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Items: 49


Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development.

Morgan CE, Huang W, Rudin SD, Taylor DJ, Kirby JE, Bonomo RA, Yu EW.

mBio. 2020 Jan 21;11(1). pii: e03117-19. doi: 10.1128/mBio.03117-19.


Identification of four patients with colistin-resistant Escherichia coli containing the mobile colistin resistance mcr-1 gene from a single health system in Michigan.

Henig O, Rojas LJ, Bachman MA, Rudin SD, Brennan BM, Soehnlen MK, Jones KL, Mills JP, Dombecki CR, Valyko AM, Marshall SH, Bonomo RA, Kaye KS, Washer L.

Infect Control Hosp Epidemiol. 2019 Sep;40(9):1059-1062. doi: 10.1017/ice.2019.177. Epub 2019 Jul 15.


The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Logan LK, Medernach RL, Domitrovic TN, Rispens JR, Hujer AM, Qureshi NK, Marshall SH, Nguyen DC, Rudin SD, Zheng X, Konda S, Weinstein RA, Bonomo RA.

Infect Dis Ther. 2019 Jun;8(2):243-254. doi: 10.1007/s40121-019-0237-2. Epub 2019 Feb 16.


The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Luterbach CL, Boshe A, Henderson HI, Cober E, Richter SS, Salata RA, Kalayjian RC, Watkins RR, Hujer AM, Hujer KM, Rudin SD, Domitrovic TN, Doi Y, Kaye KS, Evans S, Fowler VG Jr, Bonomo RA, van Duin D.

Open Forum Infect Dis. 2018 Dec 14;6(1):ofy351. doi: 10.1093/ofid/ofy351. eCollection 2019 Jan.


ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Jacobs MR, Abdelhamed AM, Good CE, Rhoads DD, Hujer KM, Hujer AM, Domitrovic TN, Rudin SD, Richter SS, van Duin D, Kreiswirth BN, Greco C, Fouts DE, Bonomo RA.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01801-18. doi: 10.1128/AAC.01801-18. Print 2019 Jan.


Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Logan LK, Medernach RL, Rispens JR, Marshall SH, Hujer AM, Domitrovic TN, Rudin SD, Zheng X, Qureshi NK, Konda S, Hayden MK, Weinstein RA, Bonomo RA.

Pediatr Infect Dis J. 2019 Jun;38(6):595-599. doi: 10.1097/INF.0000000000002205.


Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation.

Knight DB, Rudin SD, Bonomo RA, Rather PN.

Front Microbiol. 2018 Aug 21;9:1902. doi: 10.3389/fmicb.2018.01902. eCollection 2018.


Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae.

Kanwar A, Marshall SH, Perez F, Tomas M, Jacobs MR, Hujer AM, Domitrovic TN, Rudin SD, Rojas LJ, Kreiswirth BN, Chen L, Quinones-Mateu M, van Duin D, Bonomo RA; Antibacterial Resistance Leadership Group.

Open Forum Infect Dis. 2018 Apr 23;5(4):ofy054. doi: 10.1093/ofid/ofy054. eCollection 2018 Apr.


Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.

Papp-Wallace KM, Nguyen NQ, Jacobs MR, Bethel CR, Barnes MD, Kumar V, Bajaksouzian S, Rudin SD, Rather PN, Bhavsar S, Ravikumar T, Deshpande PK, Patil V, Yeole R, Bhagwat SS, Patel MV, van den Akker F, Bonomo RA.

J Med Chem. 2018 May 10;61(9):4067-4086. doi: 10.1021/acs.jmedchem.8b00091. Epub 2018 Apr 20.


Evaluation of Sensititre Broth Microdilution Plate for determining the susceptibility of carbapenem-resistant Klebsiella pneumoniae to polymyxins.

Richter SS, Karichu J, Otiso J, Van Heule H, Keller G, Cober E, Rojas LJ, Hujer AM, Hujer KM, Marshall S, Perez F, Rudin SD, Domitrovic TN, Kaye KS, Salata R, van Duin D, Bonomo RA.

Diagn Microbiol Infect Dis. 2018 May;91(1):89-92. doi: 10.1016/j.diagmicrobio.2018.01.005. Epub 2018 Jan 9.


"Double carbapenem" and oral fosfomycin for the treatment of complicated urinary tract infections caused by blaNDM -harboring Enterobacteriaceae in kidney transplantation.

