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Items: 1 to 50 of 85

1.

The pro-oncogenic adaptor CIN85 acts as an inhibitory binding partner of hypoxia-inducible factor prolyl hydroxylase 2.

Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T.

Cancer Res. 2019 May 29. pii: canres.3852.2018. doi: 10.1158/0008-5472.CAN-18-3852. [Epub ahead of print]

PMID:
31142511
2.

Molecular analysis of human Ero1 reveals novel regulatory mechanisms for oxidative protein folding.

Moilanen A, Korhonen K, Saaranen MJ, Ruddock LW.

Life Sci Alliance. 2018 Jun 26;1(3):e201800090. doi: 10.26508/lsa.201800090. eCollection 2018 Jun.

3.

The dimeric structure of wild-type human glycosyltransferase B4GalT1.

Harrus D, Khoder-Agha F, Peltoniemi M, Hassinen A, Ruddock L, Kellokumpu S, Glumoff T.

PLoS One. 2018 Oct 23;13(10):e0205571. doi: 10.1371/journal.pone.0205571. eCollection 2018.

4.

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease.

Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R.

Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298.

PMID:
30239752
5.

Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease.

Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW.

PLoS One. 2018 Aug 23;13(8):e0202391. doi: 10.1371/journal.pone.0202391. eCollection 2018.

6.

Crystal structure of human anterior gradient protein 3.

Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW.

Acta Crystallogr F Struct Biol Commun. 2018 Jul 1;74(Pt 7):425-430. doi: 10.1107/S2053230X18009093. Epub 2018 Jun 26.

PMID:
29969106
7.

Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.

Biterova E, Esmaeeli M, Alanen HI, Saaranen M, Ruddock LW.

Sci Rep. 2018 Apr 30;8(1):6752. doi: 10.1038/s41598-018-25237-7.

8.

NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease.

Uusimaa J, Kaarteenaho R, Paakkola T, Tuominen H, Karjalainen MK, Nadaf J, Varilo T, Uusi-Mäkelä M, Suo-Palosaari M, Pietilä I, Hiltunen AE, Ruddock L, Alanen H, Biterova E, Miinalainen I, Salminen A, Soininen R, Manninen A, Sormunen R, Kaakinen M, Vuolteenaho R, Herva R, Vieira P, Dunder T, Kokkonen H, Moilanen JS, Rantala H, Nogee LM, Majewski J, Rämet M, Hallman M, Hinttala R.

Acta Neuropathol. 2018 May;135(5):727-742. doi: 10.1007/s00401-018-1817-z. Epub 2018 Feb 8.

PMID:
29423877
9.

Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv.

Gąciarz A, Ruddock LW.

PLoS One. 2017 Dec 18;12(12):e0189964. doi: 10.1371/journal.pone.0189964. eCollection 2017.

10.

Efficient soluble expression of disulfide bonded proteins in the cytoplasm of Escherichia coli in fed-batch fermentations on chemically defined minimal media.

Gąciarz A, Khatri NK, Velez-Suberbie ML, Saaranen MJ, Uchida Y, Keshavarz-Moore E, Ruddock LW.

Microb Cell Fact. 2017 Jun 15;16(1):108. doi: 10.1186/s12934-017-0721-x.

11.

TUFT1, a novel candidate gene for metatarsophalangeal osteoarthritis, plays a role in chondrogenesis on a calcium-related pathway.

Sliz E, Taipale M, Welling M, Skarp S, Alaraudanjoki V, Ignatius J, Ruddock L, Nissi R, Männikkö M.

PLoS One. 2017 Apr 14;12(4):e0175474. doi: 10.1371/journal.pone.0175474. eCollection 2017.

12.

Identification of antibacterial peptides from endophytic microbiome.

Tejesvi MV, Picart P, Kajula M, Hautajärvi H, Ruddock L, Kristensen HH, Tossi A, Sahl HG, Ek S, Mattila S, Pirttilä AM.

Appl Microbiol Biotechnol. 2016 Nov;100(21):9283-9293. Epub 2016 Aug 19.

PMID:
27541748
13.

ALS-linked protein disulfide isomerase variants cause motor dysfunction.

Woehlbier U, Colombo A, Saaranen MJ, Pérez V, Ojeda J, Bustos FJ, Andreu CI, Torres M, Valenzuela V, Medinas DB, Rozas P, Vidal RL, Lopez-Gonzalez R, Salameh J, Fernandez-Collemann S, Muñoz N, Matus S, Armisen R, Sagredo A, Palma K, Irrazabal T, Almeida S, Gonzalez-Perez P, Campero M, Gao FB, Henny P, van Zundert B, Ruddock LW, Concha ML, Henriquez JP, Brown RH, Hetz C.

EMBO J. 2016 Apr 15;35(8):845-65. doi: 10.15252/embj.201592224. Epub 2016 Feb 11.

14.

Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli.

Gaciarz A, Veijola J, Uchida Y, Saaranen MJ, Wang C, Hörkkö S, Ruddock LW.

Microb Cell Fact. 2016 Jan 25;15:22. doi: 10.1186/s12934-016-0419-5.

