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Items: 1 to 50 of 153

1.

Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.

Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA.

J Allergy Clin Immunol. 2019 Aug 8. pii: S0091-6749(19)31029-2. doi: 10.1016/j.jaci.2019.07.033. [Epub ahead of print]

PMID:
31401286
2.

mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.

Castets P, Rion N, Théodore M, Falcetta D, Lin S, Reischl M, Wild F, Guérard L, Eickhorst C, Brockhoff M, Guridi M, Ibebunjo C, Cruz J, Sinnreich M, Rudolf R, Glass DJ, Rüegg MA.

Nat Commun. 2019 Jul 18;10(1):3187. doi: 10.1038/s41467-019-11227-4.

3.

BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle.

Delezie J, Weihrauch M, Maier G, Tejero R, Ham DJ, Gill JF, Karrer-Cardel B, Rüegg MA, Tabares L, Handschin C.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16111-16120. doi: 10.1073/pnas.1900544116. Epub 2019 Jul 18.

PMID:
31320589
4.

Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA.

Donadon I, Bussani E, Riccardi F, Licastro D, Romano G, Pianigiani G, Pinotti M, Kostantinova P, Evers M, Lin S, Rüegg MA, Pagani F.

Nucleic Acids Res. 2019 May 25. pii: gkz469. doi: 10.1093/nar/gkz469. [Epub ahead of print]

PMID:
31127278
5.

mTOR controls embryonic and adult myogenesis via mTORC1.

Rion N, Castets P, Lin S, Enderle L, Reinhard JR, Eickhorst C, Rüegg MA.

Development. 2019 Apr 8;146(7). pii: dev172460. doi: 10.1242/dev.172460.

PMID:
30872276
6.

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.

Martin SK, Fitter S, El Khawanky N, Grose RH, Walkley CR, Purton LE, Ruegg MA, Hall MN, Gronthos S, Zannettino ACW.

Sci Rep. 2018 Sep 28;8(1):14501. doi: 10.1038/s41598-018-32858-5.

7.

Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury.

Zainul Z, Heikkinen A, Koivisto H, Rautalahti I, Kallio M, Lin S, Härönen H, Norman O, Rüegg MA, Tanila H, Pihlajaniemi T.

J Neurosci. 2018 Apr 25;38(17):4243-4258. doi: 10.1523/JNEUROSCI.3119-17.2018. Epub 2018 Apr 6.

8.

Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands.

van Putten M, Aartsma-Rus A, Grounds MD, Kornegay JN, Mayhew A, Gillingwater TH, Takeda S, Rüegg MA, De Luca A, Nagaraju K, Willmann R.

J Neuromuscul Dis. 2018;5(1):29-34. doi: 10.3233/JND-170288.

9.

Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy.

Boido M, De Amicis E, Valsecchi V, Trevisan M, Ala U, Ruegg MA, Hettwer S, Vercelli A.

Front Cell Neurosci. 2018 Jan 30;12:17. doi: 10.3389/fncel.2018.00017. eCollection 2018.

10.

Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies.

Yurchenco PD, McKee KK, Reinhard JR, Rüegg MA.

Matrix Biol. 2018 Oct;71-72:174-187. doi: 10.1016/j.matbio.2017.11.009. Epub 2017 Nov 27. Review.

PMID:
29191403
11.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

12.

Neuronal LRP4 regulates synapse formation in the developing CNS.

Karakatsani A, Marichal N, Urban S, Kalamakis G, Ghanem A, Schick A, Zhang Y, Conzelmann KK, Rüegg MA, Berninger B, Ruiz de Almodovar C, Gascón S, Kröger S.

Development. 2017 Dec 15;144(24):4604-4615. doi: 10.1242/dev.150110. Epub 2017 Oct 23.

13.

Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise.

Hodson N, McGlory C, Oikawa SY, Jeromson S, Song Z, Rüegg MA, Hamilton DL, Phillips SM, Philp A.

Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C604-C611. doi: 10.1152/ajpcell.00176.2017. Epub 2017 Sep 27.

14.

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E.

Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014.

15.

Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice.

Reinhard JR, Lin S, McKee KK, Meinen S, Crosson SC, Sury M, Hobbs S, Maier G, Yurchenco PD, Rüegg MA.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal4649. doi: 10.1126/scitranslmed.aal4649.

16.

Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy.

Willmann R, Gordish-Dressman H, Meinen S, Rüegg MA, Yu Q, Nagaraju K, Kumar A, Girgenrath M, Coffey CBM, Cruz V, Van Ry PM, Bogdanik L, Lutz C, Rutkowski A, Burkin DJ.

J Neuromuscul Dis. 2017;4(2):115-126. doi: 10.3233/JND-170217. Review.

17.

LncRNA-encoded peptides: More than translational noise?

Rion N, Rüegg MA.

Cell Res. 2017 May;27(5):604-605. doi: 10.1038/cr.2017.35. Epub 2017 Mar 14.

18.

Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype.

McKee KK, Crosson SC, Meinen S, Reinhard JR, Rüegg MA, Yurchenco PD.

J Clin Invest. 2017 Mar 1;127(3):1075-1089. doi: 10.1172/JCI90854. Epub 2017 Feb 20.

19.

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.

Fitter S, Matthews MP, Martin SK, Xie J, Ooi SS, Walkley CR, Codrington JD, Ruegg MA, Hall MN, Proud CG, Gronthos S, Zannettino ACW.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00668-16. doi: 10.1128/MCB.00668-16. Print 2017 Apr 1.

20.

Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.

Brockhoff M, Rion N, Chojnowska K, Wiktorowicz T, Eickhorst C, Erne B, Frank S, Angelini C, Furling D, Rüegg MA, Sinnreich M, Castets P.

J Clin Invest. 2017 Feb 1;127(2):549-563. doi: 10.1172/JCI89616. Epub 2017 Jan 9.

21.

"Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders.

Castets P, Frank S, Sinnreich M, Rüegg MA.

J Neuromuscul Dis. 2016 May 27;3(2):127-155. Review.

22.

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA.

Nat Commun. 2016 Oct 27;7:13226. doi: 10.1038/ncomms13226.

23.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3.

Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, Krycer JR, Sylow L, Fritzen AM, Hoffman NJ, Jeppesen J, Schjerling P, Ruegg MA, Kiens B, James DE, Richter EA.

Mol Metab. 2016 Jun 22;5(8):646-655. doi: 10.1016/j.molmet.2016.06.007. eCollection 2016 Aug.

24.

The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.

Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA.

Nat Commun. 2016 May 19;7:11613. doi: 10.1038/ncomms11613.

25.

mTORC2 critically regulates renal potassium handling.

Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB.

J Clin Invest. 2016 May 2;126(5):1773-82. doi: 10.1172/JCI80304. Epub 2016 Apr 4.

26.

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.

Guridi M, Kupr B, Romanino K, Lin S, Falcetta D, Tintignac L, Rüegg MA.

Skelet Muscle. 2016 Mar 21;6:13. doi: 10.1186/s13395-016-0084-8. eCollection 2016.

27.

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.

Zhang L, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, Rüegg MA, Hall MN, Fajas L, Zehn D, Mach JP, Donda A, Romero P.

Cell Rep. 2016 Feb 9;14(5):1206-1217. doi: 10.1016/j.celrep.2015.12.095. Epub 2016 Jan 21.

28.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, 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Domi T, Porrello E, Velardo D, Capotondo A, Biffi A, Tonlorenzi R, Amadio S, Ambrosi A, Miyagoe-Suzuki Y, Takeda S, Ruegg MA, Previtali SC.

Skelet Muscle. 2015 Sep 3;5:30. doi: 10.1186/s13395-015-0055-5. eCollection 2015.

35.

mTORC1 and mTORC2 have largely distinct functions in Purkinje cells.

