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Items: 22


Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin.

Harris TA, Gattu S, Propheter DC, Kuang Z, Bel S, Ruhn KA, Chara AL, Edwards M, Zhang C, Jo JH, Raj P, Zouboulis CC, Kong HH, Segre JA, Hooper LV.

Cell Host Microbe. 2019 Jun 12;25(6):777-788.e8. doi: 10.1016/j.chom.2019.04.004. Epub 2019 May 14.


Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity.

Gattu S, Bang YJ, Pendse M, Dende C, Chara AL, Harris TA, Wang Y, Ruhn KA, Kuang Z, Sockanathan S, Hooper LV.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10911-10916. doi: 10.1073/pnas.1812069116. Epub 2019 May 16.


Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.

Propheter DC, Chara AL, Harris TA, Ruhn KA, Hooper LV.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11027-11033. doi: 10.1073/pnas.1711395114. Epub 2017 Sep 25.


The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.

Wang Y, Kuang Z, Yu X, Ruhn KA, Kubo M, Hooper LV.

Science. 2017 Sep 1;357(6354):912-916. doi: 10.1126/science.aan0677.


Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.

Bel S, Pendse M, Wang Y, Li Y, Ruhn KA, Hassell B, Leal T, Winter SE, Xavier RJ, Hooper LV.

Science. 2017 Sep 8;357(6355):1047-1052. doi: 10.1126/science.aal4677. Epub 2017 Jul 27.


The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor.

Yu X, Wang Y, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV.

Elife. 2014 Oct 13;3. doi: 10.7554/eLife.04406.


Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.

Derebe MG, Zlatkov CM, Gattu S, Ruhn KA, Vaishnava S, Diehl GE, MacMillan JB, Williams NS, Hooper LV.

Elife. 2014 Jul 29;3:e03206. doi: 10.7554/eLife.03206.


AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease.

Alto LT, Chen X, Ruhn KA, Treviño I, Tansey MG.

PLoS One. 2014 May 13;9(5):e96544. doi: 10.1371/journal.pone.0096544. eCollection 2014.


TH17 cell differentiation is regulated by the circadian clock.

Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV.

Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884.


Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice.

Nguyen TA, Frank-Cannon T, Martinez TN, Ruhn KA, Marvin M, Casey B, Treviño I, Hong JJ, Goldberg MS, Tansey MG.

J Neuroinflammation. 2013 Apr 28;10:50. doi: 10.1186/1742-2094-10-50.


The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV.

Science. 2011 Oct 14;334(6053):255-8. doi: 10.1126/science.1209791.


Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.

Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8743-8. doi: 10.1073/pnas.1019574108. Epub 2011 May 9.


TNF: a key neuroinflammatory mediator of neurotoxicity and neurodegeneration in models of Parkinson's disease.

McCoy MK, Ruhn KA, Blesch A, Tansey MG.

Adv Exp Med Biol. 2011;691:539-40. doi: 10.1007/978-1-4419-6612-4_56. No abstract available.


Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease.

Harms AS, Barnum CJ, Ruhn KA, Varghese S, Treviño I, Blesch A, Tansey MG.

Mol Ther. 2011 Jan;19(1):46-52. doi: 10.1038/mt.2010.217. Epub 2010 Oct 19.


Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.

McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG.

Neurobiol Dis. 2009 Apr;34(1):163-77.


Parkin deficiency increases vulnerability to inflammation-related nigral degeneration.

Frank-Cannon TC, Tran T, Ruhn KA, Martinez TN, Hong J, Marvin M, Hartley M, Treviño I, O'Brien DE, Casey B, Goldberg MS, Tansey MG.

J Neurosci. 2008 Oct 22;28(43):10825-34. doi: 10.1523/JNEUROSCI.3001-08.2008.


Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response.

Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG.

J Neurosci. 2008 Aug 20;28(34):8517-28. doi: 10.1523/JNEUROSCI.1806-08.2008.


Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats.

McCoy MK, Ruhn KA, Martinez TN, McAlpine FE, Blesch A, Tansey MG.

Mol Ther. 2008 Sep;16(9):1572-9. doi: 10.1038/mt.2008.146. Epub 2008 Jul 15.


The neuro-glial properties of adipose-derived adult stromal (ADAS) cells are not regulated by Notch 1 and are not derived from neural crest lineage.

Wrage PC, Tran T, To K, Keefer EW, Ruhn KA, Hong J, Hattangadi S, Treviño I, Tansey MG.

PLoS One. 2008 Jan 16;3(1):e1453. doi: 10.1371/journal.pone.0001453.


Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease.

McCoy MK, Martinez TN, Ruhn KA, Wrage PC, Keefer EW, Botterman BR, Tansey KE, Tansey MG.

Exp Neurol. 2008 Mar;210(1):14-29. Epub 2007 Nov 1.


Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

Tansey MG, Frank-Cannon TC, McCoy MK, Lee JK, Martinez TN, McAlpine FE, Ruhn KA, Tran TA.

Front Biosci. 2008 Jan 1;13:709-17. Review.


Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.

McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, Tansey KE, Tansey MG.

J Neurosci. 2006 Sep 13;26(37):9365-75.

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