15.

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides.

Pisoni GB, Ruddock LW, Bulleid N, Molinari M.

Mol Biol Cell. 2015 Oct 1;26(19):3390-400. doi: 10.1091/mbc.E15-05-0321. Epub 2015 Aug 5.

16.

Efficient export of human growth hormone, interferon α2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation.

Alanen HI, Walker KL, Lourdes Velez Suberbie M, Matos CF, Bönisch S, Freedman RB, Keshavarz-Moore E, Ruddock LW, Robinson C.

Biochim Biophys Acta. 2015 Mar;1853(3):756-63. doi: 10.1016/j.bbamcr.2014.12.027. Epub 2014 Dec 29.

17.

Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway.

Irvine AG, Wallis AK, Sanghera N, Rowe ML, Ruddock LW, Howard MJ, Williamson RA, Blindauer CA, Freedman RB.

PLoS One. 2014 Jan 20;9(1):e82511. doi: 10.1371/journal.pone.0082511. eCollection 2014.

18.

Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway in Escherichia coli CyDisCo strains.

Matos CF, Robinson C, Alanen HI, Prus P, Uchida Y, Ruddock LW, Freedman RB, Keshavarz-Moore E.

Biotechnol Prog. 2014 Mar-Apr;30(2):281-90. doi: 10.1002/btpr.1858. Epub 2014 Jan 22.

PMID:
24376243
19.

Topological plasticity of enzymes involved in disulfide bond formation allows catalysis in either the periplasm or the cytoplasm.

Hatahet F, Ruddock LW.

J Mol Biol. 2013 Sep 23;425(18):3268-76. doi: 10.1016/j.jmb.2013.04.034. Epub 2013 Jun 28.

20.

Disulfide bond formation in the cytoplasm.

Saaranen MJ, Ruddock LW.

Antioxid Redox Signal. 2013 Jul 1;19(1):46-53. doi: 10.1089/ars.2012.4868. Epub 2012 Oct 2. Review.

PMID:
22870953
21.

Low-molecular-weight oxidants involved in disulfide bond formation.

Ruddock LW.

Antioxid Redox Signal. 2012 May 15;16(10):1129-38. doi: 10.1089/ars.2011.4481. Epub 2012 Mar 2. Review.

PMID:
22206352
22.

Beyond KDEL: the role of positions 5 and 6 in determining ER localization.

Alanen HI, Raykhel IB, Luukas MJ, Salo KE, Ruddock LW.

J Mol Biol. 2011 Jun 10;409(3):291-7. doi: 10.1016/j.jmb.2011.03.070. Epub 2011 Apr 6.

PMID:
21477593
23.

Reexamination of the role of interplay between glutathione and protein disulfide isomerase.

Lappi AK, Ruddock LW.

J Mol Biol. 2011 Jun 3;409(2):238-49. doi: 10.1016/j.jmb.2011.03.024. Epub 2011 Mar 22.

PMID:
21435343
24.

Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation.

Nguyen VD, Saaranen MJ, Karala AR, Lappi AK, Wang L, Raykhel IB, Alanen HI, Salo KE, Wang CC, Ruddock LW.

J Mol Biol. 2011 Feb 25;406(3):503-15. doi: 10.1016/j.jmb.2010.12.039. Epub 2011 Jan 5.

PMID:
21215271
25.

Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E.coli.

Nguyen VD, Hatahet F, Salo KE, Enlund E, Zhang C, Ruddock LW.

Microb Cell Fact. 2011 Jan 7;10:1. doi: 10.1186/1475-2859-10-1.

26.

Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm of E. coli.

Hatahet F, Nguyen VD, Salo KE, Ruddock LW.

Microb Cell Fact. 2010 Sep 13;9:67. doi: 10.1186/1475-2859-9-67.

27.

Bacitracin is not a specific inhibitor of protein disulfide isomerase.

Karala AR, Ruddock LW.

FEBS J. 2010 Jun;277(11):2454-62. doi: 10.1111/j.1742-4658.2010.07660.x. Epub 2010 Apr 30.

28.

Modulation of an active-site cysteine pKa allows PDI to act as a catalyst of both disulfide bond formation and isomerization.

Karala AR, Lappi AK, Ruddock LW.

J Mol Biol. 2010 Mar 5;396(4):883-92. doi: 10.1016/j.jmb.2009.12.014. Epub 2009 Dec 21.

PMID:
20026073
29.

The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization.

Wallis AK, Sidhu A, Byrne LJ, Howard MJ, Ruddock LW, Williamson RA, Freedman RB.

Protein Sci. 2009 Dec;18(12):2569-77. doi: 10.1002/pro.270.

30.

The role of dehydroascorbate in disulfide bond formation.

Saaranen MJ, Karala AR, Lappi AK, Ruddock LW.

Antioxid Redox Signal. 2010 Jan;12(1):15-25. doi: 10.1089/ars.2009.2674.

PMID:
19686035
31.

Mapping of the ligand-binding site on the b' domain of human PDI: interaction with peptide ligands and the x-linker region.

