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Items: 1 to 50 of 185

1.

Effects of Diazepam on Low-Frequency and High-Frequency Electrocortical γ-Power Mediated by α1- and α2-GABAA Receptors.

Hofmann JI, Schwarz C, Rudolph U, Antkowiak B.

Int J Mol Sci. 2019 Jul 16;20(14). pii: E3486. doi: 10.3390/ijms20143486.

2.

Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene.

Bodkin JA, Coleman MJ, Godfrey LJ, Carvalho CMB, Morgan CJ, Suckow RF, Anderson T, Ongur D, Kaufman MJ, Lewandowski KE, Siegel AJ, Waldstreicher E, Grochowski CM, Javitt DC, Rujescu D, Hebbring S, Weinshilboum R, Rodriguez SB, Kirchhoff C, Visscher T, Vuckovic A, Fialkowski A, McCarthy S, Malhotra D, Sebat J, Goff DC, Hudson JI, Lupski JR, Coyle JT, Rudolph U, Levy DL.

Biol Psychiatry. 2019 May 9. pii: S0006-3223(19)31330-7. doi: 10.1016/j.biopsych.2019.04.031. [Epub ahead of print]

PMID:
31279534
3.

Effects of six-week sprint interval or endurance training on calculated power in maximal lactate steady state.

Hommel J, Öhmichen S, Rudolph UM, Hauser T, Schulz H.

Biol Sport. 2019 Mar;36(1):47-54. doi: 10.5114/biolsport.2018.78906. Epub 2018 Oct 15.

4.

Zolpidem Activation of Alpha 1-Containing GABAA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons.

Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B.

Front Pharmacol. 2019 Jan 9;9:1523. doi: 10.3389/fphar.2018.01523. eCollection 2018.

5.

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors.

Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU.

Neuropharmacology. 2018 Dec;143:71-78. doi: 10.1016/j.neuropharm.2018.09.026. Epub 2018 Sep 18.

PMID:
30240781
6.

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU.

Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0.

7.

An Emerging Circuit Pharmacology of GABAA Receptors.

Engin E, Benham RS, Rudolph U.

Trends Pharmacol Sci. 2018 Aug;39(8):710-732. doi: 10.1016/j.tips.2018.04.003. Epub 2018 Jun 11. Review.

8.

GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice.

Seifi M, Rodaway S, Rudolph U, Swinny JD.

Gastroenterology. 2018 Sep;155(3):852-864.e3. doi: 10.1053/j.gastro.2018.05.033. Epub 2018 May 23.

9.

Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes.

Grochowski CM, Gu S, Yuan B, Tcw J, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB.

Hum Mutat. 2018 Jul;39(7):939-946. doi: 10.1002/humu.23537. Epub 2018 May 11.

10.

Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.

Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT.

Biochem Pharmacol. 2018 May;151:245-251. doi: 10.1016/j.bcp.2017.12.023. Epub 2018 Jan 3.

11.

Corrigendum to "Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors" [Behav. Brain Res. 332 (2017) 172-179].

Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U.

Behav Brain Res. 2018 Feb 15;338:186-189. doi: 10.1016/j.bbr.2017.10.006. Epub 2017 Oct 22. No abstract available.

PMID:
29070432
12.

Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices.

Balk M, Hentschke H, Rudolph U, Antkowiak B, Drexler B.

Sci Rep. 2017 Jun 14;7(1):3503. doi: 10.1038/s41598-017-03154-5.

13.

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors.

Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U.

Behav Brain Res. 2017 Aug 14;332:172-179. doi: 10.1016/j.bbr.2017.05.063. Epub 2017 Jun 3. Erratum in: Behav Brain Res. 2018 Feb 15;338:186-189.

14.

Disinhibition, an emerging pharmacology of learning and memory.

Möhler H, Rudolph U.

F1000Res. 2017 Feb 3;6. pii: F1000 Faculty Rev-101. doi: 10.12688/f1000research.9947.1. eCollection 2017. Review.

15.

Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis.

Tcw J, Carvalho CMB, Yuan B, Gu S, Altheimer AN, McCarthy S, Malhotra D, Sebat J, Siegel AJ, Rudolph U, Lupski JR, Levy DL, Brennand KJ.

Stem Cell Reports. 2017 Mar 14;8(3):519-528. doi: 10.1016/j.stemcr.2017.01.010. Epub 2017 Feb 16.

16.

