Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 89


The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases.

Mishra S, Bernal C, Silvano M, Anand S, Ruiz I Altaba A.

Oncogene. 2019 Jul;38(29):5817-5837. doi: 10.1038/s41388-019-0845-z. Epub 2019 Jun 28.


Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer.

Nowak-Sliwinska P, Scapozza L, Ruiz I Altaba A.

Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):434-454. doi: 10.1016/j.bbcan.2019.04.005. Epub 2019 Apr 26. Review.


Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner.

Kuciak M, Mas C, Borges I, Sánchez-Gómez P, Ruiz I Altaba A.

Sci Rep. 2019 Mar 7;9(1):3891. doi: 10.1038/s41598-019-39473-y.


Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells.

Seth C, Mas C, Conod A, Mueller J, Siems K, Kuciak M, Borges I, Ruiz I Altaba A.

PLoS One. 2016 Dec 14;11(12):e0168170. doi: 10.1371/journal.pone.0168170. eCollection 2016.


Correction: Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling.

Seth C, Ruiz I Altaba A.

PLoS One. 2016 Aug 4;11(8):e0160904. doi: 10.1371/journal.pone.0160904. eCollection 2016.


Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling.

Seth C, Ruiz i Altaba A.

PLoS One. 2016 Mar 3;11(3):e0150697. doi: 10.1371/journal.pone.0150697. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0160904.


In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases.

Singovski G, Bernal C, Kuciak M, Siegl-Cachedenier I, Conod A, Ruiz I Altaba A.

J Mol Cell Biol. 2016 Apr;8(2):157-73. doi: 10.1093/jmcb/mjv034. Epub 2015 Jun 1.


Alberto Gulino MD, PhD (1952-2014).

Toftgård R, Ruiz I Altaba A.

Cell Death Differ. 2015 Jun;22(6):887. doi: 10.1038/cdd.2015.29. No abstract available.


The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.

Melotti A, Mas C, Kuciak M, Lorente-Trigos A, Borges I, Ruiz i Altaba A.

EMBO Mol Med. 2014 Oct;6(10):1263-78. doi: 10.15252/emmm.201404084.


A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.

Duquet A, Melotti A, Mishra S, Malerba M, Seth C, Conod A, Ruiz i Altaba A.

EMBO Mol Med. 2014 Jul;6(7):882-901. doi: 10.15252/emmm.201303799.


Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy.

Aberger F, Ruiz I Altaba A.

Semin Cell Dev Biol. 2014 Sep;33:93-104. doi: 10.1016/j.semcdb.2014.05.003. Epub 2014 May 19. Review.


Morphogenetic action through flux-limited spreading.

Verbeni M, Sánchez O, Mollica E, Siegl-Cachedenier I, Carleton A, Guerrero I, Ruiz i Altaba A, Soler J.

Phys Life Rev. 2013 Dec;10(4):457-75. doi: 10.1016/j.plrev.2013.06.004. Epub 2013 Jun 25.


Hedgehog signaling and the Gli code in stem cells, cancer, and metastases.

Ruiz i Altaba A.

Sci Signal. 2011 Nov 22;4(200):pt9. doi: 10.1126/scisignal.2002540.


BMP signaling promotes the growth of primary human colon carcinomas in vivo.

Lorente-Trigos A, Varnat F, Melotti A, Ruiz i Altaba A.

J Mol Cell Biol. 2010 Dec;2(6):318-32. doi: 10.1093/jmcb/mjq035.


Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas.

Varnat F, Siegl-Cachedenier I, Malerba M, Gervaz P, Ruiz i Altaba A.

EMBO Mol Med. 2010 Nov;2(11):440-57. doi: 10.1002/emmm.201000098.


NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53.

Zbinden M, Duquet A, Lorente-Trigos A, Ngwabyt SN, Borges I, Ruiz i Altaba A.

EMBO J. 2010 Aug 4;29(15):2659-74. doi: 10.1038/emboj.2010.137. Epub 2010 Jun 25.


Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations.

Mas C, Ruiz i Altaba A.

Biochem Pharmacol. 2010 Sep 1;80(5):712-23. doi: 10.1016/j.bcp.2010.04.016. Epub 2010 Apr 20. Review.


Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals.

Stecca B, Ruiz I Altaba A.

J Mol Cell Biol. 2010 Apr;2(2):84-95. doi: 10.1093/jmcb/mjp052. Epub 2010 Jan 17. Review.


Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.

Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A.

EMBO Mol Med. 2009 Sep;1(6-7):338-51. doi: 10.1002/emmm.200900039.


Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.

Varnat F, Zacchetti G, Ruiz i Altaba A.

Mech Dev. 2010 Jan-Feb;127(1-2):73-81. doi: 10.1016/j.mod.2009.10.005. Epub 2009 Oct 25.


Entity versus property: tracking the nature, genesis and role of stem cells in cancer. Conference on Stem cells and cancer.

Ruiz i Altaba A, Brand AH.

EMBO Rep. 2009 Aug;10(8):832-6. doi: 10.1038/embor.2009.169. Epub 2009 Jul 17. No abstract available.