Byrne LJ, Sidhu A, Wallis AK, Ruddock LW, Freedman RB, Howard MJ, Williamson RA.

Biochem J. 2009 Sep 25;423(2):209-17. doi: 10.1042/BJ20090565.

PMID:
19604149
32.

Modulating proteostasis: peptidomimetic inhibitors and activators of protein folding.

Hatahet F, Ruddock LW.

Curr Pharm Des. 2009;15(21):2488-507. Review.

PMID:
19601846
33.

Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation.

Hatahet F, Ruddock LW.

Antioxid Redox Signal. 2009 Nov;11(11):2807-50. doi: 10.1089/ARS.2009.2466. Review. Erratum in: Antioxid Redox Signal. 2010 Feb;12(2):322. Ann, Kawngseog [removed]; Benham, Adam [removed]; Craik, David [removed];Ellgaard,Lars [removed]; Ferrari, David [removed]; Ventura, Salvador [removed].

PMID:
19476414
34.

The C-terminal active site cysteine of Escherichia coli glutaredoxin 1 determines the glutathione specificity of the second step of peptide deglutathionylation.

Saaranen MJ, Salo KE, Latva-Ranta MK, Kinnula VL, Ruddock LW.

Antioxid Redox Signal. 2009 Aug;11(8):1819-28. doi: 10.1089/ARS.2008.2387.

PMID:
19361272
35.

Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase .

Rowe ML, Ruddock LW, Kelly G, Schmidt JM, Williamson RA, Howard MJ.

Biochemistry. 2009 Jun 2;48(21):4596-606. doi: 10.1021/bi9003342.

PMID:
19361226
36.

Efficient peroxide-mediated oxidative refolding of a protein at physiological pH and implications for oxidative folding in the endoplasmic reticulum.

Karala AR, Lappi AK, Saaranen MJ, Ruddock LW.

Antioxid Redox Signal. 2009 May;11(5):963-70. doi: 10.1089/ARS.2008.2326.

PMID:
19117384
37.

Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain.

Nguyen VD, Wallis K, Howard MJ, Haapalainen AM, Salo KE, Saaranen MJ, Sidhu A, Wierenga RK, Freedman RB, Ruddock LW, Williamson RA.

J Mol Biol. 2008 Nov 28;383(5):1144-55. doi: 10.1016/j.jmb.2008.08.085. Epub 2008 Sep 9.

PMID:
18801374
38.

Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation.

Reinhardt C, von Brühl ML, Manukyan D, Grahl L, Lorenz M, Altmann B, Dlugai S, Hess S, Konrad I, Orschiedt L, Mackman N, Ruddock L, Massberg S, Engelmann B.

J Clin Invest. 2008 Mar;118(3):1110-22. doi: 10.1172/JCI32376.

39.

A molecular specificity code for the three mammalian KDEL receptors.

Raykhel I, Alanen H, Salo K, Jurvansuu J, Nguyen VD, Latva-Ranta M, Ruddock L.

J Cell Biol. 2007 Dec 17;179(6):1193-204. Erratum in: J Cell Biol. 2008 Feb 11;180(3):645.

40.

Substrate recognition by the protein disulfide isomerases.

Hatahet F, Ruddock LW.

FEBS J. 2007 Oct;274(20):5223-34. Epub 2007 Sep 24. Review.

42.

Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients.

Harju TH, Peltoniemi MJ, Rytilä PH, Soini Y, Salmenkivi KM, Board PG, Ruddock LW, Kinnula VL.

Respir Res. 2007 Jul 6;8:48.

43.

A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.

van Lith M, Karala AR, Bown D, Gatehouse JA, Ruddock LW, Saunders PT, Benham AM.

Mol Biol Cell. 2007 Aug;18(8):2795-804. Epub 2007 May 16.

44.

Does s-methyl methanethiosulfonate trap the thiol-disulfide state of proteins?

Karala AR, Ruddock LW.

Antioxid Redox Signal. 2007 Apr;9(4):527-31.

PMID:
17280493
45.

N-glycan processing in ER quality control.

Ruddock LW, Molinari M.

J Cell Sci. 2006 Nov 1;119(Pt 21):4373-80. Review.

46.

Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease.

Peltoniemi MJ, Rytilä PH, Harju TH, Soini YM, Salmenkivi KM, Ruddock LW, Kinnula VL.

Respir Res. 2006 Oct 25;7:133.

47.

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

Olivari S, Cali T, Salo KE, Paganetti P, Ruddock LW, Molinari M.

Biochem Biophys Res Commun. 2006 Nov 3;349(4):1278-84. Epub 2006 Sep 12.

PMID:
16987498
48.
49.

ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.

Alanen HI, Williamson RA, Howard MJ, Hatahet FS, Salo KE, Kauppila A, Kellokumpu S, Ruddock LW.

J Biol Chem. 2006 Nov 3;281(44):33727-38. Epub 2006 Aug 28.

50.

Gaining access to ERp57 function.

Ruddock LW.

Structure. 2006 Aug;14(8):1209-10. No abstract available.

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