The Everyday Moral Judge - Autobiographical Recollections of Moral Emotions.

Körner A, Tscharaktschiew N, Schindler R, Schulz K, Rudolph U.

PLoS One. 2016 Dec 15;11(12):e0167224. doi: 10.1371/journal.pone.0167224. eCollection 2016.

17.

Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice.

Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA.

Alcohol Clin Exp Res. 2016 Nov;40(11):2445-2455. doi: 10.1111/acer.13215. Epub 2016 Sep 26.

18.

The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.

Ralvenius WT, Acuña MA, Benke D, Matthey A, Daali Y, Rudolph U, Desmeules J, Zeilhofer HU, Besson M.

Neuropharmacology. 2016 Oct;109:366-375. doi: 10.1016/j.neuropharm.2016.07.004. Epub 2016 Jul 5.

19.

Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells.

Deprez F, Vogt F, Floriou-Servou A, Lafourcade C, Rudolph U, Tyagarajan SK, Fritschy JM.

Eur J Neurosci. 2016 Sep;44(5):2258-71. doi: 10.1111/ejn.13329. Epub 2016 Jul 19.

20.

New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors.

Antkowiak B, Rudolph U.

Curr Opin Anaesthesiol. 2016 Aug;29(4):447-53. doi: 10.1097/ACO.0000000000000358. Review.

21.

A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.

Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson AJ, Yee BK, Zeilhofer HU, Engin E, Rudolph U.

Neuropsychopharmacology. 2016 Sep;41(10):2492-501. doi: 10.1038/npp.2016.49. Epub 2016 Apr 12.

22.

Modulation of anxiety and fear via distinct intrahippocampal circuits.

Engin E, Smith KS, Gao Y, Nagy D, Foster RA, Tsvetkov E, Keist R, Crestani F, Fritschy JM, Bolshakov VY, Hajos M, Heldt SA, Rudolph U.

Elife. 2016 Mar 14;5:e14120. doi: 10.7554/eLife.14120.

23.

Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus.

Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard JR.

J Neurophysiol. 2016 Mar;115(3):1183-95. doi: 10.1152/jn.00905.2015. Epub 2015 Dec 2.

24.

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14805-10. doi: 10.1073/pnas.1514657112. Epub 2015 Nov 16.

25.

Geography and end use drive the diversification of worldwide winter rye populations.

Parat F, Schwertfirm G, Rudolph U, Miedaner T, Korzun V, Bauer E, Schön CC, Tellier A.

Mol Ecol. 2016 Jan;25(2):500-14. doi: 10.1111/mec.13495. Epub 2016 Jan 18.

PMID:
26607414
26.

Corrigendum: Regulating anxiety with extrasynaptic inhibition.

Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A.

Nat Neurosci. 2015 Dec;18(12):1862. doi: 10.1038/nn1215-1862a. No abstract available.

PMID:
26605888
27.

Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference.

Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U.

J Neurosci. 2015 Oct 7;35(40):13698-712. doi: 10.1523/JNEUROSCI.1370-15.2015.

28.

Causes and Consequences of Schadenfreude and Sympathy: A Developmental Analysis.

Schindler R, Körner A, Bauer S, Hadji S, Rudolph U.

PLoS One. 2015 Oct 1;10(10):e0137669. doi: 10.1371/journal.pone.0137669. eCollection 2015.

29.

α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice.

Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA.

Psychopharmacology (Berl). 2015 Dec;232(23):4359-69. doi: 10.1007/s00213-015-4069-9. Epub 2015 Sep 17.

30.

Regulating anxiety with extrasynaptic inhibition.

Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A.

Nat Neurosci. 2015 Oct;18(10):1493-500. doi: 10.1038/nn.4102. Epub 2015 Aug 31. Erratum in: Nat Neurosci. 2015 Dec;18(12):1862.

31.

Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.

Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U, Pearce RA.

J Neurosci. 2015 Jul 1;35(26):9707-16. doi: 10.1523/JNEUROSCI.0315-15.2015.

32.

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.

Ralvenius WT, Benke D, Acuña MA, Rudolph U, Zeilhofer HU.

Nat Commun. 2015 Apr 13;6:6803. doi: 10.1038/ncomms7803.

33.

Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor.

Zarnowska ED, Rodgers FC, Oh I, Rau V, Lor C, Laha KT, Jurd R, Rudolph U, Eger EI Nd, Pearce RA.

