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Items: 23

1.

Impaired microRNA processing in neutrophils from rheumatoid arthritis patients confers their pathogenic profile. Modulation by biological therapies.

Arias de la Rosa I, Perez-Sanchez C, Ruiz-Limon P, Patiño-Trives A, Torres-Granados C, Jimenez-Gomez Y, Abalos-Aguilera MDC, Cecchi I, Ortega R, Caracuel MA, Calvo-Gutierrez J, Escudero-Contreras A, Collantes-Estevez E, Lopez-Pedrera C, Barbarroja N.

Haematologica. 2020 Jan 16. pii: haematol.2018.205047. doi: 10.3324/haematol.2018.205047. [Epub ahead of print]

2.

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis.

Ruiz-Limon P, Ortega-Castro R, Barbarroja N, Perez-Sanchez C, Jamin C, Patiño-Trives AM, Luque-Tevar M, Ibáñez-Costa A, Perez-Sanchez L, de la Rosa IA, Abalos-Aguilera M, Jimenez-Gomez Y, Calvo-Gutierrez J, Font P, Escudero-Contreras A, Alarcon-Riquelme ME, Collantes-Estevez E, López-Pedrera C; PRECISESADS Clinical Consortium and Flow Cytometry Study Group.

Front Immunol. 2019 May 21;10:1111. doi: 10.3389/fimmu.2019.01111. eCollection 2019.

3.

Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome.

Pérez-Sánchez C, Arias-de la Rosa I, Aguirre MÁ, Luque-Tévar M, Ruiz-Limón P, Barbarroja N, Jiménez-Gómez Y, Ábalos-Aguilera MC, Collantes-Estévez E, Segui P, Velasco F, Herranz MT, Lozano-Herrero J, Hernandez-Vidal MJ, Martínez C, González-Conejero R, Radin M, Sciascia S, Cecchi I, Cuadrado MJ, López-Pedrera C.

Haematologica. 2018 May;103(5):908-918. doi: 10.3324/haematol.2017.184416. Epub 2018 Mar 15.

4.

Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues.

Arias de la Rosa I, Escudero-Contreras A, Rodríguez-Cuenca S, Ruiz-Ponce M, Jiménez-Gómez Y, Ruiz-Limón P, Pérez-Sánchez C, Ábalos-Aguilera MC, Cecchi I, Ortega R, Calvo J, Guzmán-Ruiz R, Malagón MM, Collantes-Estevez E, Vidal-Puig A, López-Pedrera C, Barbarroja N.

J Intern Med. 2018 Jul;284(1):61-77. doi: 10.1111/joim.12743. Epub 2018 Mar 12.

PMID:
29532531
5.

Circulating microRNAs as potential biomarkers of disease activity and structural damage in ankylosing spondylitis patients.

Perez-Sanchez C, Font-Ugalde P, Ruiz-Limon P, Lopez-Pedrera C, Castro-Villegas MC, Abalos-Aguilera MC, Barbarroja N, Arias-de la Rosa I, Lopez-Montilla MD, Escudero-Contreras A, Lopez-Medina C, Collantes-Estevez E, Jimenez-Gomez Y.

Hum Mol Genet. 2018 Mar 1;27(5):875-890. doi: 10.1093/hmg/ddy008.

PMID:
29329380
6.

Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.

Pérez-Sánchez C, Aguirre MÁ, Ruiz-Limón P, Ábalos-Aguilera MC, Jiménez-Gómez Y, Arias-de la Rosa I, Rodriguez-Ariza A, Fernández-Del Río L, González-Reyes JA, Segui P, Collantes-Estévez E, Barbarroja N, Velasco F, Sciascia S, Cecchi I, Cuadrado MJ, Villalba JM, López-Pedrera C.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1923-1932. doi: 10.1161/ATVBAHA.117.309225. Epub 2017 Jul 6.

PMID:
28684614
7.

Diagnostic potential of NETosis-derived products for disease activity, atherosclerosis and therapeutic effectiveness in Rheumatoid Arthritis patients.

