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Items: 1 to 50 of 85

1.

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D.

Elife. 2019 Sep 3;8. pii: e48847. doi: 10.7554/eLife.48847. [Epub ahead of print]

2.

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C.

Nat Cell Biol. 2019 Aug;21(8):1052. doi: 10.1038/s41556-019-0370-x.

PMID:
31316187
3.

Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.

Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H.

Mol Cell. 2019 Sep 5;75(5):967-981.e9. doi: 10.1016/j.molcel.2019.06.001. Epub 2019 Jul 9.

PMID:
31300274
4.

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C.

Nat Cell Biol. 2019 Jul;21(7):889-899. doi: 10.1038/s41556-019-0347-9. Epub 2019 Jul 1. Erratum in: Nat Cell Biol. 2019 Aug;21(8):1052.

PMID:
31263264
5.

Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography.

Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ.

ACS Cent Sci. 2019 Apr 24;5(4):727-736. doi: 10.1021/acscentsci.9b00240. Epub 2019 Apr 3.

6.

A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.

Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S.

Cell Host Microbe. 2019 Mar 13;25(3):454-462.e6. doi: 10.1016/j.chom.2019.01.006. Epub 2019 Feb 28.

PMID:
30827827
7.

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D.

Nat Med. 2019 Feb;25(2):301-311. doi: 10.1038/s41591-018-0321-2. Epub 2019 Jan 14.

8.

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.

Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA.

J Immunol. 2019 Jan 15;202(2):579-590. doi: 10.4049/jimmunol.1800602. Epub 2018 Dec 10.

PMID:
30530594
9.

A Translation Tuning HuDdle for Neurons.

McMahon M, Ruggero D.

Mol Cell. 2018 Jul 19;71(2):195-196. doi: 10.1016/j.molcel.2018.07.007.

10.

A wobbly road to drug resistance in melanoma: tRNA-modifying enzymes in translation reprogramming.

McMahon M, Ruggero D.

EMBO J. 2018 Aug 1;37(15). pii: e99978. doi: 10.15252/embj.201899978. Epub 2018 Jul 2. No abstract available.

11.

Translational Control in Cancer.

Robichaud N, Sonenberg N, Ruggero D, Schneider RJ.

Cold Spring Harb Perspect Biol. 2019 Jul 1;11(7). pii: a032896. doi: 10.1101/cshperspect.a032896. Review.

PMID:
29959193
12.

Development of a stress response therapy targeting aggressive prostate cancer.

Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D.

Sci Transl Med. 2018 May 2;10(439). pii: eaar2036. doi: 10.1126/scitranslmed.aar2036.

13.

Revealing nascent proteomics in signaling pathways and cell differentiation.

Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2353-2358. doi: 10.1073/pnas.1707514115. Epub 2018 Feb 21.

14.

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.

Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA.

Cancer Cell. 2018 Jan 8;33(1):91-107.e6. doi: 10.1016/j.ccell.2017.12.003.

15.

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA.

Nat Cell Biol. 2018 Jan;20(1):104-115. doi: 10.1038/s41556-017-0006-y. Epub 2017 Dec 11.

16.

Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers.

Ruggero D, Shaw RJ.

Curr Opin Cell Biol. 2017 Apr;45:iv-vi. doi: 10.1016/j.ceb.2017.05.008. No abstract available.

PMID:
28641761
17.

New frontiers in translational control of the cancer genome.

Truitt ML, Ruggero D.

Nat Rev Cancer. 2017 Apr 24;17(5):332. doi: 10.1038/nrc.2017.30. No abstract available.

PMID:
28436470
18.

Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin.

Truillet C, Cunningham JT, Parker MFL, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ.

Clin Cancer Res. 2017 Jun 15;23(12):3045-3052. doi: 10.1158/1078-0432.CCR-16-2448. Epub 2016 Dec 22.

19.

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA.

Sci Signal. 2016 May 31;9(430):ra57. doi: 10.1126/scisignal.aad8463.

20.

New frontiers in translational control of the cancer genome.

Truitt ML, Ruggero D.

Nat Rev Cancer. 2016 Apr 26;16(5):288-304. doi: 10.1038/nrc.2016.27. Review. Erratum in: Nat Rev Cancer. 2017 Apr 24;17 (5):332.

21.

Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.

Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero D.

Sci Signal. 2015 Nov 17;8(403):ra116. doi: 10.1126/scisignal.aad5111.

22.

Differential Requirements for eIF4E Dose in Normal Development and Cancer.

Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D.

Cell. 2015 Jul 2;162(1):59-71. doi: 10.1016/j.cell.2015.05.049. Epub 2015 Jun 18.

23.

Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.

Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F.

Cancer Res. 2015 Jul 15;75(14):2851-62. doi: 10.1158/0008-5472.CAN-14-1623. Epub 2015 May 14.

24.

YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence.

Sheridan CM, Grogan TR, Nguyen HG, Galet C, Rettig MB, Hsieh AC, Ruggero D.

