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Items: 37


Transcription factors make the right contacts.

Rugg-Gunn PJ.

Nat Cell Biol. 2019 Oct;21(10):1173-1174. doi: 10.1038/s41556-019-0399-x. No abstract available.


Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD.

Nat Commun. 2018 Nov 12;9(1):4792. doi: 10.1038/s41467-018-07399-0.


Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Rulands S, Lee HJ, Clark SJ, Angermueller C, Smallwood SA, Krueger F, Mohammed H, Dean W, Nichols J, Rugg-Gunn P, Kelsey G, Stegle O, Simons BD, Reik W.

Cell Syst. 2018 Jul 25;7(1):63-76.e12. doi: 10.1016/j.cels.2018.06.012.


Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD.

Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. Erratum in: Nat Commun. 2018 Nov 12;9(1):4792.


Identifying Human Naïve Pluripotent Stem Cells - Evaluating State-Specific Reporter Lines and Cell-Surface Markers.

Collier AJ, Rugg-Gunn PJ.

Bioessays. 2018 May;40(5):e1700239. doi: 10.1002/bies.201700239. Epub 2018 Mar 25. Review.


Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition.

Novo CL, Javierre BM, Cairns J, Segonds-Pichon A, Wingett SW, Freire-Pritchett P, Furlan-Magaril M, Schoenfelder S, Fraser P, Rugg-Gunn PJ.

Cell Rep. 2018 Mar 6;22(10):2615-2627. doi: 10.1016/j.celrep.2018.02.040.


Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.

Lupo G, Nisi PS, Esteve P, Paul YL, Novo CL, Sidders B, Khan MA, Biagioni S, Liu HK, Bovolenta P, Cacci E, Rugg-Gunn PJ.

Aging Cell. 2018 Jun;17(3):e12745. doi: 10.1111/acel.12745. Epub 2018 Mar 5.


Naive pluripotent stem cells as a model for studying human developmental epigenomics: opportunities and limitations.

Rugg-Gunn PJ.

Epigenomics. 2017 Dec;9(12):1485-1488. doi: 10.2217/epi-2017-0115. Epub 2017 Nov 6. No abstract available.


Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.

Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN.

Stem Cell Reports. 2017 Jul 11;9(1):1-4. doi: 10.1016/j.stemcr.2017.05.029.


Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis.

Carucci N, Cacci E, Nisi PS, Licursi V, Paul YL, Biagioni S, Negri R, Rugg-Gunn PJ, Lupo G.

R Soc Open Sci. 2017 Apr 5;4(4):160913. doi: 10.1098/rsos.160913. eCollection 2017 Apr.


Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States.

Collier AJ, Panula SP, Schell JP, Chovanec P, Plaza Reyes A, Petropoulos S, Corcoran AE, Walker R, Douagi I, Lanner F, Rugg-Gunn PJ.

Cell Stem Cell. 2017 Jun 1;20(6):874-890.e7. doi: 10.1016/j.stem.2017.02.014. Epub 2017 Mar 23.


Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Freire-Pritchett P, Schoenfelder S, Várnai C, Wingett SW, Cairns J, Collier AJ, García-Vílchez R, Furlan-Magaril M, Osborne CS, Fraser P, Rugg-Gunn PJ, Spivakov M.

Elife. 2017 Mar 23;6. pii: e21926. doi: 10.7554/eLife.21926.


DNA methylation is dispensable for changes in global chromatin architecture but required for chromocentre formation in early stem cell differentiation.

Hassan-Zadeh V, Rugg-Gunn P, Bazett-Jones DP.

Chromosoma. 2017 Oct;126(5):605-614. doi: 10.1007/s00412-017-0625-x. Epub 2017 Jan 13.


Derivation and Culture of Epiblast Stem Cell (EpiSC) Lines.

Rugg-Gunn P.

Cold Spring Harb Protoc. 2017 Jan 3;2017(1). doi: 10.1101/pdb.prot093971.


Derivation and Culture of Extra-Embryonic Endoderm Stem Cell Lines.

Rugg-Gunn P.

Cold Spring Harb Protoc. 2017 Jan 3;2017(1). doi: 10.1101/pdb.prot093963.


XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development.

Vallot C, Patrat C, Collier AJ, Huret C, Casanova M, Liyakat Ali TM, Tosolini M, Frydman N, Heard E, Rugg-Gunn PJ, Rougeulle C.

Cell Stem Cell. 2017 Jan 5;20(1):102-111. doi: 10.1016/j.stem.2016.10.014. Epub 2016 Dec 15.


Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells.

Collinson A, Collier AJ, Morgan NP, Sienerth AR, Chandra T, Andrews S, Rugg-Gunn PJ.

Cell Rep. 2016 Dec 6;17(10):2700-2714. doi: 10.1016/j.celrep.2016.11.032.


