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Items: 25

1.

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, Dodd S, Drueckes P, Fabbro D, Gabriel T, Groell JM, Grotzfeld RM, Hassan AQ, Henry C, Iyer V, Jones D, Lombardo F, Loo A, Manley PW, Pellé X, Rummel G, Salem B, Warmuth M, Wylie AA, Zoller T, Marzinzik AL, Furet P.

J Med Chem. 2018 Sep 27;61(18):8120-8135. doi: 10.1021/acs.jmedchem.8b01040. Epub 2018 Sep 7.

PMID:
30137981
2.

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.

Hoegenauer K, Soldermann N, Zécri F, Strang RS, Graveleau N, Wolf RM, Cooke NG, Smith AB, Hollingworth GJ, Blanz J, Gutmann S, Rummel G, Littlewood-Evans A, Burkhart C.

ACS Med Chem Lett. 2017 Aug 25;8(9):975-980. doi: 10.1021/acsmedchemlett.7b00293. eCollection 2017 Sep 14.

3.

Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.

Hoegenauer K, Soldermann N, Stauffer F, Furet P, Graveleau N, Smith AB, Hebach C, Hollingworth GJ, Lewis I, Gutmann S, Rummel G, Knapp M, Wolf RM, Blanz J, Feifel R, Burkhart C, Zécri F.

ACS Med Chem Lett. 2016 Jun 2;7(8):762-7. doi: 10.1021/acsmedchemlett.6b00119. eCollection 2016 Aug 11.

4.

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.

Karpov AS, Amiri P, Bellamacina C, Bellance MH, Breitenstein W, Daniel D, Denay R, Fabbro D, Fernandez C, Galuba I, Guerro-Lagasse S, Gutmann S, Hinh L, Jahnke W, Klopp J, Lai A, Lindvall MK, Ma S, Möbitz H, Pecchi S, Rummel G, Shoemaker K, Trappe J, Voliva C, Cowan-Jacob SW, Marzinzik AL.

ACS Med Chem Lett. 2015 May 22;6(7):776-81. doi: 10.1021/acsmedchemlett.5b00102. eCollection 2015 Jul 9.

5.

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

van Eis MJ, Evenou JP, Floersheim P, Gaul C, Cowan-Jacob SW, Monovich L, Rummel G, Schuler W, Stark W, Strauss A, von Matt A, Vangrevelinghe E, Wagner J, Soldermann N.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7367-72. doi: 10.1016/j.bmcl.2011.10.025. Epub 2011 Oct 21.

PMID:
22078216
6.

Expanding the diversity of allosteric bcr-abl inhibitors.

Deng X, Okram B, Ding Q, Zhang J, Choi Y, Adrián FJ, Wojciechowski A, Zhang G, Che J, Bursulaya B, Cowan-Jacob SW, Rummel G, Sim T, Gray NS.

J Med Chem. 2010 Oct 14;53(19):6934-46. doi: 10.1021/jm100555f.

7.

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S.

J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b.

PMID:
19827831
8.

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.

Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW.

Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. Epub 2006 Dec 13.

9.

Crystal structure of osmoporin OmpC from E. coli at 2.0 A.

Baslé A, Rummel G, Storici P, Rosenbusch JP, Schirmer T.

J Mol Biol. 2006 Oct 6;362(5):933-42. Epub 2006 Aug 3.

PMID:
16949612
10.

The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentus.

Fischer B, Rummel G, Aldridge P, Jenal U.

Mol Microbiol. 2002 Apr;44(2):461-78.

11.

Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast.

Sauer O, Roth M, Schirmer T, Rummel G, Kratky C.

Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):60-9. Epub 2001 Dec 21.

PMID:
11752779
12.

Proteomic analysis of the bacterial cell cycle.

Grünenfelder B, Rummel G, Vohradsky J, Röder D, Langen H, Jenal U.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4681-6. Epub 2001 Apr 3.

13.

Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae.

Dutzler R, Rummel G, Albertí S, Hernández-Allés S, Phale P, Rosenbusch J, Benedí V, Schirmer T.

Structure. 1999 Apr 15;7(4):425-34.

14.

Detergent binding in trigonal crystals of OmpF porin from Escherichia coli.

Penel S, Pebay-Peyroula E, Rosenbusch J, Rummel G, Schirmer T, Timmins PA.

Biochimie. 1998 May-Jun;80(5-6):543-51.

PMID:
9782392
15.

Lipidic Cubic Phases: New Matrices for the Three-Dimensional Crystallization of Membrane Proteins.

Rummel G, Hardmeyer A, Widmer C, Chiu ML, Nollert P, Locher KP, Pedruzzi I I, Landau EM, Rosenbusch JP.

J Struct Biol. 1998;121(2):82-91.

PMID:
9618339
16.

X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases.

Pebay-Peyroula E, Rummel G, Rosenbusch JP, Landau EM.

Science. 1997 Sep 12;277(5332):1676-81.

17.

Structural and functional characterization of OmpF porin mutants selected for larger pore size. I. Crystallographic analysis.

Lou KL, Saint N, Prilipov A, Rummel G, Benson SA, Rosenbusch JP, Schirmer T.

J Biol Chem. 1996 Aug 23;271(34):20669-75.

18.

A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding.

Albertí S, Rodríquez-Quiñones F, Schirmer T, Rummel G, Tomás JM, Rosenbusch JP, Benedí VJ.

Infect Immun. 1995 Mar;63(3):903-10.

19.

Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli.

Jeanteur D, Schirmer T, Fourel D, Simonet V, Rummel G, Widmer C, Rosenbusch JP, Pattus F, Pagès JM.

Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10675-9.

20.

Crystal structures explain functional properties of two E. coli porins.

Cowan SW, Schirmer T, Rummel G, Steiert M, Ghosh R, Pauptit RA, Jansonius JN, Rosenbusch JP.

Nature. 1992 Aug 27;358(6389):727-33.

PMID:
1380671
21.

Trigonal crystals of porin from Escherichia coli.

Pauptit RA, Zhang H, Rummel G, Schirmer T, Jansonius JN, Rosenbusch JP.

J Mol Biol. 1991 Apr 5;218(3):505-7.

PMID:
1850001
22.

[32P studies of phosphate metabolism in metabolic acidosis of cattle].

Lachmann G, Pfüller K, Bier H, Müller D, Rummel G.

Arch Exp Veterinarmed. 1984 Mar;38(2):203-10. German. No abstract available.

PMID:
6742964
23.

Purification and characterization of the ninth component of rabbit complement.

Hänsch GM, Rummel G, Gänzler F.

Complement. 1984;1(2):116-22.

PMID:
6544183
24.

[Toxic-allergic shock caused by carbamazepine (Tegretal)].

Rummel GL.

ZFA (Stuttgart). 1979 Apr 10;55(10):627-9. German. No abstract available.

PMID:
155956
25.

[1st results with cycle-adapted estrogen-interval therapy for the prevention of migraine].

Rummel GL.

Med Welt. 1975 Apr 25;26(17):838-42. German. No abstract available.

PMID:
1177687

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