Angliker N, Burri M, Zaichuk M, Fritschy JM, Rüegg MA.

Eur J Neurosci. 2015 Oct;42(8):2595-612. doi: 10.1111/ejn.13051. Epub 2015 Sep 18.

36.

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

Tintignac LA, Brenner HR, Rüegg MA.

Physiol Rev. 2015 Jul;95(3):809-52. doi: 10.1152/physrev.00033.2014. Review.

37.

Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders.

Willmann R, Luca A, Nagaraju K, Rüegg MA.

J Neuromuscul Dis. 2015 May 14;2(2):113-117.

PMID:
27858730
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Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.

Ma S, Venkatesh A, Langellotto F, Le YZ, Hall MN, Rüegg MA, Punzo C.

Exp Eye Res. 2015 Jun;135:1-13. doi: 10.1016/j.exer.2015.04.006. Epub 2015 Apr 14.

39.

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

Venkatesh A, Ma S, Le YZ, Hall MN, Rüegg MA, Punzo C.

J Clin Invest. 2015 Apr;125(4):1446-58. doi: 10.1172/JCI79766. Epub 2015 Mar 23.

40.

Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.

Carr TD, Feehan RP, Hall MN, Rüegg MA, Shantz LM.

Carcinogenesis. 2015 Apr;36(4):487-97. doi: 10.1093/carcin/bgv012. Epub 2015 Mar 4.

41.

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation.

Martin SK, Fitter S, Dutta AK, Matthews MP, Walkley CR, Hall MN, Ruegg MA, Gronthos S, Zannettino AC.

Stem Cells. 2015 Apr;33(4):1359-65. doi: 10.1002/stem.1931.

42.

Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex.

Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Rüegg MA, Delbono O, Caputo C, Zorzato F.

Biochem J. 2015 Feb 15;466(1):123-35. doi: 10.1042/BJ20140935.

43.

Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles.

Zhang Y, Lin S, Karakatsani A, Rüegg MA, Kröger S.

Eur J Neurosci. 2015 Jan;41(1):69-78. doi: 10.1111/ejn.12768. Epub 2014 Nov 6.

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44.

mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.

Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U.

Cell Rep. 2014 Oct 23;9(2):646-60. doi: 10.1016/j.celrep.2014.09.001. Epub 2014 Oct 9.

45.

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.

Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxbøll AJ, Jordy AB, Jensen TE, Yang G, Schjerling P, Kiens B, James DE, Ruegg MA, Richter EA.

Mol Metab. 2014 Jun 27;3(6):630-41. doi: 10.1016/j.molmet.2014.06.004. eCollection 2014 Sep.

46.

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.

Steiner E, Enzmann GU, Lyck R, Lin S, Rüegg MA, Kröger S, Engelhardt B.

Cell Tissue Res. 2014 Nov;358(2):465-79. doi: 10.1007/s00441-014-1969-7. Epub 2014 Aug 9.

47.

Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function.

Zhang L, Tschumi BO, Corgnac S, Rüegg MA, Hall MN, Mach JP, Romero P, Donda A.

J Immunol. 2014 Aug 15;193(4):1759-65. doi: 10.4049/jimmunol.1400769. Epub 2014 Jul 11.

48.

Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development.

Chou PC, Oh WJ, Wu CC, Moloughney J, Rüegg MA, Hall MN, Jacinto E, Werlen G.

J Immunol. 2014 Aug 1;193(3):1162-70. doi: 10.4049/jimmunol.1303162. Epub 2014 Jun 30.

49.

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.

Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2817-26. doi: 10.1073/pnas.1402352111. Epub 2014 Jun 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6826. Sander, Lukas [corrected to Sandner, Lukas].

50.

Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.

Lebrun-Julien F, Bachmann L, Norrmén C, Trötzmüller M, Köfeler H, Rüegg MA, Hall MN, Suter U.

J Neurosci. 2014 Jun 18;34(25):8432-48. doi: 10.1523/JNEUROSCI.1105-14.2014.

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