Pérez-Sánchez C, Ruiz-Limón P, Aguirre MA, Jiménez-Gómez Y, Arias-de la Rosa I, Ábalos-Aguilera MC, Rodriguez-Ariza A, Castro-Villegas MC, Ortega-Castro R, Segui P, Martinez C, Gonzalez-Conejero R, Rodríguez-López S, Gonzalez-Reyes JA, Villalba JM, Collantes-Estévez E, Escudero A, Barbarroja N, López-Pedrera C.

J Autoimmun. 2017 Aug;82:31-40. doi: 10.1016/j.jaut.2017.04.007. Epub 2017 Apr 29.

PMID:
28465139
8.

Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation.

Ruiz-Limón P, Ortega R, Arias de la Rosa I, Abalos-Aguilera MDC, Perez-Sanchez C, Jimenez-Gomez Y, Peralbo-Santaella E, Font P, Ruiz-Vilches D, Ferrin G, Collantes-Estevez E, Escudero-Contreras A, López-Pedrera C, Barbarroja N.

Transl Res. 2017 May;183:87-103. doi: 10.1016/j.trsl.2016.12.003. Epub 2016 Dec 9.

PMID:
28027930
9.

'Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients'.

Pérez-Sánchez C, Aguirre MA, Ruiz-Limón P, Barbarroja N, Jiménez-Gómez Y, de la Rosa IA, Rodriguez-Ariza A, Collantes-Estévez E, Segui P, Velasco F, Cuadrado MJ, Teruel R, González-Conejero R, Martínez C, López-Pedrera Ch.

Sci Rep. 2016 Aug 9;6:31375. doi: 10.1038/srep31375.

10.

Immunotherapy in antiphospholipid syndrome.

Lopez-Pedrera Ch, Aguirre MA, Ruiz-Limon P, Pérez-Sánchez C, Jimenez-Gomez Y, Barbarroja N, Cuadrado MJ.

Int Immunopharmacol. 2015 Aug;27(2):200-8. doi: 10.1016/j.intimp.2015.06.006. Epub 2015 Jun 15. Review.

PMID:
26086363
11.

Circulating miRNAs as potential biomarkers of therapy effectiveness in rheumatoid arthritis patients treated with anti-TNFα.

Castro-Villegas C, Pérez-Sánchez C, Escudero A, Filipescu I, Verdu M, Ruiz-Limón P, Aguirre MA, Jiménez-Gomez Y, Font P, Rodriguez-Ariza A, Peinado JR, Collantes-Estévez E, González-Conejero R, Martinez C, Barbarroja N, López-Pedrera C.

Arthritis Res Ther. 2015 Mar 9;17:49. doi: 10.1186/s13075-015-0555-z.

12.

Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis.

Pericleous C, Ruiz-Limón P, Romay-Penabad Z, Marín AC, Garza-Garcia A, Murfitt L, Driscoll PC, Latchman DS, Isenberg DA, Giles I, Ioannou Y, Rahman A, Pierangeli SS.

Rheumatology (Oxford). 2015 Apr;54(4):722-7. doi: 10.1093/rheumatology/keu360. Epub 2014 Sep 30.

13.

Anticyclic citrullinated protein antibodies are implicated in the development of cardiovascular disease in rheumatoid arthritis.

Barbarroja N, Pérez-Sanchez C, Ruiz-Limon P, Castro-Villegas C, Aguirre MA, Carretero R, Segui P, Jimenez-Gomez Y, Sanna M, Rodriguez-Ariza A, Collantes-Estevez E, Escudero A, López-Pedrera C.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2706-16. doi: 10.1161/ATVBAHA.114.304475. Epub 2014 Sep 25.

PMID:
25256232
14.

Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment.

Ruiz-Limon P, Barbarroja N, Perez-Sanchez C, Aguirre MA, Bertolaccini ML, Khamashta MA, Rodriguez-Ariza A, Almadén Y, Segui P, Khraiwesh H, Gonzalez-Reyes JA, Villalba JM, Collantes-Estevez E, Cuadrado MJ, Lopez-Pedrera C.

Ann Rheum Dis. 2015 Jul;74(7):1450-8. doi: 10.1136/annrheumdis-2013-204351. Epub 2014 Mar 21.

PMID:
24658835
15.

Gene profiling reveals specific molecular pathways in the pathogenesis of atherosclerosis and cardiovascular disease in antiphospholipid syndrome, systemic lupus erythematosus and antiphospholipid syndrome with lupus.

