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Items: 35

1.

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.

Ruggeri FS, Šneideris T, Chia S, Vendruscolo M, Knowles TPJ.

J Vis Exp. 2019 Sep 12;(151). doi: 10.3791/60108.

PMID:
31566623
2.

Infrared nanospectroscopic mapping of a single metaphase chromosome.

Lipiec E, Ruggeri FS, Benadiba C, Borkowska AM, Kobierski JD, Miszczyk J, Wood BR, Deacon GB, Kulik A, Dietler G, Kwiatek WM.

Nucleic Acids Res. 2019 Oct 10;47(18):e108. doi: 10.1093/nar/gkz630.

3.

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D.

Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4.

4.

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.

Wright MA, Ruggeri FS, Saar KL, Challa PK, Benesch JLP, Knowles TPJ.

Analyst. 2019 Jul 21;144(14):4413-4424. doi: 10.1039/c9an00382g. Epub 2019 Jun 19.

PMID:
31215547
5.

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D.

Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3.

6.

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.

Liu X, Toprakcioglu Z, Dear AJ, Levin A, Ruggeri FS, Taylor CG, Hu M, Kumita JR, Andreasen M, Dobson CM, Shimanovich U, Knowles TPJ.

Macromol Rapid Commun. 2019 Apr;40(8):e1800898. doi: 10.1002/marc.201800898. Epub 2019 Mar 6.

PMID:
30840348
7.

Atomic force microscopy for single molecule characterisation of protein aggregation.

Ruggeri FS, Šneideris T, Vendruscolo M, Knowles TPJ.

Arch Biochem Biophys. 2019 Mar 30;664:134-148. doi: 10.1016/j.abb.2019.02.001. Epub 2019 Feb 8. Review.

8.

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.

9.

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.

Ruggeri FS, Charmet J, Kartanas T, Peter Q, Chia S, Habchi J, Dobson CM, Vendruscolo M, Knowles TPJ.

Nat Commun. 2018 Sep 24;9(1):3890. doi: 10.1038/s41467-018-06345-4.

10.

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy.

Ruggeri FS, Marcott C, Dinarelli S, Longo G, Girasole M, Dietler G, Knowles TPJ.

Int J Mol Sci. 2018 Aug 30;19(9). pii: E2582. doi: 10.3390/ijms19092582.

11.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

DeGuire SM, Ruggeri FS, Fares MB, Chiki A, Cendrowska U, Dietler G, Lashuel HA.

J Biol Chem. 2018 Nov 30;293(48):18540-18558. doi: 10.1074/jbc.RA118.004621. Epub 2018 Sep 5.

12.

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection.

Etezadi D, Warner Iv JB, Ruggeri FS, Dietler G, Lashuel HA, Altug H.

Light Sci Appl. 2017 Aug 25;6(8):e17029. doi: 10.1038/lsa.2017.29. eCollection 2017 Aug.

13.

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes.

Li Z, Tuffin J, Lei IM, Ruggeri FS, Lewis NS, Gill EL, Savin T, Huleihel L, Badylak SF, Knowles T, Satchell SC, Welsh GI, Saleem MA, Huang YYS.

Acta Biomater. 2018 Sep 15;78:111-122. doi: 10.1016/j.actbio.2018.08.010. Epub 2018 Aug 10.

PMID:
30099199
14.

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

Mannini B, Habchi J, Chia S, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Dec 19;9(12):2959-2971. doi: 10.1021/acschemneuro.8b00141. Epub 2018 Aug 10.

PMID:
29986583
15.

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7230-7235. doi: 10.1073/pnas.1721220115. Epub 2018 Jun 25.

16.

Determination of Polypeptide Conformation with Nanoscale Resolution in Water.

Ramer G, Ruggeri FS, Levin A, Knowles TPJ, Centrone A.

ACS Nano. 2018 Jul 24;12(7):6612-6619. doi: 10.1021/acsnano.8b01425. Epub 2018 Jun 28.

PMID:
29932670
17.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
18.

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, Kaminski Schierle GS, Kaminski CF, Holt CE, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P.

Cell. 2018 Apr 19;173(3):720-734.e15. doi: 10.1016/j.cell.2018.03.056.

