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Items: 1 to 50 of 98

1.

Dupilumab improves lung function in patients with uncontrolled, moderate-to-severe asthma.

Castro M, Rabe KF, Corren J, Pavord ID, Katelaris CH, Tohda Y, Zhang B, Rice MS, Maroni J, Rowe P, Pirozzi G, Amin N, Ruddy M, Akinlade B, Graham NMH, Teper A.

ERJ Open Res. 2020 Jan 27;6(1). pii: 00204-2019. doi: 10.1183/23120541.00204-2019. eCollection 2020 Jan.

2.

Clinically Meaningful Responses to Dupilumab in Adolescents with Uncontrolled Moderate-to-Severe Atopic Dermatitis: Post-hoc Analyses from a Randomized Clinical Trial.

Paller AS, Bansal A, Simpson EL, Boguniewicz M, Blauvelt A, Siegfried EC, Guttman-Yassky E, Hultsch T, Chen Z, Mina-Osorio P, Lu Y, Rossi AB, He X, Kamal M, Graham NMH, Pirozzi G, Ruddy M, Eckert L, Gadkari A.

Am J Clin Dermatol. 2020 Feb;21(1):119-131. doi: 10.1007/s40257-019-00478-y.

3.

Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial.

Simpson EL, Paller AS, Siegfried EC, Boguniewicz M, Sher L, Gooderham MJ, Beck LA, Guttman-Yassky E, Pariser D, Blauvelt A, Weisman J, Lockshin B, Hultsch T, Zhang Q, Kamal MA, Davis JD, Akinlade B, Staudinger H, Hamilton JD, Graham NMH, Pirozzi G, Gadkari A, Eckert L, Stahl N, Yancopoulos GD, Ruddy M, Bansal A.

JAMA Dermatol. 2019 Nov 6. doi: 10.1001/jamadermatol.2019.3336. [Epub ahead of print]

4.

Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension.

Cork MJ, Thaçi D, Eichenfield LF, Arkwright PD, Hultsch T, Davis JD, Zhang Y, Zhu X, Chen Z, Li M, Ardeleanu M, Teper A, Akinlade B, Gadkari A, Eckert L, Kamal MA, Ruddy M, Graham NMH, Pirozzi G, Stahl N, DiCioccio AT, Bansal A.

Br J Dermatol. 2020 Jan;182(1):85-96. doi: 10.1111/bjd.18476. Epub 2019 Oct 8.

5.

Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies.

Jones R, Velasco MS, Harris LG, Morgan S, Temple M, Ruddy MC, Williams R, Perry MD, Hitchings M, Wilkinson TS, Humphrey T, Gilbert MTP, Davies AP.

Tuberculosis (Edinb). 2019 Dec;119:101865. doi: 10.1016/j.tube.2019.101865. Epub 2019 Sep 23.

PMID:
31563810
6.

Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.

Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, Mullol J, Greos LS, Bosso JV, Laidlaw TM, Cervin AU, Maspero JF, Hopkins C, Olze H, Canonica GW, Paggiaro P, Cho SH, Fokkens WJ, Fujieda S, Zhang M, Lu X, Fan C, Draikiwicz S, Kamat SA, Khan A, Pirozzi G, Patel N, Graham NMH, Ruddy M, Staudinger H, Weinreich D, Stahl N, Yancopoulos GD, Mannent LP.

Lancet. 2019 Nov 2;394(10209):1638-1650. doi: 10.1016/S0140-6736(19)31881-1. Epub 2019 Sep 19. Erratum in: Lancet. 2019 Nov 2;394(10209):1618.

PMID:
31543428
7.

Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma.

Corren J, Castro M, O'Riordan T, Hanania NA, Pavord ID, Quirce S, Chipps BE, Wenzel SE, Thangavelu K, Rice MS, Harel S, Jagerschmidt A, Khan AH, Kamat S, Maroni J, Rowe P, Lu Y, Amin N, Pirozzi G, Ruddy M, Graham NMH, Teper A.

J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526. doi: 10.1016/j.jaip.2019.08.050. Epub 2019 Sep 12.

8.
9.