Rosa R, Rudin SD, Rojas LJ, Hujer AM, Perez-Cardona A, Perez F, Bonomo RA, Martinez O, Abbo LM, Camargo JF.

Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12795. Epub 2017 Nov 27.


A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.

Henig O, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC, Watkins RR, Marshall S, Rudin SD, Domitrovic TN, Hujer AM, Hujer KM, Doi Y, Evans S, Fowler VG Jr, Bonomo RA, van Duin D, Kaye KS; Antibacterial Resistance Leadership Group.

Open Forum Infect Dis. 2017 Jul 27;4(3):ofx157. doi: 10.1093/ofid/ofx157. eCollection 2017 Summer.


Application of "Precision Medicine" Through the Molecular Characterization of Extensively Drug-Resistant Klebsiella pneumoniae in a Multivisceral Transplant Patient.

Rosa R, Rudin SD, Rojas LJ, Perez-Cardona A, Aragon L, Nicolau DP, Perez F, Hujer AM, Tekin A, Martinez O, Camargo JF, Bonomo RA, Abbo LM.

Clin Infect Dis. 2017 Aug 15;65(4):701-702. doi: 10.1093/cid/cix387. No abstract available.


Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing blaOXA-237 Carried on a Plasmid.

Hujer AM, Higgins PG, Rudin SD, Buser GL, Marshall SH, Xanthopoulou K, Seifert H, Rojas LJ, Domitrovic TN, Cassidy PM, Cunningham MC, Vega R, Furuno JP, Pfeiffer CD, Beldavs ZG, Wright MS, Jacobs MR, Adams MD, Bonomo RA.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00797-17. doi: 10.1128/AAC.00797-17. Print 2017 Nov.


The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination.

Anderson DJ, Addison R, Lokhnygina Y, Warren B, Sharma-Kuinkel B, Rojas LJ, Rudin SD, Lewis SS, Moehring RW, Weber DJ, Rutala WA, Bonomo RA, Fowler VG, Sexton DJ; CDC Prevention Epicenters Program.

Infect Control Hosp Epidemiol. 2017 Oct;38(10):1147-1154. doi: 10.1017/ice.2017.181. Epub 2017 Aug 29.


NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

Rojas LJ, Hujer AM, Rudin SD, Wright MS, Domitrovic TN, Marshall SH, Hujer KM, Richter SS, Cober E, Perez F, Adams MD, van Duin D, Bonomo RA.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00454-17. doi: 10.1128/AAC.00454-17. Print 2017 Jul.


Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 β-Lactamase.

Ruggiero M, Papp-Wallace KM, Taracila MA, Mojica MF, Bethel CR, Rudin SD, Zeiser ET, Gutkind G, Bonomo RA, Power P.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02476-16. doi: 10.1128/AAC.02476-16. Print 2017 Jun.


Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

Marshall S, Hujer AM, Rojas LJ, Papp-Wallace KM, Humphries RM, Spellberg B, Hujer KM, Marshall EK, Rudin SD, Perez F, Wilson BM, Wasserman RB, Chikowski L, Paterson DL, Vila AJ, van Duin D, Kreiswirth BN, Chambers HF, Fowler VG Jr, Jacobs MR, Pulse ME, Weiss WJ, Bonomo RA.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02243-16. doi: 10.1128/AAC.02243-16. Print 2017 Apr.


Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Rojas LJ, Salim M, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC, Watkins RR, Marshall S, Rudin SD, Domitrovic TN, Hujer AM, Hujer KM, Doi Y, Kaye KS, Evans S, Fowler VG Jr, Bonomo RA, van Duin D; Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2017 Mar 15;64(6):711-718. doi: 10.1093/cid/ciw805.


First Report of a Verona Integron-Encoded Metallo-β-Lactamase-Producing Klebsiella pneumoniae Infection in a Child in the United States.

Tamma PD, Suwantarat N, Rudin SD, Logan LK, Simner PJ, Rojas LJ, Mojica MF, Carroll KC, Bonomo RA.

J Pediatric Infect Dis Soc. 2016 Sep;5(3):e24-7. doi: 10.1093/jpids/piw025. Epub 2016 May 4.


Mutations Decreasing Intrinsic β-Lactam Resistance Are Linked to Cell Division in the Nosocomial Pathogen Acinetobacter baumannii.

Knight D, Dimitrova DD, Rudin SD, Bonomo RA, Rather PN.

