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Items: 1 to 50 of 124

1.

Unconventional transport of metal ions and protons by Nramps.

Rudnick G.

J Gen Physiol. 2019 Nov 5. pii: jgp.201912464. doi: 10.1085/jgp.201912464. [Epub ahead of print] No abstract available.

PMID:
31690583
2.

A 100-kiloparsec wind feeding the circumgalactic medium of a massive compact galaxy.

Rupke DSN, Coil A, Geach JE, Tremonti C, Diamond-Stanic AM, George ER, Hickox RC, Kepley AA, Leung G, Moustakas J, Rudnick G, Sell PH.

Nature. 2019 Oct;574(7780):643-646. doi: 10.1038/s41586-019-1686-1. Epub 2019 Oct 30.

PMID:
31666723
3.

Serotonin transport in the 21st century.

Rudnick G, Sandtner W.

J Gen Physiol. 2019 Nov 4;151(11):1248-1264. doi: 10.1085/jgp.201812066. Epub 2019 Sep 30. Review.

PMID:
31570504
4.

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.

Zhang YW, Tavoulari S, Sinning S, Aleksandrova AA, Forrest LR, Rudnick G.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8854-E8862. doi: 10.1073/pnas.1716870115. Epub 2018 Sep 4.

5.

Control of serotonin transporter phosphorylation by conformational state.

Zhang YW, Turk BE, Rudnick G.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2776-83. doi: 10.1073/pnas.1603282113. Epub 2016 May 2.

6.

Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog.

Tavoulari S, Margheritis E, Nagarajan A, DeWitt DC, Zhang YW, Rosado E, Ravera S, Rhoades E, Forrest LR, Rudnick G.

J Biol Chem. 2016 Jan 15;291(3):1456-71. doi: 10.1074/jbc.M115.692012. Epub 2015 Nov 18.

7.

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang YW, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH.

Mol Pharmacol. 2016 Jan;89(1):165-75. doi: 10.1124/mol.115.101394. Epub 2015 Oct 30.

8.

Stellar feedback as the origin of an extended molecular outflow in a starburst galaxy.

Geach JE, Hickox RC, Diamond-Stanic AM, Krips M, Rudnick GH, Tremonti CA, Sell PH, Coil AL, Moustakas J.

Nature. 2014 Dec 4;516(7529):68-70. doi: 10.1038/nature14012.

PMID:
25471881
9.

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.

Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, Forrest LR.

Biochemistry. 2014 Aug 26;53(33):5444-60. doi: 10.1021/bi500637f. Epub 2014 Aug 15.

10.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

11.

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction.

Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F.

Pflugers Arch. 2014 Jan;466(1):25-42. doi: 10.1007/s00424-013-1410-1. Epub 2013 Dec 13. Review.

12.

How do transporters couple solute movements?

Rudnick G.

Mol Membr Biol. 2013 Nov;30(7):355-9. doi: 10.3109/09687688.2013.842658.

13.

Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder.

Porton B, Greenberg BD, Askland K, Serra LM, Gesmonde J, Rudnick G, Rasmussen SA, Kao HT.

Transl Psychiatry. 2013 May 21;3:e259. doi: 10.1038/tp.2013.35.

14.

Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.

Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G.

J Biol Chem. 2012 Oct 19;287(43):36051-8. doi: 10.1074/jbc.M112.394726. Epub 2012 Aug 31.

15.

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters.

Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W.

J Biol Chem. 2012 May 25;287(22):18524-34. doi: 10.1074/jbc.M112.343681. Epub 2012 Mar 26.

16.

Unifying concept of serotonin transporter-associated currents.

Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W.

J Biol Chem. 2012 Jan 2;287(1):438-45. doi: 10.1074/jbc.M111.304261. Epub 2011 Nov 9.

17.

Cytoplasmic permeation pathway of neurotransmitter transporters.

Rudnick G.

Biochemistry. 2011 Sep 6;50(35):7462-75. doi: 10.1021/bi200926b. Epub 2011 Aug 10. Review.

18.

A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport.

Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, Meiler J, Blakely RD.

J Biol Chem. 2011 Sep 2;286(35):30823-36. doi: 10.1074/jbc.M111.250308. Epub 2011 Jul 5.

19.

Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue.

Tavoulari S, Rizwan AN, Forrest LR, Rudnick G.

J Biol Chem. 2011 Jan 28;286(4):2834-42. doi: 10.1074/jbc.M110.186064. Epub 2010 Nov 29.

20.

Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.

Zhang YW, Rudnick G.

J Biol Chem. 2011 Jan 28;286(4):2461-8. doi: 10.1074/jbc.M110.203935. Epub 2010 Nov 19.

21.

The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

Forrest LR, Rudnick G.

Physiology (Bethesda). 2009 Dec;24:377-86. doi: 10.1152/physiol.00030.2009. Review.

22.

Ligand effects on cross-linking support a conformational mechanism for serotonin transport.

Tao Z, Zhang YW, Agyiri A, Rudnick G.

J Biol Chem. 2009 Dec 4;284(49):33807-14. doi: 10.1074/jbc.M109.071977. Epub 2009 Oct 16.

