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Items: 1 to 50 of 159

1.

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.

Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita Y, Rudolph KL.

J Exp Med. 2019 Jan 7;216(1):152-175. doi: 10.1084/jem.20181505. Epub 2018 Dec 7.

2.

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma.

Gapp K, van Steenwyk G, Germain PL, Matsushima W, Rudolph KLM, Manuella F, Roszkowski M, Vernaz G, Ghosh T, Pelczar P, Mansuy IM, Miska EA.

Mol Psychiatry. 2018 Oct 30. doi: 10.1038/s41380-018-0271-6. [Epub ahead of print]

PMID:
30374190
3.

Terminal uridylyltransferases target RNA viruses as part of the innate immune system.

Le Pen J, Jiang H, Di Domenico T, Kneuss E, Kosałka J, Leung C, Morgan M, Much C, Rudolph KLM, Enright AJ, O'Carroll D, Wang D, Miska EA.

Nat Struct Mol Biol. 2018 Sep;25(9):778-786. doi: 10.1038/s41594-018-0106-9. Epub 2018 Aug 13.

PMID:
30104661
4.

Cellular and epigenetic drivers of stem cell ageing.

Ermolaeva M, Neri F, Ori A, Rudolph KL.

Nat Rev Mol Cell Biol. 2018 Sep;19(9):594-610. doi: 10.1038/s41580-018-0020-3. Review.

PMID:
29858605
5.

Telomeres in cancer.

Gunes C, Avila AI, Rudolph KL.

Differentiation. 2018 Jan - Feb;99:41-50. doi: 10.1016/j.diff.2017.12.004. Epub 2017 Dec 21. Review.

PMID:
29291448
6.

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.

Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL.

Leukemia. 2017 Dec;31(12):2853. doi: 10.1038/leu.2017.224. Epub 2017 Nov 10.

7.

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, Fagagna FDD, Günes C, Rudolph KL.

EMBO J. 2017 Oct 2;36(19):2922-2924. doi: 10.15252/embj.201797470. No abstract available.

8.

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.

Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M, Rudolph KL.

EMBO J. 2017 Oct 2;36(19):2920-2921. doi: 10.15252/embj.201797813. No abstract available.

9.

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription.

Akay A, Di Domenico T, Suen KM, Nabih A, Parada GE, Larance M, Medhi R, Berkyurek AC, Zhang X, Wedeles CJ, Rudolph KLM, Engelhardt J, Hemberg M, Ma P, Lamond AI, Claycomb JM, Miska EA.

Dev Cell. 2017 Aug 7;42(3):241-255.e6. doi: 10.1016/j.devcel.2017.07.002.

10.

The Profile and Dynamics of RNA Modifications in Animals.

van Delft P, Akay A, Huber SM, Bueschl C, Rudolph KLM, Di Domenico T, Schuhmacher R, Miska EA, Balasubramanian S.

Chembiochem. 2017 Jun 1;18(11):979-984. doi: 10.1002/cbic.201700093. Epub 2017 Apr 27.

11.

The use of urinary proteomics in the assessment of suitability of mouse models for ageing.

Nkuipou-Kenfack E, Schanstra JP, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands JL, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber TB, Rudolph KL, Pich A, Mischak H, Zürbig P.

PLoS One. 2017 Feb 15;12(2):e0166875. doi: 10.1371/journal.pone.0166875. eCollection 2017.

12.

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.

Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn J, Tümpel S, Rudolph KL.

Nature. 2016 Dec 15;540(7633):428-432. doi: 10.1038/nature20603. Epub 2016 Nov 30.

13.

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.

Scheffold A, Holtman IR, Dieni S, Brouwer N, Katz SF, Jebaraj BM, Kahle PJ, Hengerer B, Lechel A, Stilgenbauer S, Boddeke EW, Eggen BJ, Rudolph KL, Biber K.

Acta Neuropathol Commun. 2016 Aug 22;4(1):87. doi: 10.1186/s40478-016-0364-x.

14.

p21 shapes cancer evolution.

Romanov VS, Rudolph KL.

Nat Cell Biol. 2016 Jun 28;18(7):722-4. doi: 10.1038/ncb3382.

