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Items: 1 to 50 of 172

1.

Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.

Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10968-10977. doi: 10.1073/pnas.1901214116. Epub 2019 May 10.

PMID:
31076555
2.

Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication.

Desfosses A, Milles S, Jensen MR, Guseva S, Colletier JP, Maurin D, Schoehn G, Gutsche I, Ruigrok RWH, Blackledge M.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201816417. doi: 10.1073/pnas.1816417116. [Epub ahead of print]

PMID:
30787192
3.

An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function.

Milles S, Jensen MR, Lazert C, Guseva S, Ivashchenko S, Communie G, Maurin D, Gerlier D, Ruigrok RWH, Blackledge M.

Sci Adv. 2018 Aug 22;4(8):eaat7778. doi: 10.1126/sciadv.aat7778. eCollection 2018 Aug.

4.

Structural analysis of the complex between influenza B nucleoprotein and human importin-α.

Labaronne A, Milles S, Donchet A, Jensen MR, Blackledge M, Bourhis JM, Ruigrok RWH, Crépin T.

Sci Rep. 2017 Dec 7;7(1):17164. doi: 10.1038/s41598-017-17458-z.

5.

Binding of RNA by the Nucleoproteins of Influenza Viruses A and B.

Labaronne A, Swale C, Monod A, Schoehn G, Crépin T, Ruigrok RW.

Viruses. 2016 Sep 13;8(9). pii: E247. doi: 10.3390/v8090247.

6.

Self-Assembly of Measles Virus Nucleocapsid-like Particles: Kinetics and RNA Sequence Dependence.

Milles S, Jensen MR, Communie G, Maurin D, Schoehn G, Ruigrok RW, Blackledge M.

Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9356-60. doi: 10.1002/anie.201602619. Epub 2016 Jun 6.

PMID:
27270664
7.

Identification of Dynamic Modes in an Intrinsically Disordered Protein Using Temperature-Dependent NMR Relaxation.

Abyzov A, Salvi N, Schneider R, Maurin D, Ruigrok RW, Jensen MR, Blackledge M.

J Am Chem Soc. 2016 May 18;138(19):6240-51. doi: 10.1021/jacs.6b02424. Epub 2016 May 6.

PMID:
27112095
8.

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T.

Sci Rep. 2016 Apr 20;6:24727. doi: 10.1038/srep24727.

9.

Structural virology. Near-atomic cryo-EM structure of the helical measles virus nucleocapsid.

Gutsche I, Desfosses A, Effantin G, Ling WL, Haupt M, Ruigrok RW, Sachse C, Schoehn G.

Science. 2015 May 8;348(6235):704-7. doi: 10.1126/science.aaa5137. Epub 2015 Apr 16.

10.

Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.

Monod A, Swale C, Tarus B, Tissot A, Delmas B, Ruigrok RW, Crépin T, Slama-Schwok A.

Expert Opin Drug Discov. 2015 Apr;10(4):345-71. doi: 10.1517/17460441.2015.1019859. Review.

PMID:
25792362
11.

Visualizing the molecular recognition trajectory of an intrinsically disordered protein using multinuclear relaxation dispersion NMR.

Schneider R, Maurin D, Communie G, Kragelj J, Hansen DF, Ruigrok RW, Jensen MR, Blackledge M.

J Am Chem Soc. 2015 Jan 28;137(3):1220-9. doi: 10.1021/ja511066q. Epub 2015 Jan 16.

PMID:
25551399
12.

Structural insight into cap-snatching and RNA synthesis by influenza polymerase.

Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S.

Nature. 2014 Dec 18;516(7531):361-6. doi: 10.1038/nature14009. Epub 2014 Nov 19.

PMID:
25409151
13.

Insights into the structure and dynamics of measles virus nucleocapsids by 1H-detected solid-state NMR.

Barbet-Massin E, Felletti M, Schneider R, Jehle S, Communie G, Martinez N, Jensen MR, Ruigrok RW, Emsley L, Lesage A, Blackledge M, Pintacuda G.