Dupilumab Efficacy in Uncontrolled, Moderate-to-Severe Asthma with Self-Reported Chronic Rhinosinusitis.

Maspero JF, Katelaris CH, Busse WW, Castro M, Corren J, Chipps BE, Peters AT, Pavord ID, Ford LB, Sher L, Rabe KF, Rice MS, Rowe P, Lu Y, Harel S, Jagerschmidt A, Khan AH, Kamat S, Pirozzi G, Amin N, Ruddy M, Graham NMH, Mannent LP, Teper A.

J Allergy Clin Immunol Pract. 2020 Feb;8(2):527-539.e9. doi: 10.1016/j.jaip.2019.07.016. Epub 2019 Jul 24.

10.

Potentially Avoidable Hospital Readmissions in Patients With Advanced Cancer.

Johnson PC, Xiao Y, Wong RL, D'Arpino S, Moran SMC, Lage DE, Temel B, Ruddy M, Traeger LN, Greer JA, Hochberg EP, Temel JS, El-Jawahri A, Nipp RD.

J Oncol Pract. 2019 May;15(5):e420-e427. doi: 10.1200/JOP.18.00595. Epub 2019 Apr 4.

PMID:
30946642
11.

Phylogenetic Analysis of Mycobacterium tuberculosis Strains in Wales by Use of Core Genome Multilocus Sequence Typing To Analyze Whole-Genome Sequencing Data.

Jones RC, Harris LG, Morgan S, Ruddy MC, Perry M, Williams R, Humphrey T, Temple M, Davies AP.

J Clin Microbiol. 2019 May 24;57(6). pii: e02025-18. doi: 10.1128/JCM.02025-18. Print 2019 Jun.

12.

Pilot randomized trial of an electronic symptom monitoring intervention for hospitalized patients with cancer.

Nipp RD, El-Jawahri A, Ruddy M, Fuh C, Temel B, D'Arpino SM, Cashavelly BJ, Jackson VA, Ryan DP, Hochberg EP, Greer JA, Temel JS.

Ann Oncol. 2019 Feb 1;30(2):274-280. doi: 10.1093/annonc/mdy488.

13.

Pilot Randomized Trial of a Pharmacy Intervention for Older Adults with Cancer.

Nipp RD, Ruddy M, Fuh CX, Zangardi ML, Chio C, Kim EB, Li BKM, Long Y, Blouin GC, Lage D, Ryan DP, Greer JA, El-Jawahri A, Temel JS.

Oncologist. 2019 Feb;24(2):211-218. doi: 10.1634/theoncologist.2018-0408. Epub 2018 Oct 19.

14.

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.

Rabe KF, Nair P, Brusselle G, Maspero JF, Castro M, Sher L, Zhu H, Hamilton JD, Swanson BN, Khan A, Chao J, Staudinger H, Pirozzi G, Antoni C, Amin N, Ruddy M, Akinlade B, Graham NMH, Stahl N, Yancopoulos GD, Teper A.

N Engl J Med. 2018 Jun 28;378(26):2475-2485. doi: 10.1056/NEJMoa1804093. Epub 2018 May 21.

15.

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.

Castro M, Corren J, Pavord ID, Maspero J, Wenzel S, Rabe KF, Busse WW, Ford L, Sher L, FitzGerald JM, Katelaris C, Tohda Y, Zhang B, Staudinger H, Pirozzi G, Amin N, Ruddy M, Akinlade B, Khan A, Chao J, Martincova R, Graham NMH, Hamilton JD, Swanson BN, Stahl N, Yancopoulos GD, Teper A.

N Engl J Med. 2018 Jun 28;378(26):2486-2496. doi: 10.1056/NEJMoa1804092. Epub 2018 May 21.

16.

Dose-dependent quantitative effects of acute fructose administration on hepatic de novo lipogenesis in healthy humans.

Beysen C, Ruddy M, Stoch A, Mixson L, Rosko K, Riiff T, Turner SM, Hellerstein MK, Murphy EJ.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E126-E132. doi: 10.1152/ajpendo.00470.2017. Epub 2018 Mar 20.

17.