PMID:
27350444
15.

Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States.

Rudolph KL, Schmitt BM, Villar D, White RJ, Marioni JC, Kutter C, Odom DT.

PLoS Genet. 2016 May 11;12(5):e1006024. doi: 10.1371/journal.pgen.1006024. eCollection 2016 May.

16.

Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.

Wang J, Morita Y, Han B, Niemann S, Löffler B, Rudolph KL.

Nat Cell Biol. 2016 May;18(5):480-90. doi: 10.1038/ncb3342. Epub 2016 Apr 18.

PMID:
27088856
17.

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.

Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z.

Cell Stem Cell. 2016 Apr 7;18(4):495-507. doi: 10.1016/j.stem.2016.03.005.

18.

Telomere shortening leads to earlier age of onset in ALS mice.

Linkus B, Wiesner D, Meßner M, Karabatsiakis A, Scheffold A, Rudolph KL, Thal DR, Weishaupt JH, Ludolph AC, Danzer KM.

Aging (Albany NY). 2016 Feb;8(2):382-93.

19.

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.

Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL.

J Exp Med. 2016 Apr 4;213(4):535-53. doi: 10.1084/jem.20151100. Epub 2016 Mar 7.

20.

Identification of ageing-associated naturally occurring peptides in human urine.

Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H.

Oncotarget. 2015 Oct 27;6(33):34106-17. doi: 10.18632/oncotarget.5896.

21.

Telomere Dysfunction, Chromosomal Instability and Cancer.

Meena J, Rudolph KL, Günes C.

Recent Results Cancer Res. 2015;200:61-79. doi: 10.1007/978-3-319-20291-4_3. Review.

PMID:
26376872
22.

Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo.

Rinkenauer AC, Press AT, Raasch M, Pietsch C, Schweizer S, Schwörer S, Rudolph KL, Mosig A, Bauer M, Traeger A, Schubert US.

J Control Release. 2015 Oct 28;216:158-68. doi: 10.1016/j.jconrel.2015.08.008. Epub 2015 Aug 12.

PMID:
26277064
23.

Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.

Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A.

Nat Commun. 2015 Jul 29;6:7677. doi: 10.1038/ncomms8677.

24.

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.

Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL.

Leukemia. 2016 Mar;30(3):749-53. doi: 10.1038/leu.2015.173. Epub 2015 Jul 2. No abstract available. Erratum in: Leukemia. 2017 Nov 10;:.

25.

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.

Adams PD, Jasper H, Rudolph KL.

Cell Stem Cell. 2015 Jun 4;16(6):601-12. doi: 10.1016/j.stem.2015.05.002. Review.

26.

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Yi W, Hu X, Chen Z, Liu L, Tian Y, Chen H, Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y, Ju Z.

Blood. 2015 Jul 30;126(5):620-8. doi: 10.1182/blood-2015-02-624114. Epub 2015 May 26.

27.

Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

28.

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.

Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z.

Nat Commun. 2015 Apr 16;6:6808. doi: 10.1038/ncomms7808.

PMID:
25879755
29.

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, d'Adda di Fagagna F, Günes C, Rudolph KL.

EMBO J. 2015 May 12;34(10):1371-84. doi: 10.15252/embj.201490070. Epub 2015 Mar 27. Erratum in: EMBO J. 2017 Oct 2;36(19):2922-2924.

30.

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.

Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ.

Gastroenterology. 2015 Jul;149(1):177-189.e10. doi: 10.1053/j.gastro.2015.03.016. Epub 2015 Mar 19.

PMID:
25797700
31.

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.

Li T, Shi Y, Wang P, Guachalla LM, Sun B, Joerss T, Chen YS, Groth M, Krueger A, Platzer M, Yang YG, Rudolph KL, Wang ZQ.

EMBO J. 2015 Jun 12;34(12):1630-47. doi: 10.15252/embj.201489947. Epub 2015 Mar 14.

32.

Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin.

Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z.

Hepatology. 2015 Jun;61(6):2030-41. doi: 10.1002/hep.27755. Epub 2015 Mar 25.

PMID:
25704606
33.

Genome instability of ageing stem cells--Induction and defence mechanisms.

