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Electromechanics of the Normal Human Heart In Situ.

Andrews C, Cupps BP, Pasque MK, Rudy Y.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007484. doi: 10.1161/CIRCEP.119.007484. Epub 2019 Nov 8. No abstract available.


Noninvasive Mapping of the Electrophysiological Substrate in Cardiac Amyloidosis and Its Relationship to Structural Abnormalities.

Orini M, Graham AJ, Martinez-Naharro A, Andrews CM, de Marvao A, Statton B, Cook SA, O'Regan DP, Hawkins PN, Rudy Y, Fontana M, Lambiase PD.

J Am Heart Assoc. 2019 Sep 17;8(18):e012097. doi: 10.1161/JAHA.119.012097. Epub 2019 Sep 8.


Letter to the Editor-ECG imaging and activation mapping.

Rudy Y.

Heart Rhythm. 2019 Jun;16(6):e50-e51. doi: 10.1016/j.hrthm.2019.02.001. Epub 2019 Feb 5. No abstract available.


Phase I/II Trial of Electrophysiology-Guided Noninvasive Cardiac Radioablation for Ventricular Tachycardia.

Robinson CG, Samson PP, Moore KMS, Hugo GD, Knutson N, Mutic S, Goddu SM, Lang A, Cooper DH, Faddis M, Noheria A, Smith TW, Woodard PK, Gropler RJ, Hallahan DE, Rudy Y, Cuculich PS.

Circulation. 2019 Jan 15;139(3):313-321. doi: 10.1161/CIRCULATIONAHA.118.038261.


Effects of β-subunit on gating of a potassium ion channel: Molecular simulations of cardiac IKs activation.

Xu J, Rudy Y.

J Mol Cell Cardiol. 2018 Nov;124:35-44. doi: 10.1016/j.yjmcc.2018.10.003. Epub 2018 Oct 4.


The Structural Basis of IKs Ion-Channel Activation: Mechanistic Insights from Molecular Simulations.

Ramasubramanian S, Rudy Y.

Biophys J. 2018 Jun 5;114(11):2584-2594. doi: 10.1016/j.bpj.2018.04.023.


Role for electrocardiographic imaging in cardiac resynchronization therapy?

Rudy Y.

Heart Rhythm. 2018 Jul;15(7):1070-1071. doi: 10.1016/j.hrthm.2018.03.011. Epub 2018 Mar 9. No abstract available.


Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia.

Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, Faddis M, Gleva M, Noheria A, Smith TW, Hallahan D, Rudy Y, Robinson CG.

N Engl J Med. 2017 Dec 14;377(24):2325-2336. doi: 10.1056/NEJMoa1613773.


Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling.

Lee HC, Rudy Y, Liang H, Chen CC, Luo CH, Sheu SH, Cui J.

J Med Biol Eng. 2017 Oct;37(5):780-789. doi: 10.1007/s40846-017-0257-x. Epub 2017 Jul 5.


The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients.

Zhang J, Hocini M, Strom M, Cuculich PS, Cooper DH, Sacher F, Haïssaguerre M, Rudy Y.

JACC Clin Electrophysiol. 2017 Aug;3(8):894-904. doi: 10.1016/j.jacep.2016.12.017.


Response by Andrews et al to Letter Regarding Article, "Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging".

Andrews CM, Srinivasan NT, Rosmini S, Bulluck H, Orini M, Jenkins S, Pantazis A, McKenna WJ, Moon JC, Lambiase PD, Rudy Y.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005768. doi: 10.1161/CIRCEP.117.005768. No abstract available.


Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging.

Andrews CM, Srinivasan NT, Rosmini S, Bulluck H, Orini M, Jenkins S, Pantazis A, McKenna WJ, Moon JC, Lambiase PD, Rudy Y.

Circ Arrhythm Electrophysiol. 2017 Jul;10(7). pii: e005105. doi: 10.1161/CIRCEP.116.005105.


Noninvasive ECG imaging (ECGI): Mapping the arrhythmic substrate of the human heart.

Rudy Y.

Int J Cardiol. 2017 Jun 15;237:13-14. doi: 10.1016/j.ijcard.2017.02.104. Epub 2017 Feb 27. Review.


Methodology Considerations in Phase Mapping of Human Cardiac Arrhythmias.

Vijayakumar R, Vasireddi SK, Cuculich PS, Faddis MN, Rudy Y.

Circ Arrhythm Electrophysiol. 2016 Nov;9(11). pii: e004409.


Electrophysiologic Scar Substrate in Relation to VT: Noninvasive High-Resolution Mapping and Risk Assessment with ECGI.

Zhang J, Cooper DH, Desouza KA, Cuculich PS, Woodard PK, Smith TW, Rudy Y.