Oncotarget. 2015 Apr 10;6(10):7470-80.

25.

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

Pelletier J, Graff J, Ruggero D, Sonenberg N.

Cancer Res. 2015 Jan 15;75(2):250-63. doi: 10.1158/0008-5472.CAN-14-2789. Review.

26.

Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease.

McMahon M, Contreras A, Ruggero D.

Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):173-89. doi: 10.1002/wrna.1266. Epub 2014 Oct 31. Review.

27.

Marrow failure: a window into ribosome biology.

Ruggero D, Shimamura A.

Blood. 2014 Oct 30;124(18):2784-92. doi: 10.1182/blood-2014-04-526301. Epub 2014 Sep 18. Review.

28.

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.

Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D.

Cell. 2014 May 22;157(5):1088-103. doi: 10.1016/j.cell.2014.03.052. Erratum in: Cell. 2014 Jul 31;158(3):689.

29.

Tailor made protein synthesis for HSCs.

Barna M, Ruggero D.

Cell Stem Cell. 2014 Apr 3;14(4):423-4. doi: 10.1016/j.stem.2014.03.011.

30.

Parallel measurement of dynamic changes in translation rates in single cells.

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T.

Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10.

31.

New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization.

Cunningham JT, Ruggero D.

Cancer Discov. 2013 Oct;3(10):1099-102. doi: 10.1158/2159-8290.CD-13-0581.

32.

The translational landscape of the mammalian cell cycle.

Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D.

Mol Cell. 2013 Nov 21;52(4):574-82. doi: 10.1016/j.molcel.2013.09.018. Epub 2013 Oct 10.

33.

Assessing gene-level translational control from ribosome profiling.

Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS.

Bioinformatics. 2013 Dec 1;29(23):2995-3002. doi: 10.1093/bioinformatics/btt533. Epub 2013 Sep 18.

34.

Investigating Myc-dependent translational regulation in normal and cancer cells.

Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D.

Methods Mol Biol. 2013;1012:201-12. doi: 10.1007/978-1-62703-429-6_13.

35.

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.

Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11988-93. doi: 10.1073/pnas.1310230110. Epub 2013 Jun 26. Erratum in: Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):1760.

36.

H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation.

Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D.

Cell Rep. 2013 May 30;3(5):1493-502. doi: 10.1016/j.celrep.2013.04.030. Epub 2013 May 23.

37.

Common variable immunodeficiency as the initial presentation of dyskeratosis congenita.

Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR.

J Allergy Clin Immunol. 2013 Jul;132(1):223-6. doi: 10.1016/j.jaci.2012.11.052. Epub 2013 Feb 10. No abstract available.

38.

Exaggerated translation causes synaptic and behavioural aberrations associated with autism.

Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E.

Nature. 2013 Jan 17;493(7432):411-5. doi: 10.1038/nature11782. Epub 2012 Dec 23.

39.

Autism-related deficits via dysregulated eIF4E-dependent translational control.

Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N.

Nature. 2013 Jan 17;493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21.

40.

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C.

J Clin Invest. 2012 Dec;122(12):4621-34. doi: 10.1172/JCI62973. Epub 2012 Nov 12.

41.

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.

Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.

42.

Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling.

Ruggero D.

Sci Signal. 2012 Sep 11;5(241):pe38. doi: 10.1126/scisignal.2003477. Review.

43.

Translational control in cancer etiology.

Ruggero D.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a012336. doi: 10.1101/cshperspect.a012336. Review. Erratum in: Cold Spring Harb Perspect Biol. 2012 Nov;4(11). doi:10.1101/cshperspect.a015891.

44.

The translational landscape of mTOR signalling steers cancer initiation and metastasis.

Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D.

Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912.

45.

rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.

Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD.

Mol Cell. 2011 Nov 18;44(4):660-6. doi: 10.1016/j.molcel.2011.09.017.

46.

Oncogenic AKTivation of translation as a therapeutic target.

Hsieh AC, Truitt ML, Ruggero D.

Br J Cancer. 2011 Jul 26;105(3):329-36. doi: 10.1038/bjc.2011.241. Epub 2011 Jul 19. Review.

47.

The cancerous translation apparatus.

Stumpf CR, Ruggero D.

Curr Opin Genet Dev. 2011 Aug;21(4):474-83. doi: 10.1016/j.gde.2011.03.007. Epub 2011 May 3. Review.

48.

Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer.

Hsieh AC, Ruggero D.

Clin Cancer Res. 2010 Oct 15;16(20):4914-20. doi: 10.1158/1078-0432.CCR-10-0433. Epub 2010 Aug 11.

49.

Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.

Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D.

Cancer Res. 2010 Jul 15;70(14):6026-35. doi: 10.1158/0008-5472.CAN-09-4730. Epub 2010 Jun 29.

50.

Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita.

Bellodi C, Kopmar N, Ruggero D.

EMBO J. 2010 Jun 2;29(11):1865-76. doi: 10.1038/emboj.2010.83. Epub 2010 May 7.

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