Perez-Sanchez C, Barbarroja N, Messineo S, Ruiz-Limon P, Rodriguez-Ariza A, Jimenez-Gomez Y, Khamashta MA, Collantes-Estevez E, Cuadrado MJ, Aguirre MA, Lopez-Pedrera C.

Ann Rheum Dis. 2015 Jul;74(7):1441-9. doi: 10.1136/annrheumdis-2013-204600. Epub 2014 Mar 11.

PMID:
24618261
16.

Value of isolated IgA anti-β2 -glycoprotein I positivity in the diagnosis of the antiphospholipid syndrome.

Murthy V, Willis R, Romay-Penabad Z, Ruiz-Limón P, Martínez-Martínez LA, Jatwani S, Jajoria P, Seif A, Alarcón GS, Papalardo E, Liu J, Vilá LM, McGwin G Jr, McNearney TA, Maganti R, Sunkureddi P, Parekh T, Tarantino M, Akhter E, Fang H, Gonzalez EB, Binder WR, Norman GL, Shums Z, Teodorescu M, Reveille JD, Petri M, Pierangeli SS.

Arthritis Rheum. 2013 Dec;65(12):3186-93. doi: 10.1002/art.38131.

17.

A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients.

Erkan D, Willis R, Murthy VL, Basra G, Vega J, Ruiz-Limón P, Carrera AL, Papalardo E, Martínez-Martínez LA, González EB, Pierangeli SS.

Ann Rheum Dis. 2014 Jun;73(6):1176-80. doi: 10.1136/annrheumdis-2013-203622. Epub 2013 Aug 9.

18.

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment.

Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, Bertolaccini ML, Khamashta MA, Rodriguez-Ariza A, Segui P, Collantes-Estevez E, Barbarroja N, Khraiwesh H, Gonzalez-Reyes JA, Villalba JM, Velasco F, Cuadrado MJ, Lopez-Pedrera C.

Blood. 2012 Jun 14;119(24):5859-70. doi: 10.1182/blood-2011-12-400986. Epub 2012 Apr 23.

PMID:
22529290
19.

To cardiovascular disease and beyond: new therapeutic perspectives of statins in autoimmune diseases and cancer.

Lopez-Pedrera C, Ruiz-Limon P, Valverde-Estepa A, Barbarroja N, Rodriguez-Ariza A.

Curr Drug Targets. 2012 Jun;13(6):829-41. Review.

PMID:
22250652
20.

Potential use of statins in the treatment of antiphospholipid syndrome.

Lopez-Pedrera C, Ruiz-Limon P, Aguirre MA, Rodriguez-Ariza A, Cuadrado MJ.

Curr Rheumatol Rep. 2012 Feb;14(1):87-94. doi: 10.1007/s11926-011-0222-6. Review.

PMID:
22105548
21.

Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome.

López-Pedrera C, Ruiz-Limón P, Aguirre MÁ, Barbarroja N, Pérez-Sánchez C, Buendía P, Rodriguez-García IC, Rodriguez-Ariza A, Collantes-Estevez E, Velasco F, Khasmahta M, Cuadrado MJ.

Ann Rheum Dis. 2011 Apr;70(4):675-82. doi: 10.1136/ard.2010.135525. Epub 2010 Dec 20.

PMID:
21173016
22.

AEE788 is a vascular endothelial growth factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute myeloid leukemia.

Barbarroja N, Torres LA, Rodriguez-Ariza A, Valverde-Estepa A, Lopez-Sanchez LM, Ruiz-Limon P, Perez-Sanchez C, Carretero RM, Velasco F, López-Pedrera C.

Exp Hematol. 2010 Aug;38(8):641-52. doi: 10.1016/j.exphem.2010.03.017. Epub 2010 Apr 7.

PMID:
20380868
23.

Differential expression of protease-activated receptors in monocytes from patients with primary antiphospholipid syndrome.

López-Pedrera C, Aguirre MA, Buendía P, Barbarroja N, Ruiz-Limón P, Collantes-Estevez E, Velasco F, Khamashta M, Cuadrado MJ.

Arthritis Rheum. 2010 Mar;62(3):869-77. doi: 10.1002/art.27299.

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