Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 278

1.

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.

Sluka SHM, Stämpfli SF, Akhmedov A, Klein-Rodewald T, Sanz-Moreno A, Horsch M, Grest P, Rothmeier AS, Rathkolb B, Schrewe A, Beckers J, Neff F, Wolf E, Camici GG, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Lüscher TF, Ruf W, Tanner FC.

Haematologica. 2019 Sep 5. pii: haematol.2019.218818. doi: 10.3324/haematol.2019.218818. [Epub ahead of print]

2.

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.

Kroone C, Vos M, Rademakers T, Kuijpers M, Hoogenboezem M, van Buul J, Heemskerk JWM, Ruf W, van Hylckama Vlieg A, Versteeg HH, Goumans MJ, de Vries CJM, Kurakula K; INVENT Consortium.

Haematologica. 2019 Aug 29. pii: haematol.2018.203026. doi: 10.3324/haematol.2018.203026. [Epub ahead of print]

3.

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis.

Müller-Calleja N, Hollerbach A, Ritter S, Pedrosa DG, Strand D, Graf C, Reinhardt C, Strand S, Poncelet P, Griffin JH, Lackner KJ, Ruf W.

Blood. 2019 Aug 21. pii: blood.2019001530. doi: 10.1182/blood.2019001530. [Epub ahead of print]

PMID:
31434703
4.

Translational Research in Thrombosis and Haemostasis.

Ruf W.

Hamostaseologie. 2019 Jun;39(2):115-116. doi: 10.1055/s-0039-1691751. Epub 2019 Jul 30. No abstract available.

PMID:
31362324
5.

Center for Thrombosis and Hemostasis Mainz.

Konstantinides SV, Münzel T, Ruf W.

Eur Heart J. 2019 Jun 14;40(23):1827-1829. doi: 10.1093/eurheartj/ehz380. No abstract available.

PMID:
31199495
6.

Coagulation Signalling and Metabolic Disorders: Lessons Learned from Animal Models.

Madhusudhan T, Ruf W.

Hamostaseologie. 2019 Jun;39(2):164-172. doi: 10.1055/s-0039-1688800. Epub 2019 May 27.

PMID:
31132800
7.

Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles.

Koizume S, Takahashi T, Yoshihara M, Nakamura Y, Ruf W, Takenaka K, Miyagi E, Miyagi Y.

Thromb Haemost. 2019 Jul;119(7):1058-1071. doi: 10.1055/s-0039-1687876. Epub 2019 May 5.

PMID:
31055798
8.

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.

Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, Jabri B, Chirdo FG, Casqueiro J, Surette MG, Vergnolle N, Verdu EF.

Nat Commun. 2019 Mar 13;10(1):1198. doi: 10.1038/s41467-019-09037-9.

9.

Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells.

Rothmeier AS, Versteeg HH, Ruf W.

J Thromb Haemost. 2019 Apr;17(4):627-634. doi: 10.1111/jth.14406. Epub 2019 Mar 1.

PMID:
30740873
10.

Virus envelope tissue factor promotes infection in mice.

Sutherland MR, Simon AY, Shanina I, Horwitz MS, Ruf W, Pryzdial ELG.

J Thromb Haemost. 2019 Mar;17(3):482-491. doi: 10.1111/jth.14389. Epub 2019 Feb 20.

PMID:
30659719
11.

A biallelic mutation links MYORG to autosomal-recessive primary familial brain calcification.

Forouhideh Y, Müller K, Ruf W, Assi M, Seker T, Tunca C, Knehr A, Strom TM, Gorges M, Schradt F, Meitinger T, Ludolph AC, Pinkhardt EH, Basak AN, Kassubek J, Uttner I, Weishaupt JH.

Brain. 2019 Feb 1;142(2):e4. doi: 10.1093/brain/awy343. No abstract available.

PMID:
30649222
12.

Microbiota-Derived Trimethylamine.

Kiouptsi K, Ruf W, Reinhardt C.

Circ Res. 2018 Oct 26;123(10):1112-1114. doi: 10.1161/CIRCRESAHA.118.314039. No abstract available.

PMID:
30359194
13.

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.

Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H.

Res Pract Thromb Haemost. 2018 Apr 12;2(3):407-428. doi: 10.1002/rth2.12095. eCollection 2018 Jul. Review.

14.

ISTH 2017 Berlin revisited.

Ruf W.

Res Pract Thromb Haemost. 2017 Dec 8;2(1):17-18. doi: 10.1002/rth2.12063. eCollection 2018 Jan. No abstract available.

15.

Tissue factor at the crossroad of coagulation and cell signaling.

Zelaya H, Rothmeier AS, Ruf W.

J Thromb Haemost. 2018 Oct;16(10):1941-1952. doi: 10.1111/jth.14246. Epub 2018 Aug 16. Review.

PMID:
30030891
16.

Extravascular coagulation in hematopoietic stem and progenitor cell regulation.

Nguyen TS, Lapidot T, Ruf W.

Blood. 2018 Jul 12;132(2):123-131. doi: 10.1182/blood-2017-12-768986. Epub 2018 Jun 4. Review.

