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Select item 189482781.

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.

Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, Gutman GA, Laudet V, Neubig RR, Ohlstein EH, Olsen RW, Peters J, Pin JP, Ruffolo RR, Searls DB, Wright MW, Spedding M.

Nucleic Acids Res. 2009 Jan;37(Database issue):D680-5. doi: 10.1093/nar/gkn728. Epub 2008 Oct 23.

PMID:: 18948278

Free PMC Article

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Select item 177140192.

Discontinued drugs in 2006: cardiovascular drugs translational medicine perspective.

Feuerstein GZ, Ruffolo RR.

Expert Opin Investig Drugs. 2007 Sep;16(9):1315-26. Review.

PMID:: 17714019

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Select item 175796583.

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.

Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL.

J Cereb Blood Flow Metab. 2008 Jan;28(1):217-9. Epub 2007 Jun 20. Review.

PMID:: 17579658

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Select item 170018014.

An audience with... Robert R Ruffolo, Jr. Interview by Joanna Owens.

Ruffolo RR Jr.

Nat Rev Drug Discov. 2006 Sep;5(9):714. No abstract available.

PMID:: 17001801

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Select item 234957935.

Why has R&D productivity declined in the pharmaceutical industry?

Ruffolo RR.

Expert Opin Drug Discov. 2006 Jul;1(2):99-102. doi: 10.1517/17460441.1.2.99.

PMID:: 23495793

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Select item 235060346.

Carvedilol case history: the discovery and development of the first β-blocker for the treatment of congestive heart failure.

Ruffolo RR, Feuerstein GZ.

Expert Opin Drug Discov. 2006 Jun;1(1):85-9. doi: 10.1517/17460441.1.1.85.

PMID:: 23506034

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Select item 159919867.

Pharmacology of the angiotensin II receptor antagonist, eprosartan.

Edwards RM, Ruffolo RR Jr, Brooks DP.

Expert Opin Investig Drugs. 1998 Mar;7(3):463-9.

PMID:: 15991986

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Select item 114085458.

Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology.

Naselsky DP, Ashton D, Ruffolo RR Jr, Hieble JP.

J Pharmacol Exp Ther. 2001 Jul;298(1):219-25.

PMID:: 11408545

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Select item 110110419.

Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model.

Gao F, Chen J, Lopez BL, Christopher TA, Gu J, Lysko P, Ruffolo RR Jr, Ohlstein EH, Ma XL, Yue TL.

Eur J Pharmacol. 2000 Oct 6;406(1):109-16.

PMID:: 11011041

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Select item 1094217210.

A comparison of carvedilol and metoprolol antioxidant activities in vitro.

Lysko PG, Webb CL, Gu JL, Ohlstein EH, Ruffolo RR Jr, Yue TL.

J Cardiovasc Pharmacol. 2000 Aug;36(2):277-81.

PMID:: 10942172

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Select item 1083613211.

Drug discovery in the next millennium.

Ohlstein EH, Ruffolo RR Jr, Elliott JD.

Annu Rev Pharmacol Toxicol. 2000;40:177-91. Review.

PMID:: 10836132

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Select item 1046722012.

Pharmacology of eprosartan, an angiotensin II receptor antagonist: exploring hypotheses from clinical data.

Brooks DP, Ohlstein EH, Ruffolo RR Jr.

Am Heart J. 1999 Sep;138(3 Pt 2):246-51. Review.

PMID:: 10467220

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Select item 1046506413.

Pharmacological mechanism of angiotensin II receptor antagonists: implications for the treatment of elevated systolic blood pressure.

Brooks DP, Ruffolo RR Jr.

J Hypertens Suppl. 1999 Jun;17(2):S27-32. Review.

PMID:: 10465064

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Select item 1041984114.

Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases.

Yue TL, Ohlstein EH, Ruffolo RR Jr.

Curr Opin Chem Biol. 1999 Aug;3(4):474-80. Review.

PMID:: 10419841

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Select item 1040825115.

Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity.

Hieble JP, Kolpak DC, McCafferty GP, Ruffolo RR Jr, Testa R, Leonardi A.

Eur J Pharmacol. 1999 May 28;373(1):51-62.

PMID:: 10408251

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Select item 1039346816.

Adrenoceptor pharmacology: urogenital applications.

Ruffolo RR Jr, Hieble JP.

Eur Urol. 1999;36 Suppl 1:17-22. Review.

PMID:: 10393468

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Select item 1008698617.

In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats.

Willette RN, Aiyar N, Yue TL, Mitchell MP, Disa J, Storer BL, Naselsky DP, Stadel JM, Ohlstein EH, Ruffolo RR Jr.

J Pharmacol Exp Ther. 1999 Apr;289(1):48-53.

PMID:: 10086986

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Select item 983629718.

Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors.

Hieble JP, Hehr A, Li YO, Ruffolo RR Jr.

Proc West Pharmacol Soc. 1998;41:225-8. Review.

PMID:: 9836297

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Select item 977437419.

