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Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements.

Johansson HE, Edholm D, Kullberg J, Rosqvist F, Rudling M, Straniero S, Karlsson FA, Ahlström H, Sundbom M, Risérus U.

Nutr Diabetes. 2019 Nov 4;9(1):34. doi: 10.1038/s41387-019-0100-2.


Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial.

Rosqvist F, Kullberg J, Ståhlman M, Cedernaes J, Heurling K, Johansson HE, Iggman D, Wilking H, Larsson A, Eriksson O, Johansson L, Straniero S, Rudling M, Antoni G, Lubberink M, Orho-Melander M, Borén J, Ahlström H, Risérus U.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6207-6219. doi: 10.1210/jc.2019-00160.


Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids.

Rudling M, Laskar A, Straniero S.

J Lipid Res. 2019 Mar;60(3):498-505. doi: 10.1194/jlr.S091199. Epub 2019 Jan 4.


Erratum: Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol.

Ghosh M, Galman C, Rudling M, Angelin B.

J Lipid Res. 2018 Nov;59(11):2253. doi: 10.1194/jlr.M055780ERR. No abstract available.


Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism.

Al-Khaifi A, Straniero S, Voronova V, Chernikova D, Sokolov V, Kumar C, Angelin B, Rudling M.

J Intern Med. 2018 Nov;284(5):546-559. doi: 10.1111/joim.12811. Epub 2018 Jul 31.


An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers.

Al-Khaifi A, Rudling M, Angelin B.

Gastroenterology. 2018 Oct;155(4):1012-1016. doi: 10.1053/j.gastro.2018.06.038. Epub 2018 Jun 19.


Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated.

Sjöberg BG, Straniero S, Angelin B, Rudling M.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E167-E174. doi: 10.1152/ajpendo.00416.2016. Epub 2017 May 9.


Acute caloric restriction counteracts hepatic bile acid and cholesterol deficiency in morbid obesity.

Straniero S, Rosqvist F, Edholm D, Ahlström H, Kullberg J, Sundbom M, Risérus U, Rudling M.

J Intern Med. 2017 May;281(5):507-517. doi: 10.1111/joim.12599. Epub 2017 Mar 6.


Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III.

Ghosh Laskar M, Eriksson M, Rudling M, Angelin B.

J Intern Med. 2017 Jun;281(6):575-585. doi: 10.1111/joim.12594. Epub 2017 Feb 1.


Understanding mouse bile acid formation: Is it time to unwind why mice and rats make unique bile acids?

Rudling M.

J Lipid Res. 2016 Dec;57(12):2097-2098. Epub 2016 Oct 24. No abstract available.


Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report.

Apro J, Tietge UJ, Dikkers A, Parini P, Angelin B, Rudling M.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):787-91. doi: 10.1161/ATVBAHA.116.307385. Epub 2016 Mar 31.


Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans.

Lehtihet M, Bonde Y, Beckman L, Berinder K, Hoybye C, Rudling M, Sloan JH, Konrad RJ, Angelin B.

PLoS One. 2016 Feb 11;11(2):e0148802. doi: 10.1371/journal.pone.0148802. eCollection 2016.


Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism.

Bonde Y, Eggertsen G, Rudling M.

PLoS One. 2016 Jan 29;11(1):e0147772. doi: 10.1371/journal.pone.0147772. eCollection 2016.


Letter to the Editor: Potential Role for FGF21 as a Mediator of Thyroid Hormone Effects on Metabolic Regulation.

Bonde Y, Angelin B, Rudling M.

J Clin Endocrinol Metab. 2015 Dec;100(12):L130-1. doi: 10.1210/jc.2015-3548. No abstract available.


Specific inhibition of bile acid transport alters plasma lipids and GLP-1.

Rudling M, Camilleri M, Graffner H, Holst JJ, Rikner L.

BMC Cardiovasc Disord. 2015 Jul 22;15:75. doi: 10.1186/s12872-015-0070-9.


Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients.

Apro J, Parini P, Broijersén A, Angelin B, Rudling M.

J Lipid Res. 2015 Aug;56(8):1633-9. doi: 10.1194/jlr.P058842. Epub 2015 Jun 19.


Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study.

Rosqvist F, Smedman A, Lindmark-Månsson H, Paulsson M, Petrus P, Straniero S, Rudling M, Dahlman I, Risérus U.

Am J Clin Nutr. 2015 Jul;102(1):20-30. doi: 10.3945/ajcn.115.107045. Epub 2015 May 27.


