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Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia.

Alfedi G, Luffarelli R, Condò I, Pedini G, Mannucci L, Massaro DS, Benini M, Toschi N, Alaimo G, Panarello L, Pacini L, Fortuni S, Serio D, Malisan F, Testi R, Rufini A.

Mov Disord. 2019 Mar;34(3):323-334. doi: 10.1002/mds.27604. Epub 2019 Jan 9.


Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity.

Myint NNM, Verma AM, Fernandez-Garcia D, Sarmah P, Tarpey PS, Al-Aqbi SS, Cai H, Trigg R, West K, Howells LM, Thomas A, Brown K, Guttery DS, Singh B, Pringle HJ, McDermott U, Shaw JA, Rufini A.

Cell Death Dis. 2018 Aug 30;9(9):894. doi: 10.1038/s41419-018-0934-x.


Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.

Alexandrou C, Al-Aqbi SS, Higgins JA, Boyle W, Karmokar A, Andreadi C, Luo JL, Moore DA, Viskaduraki M, Blades M, Murray GI, Howells LM, Thomas A, Brown K, Cheng PN, Rufini A.

Sci Rep. 2018 Aug 14;8(1):12096. doi: 10.1038/s41598-018-30591-7.


Biophysical characterisation of the recombinant human frataxin precursor.

Castro IH, Ferrari A, Herrera MG, Noguera ME, Maso L, Benini M, Rufini A, Testi R, Costantini P, Santos J.

FEBS Open Bio. 2018 Jan 25;8(3):390-405. doi: 10.1002/2211-5463.12376. eCollection 2018 Mar.


p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile.

Agostini M, Niklison-Chirou MV, Annicchiarico-Petruzzelli MM, Grelli S, Di Daniele N, Pestlikis I, Knight RA, Melino G, Rufini A.

Mol Neurobiol. 2018 Apr;55(4):3237-3250. doi: 10.1007/s12035-017-0517-3. Epub 2017 May 6.


Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.

González R, De la Rosa ÁJ, Rufini A, Rodríguez-Hernández MA, Navarro-Villarán E, Marchal T, Pereira S, De la Mata M, Müller-Schilling M, Pascasio-Acevedo JM, Ferrer-Ríos MT, Gómez-Bravo MA, Padillo FJ, Muntané J.

PLoS One. 2017 Mar 28;12(3):e0174326. doi: 10.1371/journal.pone.0174326. eCollection 2017.


E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.

Benini M, Fortuni S, Condò I, Alfedi G, Malisan F, Toschi N, Serio D, Massaro DS, Arcuri G, Testi R, Rufini A.

Cell Rep. 2017 Feb 21;18(8):2007-2017. doi: 10.1016/j.celrep.2017.01.079.


C-reactive protein levels in the perioperative period as a predictive marker of endoscopic recurrence after ileo-colonic resection for Crohn's disease.

Iaculli E, Agostini M, Biancone L, Fiorani C, Di Vizia A, Montagnese F, Sibio S, Manzelli A, Tesauro M, Rufini A, Sica GS.

Cell Death Discov. 2016 May 23;2:16032. doi: 10.1038/cddiscovery.2016.32. eCollection 2016.


Response to comment on "Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice".

Brown K, Rufini A, Gescher A.

Sci Transl Med. 2016 Aug 3;8(350):350lr2. doi: 10.1126/scitranslmed.aag2816.


Metabolic pathways regulated by TAp73 in response to oxidative stress.

Agostini M, Annicchiarico-Petruzzelli M, Melino G, Rufini A.

Oncotarget. 2016 May 24;7(21):29881-900. doi: 10.18632/oncotarget.8935.


New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers.

Brown K, Rufini A.

Ecancermedicalscience. 2015 Nov 24;9:601. doi: 10.3332/ecancer.2015.601. eCollection 2015. Review.


Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619.


Src inhibitors modulate frataxin protein levels.

Cherubini F, Serio D, Guccini I, Fortuni S, Arcuri G, Condò I, Rufini A, Moiz S, Camerini S, Crescenzi M, Testi R, Malisan F.

Hum Mol Genet. 2015 Aug 1;24(15):4296-305. doi: 10.1093/hmg/ddv162. Epub 2015 May 6.


Do not throw out the resveratrol with the bath water.

Brown K, Rufini A, Gescher A.

JAMA Intern Med. 2015 Jan;175(1):140-1. doi: 10.1001/jamainternmed.2014.7000. No abstract available.


TAp73 promotes anti-senescence-anabolism not proliferation.

Agostini M, Niklison-Chirou MV, Catani MV, Knight RA, Melino G, Rufini A.

Aging (Albany NY). 2014 Nov;6(11):921-30.


Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.

Rufini A, Cavallo F, Condò I, Fortuni S, De Martino G, Incani O, Di Venere A, Benini M, Massaro DS, Arcuri G, Serio D, Malisan F, Testi R.

Neurobiol Dis. 2015 Mar;75:91-9. doi: 10.1016/j.nbd.2014.12.011. Epub 2014 Dec 27.


TAp73 promotes anabolism.

Amelio I, Antonov AA, Catani MV, Massoud R, Bernassola F, Knight RA, Melino G, Rufini A.

Oncotarget. 2014 Dec 30;5(24):12820-934.


TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21.


p73 regulates serine biosynthesis in cancer.

Amelio I, Markert EK, Rufini A, Antonov AV, Sayan BS, Tucci P, Agostini M, Mineo TC, Levine AJ, Melino G.

Oncogene. 2014 Oct 16;33(42):5039-46. doi: 10.1038/onc.2013.456. Epub 2013 Nov 4.


PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.

Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW.

Oncogene. 2014 Feb 20;33(8):1047-54. doi: 10.1038/onc.2013.24. Epub 2013 Feb 25.


Senescence and aging: the critical roles of p53.

Rufini A, Tucci P, Celardo I, Melino G.

Oncogene. 2013 Oct 24;32(43):5129-43. doi: 10.1038/onc.2012.640. Epub 2013 Feb 18. Review.


Nutrient availability links mitochondria, apoptosis, and obesity.

Pintus F, Floris G, Rufini A.

Aging (Albany NY). 2012 Nov;4(11):734-41. Review.


TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2009-14. doi: 10.1101/gad.197640.112.


Relative expression of TAp73 and ΔNp73 isoforms.

Conforti F, Yang AL, Agostini M, Rufini A, Tucci P, Nicklison-Chirou MV, Grespi F, Velletri T, Knight RA, Melino G, Sayan BS.

Aging (Albany NY). 2012 Mar;4(3):202-5.


7th Tuscany Retreat on Cancer Research: genetic profiling, resistance mechanism and novel treatment concepts in cancer.

Leprivier G, Rufini A, García-Sáez AJ, Borner C, Rotblat B.

Cell Death Differ. 2012 Mar;19(3):546-8. doi: 10.1038/cdd.2011.186. Epub 2011 Dec 16. No abstract available.


Cell death pathology: the war against cancer.

Rufini A, Melino G.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):445-50. doi: 10.1016/j.bbrc.2011.09.110. Epub 2011 Sep 28. Review.


p63 in tooth development.

Rufini A, Barlattani A, Docimo R, Velletri T, Niklison-Chirou MV, Agostini M, Melino G.

Biochem Pharmacol. 2011 Nov 15;82(10):1256-61. doi: 10.1016/j.bcp.2011.07.068. Epub 2011 Jul 20. Review.


p73 in Cancer.

Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, Niklison-Chirou MV, Conforti F, Velletri T, Mastino A, Mak TW, Melino G, Knight RA.

Genes Cancer. 2011 Apr;2(4):491-502. doi: 10.1177/1947601911408890.


The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk.

Arpaia E, Blaser H, Quintela-Fandino M, Duncan G, Leong HS, Ablack A, Nambiar SC, Lind EF, Silvester J, Fleming CK, Rufini A, Tusche MW, Brüstle A, Ohashi PS, Lewis JD, Mak TW.

Oncogene. 2012 Feb 16;31(7):884-96. doi: 10.1038/onc.2011.288. Epub 2011 Jul 18.


p73: a multifunctional protein in neurobiology.

Killick R, Niklison-Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, Velletri T, Tucci P, Sayan BS, Conforti F, Gallagher E, Nicotera P, Mak TW, Melino G, Knight RA, Agostini M.

Mol Neurobiol. 2011 Apr;43(2):139-46. doi: 10.1007/s12035-011-8172-6. Epub 2011 Mar 8. Review.


Frataxin participates to the hypoxia-induced response in tumors.

Guccini I, Serio D, Condò I, Rufini A, Tomassini B, Mangiola A, Maira G, Anile C, Fina D, Pallone F, Mongiardi MP, Levi A, Ventura N, Testi R, Malisan F.

Cell Death Dis. 2011 Feb 24;2:e123. doi: 10.1038/cddis.2011.5.


Preventing the ubiquitin-proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia.

Rufini A, Fortuni S, Arcuri G, Condò I, Serio D, Incani O, Malisan F, Ventura N, Testi R.

Hum Mol Genet. 2011 Apr 1;20(7):1253-61. doi: 10.1093/hmg/ddq566. Epub 2011 Jan 7.


Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.

Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW.

