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Items: 1 to 50 of 310

1.

Humanized GPIbα-von Willebrand factor interaction in the mouse.

Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM.

Blood Adv. 2018 Oct 9;2(19):2522-2532. doi: 10.1182/bloodadvances.2018023507.

2.

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.

Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H.

Nat Commun. 2018 Sep 6;9(1):3608. doi: 10.1038/s41467-018-05806-0.

3.

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.

Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8228-E8235. doi: 10.1073/pnas.1807000115. Epub 2018 Aug 13.

4.

Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics.

Oldstone MBA, Ware BC, Horton LE, Welch MJ, Aiolfi R, Zarpellon A, Ruggeri ZM, Sullivan BM.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7814-E7823. doi: 10.1073/pnas.1804674115. Epub 2018 Jul 30.

5.

GPIbα is required for platelet-mediated hepatic thrombopoietin generation.

Xu M, Li J, Neves MAD, Zhu G, Carrim N, Yu R, Gupta S, Marshall J, Rotstein O, Peng J, Hou M, Kunishima S, Ware J, Branch DR, Lazarus AH, Ruggeri ZM, Freedman J, Ni H.

Blood. 2018 Aug 9;132(6):622-634. doi: 10.1182/blood-2017-12-820779. Epub 2018 May 24.

6.

14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.

Chen Y, Ruggeri ZM, Du X.

Blood. 2018 May 31;131(22):2436-2448. doi: 10.1182/blood-2017-09-742650. Epub 2018 Apr 5. Review.

7.

Complement Component C3 Binds to the A3 Domain of von Willebrand Factor.

Nolasco JG, Nolasco LH, Da Q, Cirlos S, Ruggeri ZM, Moake JL, Cruz MA.

TH Open. 2018;2(3):e338-e345. doi: 10.1055/s-0038-1672189.

8.

Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions.

Biasetti J, Sampath K, Cortez A, Azhir A, Gilad AA, Kickler TS, Obser T, Ruggeri ZM, Katz J.

Int J Biomed Imaging. 2017;2017:8318906. doi: 10.1155/2017/8318906. Epub 2017 Nov 6.

9.

Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.

Kamikubo Y, Mendolicchio GL, Zampolli A, Marchese P, Rothmeier AS, Orje JN, Gale AJ, Krishnaswamy S, Gruber A, Østergaard H, Petersen LC, Ruf W, Ruggeri ZM.

Blood. 2017 Oct 5;130(14):1661-1670. doi: 10.1182/blood-2017-02-767079. Epub 2017 Jul 20.

10.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

11.

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C.

Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.

12.

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W.

Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1323-1331. doi: 10.1161/ATVBAHA.117.309315. Epub 2017 May 11.

13.

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension.

Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah4923. doi: 10.1126/scitranslmed.aah4923.

PMID:
28148841
14.

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va.

Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJT, Cohen MJ, Griffin JH.

Blood. 2016 Oct 6;128(14):1870-1878. doi: 10.1182/blood-2016-03-707679. Epub 2016 Jul 15.

15.

Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.

Weber MR, Zuka M, Lorger M, Tschan M, Torbett BE, Zijlstra A, Quigley JP, Staflin K, Eliceiri BP, Krueger JS, Marchese P, Ruggeri ZM, Felding BH.

Thromb Res. 2016 Apr;140 Suppl 1:S27-36. doi: 10.1016/S0049-3848(16)30095-0.

16.

Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation.

Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X.

Blood. 2016 Feb 4;127(5):626-36. doi: 10.1182/blood-2015-04-638387. Epub 2015 Nov 19.

17.

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

Kaplan ZS, Zarpellon A, Alwis I, Yuan Y, McFadyen J, Ghasemzadeh M, Schoenwaelder SM, Ruggeri ZM, Jackson SP.

Nat Commun. 2015 Jul 23;6:7835. doi: 10.1038/ncomms8835.

PMID:
26204458
18.

Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M.

Cell. 2015 Apr 23;161(3):486-500. doi: 10.1016/j.cell.2015.03.005. Epub 2015 Apr 16.

19.

Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles.

Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg MH, Ruggeri ZM, Ruf W.

J Clin Invest. 2015 Apr;125(4):1471-84. doi: 10.1172/JCI79329. Epub 2015 Feb 23.

20.

