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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.

Rudd CE, Chanthong K, Taylor A.

Cell Rep. 2020 Feb 18;30(7):2075-2082.e4. doi: 10.1016/j.celrep.2020.01.076.


B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.

Rieder SA, Wang J, White N, Qadri A, Menard C, Stephens G, Karnell JL, Rudd CE, Kolbeck R.

Cell Mol Immunol. 2020 Jan 31. doi: 10.1038/s41423-020-0361-7. [Epub ahead of print]


A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade.

Rudd CE.

Sci Immunol. 2020 Jan 3;5(43). pii: eaaz8128. doi: 10.1126/sciimmunol.aaz8128. Review.


Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells.

Xiong Y, Yi Y, Wang Y, Yang N, Rudd CE, Liu H.

J Immunol. 2019 Dec 1;203(11):3023-3036. doi: 10.4049/jimmunol.1900556. Epub 2019 Oct 30.


GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.

Thaker YR, Raab M, Strebhardt K, Rudd CE.

Nat Commun. 2019 Oct 22;10(1):4804. doi: 10.1038/s41467-019-12544-4.


Advances in T-cell co-receptor biology and cancer immunotherapy.

Rudd CE.

Semin Immunol. 2019 Apr;42:101281. doi: 10.1016/j.smim.2019.101281. No abstract available.


Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications.

Krueger J, Rudd CE, Taylor A.

Semin Immunol. 2019 Apr;42:101295. doi: 10.1016/j.smim.2019.101295. Review.


Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy.

Taylor A, Rudd CE.

Adv Exp Med Biol. 2019;1164:225-233. doi: 10.1007/978-3-030-22254-3_17. Review.


Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.

Raab M, Strebhardt K, Rudd CE.

Sci Rep. 2019 Jul 18;9(1):10462. doi: 10.1038/s41598-019-45627-9.


Commentary: Small Molecule Inhibition of PD-1 Transcription is an Effective Alternative to Antibody Blockade in Cancer Therapy.

Taylor A, Rudd CE.

J Immunol Sci. 2019 May 7;3(1):9-12. doi: 10.29245/2578-3009/2019/1.1167. No abstract available.


CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy.

Brunner-Weinzierl MC, Rudd CE.

Front Immunol. 2018 Nov 27;9:2737. doi: 10.3389/fimmu.2018.02737. eCollection 2018. Review.


Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region.

Raab M, Strebhardt K, Rudd CE.

BMC Res Notes. 2018 Dec 6;11(1):869. doi: 10.1186/s13104-018-3976-3.


Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy.

Taylor A, Rothstein D, Rudd CE.

Cancer Res. 2018 Feb 1;78(3):706-717. doi: 10.1158/0008-5472.CAN-17-0491. Epub 2017 Oct 20.


LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

Raab M, Lu Y, Kohler K, Smith X, Strebhardt K, Rudd CE.

Nat Commun. 2017 Jul 12;8:16001. doi: 10.1038/ncomms16001.


Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells.

Krueger J, Rudd CE.

Immunity. 2017 Apr 18;46(4):529-531. doi: 10.1016/j.immuni.2017.04.003.


Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.

Thaker YR, Recino A, Raab M, Jabeen A, Wallberg M, Fernandez N, Rudd CE.

J Biol Chem. 2017 Apr 14;292(15):6281-6290. doi: 10.1074/jbc.M116.759555. Epub 2017 Feb 10.


CD28 family of receptors inter-connect in the regulation of T-cells.

Krueger J, Jules F, Rieder SA, Rudd CE.

Receptors Clin Investig. 2017;4. pii: e1581. Epub 2017 Sep 25.


SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells.

Sauer MG, Herbst J, Diekmann U, Rudd CE, Kardinal C.

Mol Cell Biol. 2016 Nov 28;36(24):3113-3127. Print 2016 Dec 15.


CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells.

Zhang Q, Dai H, Yatim KM, Abou-Daya K, Williams AL, Oberbarnscheidt MH, Camirand G, Rudd CE, Lakkis FG.

J Immunol. 2016 Aug 15;197(4):1471-6. doi: 10.4049/jimmunol.1600832. Epub 2016 Jun 29.


T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice.

Smith X, Taylor A, Rudd CE.

Immunol Lett. 2016 Aug;176:122-7. doi: 10.1016/j.imlet.2016.04.007. Epub 2016 May 12.


Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.


Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1.

Lim D, Lu Y, Rudd CE.

Immunol Lett. 2016 Apr;172:40-6. doi: 10.1016/j.imlet.2016.02.004. Epub 2016 Feb 19.


Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.

Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga EI, Rudd CE.

Immunity. 2016 Feb 16;44(2):274-86. doi: 10.1016/j.immuni.2016.01.018.


Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.

Lim HS, Cordoba SP, Dushek O, Goyette J, Taylor A, Rudd CE, van der Merwe PA.

J Immunol. 2015 Dec 1;195(11):5432-9. doi: 10.4049/jimmunol.1500707. Epub 2015 Oct 23.


The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE.

Mol Cell. 2015 Sep 3;59(5):840-9. doi: 10.1016/j.molcel.2015.07.015. Epub 2015 Aug 27.


ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.

Li C, Li W, Xiao J, Jiao S, Teng F, Xue S, Zhang C, Sheng C, Leng Q, Rudd CE, Wei B, Wang H.

EMBO Mol Med. 2015 Jun;7(6):754-69. doi: 10.15252/emmm.201404578.


Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.

Schneider H, Rudd CE.

Front Immunol. 2014 Dec 4;5:619. doi: 10.3389/fimmu.2014.00619. eCollection 2014. Review.


TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.

Thaker YR, Schneider H, Rudd CE.

Immunol Lett. 2015 Jan;163(1):113-9. doi: 10.1016/j.imlet.2014.10.020. Epub 2014 Oct 23.


CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Erratum in: Nature. 2016 Aug 18;536(7616):359.


CD45 ligation expands Tregs by promoting interactions with DCs.

Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM.

J Clin Invest. 2014 Oct;124(10):4603-13. doi: 10.1172/JCI74087. Epub 2014 Sep 9.


Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.

Banton MC, Inder KL, Valk E, Rudd CE, Schneider H.

Mol Cell Biol. 2014 Apr;34(8):1486-99. doi: 10.1128/MCB.01331-13. Epub 2014 Feb 10.


Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors.

Wei B, Han L, Abbink TE, Groppelli E, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H, Rudd CE.

Retrovirology. 2013 Sep 18;10:101. doi: 10.1186/1742-4690-10-101.


SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.

Liu H, Thaker YR, Stagg L, Schneider H, Ladbury JE, Rudd CE.

J Biol Chem. 2013 Oct 11;288(41):29539-49. doi: 10.1074/jbc.M112.424846. Epub 2013 Aug 9.


The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76.

Smith X, Schneider H, Köhler K, Liu H, Lu Y, Rudd CE.

Sci Signal. 2013 Jul 30;6(286):ra65. doi: 10.1126/scisignal.2004018.


Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.

Lu Y, Schneider H, Rudd CE.

Blood. 2012 Nov 29;120(23):4560-70. doi: 10.1182/blood-2012-04-421420. Epub 2012 Oct 9.


A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).

Jarvis GE, Bihan D, Hamaia S, Pugh N, Ghevaert CJ, Pearce AC, Hughes CE, Watson SP, Ware J, Rudd CE, Farndale RW.

J Thromb Haemost. 2012 Feb;10(2):268-77. doi: 10.1111/j.1538-7836.2011.04567.x.


Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.

Gibbons DL, Abeler-Dörner L, Raine T, Hwang IY, Jandke A, Wencker M, Deban L, Rudd CE, Irving PM, Kehrl JH, Hayday AC.

J Immunol. 2011 Sep 1;187(5):2067-71. doi: 10.4049/jimmunol.1100833. Epub 2011 Jul 27.


SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.

Raab M, Smith X, Matthess Y, Strebhardt K, Rudd CE.

J Biol Chem. 2011 Aug 26;286(34):29663-70. doi: 10.1074/jbc.M111.222661. Epub 2011 Jun 13.


CD28 co-signaling in the adaptive immune response.

Riha P, Rudd CE.

Self Nonself. 2010 Jul;1(3):231-240. Epub 2010 Jul 12.


Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988.

Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF.

J Immunol. 2010 Sep 1;185(5):2645-9. No abstract available.


SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.

Liu H, Purbhoo MA, Davis DM, Rudd CE.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10166-71. doi: 10.1073/pnas.0909112107. Epub 2010 May 13.


Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse.

Purbhoo MA, Liu H, Oddos S, Owen DM, Neil MA, Pageon SV, French PM, Rudd CE, Davis DM.

Sci Signal. 2010 May 11;3(121):ra36. doi: 10.1126/scisignal.2000645.


T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, Ladbury JE, Rudd CE.

Immunity. 2010 Apr 23;32(4):541-56. doi: 10.1016/j.immuni.2010.03.007. Epub 2010 Mar 25.


T-cell signaling and immunopathologies.

Rudd CE.

Semin Immunopathol. 2010 Jun;32(2):91-4. doi: 10.1007/s00281-010-0203-2. No abstract available.


Immunopathologies linked to integrin signalling.

Wang H, Lim D, Rudd CE.

Semin Immunopathol. 2010 Jun;32(2):173-82. doi: 10.1007/s00281-010-0202-3. Epub 2010 Mar 10. Review.


SKAP1 is dispensable for chemokine-induced migration of primary T-cells.

Wang H, Lu Y, Rudd CE.

Immunol Lett. 2010 Feb 16;128(2):148-53. doi: 10.1016/j.imlet.2009.10.010. Epub 2009 Oct 31.


SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

Wang H, Wei B, Bismuth G, Rudd CE.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12436-41. doi: 10.1073/pnas.0900510106. Epub 2009 Jul 15.


CD28 and CTLA-4 coreceptor expression and signal transduction.

Rudd CE, Taylor A, Schneider H.

Immunol Rev. 2009 May;229(1):12-26. doi: 10.1111/j.1600-065X.2009.00770.x. Review.


CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets.

Rudd CE.

Eur J Immunol. 2009 Mar;39(3):687-90. doi: 10.1002/eji.200939261.

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