Biophys J. 2014 Aug 19;107(4):941-6. doi: 10.1016/j.bpj.2014.05.048.

14.

Structure of Nipah virus unassembled nucleoprotein in complex with its viral chaperone.

Yabukarski F, Lawrence P, Tarbouriech N, Bourhis JM, Delaforge E, Jensen MR, Ruigrok RW, Blackledge M, Volchkov V, Jamin M.

Nat Struct Mol Biol. 2014 Sep;21(9):754-9. doi: 10.1038/nsmb.2868. Epub 2014 Aug 10.

PMID:
25108352
15.

Editorial overview: virus structure and function.

Chiu W, Crépin T, Ruigrok RW.

Curr Opin Virol. 2014 Apr;5:viii-ix. doi: 10.1016/j.coviro.2014.03.003. Epub 2014 Apr 13. No abstract available.

16.

Intrinsically disordered proteins implicated in paramyxoviral replication machinery.

Communie G, Ruigrok RW, Jensen MR, Blackledge M.

Curr Opin Virol. 2014 Apr;5:72-81. doi: 10.1016/j.coviro.2014.02.001. Epub 2014 Mar 13. Review.

PMID:
24631901
17.

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains.

Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S.

PLoS One. 2014 Jan 15;9(1):e84973. doi: 10.1371/journal.pone.0084973. eCollection 2014.

18.

Influenza virus nucleoprotein: structure, RNA binding, oligomerization and antiviral drug target.

Chenavas S, Crépin T, Delmas B, Ruigrok RW, Slama-Schwok A.

Future Microbiol. 2013 Dec;8(12):1537-45. doi: 10.2217/fmb.13.128. Review.

PMID:
24266354
19.

Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.

Communie G, Habchi J, Yabukarski F, Blocquel D, Schneider R, Tarbouriech N, Papageorgiou N, Ruigrok RW, Jamin M, Jensen MR, Longhi S, Blackledge M.

PLoS Pathog. 2013;9(9):e1003631. doi: 10.1371/journal.ppat.1003631. Epub 2013 Sep 26.

20.

Structure of the C-terminal domain of lettuce necrotic yellows virus phosphoprotein.

Martinez N, Ribeiro EA Jr, Leyrat C, Tarbouriech N, Ruigrok RW, Jamin M.

J Virol. 2013 Sep;87(17):9569-78. doi: 10.1128/JVI.00999-13. Epub 2013 Jun 19.

21.

Structure of the tetramerization domain of measles virus phosphoprotein.

Communie G, Crépin T, Maurin D, Jensen MR, Blackledge M, Ruigrok RW.

J Virol. 2013 Jun;87(12):7166-9. doi: 10.1128/JVI.00487-13. Epub 2013 Apr 10.

22.

Monomeric nucleoprotein of influenza A virus.

Chenavas S, Estrozi LF, Slama-Schwok A, Delmas B, Di Primo C, Baudin F, Li X, Crépin T, Ruigrok RW.

PLoS Pathog. 2013 Mar;9(3):e1003275. doi: 10.1371/journal.ppat.1003275. Epub 2013 Mar 28.

23.

Describing intrinsically disordered proteins at atomic resolution by NMR.

Jensen MR, Ruigrok RW, Blackledge M.

Curr Opin Struct Biol. 2013 Jun;23(3):426-35. doi: 10.1016/j.sbi.2013.02.007. Epub 2013 Mar 29. Review.

PMID:
23545493
24.

Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus.

Lejal N, Tarus B, Bouguyon E, Chenavas S, Bertho N, Delmas B, Ruigrok RW, Di Primo C, Slama-Schwok A.

Antimicrob Agents Chemother. 2013 May;57(5):2231-42. doi: 10.1128/AAC.02335-12. Epub 2013 Mar 4.

25.

Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape.

Desfosses A, Ribeiro EA Jr, Schoehn G, Blondel D, Guilligay D, Jamin M, Ruigrok RW, Gutsche I.

Nat Commun. 2013;4:1429. doi: 10.1038/ncomms2435.

PMID:
23385574
26.

Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase.

Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S.