Neuropharmacology. 2015 Jun;93:171-178. doi: 10.1016/j.neuropharm.2015.01.011. Epub 2015 Feb 11.

34.

Preface: A tribute to professor Hanns Möhler.

Rudolph U, Enna SJ.

Adv Pharmacol. 2015;73:ix-xii. doi: 10.1016/S1054-3589(15)00022-8. No abstract available.

PMID:
25637444
35.

Preface: a tribute to professor Hanns Möhler.

Rudolph U, Enna SJ.

Adv Pharmacol. 2015;72:ix-xii. doi: 10.1016/S1054-3589(15)00008-3. No abstract available.

PMID:
25600374
36.

Behavioral functions of GABAA receptor subtypes--the Zurich experience.

Crestani F, Rudolph U.

Adv Pharmacol. 2015;72:37-51. doi: 10.1016/bs.apha.2014.10.001. Epub 2014 Dec 4. Review.

PMID:
25600366
37.

The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II.

Labrakakis C, Rudolph U, De Koninck Y.

Front Cell Neurosci. 2014 Dec 11;8:424. doi: 10.3389/fncel.2014.00424. eCollection 2014.

38.

Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule.

Behrens HM, Warneke VS, Böger C, Garbrecht N, Jüttner E, Klapper W, Mathiak M, Oschlies I, Rudolph U, Stuhlmann-Laeisz C, Trick D, Röcken C, Hufnagl P.

Cancer Med. 2015 Feb;4(2):235-44. doi: 10.1002/cam4.365. Epub 2014 Dec 16.

39.

Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones.

Eckle VS, Rudolph U, Antkowiak B, Grasshoff C.

Br J Anaesth. 2015 Mar;114(3):491-8. doi: 10.1093/bja/aeu269. Epub 2014 Aug 23.

40.

Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.

Martin CB, Gassmann M, Chevarin C, Hamon M, Rudolph U, Bettler B, Lanfumey L, Mongeau R.

J Neurochem. 2014 Dec;131(5):566-72. doi: 10.1111/jnc.12929. Epub 2014 Sep 4.

41.

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD.

J Neurosci. 2014 Jul 30;34(31):10361-78. doi: 10.1523/JNEUROSCI.0441-14.2014.

42.

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus.

Corteen NL, Carter JA, Rudolph U, Belelli D, Lambert JJ, Swinny JD.

Brain Struct Funct. 2015 Sep;220(5):2739-63. doi: 10.1007/s00429-014-0824-7. Epub 2014 Jun 29.

PMID:
24973971
43.

Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.

Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE.

J Neurosci. 2014 Mar 5;34(10):3653-67. doi: 10.1523/JNEUROSCI.2274-13.2014.

44.

Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens.

Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U.

Neuropsychopharmacology. 2014 Jul;39(8):1805-15. doi: 10.1038/npp.2014.41. Epub 2014 Feb 19.

45.

Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment.

Licata SC, Shinday NM, Huizenga MN, Darnell SB, Sangrey GR, Rudolph U, Rowlett JK, Sadri-Vakili G.

PLoS One. 2013 Dec 19;8(12):e84806. doi: 10.1371/journal.pone.0084806. eCollection 2013.

46.

Diversity of neuronal inhibition: a path to novel treatments for neuropsychiatric disorders.

Benham RS, Engin E, Rudolph U.

JAMA Psychiatry. 2014 Jan;71(1):91-3. doi: 10.1001/jamapsychiatry.2013.3059. Review. No abstract available.

47.

GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.

Rudolph U, Möhler H.

Annu Rev Pharmacol Toxicol. 2014;54:483-507. doi: 10.1146/annurev-pharmtox-011613-135947. Epub 2013 Oct 23. Review.

48.

Daniel has fallen into a muddy puddle--schadenfreude or sympathy?

Schulz K, Rudolph A, Tscharaktschiew N, Rudolph U.

Br J Dev Psychol. 2013 Nov;31(4):363-78. doi: 10.1111/bjdp.12013. Epub 2013 May 6.

PMID:
24128169
49.

Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites.

Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU.

Neuropsychopharmacology. 2014 Jan;39(2):477-87. doi: 10.1038/npp.2013.221. Epub 2013 Aug 28.

50.

Endogenous positive allosteric modulation of GABA(A) receptors by diazepam binding inhibitor.

Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR.

Neuron. 2013 Jun 19;78(6):1063-74. doi: 10.1016/j.neuron.2013.04.026. Epub 2013 May 30.

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