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Items: 1 to 20 of 88

1.

Applications of catalyzed cytoplasmic disulfide bond formation.

Saaranen MJ, Ruddock LW.

Biochem Soc Trans. 2019 Oct 31;47(5):1223-1231. doi: 10.1042/BST20190088.

PMID:
31671179
2.

Efficient production of wild-type lipase B from Candida antarctica in the cytoplasm of Escherichia coli.

Van Tassel L, Moilanen A, Ruddock LW.

Protein Expr Purif. 2020 Jan;165:105498. doi: 10.1016/j.pep.2019.105498. Epub 2019 Sep 12.

PMID:
31521797
3.

The crystal structure of human microsomal triglyceride transfer protein.

Biterova EI, Isupov MN, Keegan RM, Lebedev AA, Sohail AA, Liaqat I, Alanen HI, Ruddock LW.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17251-17260. doi: 10.1073/pnas.1903029116. Epub 2019 Aug 8.

4.

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T.

Cancer Res. 2019 Aug 15;79(16):4042-4056. doi: 10.1158/0008-5472.CAN-18-3852. Epub 2019 May 29.

PMID:
31142511
5.

Molecular analysis of human Ero1 reveals novel regulatory mechanisms for oxidative protein folding.

Moilanen A, Korhonen K, Saaranen MJ, Ruddock LW.

Life Sci Alliance. 2018 Jun 26;1(3):e201800090. doi: 10.26508/lsa.201800090. eCollection 2018 Jun.

6.

The dimeric structure of wild-type human glycosyltransferase B4GalT1.

Harrus D, Khoder-Agha F, Peltoniemi M, Hassinen A, Ruddock L, Kellokumpu S, Glumoff T.

PLoS One. 2018 Oct 23;13(10):e0205571. doi: 10.1371/journal.pone.0205571. eCollection 2018.

7.

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease.

Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R.

Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298.

PMID:
30239752
8.

Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease.

Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW.

PLoS One. 2018 Aug 23;13(8):e0202391. doi: 10.1371/journal.pone.0202391. eCollection 2018.

9.

Crystal structure of human anterior gradient protein 3.

Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW.

Acta Crystallogr F Struct Biol Commun. 2018 Jul 1;74(Pt 7):425-430. doi: 10.1107/S2053230X18009093. Epub 2018 Jun 26.

PMID:
29969106
10.

Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.

Biterova E, Esmaeeli M, Alanen HI, Saaranen M, Ruddock LW.

Sci Rep. 2018 Apr 30;8(1):6752. doi: 10.1038/s41598-018-25237-7.

11.

NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease.

Uusimaa J, Kaarteenaho R, Paakkola T, Tuominen H, Karjalainen MK, Nadaf J, Varilo T, Uusi-Mäkelä M, Suo-Palosaari M, Pietilä I, Hiltunen AE, Ruddock L, Alanen H, Biterova E, Miinalainen I, Salminen A, Soininen R, Manninen A, Sormunen R, Kaakinen M, Vuolteenaho R, Herva R, Vieira P, Dunder T, Kokkonen H, Moilanen JS, Rantala H, Nogee LM, Majewski J, Rämet M, Hallman M, Hinttala R.

Acta Neuropathol. 2018 May;135(5):727-742. doi: 10.1007/s00401-018-1817-z. Epub 2018 Feb 8.

PMID:
29423877
12.

Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv.

Gąciarz A, Ruddock LW.

PLoS One. 2017 Dec 18;12(12):e0189964. doi: 10.1371/journal.pone.0189964. eCollection 2017.

13.

Efficient soluble expression of disulfide bonded proteins in the cytoplasm of Escherichia coli in fed-batch fermentations on chemically defined minimal media.

Gąciarz A, Khatri NK, Velez-Suberbie ML, Saaranen MJ, Uchida Y, Keshavarz-Moore E, Ruddock LW.

Microb Cell Fact. 2017 Jun 15;16(1):108. doi: 10.1186/s12934-017-0721-x.

14.

TUFT1, a novel candidate gene for metatarsophalangeal osteoarthritis, plays a role in chondrogenesis on a calcium-related pathway.

Sliz E, Taipale M, Welling M, Skarp S, Alaraudanjoki V, Ignatius J, Ruddock L, Nissi R, Männikkö M.

PLoS One. 2017 Apr 14;12(4):e0175474. doi: 10.1371/journal.pone.0175474. eCollection 2017.

15.

Identification of antibacterial peptides from endophytic microbiome.

Tejesvi MV, Picart P, Kajula M, Hautajärvi H, Ruddock L, Kristensen HH, Tossi A, Sahl HG, Ek S, Mattila S, Pirttilä AM.

Appl Microbiol Biotechnol. 2016 Nov;100(21):9283-9293. Epub 2016 Aug 19.

PMID:
27541748
16.

ALS-linked protein disulfide isomerase variants cause motor dysfunction.

Woehlbier U, Colombo A, Saaranen MJ, Pérez V, Ojeda J, Bustos FJ, Andreu CI, Torres M, Valenzuela V, Medinas DB, Rozas P, Vidal RL, Lopez-Gonzalez R, Salameh J, Fernandez-Collemann S, Muñoz N, Matus S, Armisen R, Sagredo A, Palma K, Irrazabal T, Almeida S, Gonzalez-Perez P, Campero M, Gao FB, Henny P, van Zundert B, Ruddock LW, Concha ML, Henriquez JP, Brown RH, Hetz C.

EMBO J. 2016 Apr 15;35(8):845-65. doi: 10.15252/embj.201592224. Epub 2016 Feb 11.

17.

Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli.

Gaciarz A, Veijola J, Uchida Y, Saaranen MJ, Wang C, Hörkkö S, Ruddock LW.

Microb Cell Fact. 2016 Jan 25;15:22. doi: 10.1186/s12934-016-0419-5.

18.

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides.

Pisoni GB, Ruddock LW, Bulleid N, Molinari M.

Mol Biol Cell. 2015 Oct 1;26(19):3390-400. doi: 10.1091/mbc.E15-05-0321. Epub 2015 Aug 5.

19.

Efficient export of human growth hormone, interferon α2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation.

Alanen HI, Walker KL, Lourdes Velez Suberbie M, Matos CF, Bönisch S, Freedman RB, Keshavarz-Moore E, Ruddock LW, Robinson C.

Biochim Biophys Acta. 2015 Mar;1853(3):756-63. doi: 10.1016/j.bbamcr.2014.12.027. Epub 2014 Dec 29.

20.

Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway.

Irvine AG, Wallis AK, Sanghera N, Rowe ML, Ruddock LW, Howard MJ, Williamson RA, Blindauer CA, Freedman RB.

PLoS One. 2014 Jan 20;9(1):e82511. doi: 10.1371/journal.pone.0082511. eCollection 2014.

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