17.

Proteases, Protease-Activated Receptors, and Atherosclerosis.

Ruf W.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1252-1254. doi: 10.1161/ATVBAHA.118.311139. No abstract available.

18.

Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies.

Müller-Calleja N, Ritter S, Hollerbach A, Falter T, Lackner KJ, Ruf W.

Blood Adv. 2018 May 8;2(9):979-986. doi: 10.1182/bloodadvances.2018017095.

19.

Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation.

Graf C, Ruf W.

Thromb Res. 2018 Apr;164 Suppl 1:S143-S147. doi: 10.1016/j.thromres.2018.01.023. Epub 2018 Jan 13.

PMID:
29703473
20.

Tissue Factor Coagulant Activity is Regulated by the Plasma Membrane Microenvironment.

Yu Y, Böing AN, Hau CM, Hajji N, Ruf W, Sturk A, Nieuwland R.

Thromb Haemost. 2018 Jun;118(6):990-1000. doi: 10.1055/s-0038-1642031. Epub 2018 Apr 21.

PMID:
29679947
21.

Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity.

Kurakula K, Koenis DS, Herzik MA Jr, Liu Y, Craft JW Jr, van Loenen PB, Vos M, Tran MK, Versteeg HH, Goumans MTH, Ruf W, de Vries CJM, Şen M.

Haematologica. 2018 Jun;103(6):1073-1082. doi: 10.3324/haematol.2017.183087. Epub 2018 Mar 15.

22.

Paraoxonase-2 regulates coagulation activation through endothelial tissue factor.

Ebert J, Wilgenbus P, Teiber JF, Jurk K, Schwierczek K, Döhrmann M, Xia N, Li H, Spiecker L, Ruf W, Horke S.

Blood. 2018 May 10;131(19):2161-2172. doi: 10.1182/blood-2017-09-807040. Epub 2018 Feb 9.

23.

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, Vajen T, Alshaikh NA, Wolberg AS, Macrae FL, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers JCM, Heestermans M, Renné T, Dólleman S, Chayouâ W, Ariëns RAS, Baaten CC, Nagy M, Kuliopulos A, Posma JJ, Harrison P, Vries MJ, Crijns HJGM, Dudink EAMP, Buller HR, Henskens YMC, Själander A, Zwaveling S, Erküner O, Eikelboom JW, Gulpen A, Peeters FECM, Douxfils J, Olie RH, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom HMM, Mosnier LO, van der Vorm L, Declerck P, Visser M, Dippel DWJ, Strijbis VJ, Pertiwi K, Ten Cate-Hoek AJ, Ten Cate H.

Thromb Haemost. 2018 Feb;118(2):229-250. doi: 10.1160/TH17-07-0492. Epub 2018 Jan 29.

24.

Hot-spot KIF5A mutations cause familial ALS.

Brenner D, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Strom TM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET.

Brain. 2018 Mar 1;141(3):688-697. doi: 10.1093/brain/awx370.

25.

Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling.

Rothmeier AS, Liu E, Chakrabarty S, Disse J, Mueller BM, Østergaard H, Ruf W.

Blood. 2018 Feb 8;131(6):674-685. doi: 10.1182/blood-2017-02-768218. Epub 2017 Dec 15.

26.

Engineering of a membrane-triggered activity switch in coagulation factor VIIa.

Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sørensen BB, Ruf W, Olsen OH, Østergaard H.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12454-12459. doi: 10.1073/pnas.1618713114. Epub 2017 Nov 6.

27.

Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.

Kamikubo Y, Mendolicchio GL, Zampolli A, Marchese P, Rothmeier AS, Orje JN, Gale AJ, Krishnaswamy S, Gruber A, Østergaard H, Petersen LC, Ruf W, Ruggeri ZM.

Blood. 2017 Oct 5;130(14):1661-1670. doi: 10.1182/blood-2017-02-767079. Epub 2017 Jul 20.

28.

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.

Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7.

29.

State of the Art 2017.

Ruf W, Preissner KT.

J Thromb Haemost. 2017 Jul;15(7):1239. doi: 10.1111/jth.13732. Epub 2017 Jun 7. No abstract available.

30.

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C.

Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.

31.

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W.

Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1323-1331. doi: 10.1161/ATVBAHA.117.309315. Epub 2017 May 11.

32.

Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development.

Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W.

Blood. 2017 Apr 20;129(16):2291-2302. doi: 10.1182/blood-2016-11-749879. Epub 2017 Feb 21.

33.

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension.

Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah4923. doi: 10.1126/scitranslmed.aah4923.

PMID:
28148841
34.

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

Reiner MF, Akhmedov A, Stivala S, Keller S, Gaul DS, Bonetti NR, Savarese G, Glanzmann M, Zhu C, Ruf W, Yang Z, Matter CM, Lüscher TF, Camici GG, Beer JH.

Cardiovasc Res. 2017 Jan;113(1):61-69. doi: 10.1093/cvr/cvw233. Epub 2016 Nov 15.

PMID:
28028070
35.