Influence of dietary sugar on cholesterol and bile acid metabolism in the rat: Marked reduction of hepatic Abcg5/8 expression following sucrose ingestion.

Apro J, Beckman L, Angelin B, Rudling M.

Biochem Biophys Res Commun. 2015 Jun 12;461(4):592-7. doi: 10.1016/j.bbrc.2015.04.070. Epub 2015 Apr 22.


Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol.

Ghosh M, Gälman C, Rudling M, Angelin B.

J Lipid Res. 2015 Feb;56(2):463-9. doi: 10.1194/jlr.M055780. Epub 2014 Dec 22. Erratum in: J Lipid Res. 2018 Nov;59(11):2253.


The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Nov 4;20(5):787-798. doi: 10.1016/j.cmet.2014.09.004.


Role of dietary fats in modulating cardiometabolic risk during moderate weight gain: a randomized double-blind overfeeding trial (LIPOGAIN study).

Iggman D, Rosqvist F, Larsson A, Arnlöv J, Beckman L, Rudling M, Risérus U.

J Am Heart Assoc. 2014 Oct 15;3(5):e001095. doi: 10.1161/JAHA.114.001095.


Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans.

Bonde Y, Breuer O, Lütjohann D, Sjöberg S, Angelin B, Rudling M.

J Lipid Res. 2014 Nov;55(11):2408-15. doi: 10.1194/jlr.M051664. Epub 2014 Aug 29.


Authors' response: bile acids are important in the pathophysiology of IBS.

Bajor A, Törnblom H, Rudling M, Ung KA, Simrén M.

Gut. 2015 May;64(5):851-2. doi: 10.1136/gutjnl-2014-308037. Epub 2014 Jul 23. No abstract available.


Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.

Bajor A, Törnblom H, Rudling M, Ung KA, Simrén M.

Gut. 2015 Jan;64(1):84-92. doi: 10.1136/gutjnl-2013-305965. Epub 2014 Apr 12.


Imitation (rather than core language) predicts pragmatic development in young children with ASD: a preliminary longitudinal study using CDI parental reports.

Miniscalco C, Rudling M, Råstam M, Gillberg C, Johnels JÅ.

Int J Lang Commun Disord. 2014 May-Jun;49(3):369-75. doi: 10.1111/1460-6984.12085. Epub 2014 Mar 31.


Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism.

Hu X, Bonde Y, Eggertsen G, Rudling M.

J Intern Med. 2014 Jan;275(1):27-38. doi: 10.1111/joim.12140. Epub 2013 Oct 11. Erratum in: J Intern Med. 2015 Jul;278(1):97.


Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans.

Lundberg J, Höybye C, Krusenstjerna-Hafstrøm T, Bina HA, Kharitonenkov A, Angelin B, Rudling M.

J Intern Med. 2013 Sep;274(3):227-32. doi: 10.1111/joim.12112. Epub 2013 Jul 24.


Interstitial fluid lipoproteins.

Lundberg J, Rudling M, Angelin B.

Curr Opin Lipidol. 2013 Aug;24(4):327-31. doi: 10.1097/MOL.0b013e3283630846. Review.


Observations suggesting bioactive Fgf15 is not present in mouse blood.

Rudling M.

Gut. 2014 Jan;63(1):205-6. doi: 10.1136/gutjnl-2013-305227. Epub 2013 Jun 8. No abstract available.


Effects of food or sleep deprivation during civilian survival training on clinical chemistry variables.

Ståhle L, Granström E, Ljungdahl Ståhle E, Isaksson S, Samuelsson A, Rudling M, Sepp H.

Wilderness Environ Med. 2013 Jun;24(2):146-52. doi: 10.1016/j.wem.2012.11.008. Epub 2013 Feb 21.


Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis.

Klingenberg R, Gerdes N, Badeau RM, Gisterå A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Lüscher TF, Jauhiainen M, Sparwasser T, Hansson GK.

J Clin Invest. 2013 Mar;123(3):1323-34. doi: 10.1172/JCI63891. Epub 2013 Feb 15.


Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.

Angelin B, Larsson TE, Rudling M.

Cell Metab. 2012 Dec 5;16(6):693-705. doi: 10.1016/j.cmet.2012.11.001. Review.


Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex.

Bonde Y, Plösch T, Kuipers F, Angelin B, Rudling M.

Hepatology. 2012 Nov;56(5):1828-37. doi: 10.1002/hep.25861. Epub 2012 Oct 14.


Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration.

Troutt JS, Rudling M, Persson L, Ståhle L, Angelin B, Butterfield AM, Schade AE, Cao G, Konrad RJ.