Crosstalk between pluripotency factors and higher-order chromatin organization.

Lopes Novo C, Rugg-Gunn P.

Nucleus. 2016 Sep 2;7(5):447-452. Review.


Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.

von Meyenn F, Berrens RV, Andrews S, Santos F, Collier AJ, Krueger F, Osorno R, Dean W, Rugg-Gunn PJ, Reik W.

Dev Cell. 2016 Oct 10;39(1):104-115. doi: 10.1016/j.devcel.2016.09.015.


The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.

Novo CL, Tang C, Ahmed K, Djuric U, Fussner E, Mullin NP, Morgan NP, Hayre J, Sienerth AR, Elderkin S, Nishinakamura R, Chambers I, Ellis J, Bazett-Jones DP, Rugg-Gunn PJ.

Genes Dev. 2016 May 1;30(9):1101-15. doi: 10.1101/gad.275685.115. Epub 2016 Apr 28.


Chromatin organization in pluripotent cells: emerging approaches to study and disrupt function.

Lopes Novo C, Rugg-Gunn PJ.

Brief Funct Genomics. 2016 Jul;15(4):305-14. doi: 10.1093/bfgp/elv029. Epub 2015 Jul 23. Review.


Annual meeting of the EpiGeneSys Network of Excellence--Advancing epigenetics towards systems biology.

Houseley J, Hill CS, Rugg-Gunn PJ.

Bioessays. 2015 Jun;37(6):592-5. doi: 10.1002/bies.201500015. Epub 2015 Mar 16. No abstract available.


Epigenetic features of the mouse trophoblast.

Rugg-Gunn PJ.

Reprod Biomed Online. 2012 Jul;25(1):21-30. doi: 10.1016/j.rbmo.2012.01.012. Epub 2012 Jan 25. Review.


Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T.

Dev Cell. 2012 Apr 17;22(4):887-901. doi: 10.1016/j.devcel.2012.01.005. Epub 2012 Mar 15.


Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.

Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP.

PLoS One. 2010 May 7;5(5):e10531. doi: 10.1371/journal.pone.0010531.


Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo.

Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10783-90. doi: 10.1073/pnas.0914507107. Epub 2010 May 17.


Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.

Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J.

Development. 2010 Feb;137(3):395-403. doi: 10.1242/dev.038828.


Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways.

Vallier L, Touboul T, Chng Z, Brimpari M, Hannan N, Millan E, Smithers LE, Trotter M, Rugg-Gunn P, Weber A, Pedersen RA.

PLoS One. 2009 Jun 30;4(6):e6082. doi: 10.1371/journal.pone.0006082.


The challenge of regulating rapidly changing science: stem cell legislation in Canada.

Rugg-Gunn PJ, Ogbogu U, Rossant J, Caulfield T.

Cell Stem Cell. 2009 Apr 3;4(4):285-8. doi: 10.1016/j.stem.2009.03.004.


Activin/Nodal signalling maintains pluripotency by controlling Nanog expression.

Vallier L, Mendjan S, Brown S, Chng Z, Teo A, Smithers LE, Trotter MW, Cho CH, Martinez A, Rugg-Gunn P, Brons G, Pedersen RA.

Development. 2009 Apr;136(8):1339-49. doi: 10.1242/dev.033951. Epub 2009 Mar 11.


Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.

Kim K, Ng K, Rugg-Gunn PJ, Shieh JH, Kirak O, Jaenisch R, Wakayama T, Moore MA, Pedersen RA, Daley GQ.

Cell Stem Cell. 2007 Sep 13;1(3):346-52. doi: 10.1016/j.stem.2007.07.001. Epub 2007 Aug 2.


Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines.

Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA.

Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R243-51. Review.


Derivation of pluripotent epiblast stem cells from mammalian embryos.

Brons IG, Smithers LE, Trotter MW, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes SM, Howlett SK, Clarkson A, Ahrlund-Richter L, Pedersen RA, Vallier L.

Nature. 2007 Jul 12;448(7150):191-5. Epub 2007 Jun 27.


Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.

International Stem Cell Initiative, Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'Brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W.

Nat Biotechnol. 2007 Jul;25(7):803-16. Epub 2007 Jun 17.


Human embryonic stem cells as a model for studying epigenetic regulation during early development.

Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA.

Cell Cycle. 2005 Oct;4(10):1323-6. Epub 2005 Oct 2.


Epigenetic status of human embryonic stem cells.

Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA.

Nat Genet. 2005 Jun;37(6):585-7. Epub 2005 May 1.


Enhancing and diminishing gene function in human embryonic stem cells.

Vallier L, Rugg-Gunn PJ, Bouhon IA, Andersson FK, Sadler AJ, Pedersen RA.

Stem Cells. 2004;22(1):2-11.

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