It Takes a Village to Move a Hospital: Simulation Improves Intensive Care Team Preparedness for a Move to a New Site.

Francoeur C, Shea S, Ruddy M, Fontela P, Bhanji F, Razack S, Gottesman R, Di Genova T.

Hosp Pediatr. 2018 Mar;8(3):148-156. doi: 10.1542/hpeds.2017-0112. Epub 2018 Feb 15.

18.

Preparation of morselised bone for impaction grafting using a blender method.

Ruddy M, FitzPatrick DP, Stanton KT.

J Mech Behav Biomed Mater. 2018 Feb;78:91-95. doi: 10.1016/j.jmbbm.2017.11.012. Epub 2017 Nov 9.

PMID:
29145011
19.

The use of hardened bone cement as an impaction grafting extender for revision hip arthroplasty.

Ruddy M, FitzPatrick DP, Stanton KT.

J Mech Behav Biomed Mater. 2018 Feb;78:82-90. doi: 10.1016/j.jmbbm.2017.11.002. Epub 2017 Nov 13.

PMID:
29145010
20.

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD.

Cell Metab. 2017 Sep 5;26(3):576. doi: 10.1016/j.cmet.2017.08.011. No abstract available.

21.

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD.

Cell Metab. 2017 Aug 1;26(2):394-406.e6. doi: 10.1016/j.cmet.2017.07.009. Erratum in: Cell Metab. 2017 Sep 5;26(3):576.

22.

Health-related Quality of Life and Functional Outcomes in 5-year Survivors After Pancreaticoduodenectomy.

Fong ZV, Alvino DM, Castillo CF, Nipp RD, Traeger LN, Ruddy M, Lubitz CC, Johnson CD, Chang DC, Warshaw AL, Lillemoe KD, Ferrone CR.

Ann Surg. 2017 Oct;266(4):685-692. doi: 10.1097/SLA.0000000000002380.

PMID:
28657944
23.

Nurses' perceptions of caring for parents of children with chronic medical complexity in the pediatric intensive care unit.

Denis-Larocque G, Williams K, St-Sauveur I, Ruddy M, Rennick J.

Intensive Crit Care Nurs. 2017 Dec;43:149-155. doi: 10.1016/j.iccn.2017.01.010. Epub 2017 May 20.

PMID:
28539204
24.

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.

Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler IC, Chapman SJ, Clayton A, Cullen M, Daniels T, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Humphrey H, Isalska B, Jensen-Fangel S, Jönsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O'Brien C, O'Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Floto RA.

Science. 2016 Nov 11;354(6313):751-757. doi: 10.1126/science.aaf8156.

25.

More About the Role of USMLE Step 1 Scores in Resident Selection.

Ruddy MP, Eubanks JE Jr, Farrell ME 2nd.

Acad Med. 2016 Nov;91(11):1468-1469. No abstract available.

PMID:
27779521
26.

The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1β), and complement.

Leaker BR, Malkov VA, Mogg R, Ruddy MK, Nicholson GC, Tan AJ, Tribouley C, Chen G, De Lepeleire I, Calder NA, Chung H, Lavender P, Carayannopoulos LN, Hansel TT.

Mucosal Immunol. 2017 Mar;10(2):408-420. doi: 10.1038/mi.2016.74. Epub 2016 Sep 28.

27.

Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test.

Zuiker RG, Tribouley C, Diamant Z, Boot JD, Cohen AF, Van Dyck K, De Lepeleire I, Rivas VM, Malkov VA, Burggraaf J, Ruddy MK.

Eur Clin Respir J. 2016 Jul 13;3:31324. doi: 10.3402/ecrj.v3.31324. eCollection 2016.

28.

The colonization history of British water vole (Arvicola amphibius (Linnaeus, 1758)): origins and development of the Celtic fringe.

Brace S, Ruddy M, Miller R, Schreve DC, Stewart JR, Barnes I.

Proc Biol Sci. 2016 Apr 27;283(1829). pii: 20160130. doi: 10.1098/rspb.2016.0130.

29.

Practice Transformation: Professional Development Is Personal.

Ruddy MP, Thomas-Hemak L, Meade L.