Antimicrob Agents Chemother. 2016 May 23;60(6):3751-8. doi: 10.1128/AAC.00361-16. Print 2016 Jun.


Analysis of β-Lactamase Resistance Determinants in Enterobacteriaceae from Chicago Children: a Multicenter Survey.

Logan LK, Hujer AM, Marshall SH, Domitrovic TN, Rudin SD, Zheng X, Qureshi NK, Hayden MK, Scaggs FA, Karadkhele A, Bonomo RA.

Antimicrob Agents Chemother. 2016 May 23;60(6):3462-9. doi: 10.1128/AAC.00098-16. Print 2016 Jun.


The Prevalence and Molecular Epidemiology of Multidrug-Resistant Enterobacteriaceae Colonization in a Pediatric Intensive Care Unit.

Suwantarat N, Logan LK, Carroll KC, Bonomo RA, Simner PJ, Rudin SD, Milstone AM, Tekle T, Ross T, Tamma PD.

Infect Control Hosp Epidemiol. 2016 May;37(5):535-43. doi: 10.1017/ice.2016.16. Epub 2016 Feb 9.


Performance of the CLSI Carba NP and the Rosco Carb Screen Assays Using North American Carbapenemase-Producing Enterobacteriaceae and Pseudomonas aeruginosa Isolates.

Gallagher LC, Roundtree SS, Lancaster DP, Rudin SD, Bard JD, Roberts AL, Marshall SH, Bonomo RA, Sullivan KV.

J Clin Microbiol. 2015 Oct;53(10):3370-3. doi: 10.1128/JCM.01547-15. Epub 2015 Aug 12.


Community-Acquired Pyelonephritis in Pregnancy Caused by KPC-Producing Klebsiella pneumoniae.

Khatri A, Naeger Murphy N, Wiest P, Osborn M, Garber K, Hecker M, Hurless K, Rudin SD, Jacobs MR, Kalayjian RC, Salata RA, van Duin D, Perez F, Bonomo RA, Paterson DL, Harris PN.

Antimicrob Agents Chemother. 2015 Aug;59(8):4375-8. doi: 10.1128/AAC.00553-15.


Fulminant endocarditis and disseminated infection caused by carbapenem-resistant Acinetobacter baumannii in a renal-pancreas transplant recipient.

Patel G, Perez F, Hujer AM, Rudin SD, Augustine JJ, Jacobs GH, Jacobs MR, Bonomo RA.

Transpl Infect Dis. 2015 Apr;17(2):289-96. doi: 10.1111/tid.12351. Epub 2015 Feb 6.


Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.

Wright MS, Suzuki Y, Jones MB, Marshall SH, Rudin SD, van Duin D, Kaye K, Jacobs MR, Bonomo RA, Adams MD.

Antimicrob Agents Chemother. 2015 Jan;59(1):536-43. doi: 10.1128/AAC.04037-14. Epub 2014 Nov 10.


Carbapenem-resistant Enterobacter cloacae isolates producing KPC-3, North Dakota, USA.

Kiedrowski LM, Guerrero DM, Perez F, Viau RA, Rojas LJ, Mojica MF, Rudin SD, Hujer AM, Marshall SH, Bonomo RA.

Emerg Infect Dis. 2014 Sep;20(9):1583-5. doi: 10.3201/eid2009.140344. No abstract available.


Infections caused by fluoroquinolone-resistant Escherichia coli following transrectal ultrasound-guided biopsy of the prostate.

Suwantarat N, Rudin SD, Marshall SH, Hujer AM, Perez F, Hujer KM, Domitrovic TN, Dumford DM 3rd, Donskey CJ, Bonomo RA.

J Glob Antimicrob Resist. 2014 Jun 1;2(2):71-76.


Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Wright MS, Perez F, Brinkac L, Jacobs MR, Kaye K, Cober E, van Duin D, Marshall SH, Hujer AM, Rudin SD, Hujer KM, Bonomo RA, Adams MD.

Antimicrob Agents Chemother. 2014 Aug;58(8):4961-5. doi: 10.1128/AAC.00125-14. Epub 2014 Jun 9.


Complex prosthetic joint infections due to carbapenemase-producing Klebsiella pneumoniae: a unique challenge in the era of untreatable infections.

de Sanctis J, Teixeira L, van Duin D, Odio C, Hall G, Tomford JW, Perez F, Rudin SD, Bonomo RA, Barsoum WK, Joyce M, Krebs V, Schmitt S.