Pacing Clin Electrophysiol. 2016 Aug;39(8):781-91. doi: 10.1111/pace.12882. Epub 2016 Jun 6.


Conformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1.

Nekouzadeh A, Rudy Y.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):18-27. doi: 10.1016/j.pbiomolbio.2015.12.014. Epub 2015 Dec 30.


The forward problem of electrocardiography revisited.

Rudy Y.

Circ Arrhythm Electrophysiol. 2015 Jun;8(3):526-8. doi: 10.1161/CIRCEP.115.003056. No abstract available.


Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients.

Zhang J, Sacher F, Hoffmayer K, O'Hara T, Strom M, Cuculich P, Silva J, Cooper D, Faddis M, Hocini M, Haïssaguerre M, Scheinman M, Rudy Y.

Circulation. 2015 Jun 2;131(22):1950-9. doi: 10.1161/CIRCULATIONAHA.114.013698. Epub 2015 Mar 25.


Electrocardiographic imaging of heart rhythm disorders: from bench to bedside.

Rudy Y, Lindsay BD.

Card Electrophysiol Clin. 2015 Mar;7(1):17-35. doi: 10.1016/j.ccep.2014.11.013.


Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI).

Vijayakumar R, Silva JNA, Desouza KA, Abraham RL, Strom M, Sacher F, Van Hare GF, Haïssaguerre M, Roden DM, Rudy Y.

Circulation. 2014 Nov 25;130(22):1936-1943. doi: 10.1161/CIRCULATIONAHA.114.011359. Epub 2014 Oct 7.


Reply to the editor- amiloride concentrations in clinical practice.

Lee HC, Rudy Y, Cui J.

Heart Rhythm. 2013 Nov;10(11):e83. doi: 10.1016/j.hrthm.2013.09.055. Epub 2013 Sep 25. No abstract available.


Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis.

Heijman J, Zaza A, Johnson DM, Rudy Y, Peeters RL, Volders PG, Westra RL.

PLoS Comput Biol. 2013;9(8):e1003202. doi: 10.1371/journal.pcbi.1003202. Epub 2013 Aug 22.


Noninvasive mapping of ventricular activation in patients with transplanted hearts.

Desouza KA, Joseph SM, Cuculich PS, Ewald GA, Rudy Y.

J Electrocardiol. 2013 Nov-Dec;46(6):698-701. doi: 10.1016/j.jelectrocard.2013.05.005. Epub 2013 Jun 15.


Electrophysiologic mechanism of deteriorating cardiac function in a patient with inappropriate CRT indication and frequent ventricular ectopy.

Zhang J, Cooper DH, Rudy Y.

Pacing Clin Electrophysiol. 2013 Aug;36(8):1024-6. doi: 10.1111/pace.12194. Epub 2013 Jun 10. No abstract available.


Ionic bases for electrical remodeling of the canine cardiac ventricle.

Jeyaraj D, Wan X, Ficker E, Stelzer JE, Deschenes I, Liu H, Wilson LD, Decker KF, Said TH, Jain MK, Rudy Y, Rosenbaum DS.

Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H410-9. doi: 10.1152/ajpheart.00213.2013. Epub 2013 May 24.


Non-invasive electrophysiological imaging of acute rejection in a transplanted heart.

Desouza KA, Joseph SM, Rudy Y.

Europace. 2013 Nov;15(11):1614. doi: 10.1093/europace/eut089. Epub 2013 May 2. No abstract available.


Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization.

Lee HC, Rudy Y, Po-Yuan P, Sheu SH, Chang JG, Cui J.

Heart Rhythm. 2013 Aug;10(8):1220-8. doi: 10.1016/j.hrthm.2013.04.014. Epub 2013 Apr 19.


Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans.

Rudy Y.

Circ Res. 2013 Mar 1;112(5):863-74. doi: 10.1161/CIRCRESAHA.112.279315. Review.


Repolarization changes underlying long-term cardiac memory due to right ventricular pacing: noninvasive mapping with electrocardiographic imaging.

Marrus SB, Andrews CM, Cooper DH, Faddis MN, Rudy Y.

Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):773-81. doi: 10.1161/CIRCEP.112.970491. Epub 2012 Jul 6.


Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes.

Livshitz L, Acsai K, Antoons G, Sipido K, Rudy Y.

J Physiol. 2012 Sep 15;590(18):4423-46. doi: 10.1113/jphysiol.2012.228791. Epub 2012 Apr 30.


Continuous ECGI mapping of spontaneous VT initiation, continuation, and termination with antitachycardia pacing.

Zhang J, Desouza KA, Cuculich PS, Cooper DH, Chen J, Rudy Y.