LRRK2 contributes to monocyte dysregulation in Parkinson's disease.

Bliederhaeuser C, Zondler L, Grozdanov V, Ruf WP, Brenner D, Melrose HL, Bauer P, Ludolph AC, Gillardon F, Kassubek J, Weishaupt JH, Danzer KM.

Acta Neuropathol Commun. 2016 Nov 24;4(1):123. No abstract available.

36.

Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy.

Hu Z, Cheng J, Xu J, Ruf W, Lockwood CJ.

Angiogenesis. 2017 Feb;20(1):85-96. doi: 10.1007/s10456-016-9530-9. Epub 2016 Nov 2.

37.

The influence of physical activity during pregnancy on maternal, fetal or infant heart rate variability: a systematic review.

Dietz P, Watson ED, Sattler MC, Ruf W, Titze S, van Poppel M.

BMC Pregnancy Childbirth. 2016 Oct 26;16(1):326. Review.

38.

Impaired activation of ALS monocytes by exosomes.

Zondler L, Feiler MS, Freischmidt A, Ruf WP, Ludolph AC, Danzer KM, Weishaupt JH.

Immunol Cell Biol. 2017 Feb;95(2):207-214. doi: 10.1038/icb.2016.89. Epub 2016 Sep 12.

PMID:
27616750
39.

Hemostasis keeps the stem cell niche in order.

Ruf W.

Blood. 2016 Aug 25;128(8):1027-9. doi: 10.1182/blood-2016-07-722421. No abstract available.

40.

OC-09 - Microparticle-mediated transfer of TF hypercoagulability between cancer cells.

Shaker H, Rothmeier AS, Kirwan CC, Ruf W.

Thromb Res. 2016 Apr;140 Suppl 1:S172. doi: 10.1016/S0049-3848(16)30126-8. Epub 2016 Apr 8.

PMID:
27161681
41.

Targeting clotting proteins in cancer therapy - progress and challenges.

Ruf W, Rothmeier AS, Graf C.

Thromb Res. 2016 Apr;140 Suppl 1:S1-7. doi: 10.1016/S0049-3848(16)30090-1. Review.

42.

Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446b. No abstract available.

PMID:
27050594
43.

Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling.

Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T.

Ann N Y Acad Sci. 2016 Apr;1370(1):65-81. doi: 10.1111/nyas.13013. Epub 2016 Mar 1. Review.

44.

Peripheral monocytes are functionally altered and invade the CNS in ALS patients.

Zondler L, Müller K, Khalaji S, Bliederhäuser C, Ruf WP, Grozdanov V, Thiemann M, Fundel-Clemes K, Freischmidt A, Holzmann K, Strobel B, Weydt P, Witting A, Thal DR, Helferich AM, Hengerer B, Gottschalk KE, Hill O, Kluge M, Ludolph AC, Danzer KM, Weishaupt JH.

Acta Neuropathol. 2016 Sep;132(3):391-411. doi: 10.1007/s00401-016-1548-y. Epub 2016 Feb 24.

PMID:
26910103
45.

Tissue factor associates with survival and regulates tumour progression in osteosarcoma.

Tieken C, Verboom MC, Ruf W, Gelderblom H, Bovée JV, Reitsma PH, Cleton-Jansen AM, Versteeg HH.

Thromb Haemost. 2016 May 2;115(5):1025-33. doi: 10.1160/TH15-07-0541. Epub 2016 Jan 14.

46.

α-synuclein interacts with SOD1 and promotes its oligomerization.

Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM.

Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3.

47.

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes.

Bliederhaeuser C, Grozdanov V, Speidel A, Zondler L, Ruf WP, Bayer H, Kiechle M, Feiler MS, Freischmidt A, Brenner D, Witting A, Hengerer B, Fändrich M, Ludolph AC, Weishaupt JH, Gillardon F, Danzer KM.

Acta Neuropathol. 2016 Mar;131(3):379-91. doi: 10.1007/s00401-015-1504-2. Epub 2015 Nov 17.

PMID:
26576561
48.

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2015 Nov;21(11):1307-17. doi: 10.1038/nm.3960. Epub 2015 Oct 12. Erratum in: Nat Med. 2016 Apr;22(4):446.

49.

High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors.

Koizume S, Ito S, Yoshioka Y, Kanayama T, Nakamura Y, Yoshihara M, Yamada R, Ochiya T, Ruf W, Miyagi E, Hirahara F, Miyagi Y.

Thromb Haemost. 2016 Jan;115(2):299-310. doi: 10.1160/TH15-03-0213. Epub 2015 Oct 8.

PMID:
26446354
50.

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

van der Meijden PE, Ozaki Y, Ruf W, de Laat B, Mutch N, Diamond S, Nieuwland R, Peters TC, Heestermans M, Kremers RM, Moorlag M, Boender J, Ünlü B, Reitsma PH.

Thromb Res. 2015 Sep;136 Suppl 1:S3-7. doi: 10.1016/j.thromres.2015.07.034. No abstract available.

PMID:
26387733

Supplemental Content

Support Center