Clin Chem. 2012 Aug;58(8):1225-32. doi: 10.1373/clinchem.2012.186866. Epub 2012 Jun 7.


Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice.

Lundåsen T, Andersson EM, Snaith M, Lindmark H, Lundberg J, Östlund-Lindqvist AM, Angelin B, Rudling M.

PLoS One. 2012;7(5):e37787. doi: 10.1371/journal.pone.0037787. Epub 2012 May 25.


Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis.

Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EA, Weber C, Daemen MJ, Kuiper J, Lutgens E.

Eur Heart J. 2013 Dec;34(48):3717-27. doi: 10.1093/eurheartj/ehs106. Epub 2012 May 21.


Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial.

Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, Rudling M, Arner P, Cederholm T, Ahlström H, Risérus U.

Am J Clin Nutr. 2012 May;95(5):1003-12. doi: 10.3945/ajcn.111.030114. Epub 2012 Apr 4.


Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women.

Persson L, Henriksson P, Westerlund E, Hovatta O, Angelin B, Rudling M.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):810-4. doi: 10.1161/ATVBAHA.111.242461. Epub 2011 Dec 29.


Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19.

Gälman C, Angelin B, Rudling M.

J Intern Med. 2011 Dec;270(6):580-8. doi: 10.1111/j.1365-2796.2011.02466.x. Epub 2011 Nov 2.


Randomised clinical trial: The ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation--a double-blind study.

Simrén M, Bajor A, Gillberg PG, Rudling M, Abrahamsson H.

Aliment Pharmacol Ther. 2011 Jul;34(1):41-50. doi: 10.1111/j.1365-2036.2011.04675.x. Epub 2011 May 5.


Thyromimetics: a journey from bench to bed-side.

Tancevski I, Rudling M, Eller P.

Pharmacol Ther. 2011 Jul;131(1):33-9. doi: 10.1016/j.pharmthera.2011.04.003. Epub 2011 Apr 12. Review.


Activation of VPAC1 receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice.

Sheikine Y, Deodato B, Olofsson PS, Söderström LA, Lundberg AM, Bodin I, Rudling M, Theodorsson E, Hansson GK.

Biochem Biophys Res Commun. 2010 Nov 19;402(3):471-6. doi: 10.1016/j.bbrc.2010.10.052. Epub 2010 Oct 15.


Lipid lowering with thyroid hormone and thyromimetics.

Angelin B, Rudling M.

Curr Opin Lipidol. 2010 Dec;21(6):499-506. doi: 10.1097/MOL.0b013e3283402e9c. Review.


Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.

Persson L, Cao G, Ståhle L, Sjöberg BG, Troutt JS, Konrad RJ, Gälman C, Wallén H, Eriksson M, Hafström I, Lind S, Dahlin M, Amark P, Angelin B, Rudling M.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2666-72. doi: 10.1161/ATVBAHA.110.214130. Epub 2010 Sep 30.


Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity.

Zadravec D, Brolinson A, Fisher RM, Carneheim C, Csikasz RI, Bertrand-Michel J, Borén J, Guillou H, Rudling M, Jacobsson A.

FASEB J. 2010 Nov;24(11):4366-77. doi: 10.1096/fj.09-152298. Epub 2010 Jul 6.


The genetic background of gallstone formation: an update.

Marschall HU, Katsika D, Rudling M, Einarsson C.

Biochem Biophys Res Commun. 2010 May 21;396(1):58-62. doi: 10.1016/j.bbrc.2010.02.143. Review.


Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis.

Klingenberg R, Lebens M, Hermansson A, Fredrikson GN, Strodthoff D, Rudling M, Ketelhuth DF, Gerdes N, Holmgren J, Nilsson J, Hansson GK.

Arterioscler Thromb Vasc Biol. 2010 May;30(5):946-52. doi: 10.1161/ATVBAHA.109.202671. Epub 2010 Feb 18.


The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice.

Tancevski I, Demetz E, Eller P, Duwensee K, Hoefer J, Heim C, Stanzl U, Wehinger A, Auer K, Karer R, Huber J, Schgoer W, Van Eck M, Vanhoutte J, Fievet C, Stellaard F, Rudling M, Patsch JR, Ritsch A.

PLoS One. 2010 Jan 15;5(1):e8722. doi: 10.1371/journal.pone.0008722.


Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids.

Ung KA, Mottacki N, Rudling M, Bajor A.

Scand J Gastroenterol. 2009;44(9):1132-8.


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