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Items: 1 to 50 of 113

1.

Low thermal dependence of the contractile properties of a wing muscle in the bat Carollia perspicillata.

Rummel AD, Swartz SM, Marsh RL.

J Exp Biol. 2018 May 29. pii: jeb.180166. doi: 10.1242/jeb.180166. [Epub ahead of print]

PMID:
29844201
2.

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Stern D, Weisemann J, Le Blanc A, von Berg L, Mahrhold S, Piesker J, Laue M, Luppa PB, Dorner MB, Dorner BG, Rummel A.

PLoS Pathog. 2018 May 2;14(5):e1007048. doi: 10.1371/journal.ppat.1007048. eCollection 2018 May.

3.

Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.

Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R.

Pathog Dis. 2018 Jun 1;76(4). doi: 10.1093/femspd/fty044.

PMID:
29688327
4.

Novel in-situ lamella fabrication technique for in-situ TEM.

Canavan M, Daly D, Rummel A, McCarthy EK, McAuley C, Nicolosi V.

Ultramicroscopy. 2018 Jul;190:21-29. doi: 10.1016/j.ultramic.2018.03.024. Epub 2018 Mar 29.

PMID:
29660687
5.

Toxins 2017 conference in Madrid.

Albanese A, Cardoso F, Fujinaga Y, Jankovic J, Rummel A, Schiavo G.

Toxicon. 2018 Jun 1;147:1. doi: 10.1016/j.toxicon.2018.03.010. Epub 2018 Mar 20. No abstract available.

PMID:
29571683
6.

Do invasive plants structure microbial communities to accelerate decomposition in intermountain grasslands?

McTee MR, Lekberg Y, Mummey D, Rummel A, Ramsey PW.

Ecol Evol. 2017 Nov 21;7(24):11227-11235. doi: 10.1002/ece3.3608. eCollection 2017 Dec.

7.

The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.

Lam KH, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R.

Toxicon. 2018 Jun 1;147:19-26. doi: 10.1016/j.toxicon.2017.10.012. Epub 2017 Oct 16.

PMID:
29042313
8.

Strong indirect herbicide effects on mycorrhizal associations through plant community shifts and secondary invasions.

Lekberg Y, Wagner V, Rummel A, McLeod M, Ramsey PW.

Ecol Appl. 2017 Dec;27(8):2359-2368. doi: 10.1002/eap.1613. Epub 2017 Oct 26.

PMID:
28851018
9.

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M.

PLoS Pathog. 2017 Aug 11;13(8):e1006567. doi: 10.1371/journal.ppat.1006567. eCollection 2017 Aug.

10.

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R.

Sci Rep. 2017 Aug 7;7(1):7438. doi: 10.1038/s41598-017-07457-5.

11.

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Yao G, Lam KH, Perry K, Weisemann J, Rummel A, Jin R.

Toxins (Basel). 2017 Mar 8;9(3). pii: E93. doi: 10.3390/toxins9030093.

12.

Restoring ecological properties of acidic soils contaminated with elemental sulfur.

McTee MR, Lekberg Y, Bullington L, Rummel A, Mummey DL, Ramsey PW, Hinman NW.

Sci Total Environ. 2017 Jun 1;587-588:449-456. doi: 10.1016/j.scitotenv.2017.02.110. Epub 2017 Mar 1.

PMID:
28258748
13.

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindström M, Lista F, Lúquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC.

Toxins (Basel). 2017 Jan 18;9(1). pii: E38. doi: 10.3390/toxins9010038. Review.

14.

BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay.

Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A.

Neurotoxicology. 2017 Mar;59:1-8. doi: 10.1016/j.neuro.2016.12.008. Epub 2016 Dec 30.

PMID:
28043867
15.

Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.

Rummel A.

Curr Top Microbiol Immunol. 2017;406:1-37. doi: 10.1007/82_2016_48.

PMID:
27921176
16.

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry.

Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG.

Analyst. 2016 Sep 21;141(18):5281-97. doi: 10.1039/c6an00693k. Epub 2016 Jun 29.