Interaction of von Willebrand factor with platelets and the vessel wall.

Ruggeri ZM, Mendolicchio GL.

Hamostaseologie. 2015;35(3):211-24. doi: 10.5482/HAMO-14-12-0081. Epub 2015 Jan 23. Review.

PMID:
25612915
21.

Platelet GPIb: sensing force and responding.

Ruggeri ZM.

Blood. 2015 Jan 15;125(3):423-4. doi: 10.1182/blood-2014-12-610642. No abstract available.

22.

Tailored antiplatelet therapy in a patient with ITP and clopidogrel resistance.

Mendolicchio GL, Zavalloni D, Bacci M, Roveda M, Quagliuolo V, Anselmi CV, Rota LL, Ruggeri ZM.

Thromb Haemost. 2015 Mar;113(3):664-7. doi: 10.1160/TH14-09-0751. Epub 2014 Nov 27. No abstract available.

PMID:
25428265
23.

Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis.

Koltsova EK, Sundd P, Zarpellon A, Ouyang H, Mikulski Z, Zampolli A, Ruggeri ZM, Ley K.

Thromb Haemost. 2014 Dec;112(6):1252-63. doi: 10.1160/TH14-02-0130. Epub 2014 Aug 7.

24.

Type I interferon is a therapeutic target for virus-induced lethal vascular damage.

Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2.

25.

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice.

Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W.

J Thromb Haemost. 2014 Jan;12(1):71-81. doi: 10.1111/jth.12442.

26.

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.

Khanicheh E, Qi Y, Xie A, Mitterhuber M, Xu L, Mochizuki M, Daali Y, Jaquet V, Krause KH, Ruggeri ZM, Kuster GM, Lindner JR, Kaufmann BA.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2187-92. doi: 10.1161/ATVBAHA.113.301710. Epub 2013 Aug 1.

27.

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.

Ghasemzadeh M, Kaplan ZS, Alwis I, Schoenwaelder SM, Ashworth KJ, Westein E, Hosseini E, Salem HH, Slattery R, McColl SR, Hickey MJ, Ruggeri ZM, Yuan Y, Jackson SP.

Blood. 2013 May 30;121(22):4555-66. doi: 10.1182/blood-2012-09-459636. Epub 2013 Apr 2.

28.

Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.

Habart D, Cheli Y, Nugent DJ, Ruggeri ZM, Kunicki TJ.

PLoS One. 2013;8(1):e55094. doi: 10.1371/journal.pone.0055094. Epub 2013 Jan 24.

29.

Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.

Liu Y, Davidson BP, Yue Q, Belcik T, Xie A, Inaba Y, McCarty OJ, Tormoen GW, Zhao Y, Ruggeri ZM, Kaufmann BA, Lindner JR.

Circ Cardiovasc Imaging. 2013 Jan 1;6(1):74-82. doi: 10.1161/CIRCIMAGING.112.975193. Epub 2012 Dec 13.

30.

Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura.

Du VX, van Os G, Kremer Hovinga JA, Dienava-Verdoold I, Wollersheim J, Ruggeri ZM, Fijnheer R, de Groot PG, de Laat B.

Br J Haematol. 2012 Oct;159(1):94-103. doi: 10.1111/bjh.12004. Epub 2012 Aug 9.

PMID:
22881339
31.

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.

Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2165-72. doi: 10.1073/pnas.1209182109. Epub 2012 Jul 2.

32.

Platelet mimetic particles for targeting thrombi in flowing blood.

Doshi N, Orje JN, Molins B, Smith JW, Mitragotri S, Ruggeri ZM.

Adv Mater. 2012 Jul 24;24(28):3864-9. doi: 10.1002/adma.201200607. Epub 2012 May 29. No abstract available.

33.

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.

Scheppke L, Murphy EA, Zarpellon A, Hofmann JJ, Merkulova A, Shields DJ, Weis SM, Byzova TV, Ruggeri ZM, Iruela-Arispe ML, Cheresh DA.

Blood. 2012 Mar 1;119(9):2149-58. doi: 10.1182/blood-2011-04-348706. Epub 2011 Dec 1.

34.

The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.

Li C, Piran S, Chen P, Lang S, Zarpellon A, Jin JW, Zhu G, Reheman A, van der Wal DE, Simpson EK, Ni R, Gross PL, Ware J, Ruggeri ZM, Freedman J, Ni H.