Int J Infect Dis. 2014 Aug;25:73-8. doi: 10.1016/j.ijid.2014.01.028. Epub 2014 May 9.


Surveillance of carbapenem-resistant Klebsiella pneumoniae: tracking molecular epidemiology and outcomes through a regional network.

van Duin D, Perez F, Rudin SD, Cober E, Hanrahan J, Ziegler J, Webber R, Fox J, Mason P, Richter SS, Cline M, Hall GS, Kaye KS, Jacobs MR, Kalayjian RC, Salata RA, Segre JA, Conlan S, Evans S, Fowler VG Jr, Bonomo RA.

Antimicrob Agents Chemother. 2014 Jul;58(7):4035-41. doi: 10.1128/AAC.02636-14. Epub 2014 May 5.


OqxAB, a quinolone and olaquindox efflux pump, is widely distributed among multidrug-resistant Klebsiella pneumoniae isolates of human origin.

Perez F, Rudin SD, Marshall SH, Coakley P, Chen L, Kreiswirth BN, Rather PN, Hujer AM, Toltzis P, van Duin D, Paterson DL, Bonomo RA.

Antimicrob Agents Chemother. 2013 Sep;57(9):4602-3. doi: 10.1128/AAC.00725-13. Epub 2013 Jul 1. No abstract available.


Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio.

Endimiani A, Blackford M, Dasenbrook EC, Reed MD, Bajaksouszian S, Hujer AM, Rudin SD, Hujer KM, Perreten V, Rice LB, Jacobs MR, Konstan MW, Bonomo RA.

Antimicrob Agents Chemother. 2011 Apr;55(4):1684-92. doi: 10.1128/AAC.01308-10. Epub 2011 Jan 24.


The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae.

Rice LB, Carias LL, Hutton RA, Rudin SD, Endimiani A, Bonomo RA.

Antimicrob Agents Chemother. 2008 Sep;52(9):3427-9. doi: 10.1128/AAC.00493-08. Epub 2008 Jun 23.


Tn5386, a novel Tn916-like mobile element in Enterococcus faecium D344R that interacts with Tn916 to yield a large genomic deletion.

Rice LB, Carias LL, Marshall S, Rudin SD, Hutton-Thomas R.

J Bacteriol. 2005 Oct;187(19):6668-77.


Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium.

Rice LB, Carias LL, Hutton-Thomas R, Sifaoui F, Gutmann L, Rudin SD.

Antimicrob Agents Chemother. 2001 May;45(5):1480-6.


Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.

Lin S, Thomas M, Shlaes DM, Rudin SD, Knox JR, Anderson V, Bonomo RA.

Biochem J. 1998 Jul 15;333 ( Pt 2):395-400.


Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faecium.

Rice LB, Carias LL, Donskey CL, Rudin SD.

Antimicrob Agents Chemother. 1998 Apr;42(4):963-4.


Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations.

Bonomo RA, Knox JR, Rudin SD, Shlaes DM.

Antimicrob Agents Chemother. 1997 Sep;41(9):1940-3.


OHIO-1 beta-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime.

Bonomo RA, Rudin SD, Shlaes DM.

FEMS Microbiol Lett. 1997 Jul 15;152(2):275-8.


Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation.

Trojan J, Johnson TR, Rudin SD, Blossey BK, Kelley KM, Shevelev A, Abdul-Karim FW, Anthony DD, Tykocinski ML, Ilan J, et al.

Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6088-92.


Gene therapy of rat brain glioblastoma by an episome-based transcriptional cassette expressing antisense IGF-I cDNA.

Johnson TR, Trojan J, Anthony DD, Rudin SD, Tykocinski ML, Ilan J, Ilan J.

Indian J Biochem Biophys. 1994 Feb;31(1):1-13. No abstract available.


Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.

Trojan J, Johnson TR, Rudin SD, Ilan J, Tykocinski ML, Ilan J.

Science. 1993 Jan 1;259(5091):94-7.


Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

Trojan J, Blossey BK, Johnson TR, Rudin SD, Tykocinski M, Ilan J, Ilan J.

Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4874-8.


Transverse myelopathy: influence of body position as a cause.

Rudin SD, Goldfine LJ.

Arch Phys Med Rehabil. 1985 Apr;66(4):262-3.


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