

Leshin LS, Rund LA, Kraeling RR, Crim JW, Kiser TE.

Neuroendocrinology. 1992 Sep;56(3):436-44.

PMID:
1436381
38.
39.

Morphological differences among luteinizing hormone releasing hormone neurons from postpartum and estrous cycling cows.

Leshin LS, Rund LA, Kraeling RR, Crim JW, Kiser TE.

Neuroendocrinology. 1992 Apr;55(4):380-9.

PMID:
1565205
40.
41.

Serum prolactin and growth hormone responses to naloxone and intracerebral ventricle morphine administration in heifers.

Leshin LS, Rund LA, Thompson FN, Mahaffey MB, Chang WJ, Byerley DJ, Kiser TE.

J Anim Sci. 1990 Jun;68(6):1656-65.

PMID:
2384365
42.
44.

Difference in luteinizing hormone response to an opioid antagonist in beef heifers and cows.

Mahmoud AI, Thompson FN, Peck DD, Mizinga KM, Leshin LS, Rund LA, Stuedemann JA, Kiser TE.

Biol Reprod. 1989 Sep;41(3):431-7.

PMID:
2590714
45.

Influence of the ovary and suckling on luteinizing hormone response to naloxone in postpartum beef cows.

Rund LA, Leshin LS, Thompson FN, Rampacek GB, Kiser TE.

J Anim Sci. 1989 Jun;67(6):1527-31.

PMID:
2670869

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