PLoS Pathog. 2012;8(8):e1002831. doi: 10.1371/journal.ppat.1002831. Epub 2012 Aug 2.

27.

Ensemble structure of the modular and flexible full-length vesicular stomatitis virus phosphoprotein.

Leyrat C, Schneider R, Ribeiro EA Jr, Yabukarski F, Yao M, Gérard FC, Jensen MR, Ruigrok RW, Blackledge M, Jamin M.

J Mol Biol. 2012 Oct 19;423(2):182-97. doi: 10.1016/j.jmb.2012.07.003. Epub 2012 Jul 9.

PMID:
22789567
28.

Three-dimensional structure of the Epstein-Barr virus capsid.

Germi R, Effantin G, Grossi L, Ruigrok RW, Morand P, Schoehn G.

J Gen Virol. 2012 Aug;93(Pt 8):1769-73. doi: 10.1099/vir.0.043265-0. Epub 2012 May 16.

PMID:
22592267
29.

Oligomerization paths of the nucleoprotein of influenza A virus.

Tarus B, Bakowiez O, Chenavas S, Duchemin L, Estrozi LF, Bourdieu C, Lejal N, Bernard J, Moudjou M, Chevalier C, Delmas B, Ruigrok RW, Di Primo C, Slama-Schwok A.

Biochimie. 2012 Mar;94(3):776-85. doi: 10.1016/j.biochi.2011.11.009. Epub 2011 Nov 29.

PMID:
22155087
30.

Structural insights into the rhabdovirus transcription/replication complex.

Ivanov I, Yabukarski F, Ruigrok RW, Jamin M.

Virus Res. 2011 Dec;162(1-2):126-37. doi: 10.1016/j.virusres.2011.09.025. Epub 2011 Sep 22. Review.

PMID:
21963663
31.

Structure of the vesicular stomatitis virus N⁰-P complex.

Leyrat C, Yabukarski F, Tarbouriech N, Ribeiro EA Jr, Jensen MR, Blackledge M, Ruigrok RW, Jamin M.

PLoS Pathog. 2011 Sep;7(9):e1002248. doi: 10.1371/journal.ppat.1002248. Epub 2011 Sep 22.

32.

Nucleoproteins and nucleocapsids of negative-strand RNA viruses.

Ruigrok RW, Crépin T, Kolakofsky D.

Curr Opin Microbiol. 2011 Aug;14(4):504-10. doi: 10.1016/j.mib.2011.07.011. Epub 2011 Aug 6. Review.

PMID:
21824806
33.

Intrinsic disorder in measles virus nucleocapsids.

Jensen MR, Communie G, Ribeiro EA Jr, Martinez N, Desfosses A, Salmon L, Mollica L, Gabel F, Jamin M, Longhi S, Ruigrok RW, Blackledge M.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9839-44. doi: 10.1073/pnas.1103270108. Epub 2011 May 25.

34.

Rabies virus transcription and replication.

Albertini AA, Ruigrok RW, Blondel D.

Adv Virus Res. 2011;79:1-22. doi: 10.1016/B978-0-12-387040-7.00001-9. Review.

PMID:
21601039
35.

The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices.

Leyrat C, Jensen MR, Ribeiro EA Jr, Gérard FC, Ruigrok RW, Blackledge M, Jamin M.

Protein Sci. 2011 Mar;20(3):542-56. doi: 10.1002/pro.587. Epub 2011 Feb 16.

36.

Nucleoprotein-RNA orientation in the measles virus nucleocapsid by three-dimensional electron microscopy.

Desfosses A, Goret G, Farias Estrozi L, Ruigrok RW, Gutsche I.

J Virol. 2011 Feb;85(3):1391-5. doi: 10.1128/JVI.01459-10. Epub 2010 Nov 24.

37.

Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein.

Boulo S, Akarsu H, Lotteau V, Müller CW, Ruigrok RW, Baudin F.

Virology. 2011 Jan 5;409(1):84-90. doi: 10.1016/j.virol.2010.10.001. Epub 2010 Oct 25.

38.

Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit.