Burkhalter MD, Rudolph KL, Sperka T.

Ageing Res Rev. 2015 Sep;23(Pt A):29-36. doi: 10.1016/j.arr.2015.01.004. Epub 2015 Feb 7. Review.

34.

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.

Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M, Rudolph KL.

EMBO J. 2015 Mar 4;34(5):624-40. doi: 10.15252/embj.201490700. Epub 2015 Jan 21. Erratum in: EMBO J. 2017 Oct 2;36(19):2920-2921.

35.

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.

Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada AR, Ludolph AC, Weishaupt JH, Danzer KM.

Ann Neurol. 2015 Jan;77(1):15-32. doi: 10.1002/ana.24294. Epub 2014 Dec 19.

36.

Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.

Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL.

Nat Commun. 2014 Sep 18;5:4924. doi: 10.1038/ncomms5924.

37.

Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres.

Wang J, Lu X, Sakk V, Klein CA, Rudolph KL.

Blood. 2014 Nov 20;124(22):3237-40. doi: 10.1182/blood-2014-04-568055. Epub 2014 Sep 16.

38.

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage.

Wang J, Sun Q, Morita Y, Jiang H, Groß A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wüstefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.

Cell. 2014 Sep 11;158(6):1444. doi: 10.1016/j.cell.2014.08.033. Epub 2014 Sep 11. No abstract available.

39.

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface.

Schmitt BM, Rudolph KL, Karagianni P, Fonseca NA, White RJ, Talianidis I, Odom DT, Marioni JC, Kutter C.

Genome Res. 2014 Nov;24(11):1797-807. doi: 10.1101/gr.176784.114. Epub 2014 Aug 13.

40.

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.

Hartmann D, von Figura G, Song Z, Harden S, Scott LC, Evans TR, Rudolph KL, Bilsland AE, Keith WN.

Future Oncol. 2015;11(2):193-203.

PMID:
25040106
41.

Telomere shortening in leukocyte subpopulations in depression.

Karabatsiakis A, Kolassa IT, Kolassa S, Rudolph KL, Dietrich DE.

BMC Psychiatry. 2014 Jul 5;14:192. doi: 10.1186/1471-244X-14-192.

42.

Aging stem cells: transcriptome meets epigenome meets methylome.

Tümpel S, Rudolph KL.

Cell Stem Cell. 2014 May 1;14(5):551-2. doi: 10.1016/j.stem.2014.04.013.

43.

Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.

Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB.

J Natl Cancer Inst. 2014 Apr;106(4):dju057. doi: 10.1093/jnci/dju057. Epub 2014 Mar 28.

44.

A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.

Braig M, Pällmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brümmendorf TH.

Leukemia. 2014 Oct;28(10):2028-39. doi: 10.1038/leu.2014.95. Epub 2014 Mar 7.

PMID:
24603533
45.

Impact of genomic damage and ageing on stem cell function.

Behrens A, van Deursen JM, Rudolph KL, Schumacher B.

Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928. Review.

46.

Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion.

Oeckl P, Scheffold A, Lechel A, Rudolph KL, Ferger B.

Neuroreport. 2014 Mar 26;25(5):335-9. doi: 10.1097/WNR.0000000000000099.

PMID:
24525820
47.

Gadd45a regulates hematopoietic stem cell stress responses in mice.

Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z.

Blood. 2014 Feb 6;123(6):851-62. doi: 10.1182/blood-2013-05-504084. Epub 2013 Dec 26.

48.

Lin28a--boost your energy for youthful regeneration.

Burkhalter MD, Morita Y, Rudolph KL.

EMBO J. 2014 Jan 7;33(1):5-6. doi: 10.1002/embj.201387363. Epub 2013 Dec 19.

49.

Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells.

Zhang J, Yang R, Zhou D, Rudolph KL, Meng A, Ju Z.

Stem Cell Res. 2014 Jan;12(1):250-9. doi: 10.1016/j.scr.2013.11.001. Epub 2013 Nov 10.

50.

Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells.

Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, Gao S.

Cell Stem Cell. 2014 Jan 2;14(1):27-39. doi: 10.1016/j.stem.2013.11.005. Epub 2013 Nov 21.

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