23.

Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.

Tavoulari S, Forrest LR, Rudnick G.

J Neurosci. 2009 Jul 29;29(30):9635-43. doi: 10.1523/JNEUROSCI.0440-09.2009.

24.

Mechanism for alternating access in neurotransmitter transporters.

Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH, Rudnick G.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10338-43. doi: 10.1073/pnas.0804659105. Epub 2008 Jul 22.

25.

Vesicular ATP transport is a hard (V)NUT to crack.

Rudnick G.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):5949-50. doi: 10.1073/pnas.0802774105. Epub 2008 Apr 15. No abstract available.

26.

Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport.

Mao Y, Mathewson L, Gesmonde J, Sato Y, Holy M, Sitte HH, Rudnick G.

Mol Membr Biol. 2008 Feb;25(2):115-27. doi: 10.1080/09687680701633257.

27.

SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.

Wendland JR, DeGuzman TB, McMahon F, Rudnick G, Detera-Wadleigh SD, Murphy DL.

Psychiatr Genet. 2008 Feb;18(1):31-9. doi: 10.1097/YPG.0b013e3282f08a06.

PMID:
18197083
28.
29.

What is an antidepressant binding site doing in a bacterial transporter?

Rudnick G.

ACS Chem Biol. 2007 Sep 21;2(9):606-9. Review.

PMID:
17894444
30.

Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.

Jacobs MT, Zhang YW, Campbell SD, Rudnick G.

J Biol Chem. 2007 Oct 5;282(40):29441-7. Epub 2007 Aug 13.

31.

Identification of a chloride ion binding site in Na+/Cl -dependent transporters.

Forrest LR, Tavoulari S, Zhang YW, Rudnick G, Honig B.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12761-6. Epub 2007 Jul 24.

32.

Interaction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1.

Castagna M, Soragna A, Mari SA, Santacroce M, Betté S, Mandela PG, Rudnick G, Peres A, Sacchi VF.

Am J Physiol Cell Physiol. 2007 Oct;293(4):C1286-95. Epub 2007 Jul 11.

33.

Serotonin transporters--structure and function.

Rudnick G.

J Membr Biol. 2006;213(2):101-10. Epub 2007 Apr 6. Review. No abstract available.

PMID:
17417703
34.

Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP.

Ramamoorthy S, Samuvel DJ, Buck ER, Rudnick G, Jayanthi LD.

J Biol Chem. 2007 Apr 20;282(16):11639-47. Epub 2007 Feb 19.

35.

The cytoplasmic substrate permeation pathway of serotonin transporter.

Zhang YW, Rudnick G.

J Biol Chem. 2006 Nov 24;281(47):36213-20. Epub 2006 Sep 28.

36.
37.
38.
39.

Cysteine-scanning mutagenesis of the fifth external loop of serotonin transporter.

Keller PC 2nd, Stephan M, Glomska H, Rudnick G.

Biochemistry. 2004 Jul 6;43(26):8510-6.

PMID:
15222762
40.

Serotonin transporter: gene, genetic disorders, and pharmacogenetics.

Murphy DL, Lerner A, Rudnick G, Lesch KP.

Mol Interv. 2004 Apr;4(2):109-23. Review.

PMID:
15087484
41.

Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.

Sato Y, Zhang YW, Androutsellis-Theotokis A, Rudnick G.

J Biol Chem. 2004 May 28;279(22):22926-33. Epub 2004 Mar 25.

42.

Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype.

Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL.

Mol Psychiatry. 2003 Nov;8(11):933-6.

PMID:
14593431
43.

A human serotonin transporter mutation causes constitutive activation of transport activity.

Kilic F, Murphy DL, Rudnick G.

Mol Pharmacol. 2003 Aug;64(2):440-6.

PMID:
12869649
44.
45.

A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P.

Visiers I, Weinstein H, Rudnick G, Stephan MM.

Biochemistry. 2003 Jun 10;42(22):6784-93.

PMID:
12779333
46.

Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters.

Androutsellis-Theotokis A, Goldberg NR, Ueda K, Beppu T, Beckman ML, Das S, Javitch JA, Rudnick G.

J Biol Chem. 2003 Apr 11;278(15):12703-9. Epub 2003 Feb 4.

47.

Accessibility and conformational coupling in serotonin transporter predicted internal domains.

Androutsellis-Theotokis A, Rudnick G.

J Neurosci. 2002 Oct 1;22(19):8370-8.

48.

The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells.

Gu HH, Wu X, Giros B, Caron MG, Caplan MJ, Rudnick G.

Mol Biol Cell. 2001 Dec;12(12):3797-807.

49.

A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter.

Androutsellis-Theotokis A, Ghassemi F, Rudnick G.

J Biol Chem. 2001 Dec 7;276(49):45933-8.

50.

A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.

Ni YG, Chen JG, Androutsellis-Theotokis A, Huang CJ, Moczydlowski E, Rudnick G.

J Biol Chem. 2001 Aug 17;276(33):30942-7. Epub 2001 Jun 14.

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