Crépin T, Dias A, Palencia A, Swale C, Cusack S, Ruigrok RW.

J Virol. 2010 Sep;84(18):9096-104. doi: 10.1128/JVI.00995-10. Epub 2010 Jun 30.

39.

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms.

Boivin S, Cusack S, Ruigrok RW, Hart DJ.

J Biol Chem. 2010 Sep 10;285(37):28411-7. doi: 10.1074/jbc.R110.117531. Epub 2010 Jun 10. Review.

40.

Structural disorder within sendai virus nucleoprotein and phosphoprotein: insight into the structural basis of molecular recognition.

Jensen MR, Bernadó P, Houben K, Blanchard L, Marion D, Ruigrok RW, Blackledge M.

Protein Pept Lett. 2010 Aug;17(8):952-60. Review.

PMID:
20450486
41.

Structural disorder in proteins of the rhabdoviridae replication complex.

Leyrat C, Gérard FC, de Almeida Ribeiro E Jr, Ivanov I, Ruigrok RW, Jamin M.

Protein Pept Lett. 2010 Aug;17(8):979-87.

PMID:
20450482
42.

Structure of the dimerization domain of the rabies virus phosphoprotein.

Ivanov I, Crépin T, Jamin M, Ruigrok RW.

J Virol. 2010 Apr;84(7):3707-10. doi: 10.1128/JVI.02557-09. Epub 2010 Jan 20.

43.

Towards an atomic resolution understanding of the influenza virus replication machinery.

Ruigrok RW, Crépin T, Hart DJ, Cusack S.

Curr Opin Struct Biol. 2010 Feb;20(1):104-13. doi: 10.1016/j.sbi.2009.12.007. Epub 2010 Jan 12. Review.

PMID:
20061134
44.

Nucleoproteins of negative strand RNA viruses; RNA binding, oligomerisation and binding to polymerase co-factor.

Ruigrok RW, Crépin T.

Viruses. 2010 Jan;2(1):27-32. doi: 10.3390/v2010027. Epub 2010 Jan 7.

45.

Binding of rabies virus polymerase cofactor to recombinant circular nucleoprotein-RNA complexes.

Ribeiro Ede A Jr, Leyrat C, Gérard FC, Albertini AA, Falk C, Ruigrok RW, Jamin M.

J Mol Biol. 2009 Dec 4;394(3):558-75. doi: 10.1016/j.jmb.2009.09.042. Epub 2009 Sep 23.

PMID:
19781554
46.

Peptides that mimic the amino-terminal end of the rabies virus phosphoprotein have antiviral activity.

Castel G, Chtéoui M, Caignard G, Préhaud C, Méhouas S, Réal E, Jallet C, Jacob Y, Ruigrok RW, Tordo N.

J Virol. 2009 Oct;83(20):10808-20. doi: 10.1128/JVI.00977-09. Epub 2009 Aug 12.

47.

[New strategy for targeting influenza virus replication].

Dias A, Bouvier D, Cusack S, Ruigrok RW, Crépin T.

Med Sci (Paris). 2009 Apr;25(4):352-4. doi: 10.1051/medsci/2009254352. French. No abstract available.

48.

Modular organization of rabies virus phosphoprotein.

Gerard FC, Ribeiro Ede A Jr, Leyrat C, Ivanov I, Blondel D, Longhi S, Ruigrok RW, Jamin M.

J Mol Biol. 2009 May 22;388(5):978-96. doi: 10.1016/j.jmb.2009.03.061. Epub 2009 Mar 31.

PMID:
19341745
49.

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW.

Nature. 2009 Apr 16;458(7240):914-8. doi: 10.1038/nature07745. Epub 2009 Feb 4.

PMID:
19194459
50.

The C-terminal domains of adenovirus serotype 5 protein IX assemble into an antiparallel structure on the facets of the capsid.

Fabry CM, Rosa-Calatrava M, Moriscot C, Ruigrok RW, Boulanger P, Schoehn G.

J Virol. 2009 Jan;83(2):1135-9. doi: 10.1128/JVI.01808-08. Epub 2008 Nov 12.

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