A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers.

Stecca B, Ruiz i Altaba A.

EMBO J. 2009 Mar 18;28(6):663-76. doi: 10.1038/emboj.2009.16. Epub 2009 Feb 12.


Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Ruiz i Altaba A.

Cancer Cell. 2008 Oct 7;14(4):281-3. doi: 10.1016/j.ccr.2008.09.007.


Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP.

De Toni A, Zbinden M, Epstein JA, Ruiz i Altaba A, Prochiantz A, Caillé I.

Neural Dev. 2008 May 28;3:13. doi: 10.1186/1749-8104-3-13.


The Gli code: an information nexus regulating cell fate, stemness and cancer.

Ruiz i Altaba A, Mas C, Stecca B.

Trends Cell Biol. 2007 Sep;17(9):438-47. Epub 2007 Sep 12. Review.


Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, Beermann F, Ruiz I Altaba A.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5895-900. Epub 2007 Mar 28.


HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.

Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A.

Curr Biol. 2007 Jan 23;17(2):165-72. Epub 2006 Dec 28. Erratum in: Curr Biol. 2007 Jan 23;17(2):192.


Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors.

Stecca B, Ruiz i Altaba A.

J Neurobiol. 2005 Sep 15;64(4):476-90. Review.


Cooperative requirement of the Gli proteins in neurogenesis.

Nguyen V, Chokas AL, Stecca B, Ruiz i Altaba A.

Development. 2005 Jul;132(14):3267-79.


Interference with HH-GLI signaling inhibits prostate cancer.

Stecca B, Mas C, Ruiz i Altaba A.

Trends Mol Med. 2005 May;11(5):199-203. Review.


Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer.

Sanchez P, Clement V, Ruiz i Altaba A.

Cancer Res. 2005 Apr 15;65(8):2990-2. Review.


Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.

Palma V, Lim DA, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A.

Development. 2005 Jan;132(2):335-44. Epub 2004 Dec 16.


Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.

Sanchez P, Hernández AM, Stecca B, Kahler AJ, DeGueme AM, Barrett A, Beyna M, Datta MW, Datta S, Ruiz i Altaba A.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12561-6. Epub 2004 Aug 16.


Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer.

Ruiz i Altaba A, Stecca B, Sánchez P.

Cancer Lett. 2004 Feb 20;204(2):145-57.


Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

Palma V, Ruiz i Altaba A.

Development. 2004 Jan;131(2):337-45. Epub 2003 Dec 17.


Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.

Roessler E, Du YZ, Mullor JL, Casas E, Allen WP, Gillessen-Kaesbach G, Roeder ER, Ming JE, Ruiz i Altaba A, Muenke M.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13424-9. Epub 2003 Oct 27.


The emergent design of the neural tube: prepattern, SHH morphogen and GLI code.

Ruiz i Altaba A, Nguyên V, Palma V.

Curr Opin Genet Dev. 2003 Oct;13(5):513-21. Review.


Development. Longing for ligand: hedgehog, patched, and cell death.

Guerrero I, Ruiz i Altaba A.

Science. 2003 Aug 8;301(5634):774-6. No abstract available.


Pathways and consequences: Hedgehog signaling in human disease.

Mullor JL, Sánchez P, Ruiz i Altaba A.

Trends Cell Biol. 2002 Dec;12(12):562-9. Review.


A gene expression map of human chromosome 21 orthologues in the mouse.

Gitton Y, Dahmane N, Baik S, Ruiz i Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML; HSA21 expression map initiative.

Nature. 2002 Dec 5;420(6915):586-90.


The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway.

Stecca B, Ruiz i Altaba A.

J Biol. 2002 Nov 6;1(2):9. Review.


Gli and hedgehog in cancer: tumours, embryos and stem cells.

Ruiz i Altaba A, Sánchez P, Dahmane N.

Nat Rev Cancer. 2002 May;2(5):361-72. Review.


Hedgehog-Gli signalling and the growth of the brain.

Ruiz i Altaba A, Palma V, Dahmane N.

Nat Rev Neurosci. 2002 Jan;3(1):24-33. Review.


Growth, hedgehog and the price of GAS.

Mullor JL, Ruiz i Altaba A.

Bioessays. 2002 Jan;24(1):22-6.


The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.

Dahmane N, Sánchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz i Altaba A.

Development. 2001 Dec;128(24):5201-12.


Embryonic regionalization of the neocortex.

Ruiz i Altaba A, Gitton Y, Dahmane N.

Mech Dev. 2001 Sep;107(1-2):3-11. Review.


Wnt signals are targets and mediators of Gli function.

Mullor JL, Dahmane N, Sun T, Ruiz i Altaba A.

Curr Biol. 2001 May 15;11(10):769-73.


Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS.

Brewster R, Ruiz i Altaba A.

Mech Dev. 2000 Dec;99(1-2):159-62.


Gli2 functions in FGF signaling during antero-posterior patterning.

Brewster R, Mullor JL, Ruiz i Altaba A.

Development. 2000 Oct;127(20):4395-405.

Supplemental Content

Loading ...
Support Center