PMID:
27353114
17.

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.

Mahrhold S, Bergström T, Stern D, Dorner BG, Åstot C, Rummel A.

Biochem J. 2016 Sep 1;473(17):2645-54. doi: 10.1042/BCJ20160439. Epub 2016 Jun 16.

PMID:
27313224
18.

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R.

Nat Struct Mol Biol. 2016 Jul;23(7):656-62. doi: 10.1038/nsmb.3245. Epub 2016 Jun 13.

19.

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin.

Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A.

Toxins (Basel). 2016 May 17;8(5). pii: E154. doi: 10.3390/toxins8050154.

20.

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test.

Weisemann J, Krez N, Fiebig U, Worbs S, Skiba M, Endermann T, Dorner MB, Bergström T, Muñoz A, Zegers I, Müller C, Jenkinson SP, Avondet MA, Delbrassinne L, Denayer S, Zeleny R, Schimmel H, Åstot C, Dorner BG, Rummel A.

Toxins (Basel). 2015 Nov 26;7(12):5035-54. doi: 10.3390/toxins7124861.

21.

Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test.

Worbs S, Fiebig U, Zeleny R, Schimmel H, Rummel A, Luginbühl W, Dorner BG.

Toxins (Basel). 2015 Nov 26;7(12):4935-66. doi: 10.3390/toxins7124857.

22.

Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN).

Bigalke H, Rummel A.

Toxins (Basel). 2015 Nov 25;7(12):4895-905. doi: 10.3390/toxins7124855.

23.

The long journey of botulinum neurotoxins into the synapse.

Rummel A.

Toxicon. 2015 Dec 1;107(Pt A):9-24. doi: 10.1016/j.toxicon.2015.09.009. Epub 2015 Sep 9.

PMID:
26363288
24.

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R.

Toxicon. 2015 Dec 1;107(Pt A):43-9. doi: 10.1016/j.toxicon.2015.08.003. Epub 2015 Aug 10.

25.

Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype.

Kull S, Schulz KM, Weisemann J, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG.

PLoS One. 2015 Feb 6;10(2):e0116381. doi: 10.1371/journal.pone.0116381. eCollection 2015.

26.

Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type.

Gonzalez-Escalona N, Thirunavukkarasu N, Singh A, Toro M, Brown EW, Zink D, Rummel A, Sharma SK.

Genome Announc. 2014 Dec 11;2(6). pii: e01275-14. doi: 10.1128/genomeA.01275-14.

27.

Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca²⁺ and GTPγS.

Balletta A, Lorenz D, Rummel A, Gerhard R, Bigalke H, Wegner F.

Toxicology. 2015 Feb 3;328:48-56. doi: 10.1016/j.tox.2014.12.006. Epub 2014 Dec 11.

PMID:
25497110
28.

Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.

Matsui T, Gu S, Lam KH, Carter LG, Rummel A, Mathews II, Jin R.

J Mol Biol. 2014 Nov 11;426(22):3773-3782. doi: 10.1016/j.jmb.2014.09.009. Epub 2014 Sep 18.

29.

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.

Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R.

Science. 2014 Jun 20;344(6190):1405-10. doi: 10.1126/science.1253823.

30.

High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex.

Lee K, Lam KH, Kruel AM, Perry K, Rummel A, Jin R.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):568-73. doi: 10.1016/j.bbrc.2014.03.008. Epub 2014 Mar 12.

31.

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.

Strotmeier J, Mahrhold S, Krez N, Janzen C, Lou J, Marks JD, Binz T, Rummel A.

FEBS Lett. 2014 Apr 2;588(7):1087-93. doi: 10.1016/j.febslet.2014.02.034. Epub 2014 Feb 25.

32.

Cost variability of suggested generic treatment alternatives under the Medicare Part D benefit.

Patel RA, Walberg MP, Tong E, Tan F, Rummel AE, Woelfel JA, Carr-Lopez SM, Galal SM.

J Manag Care Spec Pharm. 2014 Mar;20(3):283-90.