Genes Dev. 2010 Mar 15;24(6):549-60. doi: 10.1101/gad.1873910. Epub 2010 Mar 1.


Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.

Condò I, Malisan F, Guccini I, Serio D, Rufini A, Testi R.

Hum Mol Genet. 2010 Apr 1;19(7):1221-9. doi: 10.1093/hmg/ddp592. Epub 2010 Jan 6.


TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity.

Tomasini R, Tsuchihara K, Tsuda C, Lau SK, Wilhelm M, Rufini A, Tsao MS, Iovanna JL, Jurisicova A, Melino G, Mak TW.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):797-802. doi: 10.1073/pnas.0812096106. Epub 2009 Jan 12. Erratum in: Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8812. Ruffini, Alessandro [corrected to Rufini, Alessandro].


TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.

Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, Khan F, Itie-Youten A, Wakeham A, Tsao MS, Iovanna JL, Squire J, Jurisica I, Kaplan D, Melino G, Jurisicova A, Mak TW.

Genes Dev. 2008 Oct 1;22(19):2677-91. doi: 10.1101/gad.1695308. Epub 2008 Sep 19.


DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.

Candi E, Rufini A, Terrinoni A, Giamboi-Miraglia A, Lena AM, Mantovani R, Knight R, Melino G.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11999-2004. Epub 2007 Jul 11.


In vivo maturation of human frataxin.

Condò I, Ventura N, Malisan F, Rufini A, Tomassini B, Testi R.

Hum Mol Genet. 2007 Jul 1;16(13):1534-40. Epub 2007 Apr 27.


TAp63 and DeltaNp63 in cancer and epidermal development.

Candi E, Dinsdale D, Rufini A, Salomoni P, Knight RA, Mueller M, Krammer PH, Melino G.

Cell Cycle. 2007 Feb 1;6(3):274-85. Epub 2007 Feb 3. Review.


p63 is upstream of IKK alpha in epidermal development.

Candi E, Terrinoni A, Rufini A, Chikh A, Lena AM, Suzuki Y, Sayan BS, Knight RA, Melino G.

J Cell Sci. 2006 Nov 15;119(Pt 22):4617-22.


p63 and p73, members of the p53 gene family, transactivate PKCdelta.

Ponassi R, Terrinoni A, Chikh A, Rufini A, Lena AM, Sayan BS, Melino G, Candi E.

Biochem Pharmacol. 2006 Nov 30;72(11):1417-22. Epub 2006 Sep 7.


Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.

Cursi S, Rufini A, Stagni V, Condò I, Matafora V, Bachi A, Bonifazi AP, Coppola L, Superti-Furga G, Testi R, Barilà D.

EMBO J. 2006 May 3;25(9):1895-905. Epub 2006 Apr 13.


Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.

Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli LG, Catani MV, Ramadan S, Knight RA, Melino G.

Cell Death Differ. 2006 Jun;13(6):1037-47.


p63 protein is essential for the embryonic development of vibrissae and teeth.

Rufini A, Weil M, McKeon F, Barlattani A, Melino G, Candi E.

Biochem Biophys Res Commun. 2006 Feb 17;340(3):737-41. Epub 2005 Dec 20.


Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII.

Holcomb M, Rufini A, Barilà D, Klemke RL.

J Biol Chem. 2006 Feb 3;281(5):2430-40. Epub 2005 Nov 1.


Transglutaminase 5 is acetylated at the N-terminal end.

Rufini A, Vilbois F, Paradisi A, Oddi S, Tartaglione R, Leta A, Bagetta G, Guerrieri P, Finazzi-Agro' A, Melino G, Candi E.

Amino Acids. 2004 Jul;26(4):425-30. Epub 2004 Jun 17.


Overexpressed transglutaminase 5 triggers cell death.

Cadot B, Rufini A, Pietroni V, Ramadan S, Guerrieri P, Melino G, Candi E.

Amino Acids. 2004 Jul;26(4):405-8. Epub 2004 Apr 8.


Caspase-dependent cleavage of c-Abl contributes to apoptosis.

Barilà D, Rufini A, Condò I, Ventura N, Dorey K, Superti-Furga G, Testi R.

Mol Cell Biol. 2003 Apr;23(8):2790-9.


Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

Malisan F, Franchi L, Tomassini B, Ventura N, Condò I, Rippo MR, Rufini A, Liberati L, Nachtigall C, Kniep B, Testi R.

J Exp Med. 2002 Dec 16;196(12):1535-41.


Human CD26 expression in transgenic mice affects murine T-cell populations and modifies their subset distribution.

Simeoni L, Rufini A, Moretti T, Forte P, Aiuti A, Fantoni A.

Hum Immunol. 2002 Sep;63(9):719-30.


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