J Clin Invest. 2011 Nov;121(11):4537-47. doi: 10.1172/JCI57850. Epub 2011 Oct 24.

35.

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice.

Furlan-Freguia C, Marchese P, Gruber A, Ruggeri ZM, Ruf W.

J Clin Invest. 2011 Jul;121(7):2932-44. doi: 10.1172/JCI46129. Epub 2011 Jun 13.

36.

Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.

Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8628-33. doi: 10.1073/pnas.1017042108. Epub 2011 May 9.

37.

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction.

Cranmer SL, Ashworth KJ, Yao Y, Berndt MC, Ruggeri ZM, Andrews RK, Jackson SP.

Blood. 2011 Mar 3;117(9):2718-27. doi: 10.1182/blood-2010-07-296194. Epub 2010 Dec 14.

38.

Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood.

Mendolicchio GL, Zavalloni D, Bacci M, Corrada E, Marconi M, Lodigiani C, Presbitero P, Rota L, Ruggeri ZM.

J Thromb Haemost. 2011 Feb;9(2):373-82. doi: 10.1111/j.1538-7836.2010.04144.x.

39.

Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib.

Ruggeri ZM, Zarpellon A, Roberts JR, Mc Clintock RA, Jing H, Mendolicchio GL.

Thromb Haemost. 2010 Nov;104(5):894-902. doi: 10.1160/TH10-09-0578. Epub 2010 Oct 12. Review.

40.

Neutrophils release brakes of coagulation.

Ruf W, Ruggeri ZM.

Nat Med. 2010 Aug;16(8):851-2. doi: 10.1038/nm0810-851. No abstract available.

PMID:
20689544
41.

Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells.

Cui X, Dean D, Ruggeri ZM, Boland T.

Biotechnol Bioeng. 2010 Aug 15;106(6):963-9. doi: 10.1002/bit.22762.

PMID:
20589673
42.

Role for ADAP in shear flow-induced platelet mechanotransduction.

Kasirer-Friede A, Ruggeri ZM, Shattil SJ.

Blood. 2010 Mar 18;115(11):2274-82. doi: 10.1182/blood-2009-08-238238. Epub 2009 Dec 7.

43.

Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity.

Heida NM, Leifheit-Nestler M, Schroeter MR, Müller JP, Cheng IF, Henkel S, Limbourg A, Limbourg FP, Alves F, Quigley JP, Ruggeri ZM, Hasenfuss G, Konstantinides S, Schäfer K.

Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):200-6. doi: 10.1161/ATVBAHA.109.192807. Epub 2009 Nov 12.

44.

Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage.

Turner NA, Nolasco L, Ruggeri ZM, Moake JL.

Blood. 2009 Dec 3;114(24):5102-11. doi: 10.1182/blood-2009-07-231597. Epub 2009 Oct 12.

45.

Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.

Mazzucato M, Cozzi MR, Battiston M, Jandrot-Perrus M, Mongiat M, Marchese P, Kunicki TJ, Ruggeri ZM, De Marco L.

Blood. 2009 Sep 24;114(13):2793-801. doi: 10.1182/blood-2008-12-193490. Epub 2009 Jul 21.

46.

Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?

Godino C, Mendolicchio L, Figini F, Latib A, Sharp AS, Cosgrave J, Calori G, Cera M, Chieffo A, Castelli A, Maseri A, Ruggeri ZM, Colombo A.

Thromb J. 2009 May 6;7:4. doi: 10.1186/1477-9560-7-4.

47.

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.

Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernández JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin JH.

Blood. 2009 Jun 4;113(23):5970-8. doi: 10.1182/blood-2008-10-183327. Epub 2009 Feb 24.

48.

Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.

Blasius AL, Brandl K, Crozat K, Xia Y, Khovananth K, Krebs P, Smart NG, Zampolli A, Ruggeri ZM, Beutler BA.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2706-11. doi: 10.1073/pnas.0813208106. Epub 2009 Feb 6.

49.

Platelet adhesion under flow.

Ruggeri ZM.

Microcirculation. 2009 Jan;16(1):58-83. doi: 10.1080/10739680802651477. Review.

50.

Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.

Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):629-34. doi: 10.1073/pnas.0711200105. Epub 2008 Jan 9.

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