Heart Rhythm. 2013 Aug;10(8):1244-5. doi: 10.1016/j.hrthm.2012.01.001. Epub 2012 Jan 2. No abstract available.


Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.

O'Hara T, Rudy Y.

Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1023-30. doi: 10.1152/ajpheart.00785.2011. Epub 2011 Dec 9.


The electrophysiological cardiac ventricular substrate in patients after myocardial infarction: noninvasive characterization with electrocardiographic imaging.

Cuculich PS, Zhang J, Wang Y, Desouza KA, Vijayakumar R, Woodard PK, Rudy Y.

J Am Coll Cardiol. 2011 Oct 25;58(18):1893-902. doi: 10.1016/j.jacc.2011.07.029.


Noninvasive electroanatomic mapping of human ventricular arrhythmias with electrocardiographic imaging.

Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, Faddis MN, Lindsay BD, Smith TW, Rudy Y.

Sci Transl Med. 2011 Aug 31;3(98):98ra84. doi: 10.1126/scitranslmed.3002152.


Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P.

Prog Biophys Mol Biol. 2011 Oct;107(1):4-10. doi: 10.1016/j.pbiomolbio.2011.07.001. Epub 2011 Jul 6.


Multiscale modeling of calcium cycling in cardiac ventricular myocyte: macroscopic consequences of microscopic dyadic function.

Gaur N, Rudy Y.

Biophys J. 2011 Jun 22;100(12):2904-12. doi: 10.1016/j.bpj.2011.05.031. Erratum in: Biophys J. 2011 Aug 17;101(4):1014.


Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation.

O'Hara T, Virág L, Varró A, Rudy Y.

PLoS Comput Biol. 2011 May;7(5):e1002061. doi: 10.1371/journal.pcbi.1002061. Epub 2011 May 26.


Continuum molecular simulation of large conformational changes during ion-channel gating.

Nekouzadeh A, Rudy Y.

PLoS One. 2011;6(5):e20186. doi: 10.1371/journal.pone.0020186. Epub 2011 May 20.


Three-residue loop closure in proteins: a new kinematic method reveals a locus of connected loop conformations.

Nekouzadeh A, Rudy Y.

J Comput Chem. 2011 Sep;32(12):2515-25. doi: 10.1002/jcc.21812. Epub 2011 May 26.


Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currents.

Acsai K, Antoons G, Livshitz L, Rudy Y, Sipido KR.

J Physiol. 2011 May 15;589(Pt 10):2569-83. doi: 10.1113/jphysiol.2010.202663. Epub 2011 Mar 8.


Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient.

Heijman J, Volders PG, Westra RL, Rudy Y.

J Mol Cell Cardiol. 2011 May;50(5):863-71. doi: 10.1016/j.yjmcc.2011.02.007. Epub 2011 Feb 21.


Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.

van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH.

Circulation. 2011 Mar 8;123(9):979-88. doi: 10.1161/CIRCULATIONAHA.110.006437. Epub 2011 Feb 21.


Electrophysiologic substrate and intraventricular left ventricular dyssynchrony in nonischemic heart failure patients undergoing cardiac resynchronization therapy.

Ghosh S, Silva JN, Canham RM, Bowman TM, Zhang J, Rhee EK, Woodard PK, Rudy Y.

Heart Rhythm. 2011 May;8(5):692-9. doi: 10.1016/j.hrthm.2011.01.017. Epub 2011 Jan 11.


Noninvasive characterization of epicardial activation in humans with diverse atrial fibrillation patterns.

Cuculich PS, Wang Y, Lindsay BD, Faddis MN, Schuessler RB, Damiano RJ Jr, Li L, Rudy Y.

Circulation. 2010 Oct 5;122(14):1364-72. doi: 10.1161/CIRCULATIONAHA.110.945709. Epub 2010 Sep 20.


Ionic mechanisms of electrophysiological heterogeneity and conduction block in the infarct border zone.

Decker KF, Rudy Y.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1588-97. doi: 10.1152/ajpheart.00362.2010. Epub 2010 Aug 13.


Cardiac muscle is not a uniform syncytium.

Shaw RM, Rudy Y.

Biophys J. 2010 Jun 16;98(12):3102-3; discussion 3104-5. doi: 10.1016/j.bpj.2010.03.030. No abstract available.


RV electrical activation in heart failure during right, left, and biventricular pacing.

Varma N, Jia P, Ramanathan C, Rudy Y.

JACC Cardiovasc Imaging. 2010 Jun;3(6):567-75. doi: 10.1016/j.jcmg.2009.12.017.


Multi-scale electrophysiology modeling: from atom to organ.

Silva JR, Rudy Y.

J Gen Physiol. 2010 Jun;135(6):575-81. doi: 10.1085/jgp.200910358. No abstract available.

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