33.

Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPγS containing intracellular solution.

Balletta A, Lorenz D, Rummel A, Gerhard R, Bigalke H, Wegner F.

Eur J Pharmacol. 2013 Nov 15;720(1-3):227-36. doi: 10.1016/j.ejphar.2013.10.022. Epub 2013 Oct 24.

PMID:
24406507
34.

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.

FEBS Lett. 2013 Nov 29;587(23):3831-6. doi: 10.1016/j.febslet.2013.10.010. Epub 2013 Oct 21.

35.

Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity.

Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R.

PLoS Pathog. 2013;9(10):e1003690. doi: 10.1371/journal.ppat.1003690. Epub 2013 Oct 10.

36.

Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity.

Stevens GB, Silver DA, Zgaga-Griesz A, Bessler WG, Vashist SK, Patel P, Achazi K, Strotmeier J, Worbs S, Dorner MB, Dorner BG, Pauly D, Rummel A, Urban GA, Krueger M.

Analyst. 2013 Oct 21;138(20):6154-62. doi: 10.1039/c3an00525a.

PMID:
23971072
37.

Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.

Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.

Toxicon. 2013 Dec 1;75:108-21. doi: 10.1016/j.toxicon.2013.06.010. Epub 2013 Jun 29.

PMID:
23817019
38.

Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples.

Bagramyan K, Kaplan BE, Cheng LW, Strotmeier J, Rummel A, Kalkum M.

Anal Chem. 2013 Jun 4;85(11):5569-76. doi: 10.1021/ac4008418. Epub 2013 May 22.

39.

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.

Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.

Biochemistry. 2013 Jun 4;52(22):3930-8. doi: 10.1021/bi4003502. Epub 2013 May 17.

PMID:
23647335
40.

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T.

Biochem J. 2013 Jul 1;453(1):37-47. doi: 10.1042/BJ20130391.

PMID:
23621114
41.

Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.

Rummel A.

Curr Top Microbiol Immunol. 2013;364:61-90. doi: 10.1007/978-3-642-33570-9_4.

PMID:
23239349
42.

Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.

Gu S, Rumpel S, Zhou J, Strotmeier J, Bigalke H, Perry K, Shoemaker CB, Rummel A, Jin R.

Science. 2012 Feb 24;335(6071):977-81. doi: 10.1126/science.1214270.

43.

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity.

Strotmeier J, Willjes G, Binz T, Rummel A.

FEBS Lett. 2012 Feb 17;586(4):310-3. doi: 10.1016/j.febslet.2011.12.037. Epub 2012 Jan 16.

44.

Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion.

Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D.

J Cell Sci. 2011 Sep 15;124(Pt 18):3066-73. doi: 10.1242/jcs.074963. Epub 2011 Aug 18.

45.

Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.

Rummel A, Mahrhold S, Bigalke H, Binz T.

FEBS J. 2011 Dec;278(23):4506-15. doi: 10.1111/j.1742-4658.2011.08196.x. Epub 2011 Jun 22.

46.

Calculations of pKa of superacids in 1,2-dichloroethane.

Trummal A, Rummel A, Lippmaa E, Koppel I, Koppel IA.

J Phys Chem A. 2011 Jun 23;115(24):6641-5. doi: 10.1021/jp202434p. Epub 2011 May 25.

PMID:
21612234
47.

The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.

Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.

Mol Microbiol. 2011 Jul;81(1):143-56. doi: 10.1111/j.1365-2958.2011.07682.x. Epub 2011 Jun 2.

48.

Quasi-static and harmonic indentation of osteonal bone.

Huja SS, Hay JL, Rummel AM, Beck FM.

J Dent Biomech. 2010 Feb 17;2010:736830. doi: 10.4061/2010/736830.

49.

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.

Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18197-201. doi: 10.1073/pnas.1007125107. Epub 2010 Oct 4.

50.

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.

Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.

Biochem J. 2010 Oct 15;431(2):207-16. doi: 10.1042/BJ20101042.

PMID:
20704566

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