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Items: 20

1.

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.

Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN.

ACS Omega. 2019 Jun 10;4(6):10056-10069. doi: 10.1021/acsomega.9b00640. eCollection 2019 Jun 30.

2.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.

Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A.

J Med Chem. 2019 Aug 22;62(16):7400-7416. doi: 10.1021/acs.jmedchem.9b00186. Epub 2019 Aug 5.

PMID:
31246024
3.

Monomer-to-dimer transition of Brucella suis type IV secretion system component VirB8 induces conformational changes.

Sharifahmadian M, Arya T, Bessette B, Lecoq L, Ruediger E, Omichinski JG, Baron C.

FEBS J. 2017 Apr;284(8):1218-1232. doi: 10.1111/febs.14049. Epub 2017 Mar 23.

4.

Minimally destructive sampling of type specimens of Pyropia (Bangiales, Rhodophyta) recovers complete plastid and mitochondrial genomes.

Hughey JR, Gabrielson PW, Rohmer L, Tortolani J, Silva M, Miller KA, Young JD, Martell C, Ruediger E.

Sci Rep. 2014 Jun 4;4:5113. doi: 10.1038/srep05113.

5.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

Belema M, Nguyen VN, Bachand C, Deon DH, Goodrich JT, James CA, Lavoie R, Lopez OD, Martel A, Romine JL, Ruediger EH, Snyder LB, St Laurent DR, Yang F, Zhu J, Wong HS, Langley DR, Adams SP, Cantor GH, Chimalakonda A, Fura A, Johnson BM, Knipe JO, Parker DD, Santone KS, Fridell RA, Lemm JA, O'Boyle DR 2nd, Colonno RJ, Gao M, Meanwell NA, Hamann LG.

J Med Chem. 2014 Mar 13;57(5):2013-32. doi: 10.1021/jm401836p. Epub 2014 Feb 12.

PMID:
24521299
6.

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

Qiu D, Lemm JA, O'Boyle DR, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA.

J Gen Virol. 2011 Nov;92(Pt 11):2502-2511. doi: 10.1099/vir.0.034801-0. Epub 2011 Jul 27.

PMID:
21795470
7.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Mastalerz H, Chang M, Chen P, Dextraze P, Fink BE, Gavai A, Goyal B, Han WC, Johnson W, Langley D, Lee FY, Marathe P, Mathur A, Oppenheimer S, Ruediger E, Tarrant J, Tokarski JS, Vite GD, Vyas DM, Wong H, Wong TW, Zhang H, Zhang G.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2036-42. Epub 2007 Jan 12.

PMID:
17270437
8.

Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors.

Beaulieu F, Ouellet C, Ruediger EH, Belema M, Qiu Y, Yang X, Banville J, Burke JR, Gregor KR, MacMaster JF, Martel A, McIntyre KW, Pattoli MA, Zusi FC, Vyas D.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1233-7. Epub 2006 Dec 9.

PMID:
17197177
9.

Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.

Saulnier MG, Balasubramanian BN, Long BH, Frennesson DB, Ruediger E, Zimmermann K, Eummer JT, St Laurent DR, Stoffan KM, Naidu BN, Mahler M, Beaulieu F, Bachand C, Lee FY, Fairchild CR, Stadnick LK, Rose WC, Solomon C, Wong H, Martel A, Wright JJ, Kramer R, Langley DR, Vyas DM.

J Med Chem. 2005 Apr 7;48(7):2258-61.

PMID:
15801816
10.

Novel 3',6'-anhydro and N12,N13-bridged glycosylated fluoroindolo[2,3-a]carbazoles as topoisomerase I inhibitors. Fluorine as a leaving group from sp3 carbon.

Saulnier MG, Langley DR, Frennesson DB, Long BH, Huang S, Gao Q, Wu D, Fairchild CR, Ruediger E, Zimmermann K, St Laurent DR, Balasubramanian BN, Vyas DM.

Org Lett. 2005 Mar 31;7(7):1271-4.

PMID:
15787484
11.

Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.

Balasubramanian BN, St Laurent DR, Saulnier MG, Long BH, Bachand C, Beaulieu F, Clarke W, Deshpande M, Eummer J, Fairchild CR, Frennesson DB, Kramer R, Lee FY, Mahler M, Martel A, Naidu BN, Rose WC, Russell J, Ruediger E, Solomon C, Stoffan KM, Wong H, Wright JJ, Zimmermann K, Vyas DM.

J Med Chem. 2004 Mar 25;47(7):1609-12. Erratum in: J Med Chem. 2005 Jan 27;48(2):654.

PMID:
15027851
12.

beta-alanine dipeptides as MC4R agonists.

Ruel R, Herpin TF, Iben L, Luo G, Martel A, Mason H, Mattson G, Poirier B, Ruediger EH, Shi D, Thibault C, Yu G, Antal Zimanyi I, Poindexter GS, Macor JE.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4341-4.

PMID:
14643322
13.

2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.

Dubowchik GM, Michne JA, Zuev D, Schwartz W, Scola PM, James CA, Ruediger EH, Pin SS, Burris KD, Balanda LA, Gao Q, Wu D, Fung L, Fiedler T, Browman KE, Taber MT, Zhang J.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3997-4000.

PMID:
14592493
14.

Novel quinolizidine salicylamide influenza fusion inhibitors.

Yu KL, Ruediger E, Luo G, Cianci C, Danetz S, Tiley L, Trehan AK, Monkovic I, Pearce B, Martel A, Krystal M, Meanwell NA.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2177-80.

PMID:
10465540
15.

Evaluation of cerebral pharmacokinetics of the novel antidepressant drug, BMS-181101, by positron emission tomography.

Christian BT, Livni E, Babich JW, Alpert NM, Dischino DD, Ruediger E, Salazar DE, Ford NF, Fischman AJ.

J Pharmacol Exp Ther. 1996 Oct;279(1):325-31.

PMID:
8859010
16.

Synthesis and antibacterial activity of some novel 6-methyl- and 6-propenyl-substituted carbapenems.

Mastalerz H, Menard M, Ruediger E, Fung-Tomc J.

J Med Chem. 1992 Mar 6;35(5):953-8.

PMID:
1548685
17.

Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.

Cipollina JA, Ruediger EH, New JS, Wire ME, Shepherd TA, Smith DW, Yevich JP.

J Med Chem. 1991 Nov;34(11):3316-28.

PMID:
1683407
18.

Information for B. and T.

Ruediger EH.

Science. 1946 Feb 8;103(2667):174. No abstract available.

PMID:
17784186
19.

The Aschheim-zondek Test for Pregnancy.

Ruediger EH.

Cal West Med. 1936 Mar;44(3):157-9. No abstract available.

20.

A PLEA IN FAVOR OF A STANDARDIZED WASSERMANN TEST.

Ruediger EH.

Cal West Med. 1924 Nov;22(11):548-53. No abstract available.

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