Effects of eprosartan on renal function and cardiac hypertrophy in rats with experimental heart failure.

Brodsky S, Gurbanov K, Abassi Z, Hoffman A, Ruffolo RR Jr, Feuerstein GZ, Winaver J.

Hypertension. 1998 Oct;32(4):746-52.

PMID:: 9774374

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Select item 977424920.

SB 211475, a metabolite of carvedilol, reduces infarct size after myocardial ischemic and reperfusion injury in rabbits.

Brunvand H, Liu G, Ma XL, Yue TL, Ruffolo RR Jr, Feuerstein GZ.

Eur J Pharmacol. 1998 Sep 4;356(2-3):193-8.

PMID:: 9774249

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Select item 973237821.

CVT-124, a novel adenosine A1 receptor antagonist with unique diuretic activity.

Gellai M, Schreiner GF, Ruffolo RR Jr, Fletcher T, DeWolf R, Brooks DP.

J Pharmacol Exp Ther. 1998 Sep;286(3):1191-6.

PMID:: 9732378

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Select item 973169222.

Neurohormonal activation, oxygen free radicals, and apoptosis in the pathogenesis of congestive heart failure.

Ruffolo RR Jr, Feuerstein GZ.

J Cardiovasc Pharmacol. 1998;32 Suppl 1:S22-30. Review.

PMID:: 9731692

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Select item 972102623.

Comparison of metoprolol and carvedilol pharmacology and cardioprotection in rabbit ischemia and reperfusion model.

Feuerstein G, Liu GL, Yue TL, Cheng HY, Hieble JP, Arch JR, Ruffolo RR Jr, Ma XL.

Eur J Pharmacol. 1998 Jun 26;351(3):341-50.

PMID:: 9721026

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Select item 971581924.

Novel mechanisms in the treatment of heart failure: inhibition of oxygen radicals and apoptosis by carvedilol.

Feuerstein G, Yue TL, Ma X, Ruffolo RR.

Prog Cardiovasc Dis. 1998 Jul-Aug;41(1 Suppl 1):17-24. Review.

PMID:: 9715819

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Select item 959545825.

Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083.

Douglas SA, Nambi P, Gellai M, Luengo JI, Xiang JN, Brooks DP, Ruffolo RR Jr, Elliott JD, Ohlstein EH.

J Cardiovasc Pharmacol. 1998;31 Suppl 1:S273-6.

PMID:: 9595458

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Select item 959359526.

Carvedilol inhibits activation of stress-activated protein kinase and reduces reperfusion injury in perfused rabbit heart.

Yue TL, Ma XL, Gu JL, Ruffolo RR Jr, Feuerstein GZ.

Eur J Pharmacol. 1998 Mar 12;345(1):61-5.

PMID:: 9593595

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Select item 951934827.

Carvedilol: preclinical profile and mechanisms of action in preventing the progression of congestive heart failure.

Ruffolo RR Jr, Feuerstein GZ.

Eur Heart J. 1998 Feb;19 Suppl B:B19-24. Review.

PMID:: 9519348

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Select item 951286528.

Congestive heart failure and genomic medicine: a look into the 21st century.

Feuerstein GZ, Ruffolo RR Jr.

Cardiovasc Drugs Ther. 1997 Dec;11(6):713-7. Review.

PMID:: 9512865

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Select item 950310129.

Recent observations with beta-adrenoceptor blockade. Beneficial effects in hypertension and heart failure.

Ruffolo RR Jr, Feuerstein GZ, Ohlstein EH.

Am J Hypertens. 1998 Jan;11(1 Pt 2):9S-14S. Review.

PMID:: 9503101

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Select item 948961830.

Effects of a hydroxylated metabolite of the beta-andrenoreceptor antagonist, carvedilol, on post-ischaemic splachnic tissue injury.

Christopher TA, Lopez BL, Ma XL, Feuerstein GZ, Ruffolo RR Jr, Yue TL.

Br J Pharmacol. 1998 Jan;123(2):292-8.

PMID:: 9489618

Free PMC Article

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Select item 946818731.

Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol.

Yue TL, Ma XL, Wang X, Romanic AM, Liu GL, Louden C, Gu JL, Kumar S, Poste G, Ruffolo RR Jr, Feuerstein GZ.

Circ Res. 1998 Feb 9;82(2):166-74.

PMID:: 9468187

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Select item 946718532.

Evaluation of intrinsic sympathomimetic activity of bucindolol and carvedilol in rat heart.

Willette RN, Mitchell MP, Ohlstein EH, Lukas MA, Ruffolo RR Jr.

Pharmacology. 1998 Jan;56(1):30-6.

PMID:: 9467185

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Select item 941254133.

Protective effects of carvedilol in the myocardium.

Feuerstein GZ, Bril A, Ruffolo RR Jr.

Am J Cardiol. 1997 Dec 4;80(11A):41L-45L. Review.

PMID:: 9412541

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Select item 939933434.

Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: relationship to differences in prejunctional angiotensin II receptor blockade.