Acad Med. 2016 May;91(5):624-7. doi: 10.1097/ACM.0000000000001059.

PMID:
26717503
30.

Kinetics of TH2 biomarkers in sputum of asthmatics following inhaled allergen.

Zuiker RG, Ruddy MK, Morelli N, Mogg R, Rivas VM, van Dyck K, De Lepeleire I, Tanen MR, Boot JD, Kamerling IM, Diamant Z.

Eur Clin Respir J. 2015 May 26;2. doi: 10.3402/ecrj.v2.28319. eCollection 2015.

31.

Nurturing 21st century physician knowledge, skills and attitudes with medical home innovations: the Wright Center for Graduate Medical Education teaching health center curriculum experience.

Thomas-Hemak L, Palamaner Subash Shantha G, Gollamudi LR, Sheth J, Ebersole B, Gardner KJ, Nardella J, Ruddy MP, Meade L.

PeerJ. 2015 Feb 10;3:e766. doi: 10.7717/peerj.766. eCollection 2015.

32.

Potential for use of the Seegene Anyplex MTB/NTM real-time detection assay in a regional reference laboratory.

Perry MD, White PL, Ruddy M.

J Clin Microbiol. 2014 May;52(5):1708-10. doi: 10.1128/JCM.03585-13. Epub 2014 Feb 19.

33.

Gene expression analysis in serial liver fine needle aspirates.

Lejnine S, Marton MJ, Wang IM, Howell BJ, Webber AL, Maxwell JW, Shire N, Malkov V, Lunceford J, Zeremski M, Sun A, Ruddy M, Talal AH.

J Viral Hepat. 2015 Jan;22(1):64-76. doi: 10.1111/jvh.12213. Epub 2014 Jan 29.

34.

Hyperpolarized Helium-3 MRI of exercise-induced bronchoconstriction during challenge and therapy.

Kruger SJ, Niles DJ, Dardzinski B, Harman A, Jarjour NN, Ruddy M, Nagle SK, Francois CJ, Sorkness RL, Burton RM, Munoz del Rio A, Fain SB.

J Magn Reson Imaging. 2014 May;39(5):1230-7. doi: 10.1002/jmri.24272. Epub 2013 Sep 4.

35.

Exercise-induced bronchoconstriction: reproducibility of hyperpolarized 3He MR imaging.

Niles DJ, Kruger SJ, Dardzinski BJ, Harman A, Jarjour NN, Ruddy M, Nagle SK, François CJ, Fain SB.

Radiology. 2013 Feb;266(2):618-25. doi: 10.1148/radiol.12111973. Epub 2012 Nov 20.

36.

Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals.

Kauh E, Mixson L, Malice MP, Mesens S, Ramael S, Burke J, Reynders T, Van Dyck K, Beals C, Rosenberg E, Ruddy M.

Eur J Endocrinol. 2012 Mar;166(3):459-67. doi: 10.1530/EJE-11-0751. Epub 2011 Dec 17.

PMID:
22180452
37.

Evaluation of an experimental urodynamic platform to identify treatment effects: a randomized, placebo-controlled, crossover study in patients with overactive bladder.

Frenkl T, Railkar R, Shore N, Bailen J, Sutherland S, Burke J, Scott BB, Ruddy M, Beals C.

Neurourol Urodyn. 2012 Jan;31(1):69-74. doi: 10.1002/nau.21094. Epub 2011 Sep 8.

PMID:
21905086
38.

Short-term metabolic effects of prednisone administration in healthy subjects.

Kauh EA, Mixson LA, Shankar S, McCarthy J, Maridakis V, Morrow L, Heinemann L, Ruddy MK, Herman GA, Kelley DE, Hompesch M.

Diabetes Obes Metab. 2011 Nov;13(11):1001-7. doi: 10.1111/j.1463-1326.2011.01432.x.

PMID:
21635675
39.

Evaluation of early biomarkers of muscle anabolic response to testosterone.

Chen F, Lam R, Shaywitz D, Hendrickson RC, Opiteck GJ, Wishengrad D, Liaw A, Song Q, Stewart AJ, Cummings CE, Beals C, Yarasheski KE, Reicin A, Ruddy M, Hu X, Yates NA, Menetski J, Herman GA.