19.

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.

Sieste S, Mack T, Synatschke CV, Schilling C, Meyer Zu Reckendorf C, Pendi L, Harvey S, Ruggeri FS, Knowles TPJ, Meier C, Ng DYW, Weil T, Knöll B.

Adv Healthc Mater. 2018 Jun;7(11):e1701485. doi: 10.1002/adhm.201701485. Epub 2018 Apr 10.

PMID:
29635761
20.

Molecular determinants of the interaction of EGCG with ordered and disordered proteins.

Fusco G, Sanz-Hernandez M, Ruggeri FS, Vendruscolo M, Dobson CM, De Simone A.

Biopolymers. 2018 Aug;109(10):e23117. doi: 10.1002/bip.23117. Epub 2018 Mar 30.

PMID:
29603125
21.

Amyloid single-cell cytotoxicity assays by nanomotion detection.

Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G.

Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017.

22.

Silk micrococoons for protein stabilisation and molecular encapsulation.

Shimanovich U, Ruggeri FS, De Genst E, Adamcik J, Barros TP, Porter D, Müller T, Mezzenga R, Dobson CM, Vollrath F, Holland C, Knowles TPJ.

Nat Commun. 2017 Jul 19;8:15902. doi: 10.1038/ncomms15902.

23.

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D.

BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6.

24.

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

Chiki A, DeGuire SM, Ruggeri FS, Sanfelice D, Ansaloni A, Wang ZM, Cendrowska U, Burai R, Vieweg S, Pastore A, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5202-5207. doi: 10.1002/anie.201611750. Epub 2017 Mar 23.

PMID:
28334491
25.

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates.

Galante D, Ruggeri FS, Dietler G, Pellistri F, Gatta E, Corsaro A, Florio T, Perico A, D'Arrigo C.

Int J Biochem Cell Biol. 2016 Oct;79:261-270. doi: 10.1016/j.biocel.2016.08.037. Epub 2016 Aug 31.

PMID:
27592450
26.

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

Ruggeri FS, Vieweg S, Cendrowska U, Longo G, Chiki A, Lashuel HA, Dietler G.

Sci Rep. 2016 Aug 8;6:31155. doi: 10.1038/srep31155.

27.

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.

Ruggeri FS, Habchi J, Cerreta A, Dietler G.

Curr Pharm Des. 2016;22(26):3950-70. Review.

28.

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.

Ruggeri FS, Longo G, Faggiano S, Lipiec E, Pastore A, Dietler G.

Nat Commun. 2015 Jul 28;6:7831. doi: 10.1038/ncomms8831.

29.

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.

Ruggeri FS, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G.

Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2462-6. doi: 10.1002/anie.201409050. Epub 2015 Jan 14.

PMID:
25588987
30.

Detecting nanoscale vibrations as signature of life.

Kasas S, Ruggeri FS, Benadiba C, Maillard C, Stupar P, Tournu H, Dietler G, Longo G.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):378-81. doi: 10.1073/pnas.1415348112. Epub 2014 Dec 29.

31.

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor α-derived peptide.

Ruggeri FS, Byrne C, Khemtemourian L, Ducouret G, Dietler G, Jacquot Y.

J Pept Sci. 2015 Feb;21(2):95-104. doi: 10.1002/psc.2730. Epub 2014 Dec 22.

PMID:
25530026
32.

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA.

J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16.

33.

Nanoscale spatially resolved infrared spectra from single microdroplets.

Müller T, Ruggeri FS, Kulik AJ, Shimanovich U, Mason TO, Knowles TP, Dietler G.

Lab Chip. 2014 Apr 7;14(7):1315-9. doi: 10.1039/c3lc51219c.

PMID:
24519414
34.

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.

Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1928-33. doi: 10.1002/anie.201307510. Epub 2014 Jan 20. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7389.

PMID:
24446188
35.

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.

Adamcik J, Lara C, Usov I, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA, Hamley IW, Mezzenga R.

Nanoscale. 2012 Aug 7;4(15):4426-9. doi: 10.1039/c2nr30768e. Epub 2012 Jun 11.

PMID:
22688679

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