Ohlstein EH, Brooks DP, Feuerstein GZ, Ruffolo RR Jr.

Pharmacology. 1997 Nov;55(5):244-51.

PMID:: 9399334

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Select item 932797635.

Beta-blockers in congestive heart failure: the pharmacology of carvedilol, a vasodilating beta-blocker and antioxidant, and its therapeutic utility in congestive heart failure.

Feuerstein G, Ruffolo RR Jr.

Adv Pharmacol. 1998;42:611-5. No abstract available.

PMID:: 9327976

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Select item 934584736.

Re-classification of NSAIDs.

Griswold DE, Ruffolo RR, Poste G, Torphy TJ.

Trends Pharmacol Sci. 1997 Sep;18(9):311-2. No abstract available.

PMID:: 9345847

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Select item 2123589337.

Apoptosis and congestive heart failure.

Feuerstein G, Ruffolo RR Jr, Yue TL.

Trends Cardiovasc Med. 1997 Oct;7(7):249-55. doi: 10.1016/S1050-1738(97)00068-6.

PMID:: 21235893

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Select item 930979738.

Ser165 of transmembrane helix IV is not involved in the interaction of catecholamines with the alpha-2a-adrenoceptor.

Hehr A, Hieble JP, Li YO, Bergsma DJ, Swift AM, Ganguly S, Ruffolo RR Jr.

Pharmacology. 1997 Jul;55(1):18-24.

PMID:: 9309797

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Select item 916879339.

Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury.

Ma XL, Lopez BL, Liu GL, Christopher TA, Gao F, Guo Y, Feuerstein GZ, Ruffolo RR Jr, Barone FC, Yue TL.

Circ Res. 1997 Jun;80(6):894-901.

PMID:: 9168793

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Select item 921101740.

Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure.

Ruffolo RR Jr, Feuerstein GZ.

Cardiovasc Drugs Ther. 1997 May;11 Suppl 1:247-56. Review.

PMID:: 9211017

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Select item 1598960541.

Recent advances in the identification of alpha1- and alpha2-adrenoceptor subtypes: therapeutic implications.

Hieble JP, Ruffolo RR Jr.

Expert Opin Investig Drugs. 1997 Apr;6(4):367-87.

PMID:: 15989605

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Select item 906595842.

Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat.

Feuerstein GZ, Fisher M, Nunnart J, Ruffolo RR Jr.

Pharmacology. 1997 Jan;54(1):24-32.

PMID:: 9065958

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Select item 881087243.

mRNA differential display: application in the discovery of novel pharmacological targets.

Wang X, Ruffolo RR Jr, Feuerstein GZ.

Trends Pharmacol Sci. 1996 Aug;17(8):276-9. Review. No abstract available.

PMID:: 8810872

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Select item 879818044.

Endothelin receptors: receptor classification, novel receptor antagonists, and potential therapeutic targets.

Ohlstein EH, Elliott JD, Feuerstein GZ, Ruffolo RR Jr.

Med Res Rev. 1996 Jul;16(4):365-90. Review.

PMID:: 8798180

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Select item 873306845.

Carvedilol, a novel vasodilating beta-blocker with the potential for cardiovascular organ protection.

Feuerstein GZ, Ruffolo RR Jr.

Eur Heart J. 1996 Apr;17 Suppl B:24-9. Review.

PMID:: 8733068

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Select item 861392346.

The selectivity in vitro of the stereoisomers of the beta-3 adrenoceptor agonist BRL 37344.

Oriowo MA, Chapman H, Kirkham DM, Sennitt MV, Ruffolo RR Jr, Cawthorne MA.

J Pharmacol Exp Ther. 1996 Apr;277(1):22-7.

PMID:: 8613923

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Select item 861390947.

Carvedilol, a new beta adrenoreceptor blocker and free radical scavenger, attenuates myocardial ischemia-reperfusion injury in hypercholesterolemic rabbits.

Ma XL, Yue TL, Lopez BL, Barone FC, Christopher TA, Ruffolo RR Jr, Feuerstein GZ.

J Pharmacol Exp Ther. 1996 Apr;277(1):128-36.

PMID:: 8613909

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Select item 888088648.

The use of alpha-adrenoceptor antagonists in the pharmacological management of benign prostatic hypertrophy: an overview.

Hieble JP, Ruffolo RR Jr.

Pharmacol Res. 1996 Mar;33(3):145-60. Review.

PMID:: 8880886

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Select item 863233149.

Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile of BRL-32872.

Bril A, Gout B, Bonhomme M, Landais L, Faivre JF, Linee P, Poyser RH, Ruffolo RR Jr.

J Pharmacol Exp Ther. 1996 Feb;276(2):637-46.

PMID:: 8632331

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Select item 896176550.

Subclassification and nomenclature of alpha 1- and alpha 2-adrenoceptors.

Hieble JP, Ruffolo RR Jr.

Prog Drug Res. 1996;47:81-130. Review. No abstract available.

PMID:: 8961765

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