J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. Epub 2011 Feb 26.

40.

Investigating transmission of Mycobacterium bovis in the United Kingdom in 2005 to 2008.

Mandal S, Bradshaw L, Anderson LF, Brown T, Evans JT, Drobniewski F, Smith G, Magee JG, Barrett A, Blatchford O, Laurenson IF, Seagar AL, Ruddy M, White PL, Myers R, Hawkey P, Abubakar I.

J Clin Microbiol. 2011 May;49(5):1943-50. doi: 10.1128/JCM.02299-10. Epub 2011 Mar 23.

41.

An enhanced bunionectomy model as a potential tool for early decision-making in the development of new analgesics.

Wang H, Gargano C, Lukac S, Jackson A, Beals C, Smiley P, Drexel M, Ruddy M, Herman G, Johnson-Levonas AO, Medve R, Webster L, Reicin A.

Adv Ther. 2010 Dec;27(12):963-80. doi: 10.1007/s12325-010-0084-8. Epub 2010 Nov 3.

PMID:
21052881
42.

Mycobacterium lentiflavum--a cause of infections in the head and neck: case report and literature review.

Philip J, Bhatia S, Sugar A, Berry N, Ruddy M.

J Oral Maxillofac Surg. 2011 Apr;69(4):1114-6. doi: 10.1016/j.joms.2010.01.020. Epub 2010 Jul 31. Review. No abstract available.

PMID:
20674119
43.

Unmet needs in managing hypertension: potential role of direct renin inhibition.

Ruddy MC.

Postgrad Med. 2010 May;122(3):203-12. doi: 10.3810/pgm.2010.05.2159. Review.

PMID:
20463431
44.

B and T lymphocyte attenuator tempers early infection immunity.

Sun Y, Brown NK, Ruddy MJ, Miller ML, Lee Y, Wang Y, Murphy KM, Pfeffer K, Chen L, Kaye J, Fu YX.

J Immunol. 2009 Aug 1;183(3):1946-51. doi: 10.4049/jimmunol.0801866. Epub 2009 Jul 8.

45.

Extensively drug-resistant tuberculosis in the UK: 1995 to 2007.

Abubakar I, Moore J, Drobniewski F, Kruijshaar M, Brown T, Yates M, Anderson C, Smith EG, Magee J, Lipman M, McMenamin J, Ruddy M, Watson JM.

Thorax. 2009 Jun;64(6):512-5. doi: 10.1136/thx.2008.108712. Epub 2009 Mar 23.

PMID:
19318348
46.

T cell-derived lymphotoxin regulates liver regeneration.

Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, Papa S, Franzoso G, Nedospasov SA, Fu YX, Anders RA.

Gastroenterology. 2009 Feb;136(2):694-704.e4. doi: 10.1053/j.gastro.2008.09.015. Epub 2008 Sep 18.

47.

Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides.

Sepp-Lorenzino L, Ruddy M.

Clin Pharmacol Ther. 2008 Nov;84(5):628-32. doi: 10.1038/clpt.2008.174. Epub 2008 Sep 17. No abstract available.

PMID:
18800034
48.

The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss.

Yu JJ, Ruddy MJ, Conti HR, Boonanantanasarn K, Gaffen SL.

Infect Immun. 2008 Sep;76(9):4206-13. doi: 10.1128/IAI.01209-07. Epub 2008 Jun 30.

49.

Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects.

Mistry GC, Bergman AJ, Zheng W, Hreniuk D, Zinny MA, Gottesdiener KM, Wagner JA, Herman GA, Ruddy M.

Br J Clin Pharmacol. 2008 Jul;66(1):36-42. doi: 10.1111/j.1365-2125.2008.03148.x. Epub 2008 May 22.

50.

An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals.

Yu JJ, Ruddy MJ, Wong GC, Sfintescu C, Baker PJ, Smith JB, Evans RT, Gaffen SL.

Blood. 2007 May 1;109(9):3794-802. Epub 2007 Jan 3.

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